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VIDEO: Gene test guides need for sentinel node biopsy in elderly melanoma patients
SAN DIEGO – The results of a gene expression test, along with tumor thickness and patient age, can guide the need for sentinel lymph node biopsy, based on results from more than1,400 consecutively tested patients from 26 U.S. surgical oncology, medical oncology and dermatologic practices.
The findings, presented by John Vetto, MD, at the annual meeting of the American Academy of Dermatology, indicate the DecisionDx test correctly identified patients aged 65 and older with T1-T2 tumors whose risk of sentinel node metastasis was lower than 5%. The most recent melanoma guidelines from the National Comprehensive Cancer Network recommend that clinicians “discuss and offer” sentinel node biopsy if a patient has a greater than 10% likelihood of a positive node. If the likelihood is 5%-10%, the recommendation is to “discuss and consider” the procedure. But if the likelihood of a positive node is less than 5%, the guidelines recommend against a biopsy.
“Sentinel node biopsy (has) risks, especially in medically compromised older patients,” Dr. Vetto, professor of surgery at the Oregon Health and Sciences University, Portland, said in an interview, in which he discussed clinical use of the test. “This test offers us a good way to assess the risk/benefit ratio so we can better care for patients, and follow the newest guidelines about sentinel node biopsy.”
The DecisionDx Melanoma, developed by Castle Biosciences, tests for the expression of 28 genes know to play a role in melanoma metastasis, and three control genes. Tumors are stratified either as Class 1, with a 3% chance of spreading within 5 years, or Class 2, with a 69% risk of metastasis. There are two subclasses: 1A, which has an extremely low risk of progression, and 2b, which has an extremely high risk of progression.
For patients with T1-T2 tumors who had a Class 1A test result (lowest risk of recurrence), SLN positivity was 4.6% for all ages, 2.8% in patients 55 years and older, and 1.6% in patients 65 years and older. For patients with T1-T2 tumors who had a Class 2B test result (highest risk of recurrence), SLN positivity was 18.8% for all ages, 16.4% in patients 55 years and older and 11.9% in patients 65 years and older.
Dr. Vetto is a paid speaker for Castle Biosciences.
SOURCE: Vetto et al. AAD 2018 late-breaking research, Abstract 6805
SAN DIEGO – The results of a gene expression test, along with tumor thickness and patient age, can guide the need for sentinel lymph node biopsy, based on results from more than1,400 consecutively tested patients from 26 U.S. surgical oncology, medical oncology and dermatologic practices.
The findings, presented by John Vetto, MD, at the annual meeting of the American Academy of Dermatology, indicate the DecisionDx test correctly identified patients aged 65 and older with T1-T2 tumors whose risk of sentinel node metastasis was lower than 5%. The most recent melanoma guidelines from the National Comprehensive Cancer Network recommend that clinicians “discuss and offer” sentinel node biopsy if a patient has a greater than 10% likelihood of a positive node. If the likelihood is 5%-10%, the recommendation is to “discuss and consider” the procedure. But if the likelihood of a positive node is less than 5%, the guidelines recommend against a biopsy.
“Sentinel node biopsy (has) risks, especially in medically compromised older patients,” Dr. Vetto, professor of surgery at the Oregon Health and Sciences University, Portland, said in an interview, in which he discussed clinical use of the test. “This test offers us a good way to assess the risk/benefit ratio so we can better care for patients, and follow the newest guidelines about sentinel node biopsy.”
The DecisionDx Melanoma, developed by Castle Biosciences, tests for the expression of 28 genes know to play a role in melanoma metastasis, and three control genes. Tumors are stratified either as Class 1, with a 3% chance of spreading within 5 years, or Class 2, with a 69% risk of metastasis. There are two subclasses: 1A, which has an extremely low risk of progression, and 2b, which has an extremely high risk of progression.
For patients with T1-T2 tumors who had a Class 1A test result (lowest risk of recurrence), SLN positivity was 4.6% for all ages, 2.8% in patients 55 years and older, and 1.6% in patients 65 years and older. For patients with T1-T2 tumors who had a Class 2B test result (highest risk of recurrence), SLN positivity was 18.8% for all ages, 16.4% in patients 55 years and older and 11.9% in patients 65 years and older.
Dr. Vetto is a paid speaker for Castle Biosciences.
SOURCE: Vetto et al. AAD 2018 late-breaking research, Abstract 6805
SAN DIEGO – The results of a gene expression test, along with tumor thickness and patient age, can guide the need for sentinel lymph node biopsy, based on results from more than1,400 consecutively tested patients from 26 U.S. surgical oncology, medical oncology and dermatologic practices.
The findings, presented by John Vetto, MD, at the annual meeting of the American Academy of Dermatology, indicate the DecisionDx test correctly identified patients aged 65 and older with T1-T2 tumors whose risk of sentinel node metastasis was lower than 5%. The most recent melanoma guidelines from the National Comprehensive Cancer Network recommend that clinicians “discuss and offer” sentinel node biopsy if a patient has a greater than 10% likelihood of a positive node. If the likelihood is 5%-10%, the recommendation is to “discuss and consider” the procedure. But if the likelihood of a positive node is less than 5%, the guidelines recommend against a biopsy.
“Sentinel node biopsy (has) risks, especially in medically compromised older patients,” Dr. Vetto, professor of surgery at the Oregon Health and Sciences University, Portland, said in an interview, in which he discussed clinical use of the test. “This test offers us a good way to assess the risk/benefit ratio so we can better care for patients, and follow the newest guidelines about sentinel node biopsy.”
The DecisionDx Melanoma, developed by Castle Biosciences, tests for the expression of 28 genes know to play a role in melanoma metastasis, and three control genes. Tumors are stratified either as Class 1, with a 3% chance of spreading within 5 years, or Class 2, with a 69% risk of metastasis. There are two subclasses: 1A, which has an extremely low risk of progression, and 2b, which has an extremely high risk of progression.
For patients with T1-T2 tumors who had a Class 1A test result (lowest risk of recurrence), SLN positivity was 4.6% for all ages, 2.8% in patients 55 years and older, and 1.6% in patients 65 years and older. For patients with T1-T2 tumors who had a Class 2B test result (highest risk of recurrence), SLN positivity was 18.8% for all ages, 16.4% in patients 55 years and older and 11.9% in patients 65 years and older.
Dr. Vetto is a paid speaker for Castle Biosciences.
SOURCE: Vetto et al. AAD 2018 late-breaking research, Abstract 6805
REPORTING FROM AAD 18
Refractory alopecia patients could consider a JAK inhibitor
SAN DIEGO – Treatment with a Janus kinase inhibitor such as tofacitinib is a reasonable option for patients with refractory alopecia who seek resolution of their hair loss and understand the adverse event risk from using this drug class, John E. Harris, MD, PhD, said at the annual meeting of the American Academy of Dermatology.
Using a Janus kinase (JAK) inhibitor to treat alopecia areata or totalis is a “highly successful, emerging therapy,” with efficacy rates for good responses of about a third or higher in a handful of published reports with experiences in more than 150 patients, said Dr. Harris, an associate professor of dermatology and director of the Vitiligo Clinic and Research Center at the University of Massachusetts Medical School in Worcester.
“Some clinicians may say ‘I’d never prescribe a JAK inhibitor for hair loss, it’s too dangerous,’ but several hundred alopecia patients have now received this with no serious adverse effects,” said Dr. Harris. He acknowledged, however, that eventually some patients treated this way will have serious adverse effects. He said that he is treating with tofacitinib a “handful” of alopecia patients who have been unresponsive to other treatments, are eager for an intervention that might regrow their hair, and who understand and accept the risk for developing an infection, shingles, or myelosuppression (with ruxolitinib treatment).
Roughly half of the alopecia patients prescribed tofacitinib (Xeljanz) by Dr. Harris have had their drug cost covered by health insurance, with the others paying for it themselves. Arranging for insurance coverage has usually involved filing an appeal, Dr. Harris said in an interview. The reported successful dosages have been 5 mg bid, with a boost to 10 mg bid for patients who don’t initially respond.
Insurance companies have not yet paid for treatment with ruxolitinib (Jakafi), which has been described in case reports in far fewer patients and which costs about $120,000 a year, he noted.
Dr. Harris said that JAK inhibitors also have great potential for treating vitiligo, a disorder he thinks shares many features in common with alopecia ( J Allergy Clin Immunol. 2017 Sept;140[3]:654-62).
“I think [JAK inhibitors] will have the same efficacy in vitiligo,” he predicted. He is particularly enthused about the possibility of administering ruxolitinib topically to patients with alopecia or vitiligo. Ruxolitinib is well suited to topical administration because of its good skin penetration, Dr. Harris said. Several trials now in progress are further studying JAK inhibitors for alopecia using oral or topical formulations.
Dr. Harris has been a consultant to and has received research funding from Pfizer, the company that markets tofacitinib (Xeljanz). He has also been a consultant to a dozen other companies, and has also received research support from Aclaris Therapeutics, Celgene, Dermavant, Genzyme, Sanofi, and Stiefel/GlaxoSmithKline.
SAN DIEGO – Treatment with a Janus kinase inhibitor such as tofacitinib is a reasonable option for patients with refractory alopecia who seek resolution of their hair loss and understand the adverse event risk from using this drug class, John E. Harris, MD, PhD, said at the annual meeting of the American Academy of Dermatology.
Using a Janus kinase (JAK) inhibitor to treat alopecia areata or totalis is a “highly successful, emerging therapy,” with efficacy rates for good responses of about a third or higher in a handful of published reports with experiences in more than 150 patients, said Dr. Harris, an associate professor of dermatology and director of the Vitiligo Clinic and Research Center at the University of Massachusetts Medical School in Worcester.
“Some clinicians may say ‘I’d never prescribe a JAK inhibitor for hair loss, it’s too dangerous,’ but several hundred alopecia patients have now received this with no serious adverse effects,” said Dr. Harris. He acknowledged, however, that eventually some patients treated this way will have serious adverse effects. He said that he is treating with tofacitinib a “handful” of alopecia patients who have been unresponsive to other treatments, are eager for an intervention that might regrow their hair, and who understand and accept the risk for developing an infection, shingles, or myelosuppression (with ruxolitinib treatment).
Roughly half of the alopecia patients prescribed tofacitinib (Xeljanz) by Dr. Harris have had their drug cost covered by health insurance, with the others paying for it themselves. Arranging for insurance coverage has usually involved filing an appeal, Dr. Harris said in an interview. The reported successful dosages have been 5 mg bid, with a boost to 10 mg bid for patients who don’t initially respond.
Insurance companies have not yet paid for treatment with ruxolitinib (Jakafi), which has been described in case reports in far fewer patients and which costs about $120,000 a year, he noted.
Dr. Harris said that JAK inhibitors also have great potential for treating vitiligo, a disorder he thinks shares many features in common with alopecia ( J Allergy Clin Immunol. 2017 Sept;140[3]:654-62).
“I think [JAK inhibitors] will have the same efficacy in vitiligo,” he predicted. He is particularly enthused about the possibility of administering ruxolitinib topically to patients with alopecia or vitiligo. Ruxolitinib is well suited to topical administration because of its good skin penetration, Dr. Harris said. Several trials now in progress are further studying JAK inhibitors for alopecia using oral or topical formulations.
Dr. Harris has been a consultant to and has received research funding from Pfizer, the company that markets tofacitinib (Xeljanz). He has also been a consultant to a dozen other companies, and has also received research support from Aclaris Therapeutics, Celgene, Dermavant, Genzyme, Sanofi, and Stiefel/GlaxoSmithKline.
SAN DIEGO – Treatment with a Janus kinase inhibitor such as tofacitinib is a reasonable option for patients with refractory alopecia who seek resolution of their hair loss and understand the adverse event risk from using this drug class, John E. Harris, MD, PhD, said at the annual meeting of the American Academy of Dermatology.
Using a Janus kinase (JAK) inhibitor to treat alopecia areata or totalis is a “highly successful, emerging therapy,” with efficacy rates for good responses of about a third or higher in a handful of published reports with experiences in more than 150 patients, said Dr. Harris, an associate professor of dermatology and director of the Vitiligo Clinic and Research Center at the University of Massachusetts Medical School in Worcester.
“Some clinicians may say ‘I’d never prescribe a JAK inhibitor for hair loss, it’s too dangerous,’ but several hundred alopecia patients have now received this with no serious adverse effects,” said Dr. Harris. He acknowledged, however, that eventually some patients treated this way will have serious adverse effects. He said that he is treating with tofacitinib a “handful” of alopecia patients who have been unresponsive to other treatments, are eager for an intervention that might regrow their hair, and who understand and accept the risk for developing an infection, shingles, or myelosuppression (with ruxolitinib treatment).
Roughly half of the alopecia patients prescribed tofacitinib (Xeljanz) by Dr. Harris have had their drug cost covered by health insurance, with the others paying for it themselves. Arranging for insurance coverage has usually involved filing an appeal, Dr. Harris said in an interview. The reported successful dosages have been 5 mg bid, with a boost to 10 mg bid for patients who don’t initially respond.
Insurance companies have not yet paid for treatment with ruxolitinib (Jakafi), which has been described in case reports in far fewer patients and which costs about $120,000 a year, he noted.
Dr. Harris said that JAK inhibitors also have great potential for treating vitiligo, a disorder he thinks shares many features in common with alopecia ( J Allergy Clin Immunol. 2017 Sept;140[3]:654-62).
“I think [JAK inhibitors] will have the same efficacy in vitiligo,” he predicted. He is particularly enthused about the possibility of administering ruxolitinib topically to patients with alopecia or vitiligo. Ruxolitinib is well suited to topical administration because of its good skin penetration, Dr. Harris said. Several trials now in progress are further studying JAK inhibitors for alopecia using oral or topical formulations.
Dr. Harris has been a consultant to and has received research funding from Pfizer, the company that markets tofacitinib (Xeljanz). He has also been a consultant to a dozen other companies, and has also received research support from Aclaris Therapeutics, Celgene, Dermavant, Genzyme, Sanofi, and Stiefel/GlaxoSmithKline.
EXPERT ANALYSIS AT AAD 18
Tips for avoiding, taming most postlaser complications
SAN DIEGO – Do not use the fractional laser on tanned skin or skin that will be getting sun exposure soon after the treatment, Tina Alster, MD, advised as one of her cardinal rules for avoiding hyperpigmentation complications.
Melanocytes are already activated and ready to deposit pigment in such patients. Also, use strict posttreatment sun protection with a mineral sunscreen, she said.
Fractional lasers – both ablative and nonablative – are remarkably safe, said Dr. Alster of Georgetown University Medical Center, Washington.
Her own 2008 study found side effects and complications in just 7.6% of 961 patients. The most frequent were acneiform eruptions (1.8%) and herpes simplex virus outbreaks (1.7%).
A more recent study comprising 730 patients treated with three different fractional lasers found an even lower complication rate of 4%. Complications included 5 herpes simplex virus breakouts, 13 acne eruptions, one abrasion, one bacterial infection, 9 cases of dermatitis, one drug eruption, 4 cases of prolonged erythema, one case of hyperpigmentation, one case of increased swelling and one of telangiectasia.
“We consistently find these very low incidences of less than 10%, and most of these I would term ‘side effects’ and not true complications,” Dr. Alster said at the annual meeting of the American Academy of Dermatology.
Still, if a clinician performs enough laser procedures, these outcomes will eventually occur. Dr. Alster gave her “top tips” for dealing with them when they do arise.
Tip #1: Adequate preoperative assessment
“You must be thorough in assessing all of these things: the type and location of the lesion, the Fitzpatrick skin phototype, any prior treatments the patient has had for the condition (and many have had them). We need to know of any pre-existing medical conditions, particularly autoimmune, and whether the patient has a history of scarring or delayed wound healing.”
Another part of this assessment is managing patient expectations upfront to avoid postprocedural dissatisfaction. “If someone comes to me and says ‘I want you to get rid of every acne scar on my face,’ I tell them right there, ‘I can’t do that,’” she said.
Tip #2: Prepare the patient for the expected – and the unexpected
“The overall risk of even the most common side effects, like prolonged erythema, is relatively small. But they can happen and patients need to be prepared for them.” The most common are prolonged erythema of more than 4 days for nonablative fractional lasers and more than a month for ablative lasers. But dermatitis may appear, as well as reactivation of acne, especially in patients who are having acne scars removed. There is also always the risk of infection and pigmentary alteration.”
Tip #3: Proper technique and close follow-up
The most expensive laser in the world still relies on good technique during deployment, she said. “I always stress, do not ‘pulse stack.’ Use side-by-side, nonoverlapping passes.”
Another key for success is to avoid using the laser on any tanned skin, or skin that will soon have sun exposure. “Any skin phototype with recent sun exposure has activated melanocytes and will have a higher tendency to develop postinflammatory hyperpigmentation. The cells are already activated and in the presence of any other damage – including a laser – they are programmed to produce more pigment.”
Individualize your treatment plan, she advised. “Do additional passes on the most severe areas, like cheek scars and perioral rhytides, and fewer passes and lower density on scar-prone areas, like the infraorbital area, mandible neck, and chest.”
Tip #4: Recognize and address complications
“Complications run the full spectrum from mild erythema to disseminated infections. I am always careful to figure out if it’s a true complication or an expected side effect. The greatest risk profiles are patients with darker skin phototypes, treatments in more sensitive areas, and patients with predisposing medical conditions like collagen or vascular diseases. You don’t need to avoid treating them, just be prepared for the higher risks.”
Dr. Alster also shared her techniques for managing some of the more common adverse events following a fractional laser procedure.
Prolonged erythema isn’t clinically serious, but it really bothers patients. They should be counseled to avoid putting any potentially irritating or allergenic product on their face, and that includes chemical sunscreens. A mineral sunscreen is a much better choice. “For management, postoperative cooling with ice packs is important. A mild topical corticosteroid and a nonsteroidal anti-inflammatory can help, too.”
Acne exacerbation is not uncommon, especially among patients being treated for acne scars. “In people who are prone to acne, I write a script for doxycycline. They don’t have to take it unless they break out. And I always avoid laser skin resurfacing in active acne.”
If a breakout does happen, stick to the well-trodden path, she advised. “We know how to treat acne. Discontinue any occlusive topical, start the patent on an antibiotic, treat topically with a clay masque to help dry things out.”
Infections can be alarming but are manageable when promptly treated. “The main thing is to diagnose and treat early. In those patients who are proven to have herpes simplex virus, I give an antiviral, like valacyclovir. I give 1 gram twice a day for a week, starting on the day of the procedure. I think a bigger question is, ‘Does everyone need a prophylactic antibiotic?’ There is probably no reason to start one routinely, and in fact, there is some evidence that if you do, you may get a more pathogenic organism if you do get an infection.”
Hyperpigmentation is always a concern. Dr Alster repeated her cardinal rule: Do not use the fractional laser on tanned skin or skin that will be getting sun exposure soon after the treatment, as melanocytes are already activated and ready to deposit pigment. Use strict posttreatment sun protection with a mineral sunscreen. While she is not “a big fan” of hydroquinone, Dr. Alster does employ other bleaching agents for postoperative hyperpigmentation, including alpha hydroxyl acid, retinoic acid, kojic acid, and lignin peroxidase.
Good technique and aftercare reduce the risk of hypertrophic scarring. This means avoiding excessive fluences and aggressive lasering techniques and early treatment of any suspected infection. “My main treatment is the 585nm pulsed dye laser, but the main thing is to avoid aggressive techniques with overlapping or stacking of pulses, strict wound care, and early treatment of any infections.”
Dr. Alster disclosed that she is a consultant to L’Oréal USA, an investigator for Revance Therapeutics and Sente Labs, and a medical advisor to Merz Aesthetics, and has investments/commercial interests in Home Skinovations.
SOURCE: Alster, T. et al, PREVENTION & MANAGEMENT OF
SAN DIEGO – Do not use the fractional laser on tanned skin or skin that will be getting sun exposure soon after the treatment, Tina Alster, MD, advised as one of her cardinal rules for avoiding hyperpigmentation complications.
Melanocytes are already activated and ready to deposit pigment in such patients. Also, use strict posttreatment sun protection with a mineral sunscreen, she said.
Fractional lasers – both ablative and nonablative – are remarkably safe, said Dr. Alster of Georgetown University Medical Center, Washington.
Her own 2008 study found side effects and complications in just 7.6% of 961 patients. The most frequent were acneiform eruptions (1.8%) and herpes simplex virus outbreaks (1.7%).
A more recent study comprising 730 patients treated with three different fractional lasers found an even lower complication rate of 4%. Complications included 5 herpes simplex virus breakouts, 13 acne eruptions, one abrasion, one bacterial infection, 9 cases of dermatitis, one drug eruption, 4 cases of prolonged erythema, one case of hyperpigmentation, one case of increased swelling and one of telangiectasia.
“We consistently find these very low incidences of less than 10%, and most of these I would term ‘side effects’ and not true complications,” Dr. Alster said at the annual meeting of the American Academy of Dermatology.
Still, if a clinician performs enough laser procedures, these outcomes will eventually occur. Dr. Alster gave her “top tips” for dealing with them when they do arise.
Tip #1: Adequate preoperative assessment
“You must be thorough in assessing all of these things: the type and location of the lesion, the Fitzpatrick skin phototype, any prior treatments the patient has had for the condition (and many have had them). We need to know of any pre-existing medical conditions, particularly autoimmune, and whether the patient has a history of scarring or delayed wound healing.”
Another part of this assessment is managing patient expectations upfront to avoid postprocedural dissatisfaction. “If someone comes to me and says ‘I want you to get rid of every acne scar on my face,’ I tell them right there, ‘I can’t do that,’” she said.
Tip #2: Prepare the patient for the expected – and the unexpected
“The overall risk of even the most common side effects, like prolonged erythema, is relatively small. But they can happen and patients need to be prepared for them.” The most common are prolonged erythema of more than 4 days for nonablative fractional lasers and more than a month for ablative lasers. But dermatitis may appear, as well as reactivation of acne, especially in patients who are having acne scars removed. There is also always the risk of infection and pigmentary alteration.”
Tip #3: Proper technique and close follow-up
The most expensive laser in the world still relies on good technique during deployment, she said. “I always stress, do not ‘pulse stack.’ Use side-by-side, nonoverlapping passes.”
Another key for success is to avoid using the laser on any tanned skin, or skin that will soon have sun exposure. “Any skin phototype with recent sun exposure has activated melanocytes and will have a higher tendency to develop postinflammatory hyperpigmentation. The cells are already activated and in the presence of any other damage – including a laser – they are programmed to produce more pigment.”
Individualize your treatment plan, she advised. “Do additional passes on the most severe areas, like cheek scars and perioral rhytides, and fewer passes and lower density on scar-prone areas, like the infraorbital area, mandible neck, and chest.”
Tip #4: Recognize and address complications
“Complications run the full spectrum from mild erythema to disseminated infections. I am always careful to figure out if it’s a true complication or an expected side effect. The greatest risk profiles are patients with darker skin phototypes, treatments in more sensitive areas, and patients with predisposing medical conditions like collagen or vascular diseases. You don’t need to avoid treating them, just be prepared for the higher risks.”
Dr. Alster also shared her techniques for managing some of the more common adverse events following a fractional laser procedure.
Prolonged erythema isn’t clinically serious, but it really bothers patients. They should be counseled to avoid putting any potentially irritating or allergenic product on their face, and that includes chemical sunscreens. A mineral sunscreen is a much better choice. “For management, postoperative cooling with ice packs is important. A mild topical corticosteroid and a nonsteroidal anti-inflammatory can help, too.”
Acne exacerbation is not uncommon, especially among patients being treated for acne scars. “In people who are prone to acne, I write a script for doxycycline. They don’t have to take it unless they break out. And I always avoid laser skin resurfacing in active acne.”
If a breakout does happen, stick to the well-trodden path, she advised. “We know how to treat acne. Discontinue any occlusive topical, start the patent on an antibiotic, treat topically with a clay masque to help dry things out.”
Infections can be alarming but are manageable when promptly treated. “The main thing is to diagnose and treat early. In those patients who are proven to have herpes simplex virus, I give an antiviral, like valacyclovir. I give 1 gram twice a day for a week, starting on the day of the procedure. I think a bigger question is, ‘Does everyone need a prophylactic antibiotic?’ There is probably no reason to start one routinely, and in fact, there is some evidence that if you do, you may get a more pathogenic organism if you do get an infection.”
Hyperpigmentation is always a concern. Dr Alster repeated her cardinal rule: Do not use the fractional laser on tanned skin or skin that will be getting sun exposure soon after the treatment, as melanocytes are already activated and ready to deposit pigment. Use strict posttreatment sun protection with a mineral sunscreen. While she is not “a big fan” of hydroquinone, Dr. Alster does employ other bleaching agents for postoperative hyperpigmentation, including alpha hydroxyl acid, retinoic acid, kojic acid, and lignin peroxidase.
Good technique and aftercare reduce the risk of hypertrophic scarring. This means avoiding excessive fluences and aggressive lasering techniques and early treatment of any suspected infection. “My main treatment is the 585nm pulsed dye laser, but the main thing is to avoid aggressive techniques with overlapping or stacking of pulses, strict wound care, and early treatment of any infections.”
Dr. Alster disclosed that she is a consultant to L’Oréal USA, an investigator for Revance Therapeutics and Sente Labs, and a medical advisor to Merz Aesthetics, and has investments/commercial interests in Home Skinovations.
SOURCE: Alster, T. et al, PREVENTION & MANAGEMENT OF
SAN DIEGO – Do not use the fractional laser on tanned skin or skin that will be getting sun exposure soon after the treatment, Tina Alster, MD, advised as one of her cardinal rules for avoiding hyperpigmentation complications.
Melanocytes are already activated and ready to deposit pigment in such patients. Also, use strict posttreatment sun protection with a mineral sunscreen, she said.
Fractional lasers – both ablative and nonablative – are remarkably safe, said Dr. Alster of Georgetown University Medical Center, Washington.
Her own 2008 study found side effects and complications in just 7.6% of 961 patients. The most frequent were acneiform eruptions (1.8%) and herpes simplex virus outbreaks (1.7%).
A more recent study comprising 730 patients treated with three different fractional lasers found an even lower complication rate of 4%. Complications included 5 herpes simplex virus breakouts, 13 acne eruptions, one abrasion, one bacterial infection, 9 cases of dermatitis, one drug eruption, 4 cases of prolonged erythema, one case of hyperpigmentation, one case of increased swelling and one of telangiectasia.
“We consistently find these very low incidences of less than 10%, and most of these I would term ‘side effects’ and not true complications,” Dr. Alster said at the annual meeting of the American Academy of Dermatology.
Still, if a clinician performs enough laser procedures, these outcomes will eventually occur. Dr. Alster gave her “top tips” for dealing with them when they do arise.
Tip #1: Adequate preoperative assessment
“You must be thorough in assessing all of these things: the type and location of the lesion, the Fitzpatrick skin phototype, any prior treatments the patient has had for the condition (and many have had them). We need to know of any pre-existing medical conditions, particularly autoimmune, and whether the patient has a history of scarring or delayed wound healing.”
Another part of this assessment is managing patient expectations upfront to avoid postprocedural dissatisfaction. “If someone comes to me and says ‘I want you to get rid of every acne scar on my face,’ I tell them right there, ‘I can’t do that,’” she said.
Tip #2: Prepare the patient for the expected – and the unexpected
“The overall risk of even the most common side effects, like prolonged erythema, is relatively small. But they can happen and patients need to be prepared for them.” The most common are prolonged erythema of more than 4 days for nonablative fractional lasers and more than a month for ablative lasers. But dermatitis may appear, as well as reactivation of acne, especially in patients who are having acne scars removed. There is also always the risk of infection and pigmentary alteration.”
Tip #3: Proper technique and close follow-up
The most expensive laser in the world still relies on good technique during deployment, she said. “I always stress, do not ‘pulse stack.’ Use side-by-side, nonoverlapping passes.”
Another key for success is to avoid using the laser on any tanned skin, or skin that will soon have sun exposure. “Any skin phototype with recent sun exposure has activated melanocytes and will have a higher tendency to develop postinflammatory hyperpigmentation. The cells are already activated and in the presence of any other damage – including a laser – they are programmed to produce more pigment.”
Individualize your treatment plan, she advised. “Do additional passes on the most severe areas, like cheek scars and perioral rhytides, and fewer passes and lower density on scar-prone areas, like the infraorbital area, mandible neck, and chest.”
Tip #4: Recognize and address complications
“Complications run the full spectrum from mild erythema to disseminated infections. I am always careful to figure out if it’s a true complication or an expected side effect. The greatest risk profiles are patients with darker skin phototypes, treatments in more sensitive areas, and patients with predisposing medical conditions like collagen or vascular diseases. You don’t need to avoid treating them, just be prepared for the higher risks.”
Dr. Alster also shared her techniques for managing some of the more common adverse events following a fractional laser procedure.
Prolonged erythema isn’t clinically serious, but it really bothers patients. They should be counseled to avoid putting any potentially irritating or allergenic product on their face, and that includes chemical sunscreens. A mineral sunscreen is a much better choice. “For management, postoperative cooling with ice packs is important. A mild topical corticosteroid and a nonsteroidal anti-inflammatory can help, too.”
Acne exacerbation is not uncommon, especially among patients being treated for acne scars. “In people who are prone to acne, I write a script for doxycycline. They don’t have to take it unless they break out. And I always avoid laser skin resurfacing in active acne.”
If a breakout does happen, stick to the well-trodden path, she advised. “We know how to treat acne. Discontinue any occlusive topical, start the patent on an antibiotic, treat topically with a clay masque to help dry things out.”
Infections can be alarming but are manageable when promptly treated. “The main thing is to diagnose and treat early. In those patients who are proven to have herpes simplex virus, I give an antiviral, like valacyclovir. I give 1 gram twice a day for a week, starting on the day of the procedure. I think a bigger question is, ‘Does everyone need a prophylactic antibiotic?’ There is probably no reason to start one routinely, and in fact, there is some evidence that if you do, you may get a more pathogenic organism if you do get an infection.”
Hyperpigmentation is always a concern. Dr Alster repeated her cardinal rule: Do not use the fractional laser on tanned skin or skin that will be getting sun exposure soon after the treatment, as melanocytes are already activated and ready to deposit pigment. Use strict posttreatment sun protection with a mineral sunscreen. While she is not “a big fan” of hydroquinone, Dr. Alster does employ other bleaching agents for postoperative hyperpigmentation, including alpha hydroxyl acid, retinoic acid, kojic acid, and lignin peroxidase.
Good technique and aftercare reduce the risk of hypertrophic scarring. This means avoiding excessive fluences and aggressive lasering techniques and early treatment of any suspected infection. “My main treatment is the 585nm pulsed dye laser, but the main thing is to avoid aggressive techniques with overlapping or stacking of pulses, strict wound care, and early treatment of any infections.”
Dr. Alster disclosed that she is a consultant to L’Oréal USA, an investigator for Revance Therapeutics and Sente Labs, and a medical advisor to Merz Aesthetics, and has investments/commercial interests in Home Skinovations.
SOURCE: Alster, T. et al, PREVENTION & MANAGEMENT OF
EXPERT ANALYSIS AT AAD 18
Biologics gaining traction in children with moderate to severe psoriasis
SAN DIEGO – Systemic therapies are increasingly being used for children with moderate to severe psoriasis; methotrexate is still the mainstay of systemic treatment, but biologics appear to achieve superior results with fewer side effects, Amy S. Paller, MD, said at the annual meeting of the American Academy of Dermatology.
Etanercept was approved in 2016 for children ages 6 and up, and ustekinumab was approved for use in patients aged 12 years or older in October 2017. Ongoing trials are examining adalimumab, apremilast, ustekinumab, and ixekizumab for use in adolescents and younger children. Trials are also being planned for other therapies that inhibit the Th17/IL-23 pathway, said Dr. Paller, the Walter J. Hamlin Professor and chair of dermatology at Northwestern University Feinberg School of Medicine, Chicago.
Further, the study found that biologic agents, primarily etanercept, were used by 27%, acitretin by nearly 15%, cyclosporine by about 8%, and fumaric acid esters by 5%. More than 1 medication was used by 19%, according to the study results.
Adverse events affected the ability to tolerate therapy, and methotrexate and biologic agents were taken for a mean duration that was 2-fold greater than the mean duration for cyclosporine or fumaric acid esters. “A prospective registry is needed to track the long-term risks of systemic agents for pediatric psoriasis,” the authors concluded.
Dr. Paller reported that, in her practice, "we're still primarily using methotrexate. It takes time to see an effect with methotrexate, and you have to let people know this up front.” She pointed to a 2015 single-site prospective study of 25 children that found just 40% achieved Psoriasis Area and Severity Index 50 at 12 weeks, with that number rising to 80% by 36 weeks. (J Derm Treat 2015; 26: 406-12)
Dr. Paller recommends baseline and annual TB testing, updated vaccinations and pregnancy counseling for all patients taking immunosuppressant therapies.
"I don't use a lot of retinoids for plaque psoriasis in kids," Dr. Paller said, "but for pustular psoriasis, I use (them) quite a bit. The beauty of retinoids is that they are not immunosuppressants, and you can start and stop them without loss of efficacy. There are many potential side effects, primarily skin and mucosal dryness."
Cyclosporine "has the greatest potential toxicity, which leaves it lower on the therapeutic ladder," Dr. Paller said. "But it has a pretty good safety record. The nice thing we can say is that (cyclosporine has) been around a long time. We have decades of experience in children, and we're using a low dose."
Benefits of biologics include convenience, infrequent dosing, and, potentially, fewer lab tests, Dr. Paller said. She added that there's no consensus about whether lab tests beyond annual TB tests are a good idea for patients on biologics.
Long-term risks are unclear, however, and drug holidays could spell trouble for efficacy when kids return to the medications.
Dr. Paller noted that biologics can cost tens of thousands of dollars for several weeks of treatment, and insurers may not cover them.
A 2014 meta-analysis of 48 randomized, controlled trials of 16,696 adult patients with psoriasis put biologics as the most effective therapies, with infliximab at the top (risk difference 76%), followed by adalimumab (RD 61%) and ustekinumab (RD 63%).
“These biologics are more effective than etanercept and all conventional treatments. Head-to-head trials indicate the superiority of adalimumab and infliximab over methotrexate (MTX), the superiority of ustekinumab over etanercept …” the meta-analysis concluded. (Br J Dermatol. 2014 Feb;170(2):274-303)
Dr. Paller disclosed that she is an investigator for Abbvie; Celgene; Eli Lilly, Janssen, Leo Foundation; Novartis. She is a consultant with honorarium for Amgen; Celgene; Eli Lilly; and Novartis.
SOURCE: Paller, A. et al, Session F025 Update on systemic therapies and emerging treatments
SAN DIEGO – Systemic therapies are increasingly being used for children with moderate to severe psoriasis; methotrexate is still the mainstay of systemic treatment, but biologics appear to achieve superior results with fewer side effects, Amy S. Paller, MD, said at the annual meeting of the American Academy of Dermatology.
Etanercept was approved in 2016 for children ages 6 and up, and ustekinumab was approved for use in patients aged 12 years or older in October 2017. Ongoing trials are examining adalimumab, apremilast, ustekinumab, and ixekizumab for use in adolescents and younger children. Trials are also being planned for other therapies that inhibit the Th17/IL-23 pathway, said Dr. Paller, the Walter J. Hamlin Professor and chair of dermatology at Northwestern University Feinberg School of Medicine, Chicago.
Further, the study found that biologic agents, primarily etanercept, were used by 27%, acitretin by nearly 15%, cyclosporine by about 8%, and fumaric acid esters by 5%. More than 1 medication was used by 19%, according to the study results.
Adverse events affected the ability to tolerate therapy, and methotrexate and biologic agents were taken for a mean duration that was 2-fold greater than the mean duration for cyclosporine or fumaric acid esters. “A prospective registry is needed to track the long-term risks of systemic agents for pediatric psoriasis,” the authors concluded.
Dr. Paller reported that, in her practice, "we're still primarily using methotrexate. It takes time to see an effect with methotrexate, and you have to let people know this up front.” She pointed to a 2015 single-site prospective study of 25 children that found just 40% achieved Psoriasis Area and Severity Index 50 at 12 weeks, with that number rising to 80% by 36 weeks. (J Derm Treat 2015; 26: 406-12)
Dr. Paller recommends baseline and annual TB testing, updated vaccinations and pregnancy counseling for all patients taking immunosuppressant therapies.
"I don't use a lot of retinoids for plaque psoriasis in kids," Dr. Paller said, "but for pustular psoriasis, I use (them) quite a bit. The beauty of retinoids is that they are not immunosuppressants, and you can start and stop them without loss of efficacy. There are many potential side effects, primarily skin and mucosal dryness."
Cyclosporine "has the greatest potential toxicity, which leaves it lower on the therapeutic ladder," Dr. Paller said. "But it has a pretty good safety record. The nice thing we can say is that (cyclosporine has) been around a long time. We have decades of experience in children, and we're using a low dose."
Benefits of biologics include convenience, infrequent dosing, and, potentially, fewer lab tests, Dr. Paller said. She added that there's no consensus about whether lab tests beyond annual TB tests are a good idea for patients on biologics.
Long-term risks are unclear, however, and drug holidays could spell trouble for efficacy when kids return to the medications.
Dr. Paller noted that biologics can cost tens of thousands of dollars for several weeks of treatment, and insurers may not cover them.
A 2014 meta-analysis of 48 randomized, controlled trials of 16,696 adult patients with psoriasis put biologics as the most effective therapies, with infliximab at the top (risk difference 76%), followed by adalimumab (RD 61%) and ustekinumab (RD 63%).
“These biologics are more effective than etanercept and all conventional treatments. Head-to-head trials indicate the superiority of adalimumab and infliximab over methotrexate (MTX), the superiority of ustekinumab over etanercept …” the meta-analysis concluded. (Br J Dermatol. 2014 Feb;170(2):274-303)
Dr. Paller disclosed that she is an investigator for Abbvie; Celgene; Eli Lilly, Janssen, Leo Foundation; Novartis. She is a consultant with honorarium for Amgen; Celgene; Eli Lilly; and Novartis.
SOURCE: Paller, A. et al, Session F025 Update on systemic therapies and emerging treatments
SAN DIEGO – Systemic therapies are increasingly being used for children with moderate to severe psoriasis; methotrexate is still the mainstay of systemic treatment, but biologics appear to achieve superior results with fewer side effects, Amy S. Paller, MD, said at the annual meeting of the American Academy of Dermatology.
Etanercept was approved in 2016 for children ages 6 and up, and ustekinumab was approved for use in patients aged 12 years or older in October 2017. Ongoing trials are examining adalimumab, apremilast, ustekinumab, and ixekizumab for use in adolescents and younger children. Trials are also being planned for other therapies that inhibit the Th17/IL-23 pathway, said Dr. Paller, the Walter J. Hamlin Professor and chair of dermatology at Northwestern University Feinberg School of Medicine, Chicago.
Further, the study found that biologic agents, primarily etanercept, were used by 27%, acitretin by nearly 15%, cyclosporine by about 8%, and fumaric acid esters by 5%. More than 1 medication was used by 19%, according to the study results.
Adverse events affected the ability to tolerate therapy, and methotrexate and biologic agents were taken for a mean duration that was 2-fold greater than the mean duration for cyclosporine or fumaric acid esters. “A prospective registry is needed to track the long-term risks of systemic agents for pediatric psoriasis,” the authors concluded.
Dr. Paller reported that, in her practice, "we're still primarily using methotrexate. It takes time to see an effect with methotrexate, and you have to let people know this up front.” She pointed to a 2015 single-site prospective study of 25 children that found just 40% achieved Psoriasis Area and Severity Index 50 at 12 weeks, with that number rising to 80% by 36 weeks. (J Derm Treat 2015; 26: 406-12)
Dr. Paller recommends baseline and annual TB testing, updated vaccinations and pregnancy counseling for all patients taking immunosuppressant therapies.
"I don't use a lot of retinoids for plaque psoriasis in kids," Dr. Paller said, "but for pustular psoriasis, I use (them) quite a bit. The beauty of retinoids is that they are not immunosuppressants, and you can start and stop them without loss of efficacy. There are many potential side effects, primarily skin and mucosal dryness."
Cyclosporine "has the greatest potential toxicity, which leaves it lower on the therapeutic ladder," Dr. Paller said. "But it has a pretty good safety record. The nice thing we can say is that (cyclosporine has) been around a long time. We have decades of experience in children, and we're using a low dose."
Benefits of biologics include convenience, infrequent dosing, and, potentially, fewer lab tests, Dr. Paller said. She added that there's no consensus about whether lab tests beyond annual TB tests are a good idea for patients on biologics.
Long-term risks are unclear, however, and drug holidays could spell trouble for efficacy when kids return to the medications.
Dr. Paller noted that biologics can cost tens of thousands of dollars for several weeks of treatment, and insurers may not cover them.
A 2014 meta-analysis of 48 randomized, controlled trials of 16,696 adult patients with psoriasis put biologics as the most effective therapies, with infliximab at the top (risk difference 76%), followed by adalimumab (RD 61%) and ustekinumab (RD 63%).
“These biologics are more effective than etanercept and all conventional treatments. Head-to-head trials indicate the superiority of adalimumab and infliximab over methotrexate (MTX), the superiority of ustekinumab over etanercept …” the meta-analysis concluded. (Br J Dermatol. 2014 Feb;170(2):274-303)
Dr. Paller disclosed that she is an investigator for Abbvie; Celgene; Eli Lilly, Janssen, Leo Foundation; Novartis. She is a consultant with honorarium for Amgen; Celgene; Eli Lilly; and Novartis.
SOURCE: Paller, A. et al, Session F025 Update on systemic therapies and emerging treatments
EXPERT ANALYSIS AT AAD 18
Oral treatment for menorrhagia shows promise for melasma
SAN DIEGO – The use of , according to Amit Pandya, MD.
Tranexamic acid is also used to treat intraoperative hemorrhage, is available over the counter in some countries, and is used widely for treating melasma in East Asia, Dr. Pandya said at a meeting of the Skin of Color Society, held the day before the annual meeting of the American Academy of Dermatology.
Dr. Pandya, professor of dermatology at the University of Texas Southwestern, Dallas, described a woman with a 20-year history of melasma who had been treated with triple combination creams, chemical peels, and Fraxel lasers “to no avail,” similar to patients he sees in his practice every week. But after 3 months of treatment with 325 mg of tranexamic acid twice daily, triple combination cream, and visible light sunscreen, she was clearer than she had been for some time, he said.
Tranexamic acid “ blocks keratinocytes from causing plasminogen to go into plasmin,” and plasmin stimulates fibroblast growth factor production, which is “one of the most potent stimulants of melanin,” he explained.
In a retrospective study published in 2016, conducted by investigators at the National Skin Center in Singapore, 561 patients with melasma were treated with oral tranexamic acid for a median of 4 months, almost 90% of the patients improved. There was one serious adverse event, a deep vein thrombosis (J Am Acad Dermatol. 2016 Aug;75[2]:385-92). The other adverse effects were mild. When Dr. Pandya spoke with the investigators about this patient, he was told that the patient had not disclosed her true medical history, which included protein S deficiency and a strong family history of thrombotic events, which would have excluded her from treatment.
Of 2,000 published cases of melasma treated with tranexamic acid to date, “this is the only severe event ever seen with tranexamic acid,” he noted.
Dr. Pandya and his associates recently published the results of a study evaluating tranexamic acid in 44 Latino women with moderate to severe melasma, which he said was the first study of tranexamic acid in the Western hemisphere. For 3 months, the women were treated with 250 mg of tranexamic acid or placebo in combination with sunscreen in both groups, then sunscreen only for 3 months in both groups. The primary outcome was the change in the modified Melasma Area and Severity Index (mMASI) score.
“Results were spectacular,” he said. At 3 months, the mMASI score had improved by 49% among those in the tranexamic acid group, compared with 18% among those on placebo and sunscreen. After 3 months on sunscreen only, there was a 26% reduction in the mMASI score from baseline among those treated with tranexamic acid, compared with 19% in the placebo group. None of the patients in either group had severe adverse events (J Am Acad Dermatol. 2018 Feb;78[2]:363-9). Side effects include GI upset, reduced menstrual flow, myalgias, and headache.
Rebound after cessation of therapy is an issue, however, and was worse in the treated group “because more melanocytes are actually created when you reduce melanin. So once you stop the tranexamic acid, it rebounds,” Dr. Pandya said. Patients should use triple combination cream when they stop taking tranexamic acid, he advised.
However, he said that patients have called him within 1 month of stopping tranexamic acid, asking to restart treatment. He has had patients on tranexamic acid for 1 year or longer, without any side effects.
Women who are pregnant or nursing, have had two or more spontaneous abortions, are on oral contraceptives or other hormone-based birth control, have a history of thrombosis, are on blood thinners, are smokers, or have significant cardiovascular or respiratory disease, subarachnoid hemorrhage, any DVT, or a strong family history of thromboembolic events should not be treated with tranexamic acid.
Dr. Pandya pointed out that the 250-mg dose used in the study is not available in the United States, where only the 650-mg dose is available. So he writes a prescription for 650 mg a day, and tells patients to cut the pill in half and take a 325-mg dose twice a day (half in the morning and half at night).
At the Skin of Color Society meeting, Nahla Shihab, MD, of Universitas Indonesia, Jakarta, presented the results of a randomized, placebo-controlled study evaluating oral tranexamic acid plus hydroquinone cream in patients with moderate to severe melasma, in collaboration with UT Southwestern and Dr. Pandya. Patients were randomized to treatment with topical hydroquinone 4% cream, sunscreen, and tranexamic acid (250 mg twice a day), or hydroquinone 4% cream, sunscreen, and placebo for 3 months, followed by 3 months of sunscreen only.
At 12 weeks, those in the tranexamic acid group had a 55% decrease in the mMASI score, compared with 10.9% in the control group. After stopping treatment, some patients experienced relapses, similar to what has been observed in other studies, but “the severity was still lower than baseline,” Dr. Shihab reported.
In addition, the improvement in the mMASI score was higher than that seen in other studies, which could be due to a synergistic effect of the fibrin inhibitor with hydroquinone, she added. Another important finding was that improvements were noticeable after 2 weeks of treatment, “which suggests that the combination of oral tranexamic acid and hydroquinone has a rapid onset of action,” she said.
In both groups, 6% of the patients experienced erythema and pruritus, which resolved with continued use of hydroquinone, and one woman on tranexamic acid had menstrual cycle changes. Further studies should evaluate a longer duration of treatment and follow-up, with tranexamic acid and hydroquinone, and in combination with other treatments, Dr. Shihab said.
Dr. Pandya reported that he is a consultant to Aclaris Therapeutics and Pfizer, and has received grants/research funding from Incyte Corp. Dr. Shihab had no disclosures.
SAN DIEGO – The use of , according to Amit Pandya, MD.
Tranexamic acid is also used to treat intraoperative hemorrhage, is available over the counter in some countries, and is used widely for treating melasma in East Asia, Dr. Pandya said at a meeting of the Skin of Color Society, held the day before the annual meeting of the American Academy of Dermatology.
Dr. Pandya, professor of dermatology at the University of Texas Southwestern, Dallas, described a woman with a 20-year history of melasma who had been treated with triple combination creams, chemical peels, and Fraxel lasers “to no avail,” similar to patients he sees in his practice every week. But after 3 months of treatment with 325 mg of tranexamic acid twice daily, triple combination cream, and visible light sunscreen, she was clearer than she had been for some time, he said.
Tranexamic acid “ blocks keratinocytes from causing plasminogen to go into plasmin,” and plasmin stimulates fibroblast growth factor production, which is “one of the most potent stimulants of melanin,” he explained.
In a retrospective study published in 2016, conducted by investigators at the National Skin Center in Singapore, 561 patients with melasma were treated with oral tranexamic acid for a median of 4 months, almost 90% of the patients improved. There was one serious adverse event, a deep vein thrombosis (J Am Acad Dermatol. 2016 Aug;75[2]:385-92). The other adverse effects were mild. When Dr. Pandya spoke with the investigators about this patient, he was told that the patient had not disclosed her true medical history, which included protein S deficiency and a strong family history of thrombotic events, which would have excluded her from treatment.
Of 2,000 published cases of melasma treated with tranexamic acid to date, “this is the only severe event ever seen with tranexamic acid,” he noted.
Dr. Pandya and his associates recently published the results of a study evaluating tranexamic acid in 44 Latino women with moderate to severe melasma, which he said was the first study of tranexamic acid in the Western hemisphere. For 3 months, the women were treated with 250 mg of tranexamic acid or placebo in combination with sunscreen in both groups, then sunscreen only for 3 months in both groups. The primary outcome was the change in the modified Melasma Area and Severity Index (mMASI) score.
“Results were spectacular,” he said. At 3 months, the mMASI score had improved by 49% among those in the tranexamic acid group, compared with 18% among those on placebo and sunscreen. After 3 months on sunscreen only, there was a 26% reduction in the mMASI score from baseline among those treated with tranexamic acid, compared with 19% in the placebo group. None of the patients in either group had severe adverse events (J Am Acad Dermatol. 2018 Feb;78[2]:363-9). Side effects include GI upset, reduced menstrual flow, myalgias, and headache.
Rebound after cessation of therapy is an issue, however, and was worse in the treated group “because more melanocytes are actually created when you reduce melanin. So once you stop the tranexamic acid, it rebounds,” Dr. Pandya said. Patients should use triple combination cream when they stop taking tranexamic acid, he advised.
However, he said that patients have called him within 1 month of stopping tranexamic acid, asking to restart treatment. He has had patients on tranexamic acid for 1 year or longer, without any side effects.
Women who are pregnant or nursing, have had two or more spontaneous abortions, are on oral contraceptives or other hormone-based birth control, have a history of thrombosis, are on blood thinners, are smokers, or have significant cardiovascular or respiratory disease, subarachnoid hemorrhage, any DVT, or a strong family history of thromboembolic events should not be treated with tranexamic acid.
Dr. Pandya pointed out that the 250-mg dose used in the study is not available in the United States, where only the 650-mg dose is available. So he writes a prescription for 650 mg a day, and tells patients to cut the pill in half and take a 325-mg dose twice a day (half in the morning and half at night).
At the Skin of Color Society meeting, Nahla Shihab, MD, of Universitas Indonesia, Jakarta, presented the results of a randomized, placebo-controlled study evaluating oral tranexamic acid plus hydroquinone cream in patients with moderate to severe melasma, in collaboration with UT Southwestern and Dr. Pandya. Patients were randomized to treatment with topical hydroquinone 4% cream, sunscreen, and tranexamic acid (250 mg twice a day), or hydroquinone 4% cream, sunscreen, and placebo for 3 months, followed by 3 months of sunscreen only.
At 12 weeks, those in the tranexamic acid group had a 55% decrease in the mMASI score, compared with 10.9% in the control group. After stopping treatment, some patients experienced relapses, similar to what has been observed in other studies, but “the severity was still lower than baseline,” Dr. Shihab reported.
In addition, the improvement in the mMASI score was higher than that seen in other studies, which could be due to a synergistic effect of the fibrin inhibitor with hydroquinone, she added. Another important finding was that improvements were noticeable after 2 weeks of treatment, “which suggests that the combination of oral tranexamic acid and hydroquinone has a rapid onset of action,” she said.
In both groups, 6% of the patients experienced erythema and pruritus, which resolved with continued use of hydroquinone, and one woman on tranexamic acid had menstrual cycle changes. Further studies should evaluate a longer duration of treatment and follow-up, with tranexamic acid and hydroquinone, and in combination with other treatments, Dr. Shihab said.
Dr. Pandya reported that he is a consultant to Aclaris Therapeutics and Pfizer, and has received grants/research funding from Incyte Corp. Dr. Shihab had no disclosures.
SAN DIEGO – The use of , according to Amit Pandya, MD.
Tranexamic acid is also used to treat intraoperative hemorrhage, is available over the counter in some countries, and is used widely for treating melasma in East Asia, Dr. Pandya said at a meeting of the Skin of Color Society, held the day before the annual meeting of the American Academy of Dermatology.
Dr. Pandya, professor of dermatology at the University of Texas Southwestern, Dallas, described a woman with a 20-year history of melasma who had been treated with triple combination creams, chemical peels, and Fraxel lasers “to no avail,” similar to patients he sees in his practice every week. But after 3 months of treatment with 325 mg of tranexamic acid twice daily, triple combination cream, and visible light sunscreen, she was clearer than she had been for some time, he said.
Tranexamic acid “ blocks keratinocytes from causing plasminogen to go into plasmin,” and plasmin stimulates fibroblast growth factor production, which is “one of the most potent stimulants of melanin,” he explained.
In a retrospective study published in 2016, conducted by investigators at the National Skin Center in Singapore, 561 patients with melasma were treated with oral tranexamic acid for a median of 4 months, almost 90% of the patients improved. There was one serious adverse event, a deep vein thrombosis (J Am Acad Dermatol. 2016 Aug;75[2]:385-92). The other adverse effects were mild. When Dr. Pandya spoke with the investigators about this patient, he was told that the patient had not disclosed her true medical history, which included protein S deficiency and a strong family history of thrombotic events, which would have excluded her from treatment.
Of 2,000 published cases of melasma treated with tranexamic acid to date, “this is the only severe event ever seen with tranexamic acid,” he noted.
Dr. Pandya and his associates recently published the results of a study evaluating tranexamic acid in 44 Latino women with moderate to severe melasma, which he said was the first study of tranexamic acid in the Western hemisphere. For 3 months, the women were treated with 250 mg of tranexamic acid or placebo in combination with sunscreen in both groups, then sunscreen only for 3 months in both groups. The primary outcome was the change in the modified Melasma Area and Severity Index (mMASI) score.
“Results were spectacular,” he said. At 3 months, the mMASI score had improved by 49% among those in the tranexamic acid group, compared with 18% among those on placebo and sunscreen. After 3 months on sunscreen only, there was a 26% reduction in the mMASI score from baseline among those treated with tranexamic acid, compared with 19% in the placebo group. None of the patients in either group had severe adverse events (J Am Acad Dermatol. 2018 Feb;78[2]:363-9). Side effects include GI upset, reduced menstrual flow, myalgias, and headache.
Rebound after cessation of therapy is an issue, however, and was worse in the treated group “because more melanocytes are actually created when you reduce melanin. So once you stop the tranexamic acid, it rebounds,” Dr. Pandya said. Patients should use triple combination cream when they stop taking tranexamic acid, he advised.
However, he said that patients have called him within 1 month of stopping tranexamic acid, asking to restart treatment. He has had patients on tranexamic acid for 1 year or longer, without any side effects.
Women who are pregnant or nursing, have had two or more spontaneous abortions, are on oral contraceptives or other hormone-based birth control, have a history of thrombosis, are on blood thinners, are smokers, or have significant cardiovascular or respiratory disease, subarachnoid hemorrhage, any DVT, or a strong family history of thromboembolic events should not be treated with tranexamic acid.
Dr. Pandya pointed out that the 250-mg dose used in the study is not available in the United States, where only the 650-mg dose is available. So he writes a prescription for 650 mg a day, and tells patients to cut the pill in half and take a 325-mg dose twice a day (half in the morning and half at night).
At the Skin of Color Society meeting, Nahla Shihab, MD, of Universitas Indonesia, Jakarta, presented the results of a randomized, placebo-controlled study evaluating oral tranexamic acid plus hydroquinone cream in patients with moderate to severe melasma, in collaboration with UT Southwestern and Dr. Pandya. Patients were randomized to treatment with topical hydroquinone 4% cream, sunscreen, and tranexamic acid (250 mg twice a day), or hydroquinone 4% cream, sunscreen, and placebo for 3 months, followed by 3 months of sunscreen only.
At 12 weeks, those in the tranexamic acid group had a 55% decrease in the mMASI score, compared with 10.9% in the control group. After stopping treatment, some patients experienced relapses, similar to what has been observed in other studies, but “the severity was still lower than baseline,” Dr. Shihab reported.
In addition, the improvement in the mMASI score was higher than that seen in other studies, which could be due to a synergistic effect of the fibrin inhibitor with hydroquinone, she added. Another important finding was that improvements were noticeable after 2 weeks of treatment, “which suggests that the combination of oral tranexamic acid and hydroquinone has a rapid onset of action,” she said.
In both groups, 6% of the patients experienced erythema and pruritus, which resolved with continued use of hydroquinone, and one woman on tranexamic acid had menstrual cycle changes. Further studies should evaluate a longer duration of treatment and follow-up, with tranexamic acid and hydroquinone, and in combination with other treatments, Dr. Shihab said.
Dr. Pandya reported that he is a consultant to Aclaris Therapeutics and Pfizer, and has received grants/research funding from Incyte Corp. Dr. Shihab had no disclosures.
REPORTING FROM THE SKIN OF COLOR SOCIETY SCIENTIFIC SYMPOSIUM
VIDEO: Parabens named ‘nonallergen’ of the year
SAN DIEGO – With propylene glycol already declared 2018 Allergen of the Year in a published journal article, the news at the Allergen of the Year session of the American Contact Dermatitis Society was announcement of the 2019 pick, parabens.
From a skin perspective, parabens are “perhaps the safest” preservative, but despite that they have a bad public reputation Donald V. Belsito, MD, said in his Allergen of the Year talk during the Society’s annual meeting held the day before the annual meeting of the American Academy of Dermatology.
There is an unfounded public perception that parabens cause endocrine disruption. Naming parabens the “nonallergen” of the year for 2019 is an effort to dispel this myth, Dr. Belsito said in a video interview.
The public prejudice against parabens, exacerbated by many products that tout being paraben free, has helped cause a crisis because preservative systems in general have been under attack and facing restrictions. Dr. Belsito cited European limitations on the preservative methylisothiazolinone (Allergen of the Year in 2013) and withdrawal of formaldehyde (2015 Allergen of the Year) from many products.
Dr. Belsito also highlighted why propylene glycol received the nod as 2018’s Allergen of the Year (Dermatitis. 2018 Jan/Feb;29[1]:3-5). Propylene glycol is a very ubiquitous emulsifier found in cosmetics, foods, and both topical and oral medications. Caution is needed when running a patch test on the agent to distinguish an irritation reaction from an allergic reaction. Interpreting the test result correctly is very important, said Dr. Belsito, professor of dermatology at Columbia University in New York.
Parabens is the 20th Allergen of the Year named by the Society, an annual event since 2000.
Dr. Belsito has participated in the program since its start.
SAN DIEGO – With propylene glycol already declared 2018 Allergen of the Year in a published journal article, the news at the Allergen of the Year session of the American Contact Dermatitis Society was announcement of the 2019 pick, parabens.
From a skin perspective, parabens are “perhaps the safest” preservative, but despite that they have a bad public reputation Donald V. Belsito, MD, said in his Allergen of the Year talk during the Society’s annual meeting held the day before the annual meeting of the American Academy of Dermatology.
There is an unfounded public perception that parabens cause endocrine disruption. Naming parabens the “nonallergen” of the year for 2019 is an effort to dispel this myth, Dr. Belsito said in a video interview.
The public prejudice against parabens, exacerbated by many products that tout being paraben free, has helped cause a crisis because preservative systems in general have been under attack and facing restrictions. Dr. Belsito cited European limitations on the preservative methylisothiazolinone (Allergen of the Year in 2013) and withdrawal of formaldehyde (2015 Allergen of the Year) from many products.
Dr. Belsito also highlighted why propylene glycol received the nod as 2018’s Allergen of the Year (Dermatitis. 2018 Jan/Feb;29[1]:3-5). Propylene glycol is a very ubiquitous emulsifier found in cosmetics, foods, and both topical and oral medications. Caution is needed when running a patch test on the agent to distinguish an irritation reaction from an allergic reaction. Interpreting the test result correctly is very important, said Dr. Belsito, professor of dermatology at Columbia University in New York.
Parabens is the 20th Allergen of the Year named by the Society, an annual event since 2000.
Dr. Belsito has participated in the program since its start.
SAN DIEGO – With propylene glycol already declared 2018 Allergen of the Year in a published journal article, the news at the Allergen of the Year session of the American Contact Dermatitis Society was announcement of the 2019 pick, parabens.
From a skin perspective, parabens are “perhaps the safest” preservative, but despite that they have a bad public reputation Donald V. Belsito, MD, said in his Allergen of the Year talk during the Society’s annual meeting held the day before the annual meeting of the American Academy of Dermatology.
There is an unfounded public perception that parabens cause endocrine disruption. Naming parabens the “nonallergen” of the year for 2019 is an effort to dispel this myth, Dr. Belsito said in a video interview.
The public prejudice against parabens, exacerbated by many products that tout being paraben free, has helped cause a crisis because preservative systems in general have been under attack and facing restrictions. Dr. Belsito cited European limitations on the preservative methylisothiazolinone (Allergen of the Year in 2013) and withdrawal of formaldehyde (2015 Allergen of the Year) from many products.
Dr. Belsito also highlighted why propylene glycol received the nod as 2018’s Allergen of the Year (Dermatitis. 2018 Jan/Feb;29[1]:3-5). Propylene glycol is a very ubiquitous emulsifier found in cosmetics, foods, and both topical and oral medications. Caution is needed when running a patch test on the agent to distinguish an irritation reaction from an allergic reaction. Interpreting the test result correctly is very important, said Dr. Belsito, professor of dermatology at Columbia University in New York.
Parabens is the 20th Allergen of the Year named by the Society, an annual event since 2000.
Dr. Belsito has participated in the program since its start.
FROM ACDS 18
Late-breaking research presented at AAD on Saturday February 17
Dermatology News will be on site later this week at the annual meeting of the American Academy of Dermatology in San Diego. Look for the latest news and video interviews from the meeting in medical, surgical, and aesthetic dermatology at edermatologynews.com starting Friday February 16.
Coverage will include the late-breaker sessions, which will be presented on Saturday February 17.
Check out another late-breaking session – on basic science, cutaneous oncology, and pathology – which will include presentations on the growing burden of melanoma, the incidence of Merkel cell carcinoma in the United States, and the inverse genetic risk between vitiligo and cutaneous melanoma.
Find out more about these and other sessions at the official 2018 AAD Annual Meeting’s page.
Dermatology News will be on site later this week at the annual meeting of the American Academy of Dermatology in San Diego. Look for the latest news and video interviews from the meeting in medical, surgical, and aesthetic dermatology at edermatologynews.com starting Friday February 16.
Coverage will include the late-breaker sessions, which will be presented on Saturday February 17.
Check out another late-breaking session – on basic science, cutaneous oncology, and pathology – which will include presentations on the growing burden of melanoma, the incidence of Merkel cell carcinoma in the United States, and the inverse genetic risk between vitiligo and cutaneous melanoma.
Find out more about these and other sessions at the official 2018 AAD Annual Meeting’s page.
Dermatology News will be on site later this week at the annual meeting of the American Academy of Dermatology in San Diego. Look for the latest news and video interviews from the meeting in medical, surgical, and aesthetic dermatology at edermatologynews.com starting Friday February 16.
Coverage will include the late-breaker sessions, which will be presented on Saturday February 17.
Check out another late-breaking session – on basic science, cutaneous oncology, and pathology – which will include presentations on the growing burden of melanoma, the incidence of Merkel cell carcinoma in the United States, and the inverse genetic risk between vitiligo and cutaneous melanoma.
Find out more about these and other sessions at the official 2018 AAD Annual Meeting’s page.
AAD 2018: Navigating the meeting
Dermatology News editorial advisor Adam Friedman, MD, provides his recommendations for navigating the American Academy of Dermatology annual meeting at the San Diego Convention Center Feb. 16-20.
We’ve all seen the “What’s new in the tool shed/box/bucket/* insert noun here*” articles, lecture, videos ... that’s not what I am talking about. Get out of your comfort zone and check out the latest on the diagnosis and treatment of genital skin disorders in session S052 on Monday, Feb. 19, from 9 a.m. to 12 p.m. Get a taste for “Oral Diseases” with session F017 on Friday, Feb. 16, from 1 p.m. to 3 p.m. And who wouldn’t benefit from beefing up on granulomatous diseases with session F092 on Sunday, Feb. 18, from 1 p.m. to 3 p.m.? That was a rhetorical question.
Yes, be basic
Oldies but goodies
I may get older but the quality of some sessions stays the same. Nicholas Soter, MD, has been lecturing on urticaria since before I can remember – make sure to check this legend out in session U081 on Monday from 7:30 a.m. to 8:30 a.m. Joseph Jorrizo, MD, “Captain Complex Med Derm” himself, is directing the session on referral dermatology (F007) on Friday, from 9 a.m. to 11 a.m. (Yes, I know it conflicts with my session – see, no bias!). Last but not least, the ever so popular “Hot Topics” session (S048) on Monday, 9 a.m. to 12 p.m. Led by former AAD Vice President Kenneth Tomecki, MD, this session covers the gamut of what’s “so hot right now” in dermatology. Not to be missed.
Dr. Friedman is director of the residency program, director of translational research, and director of the supportive oncodermatology clinic in the department of dermatology, George Washington University, Washington.
Dermatology News editorial advisor Adam Friedman, MD, provides his recommendations for navigating the American Academy of Dermatology annual meeting at the San Diego Convention Center Feb. 16-20.
We’ve all seen the “What’s new in the tool shed/box/bucket/* insert noun here*” articles, lecture, videos ... that’s not what I am talking about. Get out of your comfort zone and check out the latest on the diagnosis and treatment of genital skin disorders in session S052 on Monday, Feb. 19, from 9 a.m. to 12 p.m. Get a taste for “Oral Diseases” with session F017 on Friday, Feb. 16, from 1 p.m. to 3 p.m. And who wouldn’t benefit from beefing up on granulomatous diseases with session F092 on Sunday, Feb. 18, from 1 p.m. to 3 p.m.? That was a rhetorical question.
Yes, be basic
Oldies but goodies
I may get older but the quality of some sessions stays the same. Nicholas Soter, MD, has been lecturing on urticaria since before I can remember – make sure to check this legend out in session U081 on Monday from 7:30 a.m. to 8:30 a.m. Joseph Jorrizo, MD, “Captain Complex Med Derm” himself, is directing the session on referral dermatology (F007) on Friday, from 9 a.m. to 11 a.m. (Yes, I know it conflicts with my session – see, no bias!). Last but not least, the ever so popular “Hot Topics” session (S048) on Monday, 9 a.m. to 12 p.m. Led by former AAD Vice President Kenneth Tomecki, MD, this session covers the gamut of what’s “so hot right now” in dermatology. Not to be missed.
Dr. Friedman is director of the residency program, director of translational research, and director of the supportive oncodermatology clinic in the department of dermatology, George Washington University, Washington.
Dermatology News editorial advisor Adam Friedman, MD, provides his recommendations for navigating the American Academy of Dermatology annual meeting at the San Diego Convention Center Feb. 16-20.
We’ve all seen the “What’s new in the tool shed/box/bucket/* insert noun here*” articles, lecture, videos ... that’s not what I am talking about. Get out of your comfort zone and check out the latest on the diagnosis and treatment of genital skin disorders in session S052 on Monday, Feb. 19, from 9 a.m. to 12 p.m. Get a taste for “Oral Diseases” with session F017 on Friday, Feb. 16, from 1 p.m. to 3 p.m. And who wouldn’t benefit from beefing up on granulomatous diseases with session F092 on Sunday, Feb. 18, from 1 p.m. to 3 p.m.? That was a rhetorical question.
Yes, be basic
Oldies but goodies
I may get older but the quality of some sessions stays the same. Nicholas Soter, MD, has been lecturing on urticaria since before I can remember – make sure to check this legend out in session U081 on Monday from 7:30 a.m. to 8:30 a.m. Joseph Jorrizo, MD, “Captain Complex Med Derm” himself, is directing the session on referral dermatology (F007) on Friday, from 9 a.m. to 11 a.m. (Yes, I know it conflicts with my session – see, no bias!). Last but not least, the ever so popular “Hot Topics” session (S048) on Monday, 9 a.m. to 12 p.m. Led by former AAD Vice President Kenneth Tomecki, MD, this session covers the gamut of what’s “so hot right now” in dermatology. Not to be missed.
Dr. Friedman is director of the residency program, director of translational research, and director of the supportive oncodermatology clinic in the department of dermatology, George Washington University, Washington.
‘Cutting for Stone’ author closes out this year’s AAD plenary session
The plenary session at the 2018 American Academy of Dermatology annual meeting in San Diego includes the Clarence S. Livingood, MD Memorial Award and Lectureship, by Mary-Margaret Chren, MD, professor in residence, department of dermatology, University of California, San Francisco, on “The State of (Measuring) the Art of Dermatology.”
Dr. Chren will be followed by the AAD president’s address, given by outgoing president Henry W. Lim, MD, chairman of the department of dermatology and Clarence S. Livingood Chair in Dermatology at Henry Ford Health System in Detroit.
Following Dr. Lim, Jan T. Vilcek, MD, PhD, will give the Eugene J. Van Scott Award for Innovative Therapy of the Skin and Phillip Frost Leadership Lecture on “How a TNF Inhibitor Advanced from Modest Beginnings to Unforeseen Therapeutic Successes.” Dr. Vilcek is research professor and professor emeritus of microbiology in the department of microbiology at New York University.
Suzanne M. Olbricht, MD, president-elect of the AAD and chief of dermatology at Beth Israel Deaconess Medical Center, Boston, will follow.
Jennifer A. Doudna, PhD, professor of chemistry, and professor of biochemistry and molecular biology at the University of California, Berkeley, will give the Lila and Murray Gruber Memorial Cancer Research Award and Lectureship. Her talk is titled, “CRISPR Systems: Nature’s Toolkit for Genome Editing.”
Finally, this year’s guest speaker is Abraham Verghese, MD, whose talk is titled: “The Pathology Within: Burnout, Wellness, and the Search for Meaning in a Professional Life.”
Dr. Verghese, professor and Linda R. Meier and Joan F. Lane Provostial Professor, and vice chair for the Theory and Practice of Medicine, Stanford (Calif.) University, is the author of several books including “Cutting for Stone,” his first novel.
The plenary session is scheduled for Sunday, Feb. 18, from 8 a.m. to 11:30 a.m.
The plenary session at the 2018 American Academy of Dermatology annual meeting in San Diego includes the Clarence S. Livingood, MD Memorial Award and Lectureship, by Mary-Margaret Chren, MD, professor in residence, department of dermatology, University of California, San Francisco, on “The State of (Measuring) the Art of Dermatology.”
Dr. Chren will be followed by the AAD president’s address, given by outgoing president Henry W. Lim, MD, chairman of the department of dermatology and Clarence S. Livingood Chair in Dermatology at Henry Ford Health System in Detroit.
Following Dr. Lim, Jan T. Vilcek, MD, PhD, will give the Eugene J. Van Scott Award for Innovative Therapy of the Skin and Phillip Frost Leadership Lecture on “How a TNF Inhibitor Advanced from Modest Beginnings to Unforeseen Therapeutic Successes.” Dr. Vilcek is research professor and professor emeritus of microbiology in the department of microbiology at New York University.
Suzanne M. Olbricht, MD, president-elect of the AAD and chief of dermatology at Beth Israel Deaconess Medical Center, Boston, will follow.
Jennifer A. Doudna, PhD, professor of chemistry, and professor of biochemistry and molecular biology at the University of California, Berkeley, will give the Lila and Murray Gruber Memorial Cancer Research Award and Lectureship. Her talk is titled, “CRISPR Systems: Nature’s Toolkit for Genome Editing.”
Finally, this year’s guest speaker is Abraham Verghese, MD, whose talk is titled: “The Pathology Within: Burnout, Wellness, and the Search for Meaning in a Professional Life.”
Dr. Verghese, professor and Linda R. Meier and Joan F. Lane Provostial Professor, and vice chair for the Theory and Practice of Medicine, Stanford (Calif.) University, is the author of several books including “Cutting for Stone,” his first novel.
The plenary session is scheduled for Sunday, Feb. 18, from 8 a.m. to 11:30 a.m.
The plenary session at the 2018 American Academy of Dermatology annual meeting in San Diego includes the Clarence S. Livingood, MD Memorial Award and Lectureship, by Mary-Margaret Chren, MD, professor in residence, department of dermatology, University of California, San Francisco, on “The State of (Measuring) the Art of Dermatology.”
Dr. Chren will be followed by the AAD president’s address, given by outgoing president Henry W. Lim, MD, chairman of the department of dermatology and Clarence S. Livingood Chair in Dermatology at Henry Ford Health System in Detroit.
Following Dr. Lim, Jan T. Vilcek, MD, PhD, will give the Eugene J. Van Scott Award for Innovative Therapy of the Skin and Phillip Frost Leadership Lecture on “How a TNF Inhibitor Advanced from Modest Beginnings to Unforeseen Therapeutic Successes.” Dr. Vilcek is research professor and professor emeritus of microbiology in the department of microbiology at New York University.
Suzanne M. Olbricht, MD, president-elect of the AAD and chief of dermatology at Beth Israel Deaconess Medical Center, Boston, will follow.
Jennifer A. Doudna, PhD, professor of chemistry, and professor of biochemistry and molecular biology at the University of California, Berkeley, will give the Lila and Murray Gruber Memorial Cancer Research Award and Lectureship. Her talk is titled, “CRISPR Systems: Nature’s Toolkit for Genome Editing.”
Finally, this year’s guest speaker is Abraham Verghese, MD, whose talk is titled: “The Pathology Within: Burnout, Wellness, and the Search for Meaning in a Professional Life.”
Dr. Verghese, professor and Linda R. Meier and Joan F. Lane Provostial Professor, and vice chair for the Theory and Practice of Medicine, Stanford (Calif.) University, is the author of several books including “Cutting for Stone,” his first novel.
The plenary session is scheduled for Sunday, Feb. 18, from 8 a.m. to 11:30 a.m.