The Journal of Family Practice is a peer-reviewed and indexed journal that provides its 95,000 family physician readers with timely, practical, and evidence-based information that they can immediately put into practice. Research and applied evidence articles, plus patient-oriented departments like Practice Alert, PURLs, and Clinical Inquiries can be found in print and at jfponline.com. The Web site, which logs an average of 125,000 visitors every month, also offers audiocasts by physician specialists and interactive features like Instant Polls and Photo Rounds Friday—a weekly diagnostic puzzle.

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Proclivity ID
18805001
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Citation Name
J Fam Pract
Negative Keywords
gaming
gambling
compulsive behaviors
ammunition
assault rifle
black jack
Boko Haram
bondage
child abuse
cocaine
Daech
drug paraphernalia
explosion
gun
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ISIL
ISIS
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Growths in abdominal folds

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Growths in abdominal folds

While the lesions appeared verrucous and cauliflower-like, this seemed an unusual place for condyloma. So the FP performed a shave biopsy out of concern that this could be a benign tumor. The results came back as human papillomavirus (HPV)-related condyloma.

 

In addition to the growths that were seen under the pannus, there was also intertrigo in that area. Intertrigo is a nonspecific term for a rash in an intertriginous area. Erythema seen between skin folds is the tip-off to intertrigo. The most common causes of intertrigo are fungal infections and irritation that come from sweating and the rubbing together of skin. Another cause of an erythematous rash in an intertriginous area is inverse psoriasis.

The FP performed a potassium hydroxide (KOH) preparation by scraping the erythematous area with a microscope slide and looking at the specimen under the microscope. The KOH was negative and the diagnosis was determined to be nonspecific intertrigo related to obesity. The FP told the patient to try to keep the area dry and to try some over-the-counter 1% hydrocortisone cream for the inflammation and irritation.

Pannus condylomas are uncommon—but not rare—in this age of increasing obesity. While they are secondary to HPV, they are not necessarily sexually transmitted HPV types. Based on the patient’s sexual history, the FP did not recommend screening for sexually transmitted infections.

On the initial visit, the FP counseled the patient about the importance of weight loss for good health and hygiene. The patient chose cryotherapy for treatment of the growths. While the patient held the pannus up, the FP sprayed the condyloma with liquid nitrogen using a cryo-gun. The patient chose to have a second freeze-thaw cycle and was scheduled for a follow-up visit in 3 to 4 weeks.

 

Photos and text for Photo Rounds Friday courtesy of Richard P. Usatine, MD. This case was adapted from: Mayeaux EJ, Usatine R. Genital warts. In: Usatine R, Smith M, Mayeaux EJ, et al, eds. Color Atlas of Family Medicine. 2nd ed. New York, NY: McGraw-Hill; 2013:759-765.

To learn more about the Color Atlas of Family Medicine, see: www.amazon.com/Color-Family-Medicine-Richard-Usatine/dp/0071769641/

You can now get the second edition of the Color Atlas of Family Medicine as an app by clicking on this link: usatinemedia.com

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While the lesions appeared verrucous and cauliflower-like, this seemed an unusual place for condyloma. So the FP performed a shave biopsy out of concern that this could be a benign tumor. The results came back as human papillomavirus (HPV)-related condyloma.

 

In addition to the growths that were seen under the pannus, there was also intertrigo in that area. Intertrigo is a nonspecific term for a rash in an intertriginous area. Erythema seen between skin folds is the tip-off to intertrigo. The most common causes of intertrigo are fungal infections and irritation that come from sweating and the rubbing together of skin. Another cause of an erythematous rash in an intertriginous area is inverse psoriasis.

The FP performed a potassium hydroxide (KOH) preparation by scraping the erythematous area with a microscope slide and looking at the specimen under the microscope. The KOH was negative and the diagnosis was determined to be nonspecific intertrigo related to obesity. The FP told the patient to try to keep the area dry and to try some over-the-counter 1% hydrocortisone cream for the inflammation and irritation.

Pannus condylomas are uncommon—but not rare—in this age of increasing obesity. While they are secondary to HPV, they are not necessarily sexually transmitted HPV types. Based on the patient’s sexual history, the FP did not recommend screening for sexually transmitted infections.

On the initial visit, the FP counseled the patient about the importance of weight loss for good health and hygiene. The patient chose cryotherapy for treatment of the growths. While the patient held the pannus up, the FP sprayed the condyloma with liquid nitrogen using a cryo-gun. The patient chose to have a second freeze-thaw cycle and was scheduled for a follow-up visit in 3 to 4 weeks.

 

Photos and text for Photo Rounds Friday courtesy of Richard P. Usatine, MD. This case was adapted from: Mayeaux EJ, Usatine R. Genital warts. In: Usatine R, Smith M, Mayeaux EJ, et al, eds. Color Atlas of Family Medicine. 2nd ed. New York, NY: McGraw-Hill; 2013:759-765.

To learn more about the Color Atlas of Family Medicine, see: www.amazon.com/Color-Family-Medicine-Richard-Usatine/dp/0071769641/

You can now get the second edition of the Color Atlas of Family Medicine as an app by clicking on this link: usatinemedia.com

While the lesions appeared verrucous and cauliflower-like, this seemed an unusual place for condyloma. So the FP performed a shave biopsy out of concern that this could be a benign tumor. The results came back as human papillomavirus (HPV)-related condyloma.

 

In addition to the growths that were seen under the pannus, there was also intertrigo in that area. Intertrigo is a nonspecific term for a rash in an intertriginous area. Erythema seen between skin folds is the tip-off to intertrigo. The most common causes of intertrigo are fungal infections and irritation that come from sweating and the rubbing together of skin. Another cause of an erythematous rash in an intertriginous area is inverse psoriasis.

The FP performed a potassium hydroxide (KOH) preparation by scraping the erythematous area with a microscope slide and looking at the specimen under the microscope. The KOH was negative and the diagnosis was determined to be nonspecific intertrigo related to obesity. The FP told the patient to try to keep the area dry and to try some over-the-counter 1% hydrocortisone cream for the inflammation and irritation.

Pannus condylomas are uncommon—but not rare—in this age of increasing obesity. While they are secondary to HPV, they are not necessarily sexually transmitted HPV types. Based on the patient’s sexual history, the FP did not recommend screening for sexually transmitted infections.

On the initial visit, the FP counseled the patient about the importance of weight loss for good health and hygiene. The patient chose cryotherapy for treatment of the growths. While the patient held the pannus up, the FP sprayed the condyloma with liquid nitrogen using a cryo-gun. The patient chose to have a second freeze-thaw cycle and was scheduled for a follow-up visit in 3 to 4 weeks.

 

Photos and text for Photo Rounds Friday courtesy of Richard P. Usatine, MD. This case was adapted from: Mayeaux EJ, Usatine R. Genital warts. In: Usatine R, Smith M, Mayeaux EJ, et al, eds. Color Atlas of Family Medicine. 2nd ed. New York, NY: McGraw-Hill; 2013:759-765.

To learn more about the Color Atlas of Family Medicine, see: www.amazon.com/Color-Family-Medicine-Richard-Usatine/dp/0071769641/

You can now get the second edition of the Color Atlas of Family Medicine as an app by clicking on this link: usatinemedia.com

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At first, the FP considered the diagnosis of seborrheic keratosis, as the lesions were verrucous and pigmented. But after asking to see the patient’s genital area, the FP made the diagnosis of condyloma acuminata.

 

This is a good example of how seeing the whole picture beyond what the patient shows you can lead to a more accurate diagnosis. Verrucous lesions on the penis are usually condyloma acuminata, but it is important to know that condyloma can spread up the abdomen and onto the upper thighs, as was seen in this case. The lesions can also be hyperpigmented in people of color. If any doubts remain, a shave biopsy of one of the abdominal lesions would prove the diagnosis of condyloma by demonstrating human papillomavirus (HPV) changes histologically.

In this case, the FP discussed the risk of other sexually transmitted infections with the patient. Syphilis and human immunodeficiency virus tests were ordered, and both turned out to be negative.

The patient chose cryotherapy as a treatment option and the lesions were frozen with liquid nitrogen using a standard cryo-gun and a 1 mm halo, creating an appropriate freeze ball for each lesion. The patient tolerated the procedure well and was willing to have a second freeze thaw cycle for a more rapid treatment response. The FP suggested a follow-up visit in 3 to 4 weeks for a second round of cryotherapy. The patient indicated that he would be willing to try topical imiquimod after the next visit if the cryotherapy didn’t fully work.

 

Photos and text for Photo Rounds Friday courtesy of Richard P. Usatine, MD. This case was adapted from: Mayeaux EJ, Usatine R. Genital warts. In: Usatine R, Smith M, Mayeaux EJ, et al, eds. Color Atlas of Family Medicine. 2nd ed. New York, NY: McGraw-Hill; 2013:759-765.

To learn more about the Color Atlas of Family Medicine, see: www.amazon.com/Color-Family-Medicine-Richard-Usatine/dp/0071769641/

You can now get the second edition of the Color Atlas of Family Medicine as an app by clicking on this link: usatinemedia.com

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At first, the FP considered the diagnosis of seborrheic keratosis, as the lesions were verrucous and pigmented. But after asking to see the patient’s genital area, the FP made the diagnosis of condyloma acuminata.

 

This is a good example of how seeing the whole picture beyond what the patient shows you can lead to a more accurate diagnosis. Verrucous lesions on the penis are usually condyloma acuminata, but it is important to know that condyloma can spread up the abdomen and onto the upper thighs, as was seen in this case. The lesions can also be hyperpigmented in people of color. If any doubts remain, a shave biopsy of one of the abdominal lesions would prove the diagnosis of condyloma by demonstrating human papillomavirus (HPV) changes histologically.

In this case, the FP discussed the risk of other sexually transmitted infections with the patient. Syphilis and human immunodeficiency virus tests were ordered, and both turned out to be negative.

The patient chose cryotherapy as a treatment option and the lesions were frozen with liquid nitrogen using a standard cryo-gun and a 1 mm halo, creating an appropriate freeze ball for each lesion. The patient tolerated the procedure well and was willing to have a second freeze thaw cycle for a more rapid treatment response. The FP suggested a follow-up visit in 3 to 4 weeks for a second round of cryotherapy. The patient indicated that he would be willing to try topical imiquimod after the next visit if the cryotherapy didn’t fully work.

 

Photos and text for Photo Rounds Friday courtesy of Richard P. Usatine, MD. This case was adapted from: Mayeaux EJ, Usatine R. Genital warts. In: Usatine R, Smith M, Mayeaux EJ, et al, eds. Color Atlas of Family Medicine. 2nd ed. New York, NY: McGraw-Hill; 2013:759-765.

To learn more about the Color Atlas of Family Medicine, see: www.amazon.com/Color-Family-Medicine-Richard-Usatine/dp/0071769641/

You can now get the second edition of the Color Atlas of Family Medicine as an app by clicking on this link: usatinemedia.com

At first, the FP considered the diagnosis of seborrheic keratosis, as the lesions were verrucous and pigmented. But after asking to see the patient’s genital area, the FP made the diagnosis of condyloma acuminata.

 

This is a good example of how seeing the whole picture beyond what the patient shows you can lead to a more accurate diagnosis. Verrucous lesions on the penis are usually condyloma acuminata, but it is important to know that condyloma can spread up the abdomen and onto the upper thighs, as was seen in this case. The lesions can also be hyperpigmented in people of color. If any doubts remain, a shave biopsy of one of the abdominal lesions would prove the diagnosis of condyloma by demonstrating human papillomavirus (HPV) changes histologically.

In this case, the FP discussed the risk of other sexually transmitted infections with the patient. Syphilis and human immunodeficiency virus tests were ordered, and both turned out to be negative.

The patient chose cryotherapy as a treatment option and the lesions were frozen with liquid nitrogen using a standard cryo-gun and a 1 mm halo, creating an appropriate freeze ball for each lesion. The patient tolerated the procedure well and was willing to have a second freeze thaw cycle for a more rapid treatment response. The FP suggested a follow-up visit in 3 to 4 weeks for a second round of cryotherapy. The patient indicated that he would be willing to try topical imiquimod after the next visit if the cryotherapy didn’t fully work.

 

Photos and text for Photo Rounds Friday courtesy of Richard P. Usatine, MD. This case was adapted from: Mayeaux EJ, Usatine R. Genital warts. In: Usatine R, Smith M, Mayeaux EJ, et al, eds. Color Atlas of Family Medicine. 2nd ed. New York, NY: McGraw-Hill; 2013:759-765.

To learn more about the Color Atlas of Family Medicine, see: www.amazon.com/Color-Family-Medicine-Richard-Usatine/dp/0071769641/

You can now get the second edition of the Color Atlas of Family Medicine as an app by clicking on this link: usatinemedia.com

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The FP diagnosed this patient with condyloma acuminata, also known as genital warts. The warts were well-keratinized since the patient was circumcised and the warts were not under foreskin. Genital warts found in the moist area under the foreskin of uncircumcised men tend to look more cauliflower-like.

 

Genital warts are caused by human papillomavirus infection, which encompasses a family of primarily sexually transmitted double-stranded DNA viruses. The incubation period after exposure ranges from 3 weeks to 8 months.

Anogenital warts are the most common viral sexually transmitted disease (STD) in the United States. There are approximately one million new cases of genital warts per year in the United States. Most infections are transient and clear up within 2 years, but some infections persist and recur, causing a great deal of distress for patients.

The diagnosis is usually clinical. Genital warts are typically asymptomatic and present as flesh-colored, exophytic lesions on the genitalia, including the penis, vulva, vagina, scrotum, perineum, and perianal skin. External warts can appear as small bumps, or they may be flat, verrucous, or pedunculated.

The FP discussed the patient’s history of unsafe sex and recommended that he receive screening for other STDs. The patient did not believe he had human immunodeficiency virus (HIV), but was willing to be tested for it and for syphilis. He denied any urethral discharge or burning on urination, but wanted to be screened for gonorrhea and chlamydia, as well. The FP ordered blood tests for syphilis and HIV and a urine screen for gonorrhea and chlamydia which were all negative.

After discussing treatment options, the patient opted to pursue cryotherapy. The FP sprayed the condyloma with liquid nitrogen using a freeze/thaw/freeze cycle and offered the patient a prescription for imiquimod cream. However, the patient preferred to return for additional cryotherapy. A follow-up appointment was set for 3 weeks.

 

Photos and text for Photo Rounds Friday courtesy of Richard P. Usatine, MD. This case was adapted from: Mayeaux EJ, Usatine R. In: Usatine R, Smith M, Mayeaux EJ, et al, eds. Color Atlas of Family Medicine. 2nd ed. New York, NY: McGraw-Hill; 2013:759-765.

To learn more about the Color Atlas of Family Medicine, see: www.amazon.com/Color-Family-Medicine-Richard-Usatine/dp/0071769641/

You can now get the second edition of the Color Atlas of Family Medicine as an app by clicking on this link: usatinemedia.com

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The FP diagnosed this patient with condyloma acuminata, also known as genital warts. The warts were well-keratinized since the patient was circumcised and the warts were not under foreskin. Genital warts found in the moist area under the foreskin of uncircumcised men tend to look more cauliflower-like.

 

Genital warts are caused by human papillomavirus infection, which encompasses a family of primarily sexually transmitted double-stranded DNA viruses. The incubation period after exposure ranges from 3 weeks to 8 months.

Anogenital warts are the most common viral sexually transmitted disease (STD) in the United States. There are approximately one million new cases of genital warts per year in the United States. Most infections are transient and clear up within 2 years, but some infections persist and recur, causing a great deal of distress for patients.

The diagnosis is usually clinical. Genital warts are typically asymptomatic and present as flesh-colored, exophytic lesions on the genitalia, including the penis, vulva, vagina, scrotum, perineum, and perianal skin. External warts can appear as small bumps, or they may be flat, verrucous, or pedunculated.

The FP discussed the patient’s history of unsafe sex and recommended that he receive screening for other STDs. The patient did not believe he had human immunodeficiency virus (HIV), but was willing to be tested for it and for syphilis. He denied any urethral discharge or burning on urination, but wanted to be screened for gonorrhea and chlamydia, as well. The FP ordered blood tests for syphilis and HIV and a urine screen for gonorrhea and chlamydia which were all negative.

After discussing treatment options, the patient opted to pursue cryotherapy. The FP sprayed the condyloma with liquid nitrogen using a freeze/thaw/freeze cycle and offered the patient a prescription for imiquimod cream. However, the patient preferred to return for additional cryotherapy. A follow-up appointment was set for 3 weeks.

 

Photos and text for Photo Rounds Friday courtesy of Richard P. Usatine, MD. This case was adapted from: Mayeaux EJ, Usatine R. In: Usatine R, Smith M, Mayeaux EJ, et al, eds. Color Atlas of Family Medicine. 2nd ed. New York, NY: McGraw-Hill; 2013:759-765.

To learn more about the Color Atlas of Family Medicine, see: www.amazon.com/Color-Family-Medicine-Richard-Usatine/dp/0071769641/

You can now get the second edition of the Color Atlas of Family Medicine as an app by clicking on this link: usatinemedia.com

The FP diagnosed this patient with condyloma acuminata, also known as genital warts. The warts were well-keratinized since the patient was circumcised and the warts were not under foreskin. Genital warts found in the moist area under the foreskin of uncircumcised men tend to look more cauliflower-like.

 

Genital warts are caused by human papillomavirus infection, which encompasses a family of primarily sexually transmitted double-stranded DNA viruses. The incubation period after exposure ranges from 3 weeks to 8 months.

Anogenital warts are the most common viral sexually transmitted disease (STD) in the United States. There are approximately one million new cases of genital warts per year in the United States. Most infections are transient and clear up within 2 years, but some infections persist and recur, causing a great deal of distress for patients.

The diagnosis is usually clinical. Genital warts are typically asymptomatic and present as flesh-colored, exophytic lesions on the genitalia, including the penis, vulva, vagina, scrotum, perineum, and perianal skin. External warts can appear as small bumps, or they may be flat, verrucous, or pedunculated.

The FP discussed the patient’s history of unsafe sex and recommended that he receive screening for other STDs. The patient did not believe he had human immunodeficiency virus (HIV), but was willing to be tested for it and for syphilis. He denied any urethral discharge or burning on urination, but wanted to be screened for gonorrhea and chlamydia, as well. The FP ordered blood tests for syphilis and HIV and a urine screen for gonorrhea and chlamydia which were all negative.

After discussing treatment options, the patient opted to pursue cryotherapy. The FP sprayed the condyloma with liquid nitrogen using a freeze/thaw/freeze cycle and offered the patient a prescription for imiquimod cream. However, the patient preferred to return for additional cryotherapy. A follow-up appointment was set for 3 weeks.

 

Photos and text for Photo Rounds Friday courtesy of Richard P. Usatine, MD. This case was adapted from: Mayeaux EJ, Usatine R. In: Usatine R, Smith M, Mayeaux EJ, et al, eds. Color Atlas of Family Medicine. 2nd ed. New York, NY: McGraw-Hill; 2013:759-765.

To learn more about the Color Atlas of Family Medicine, see: www.amazon.com/Color-Family-Medicine-Richard-Usatine/dp/0071769641/

You can now get the second edition of the Color Atlas of Family Medicine as an app by clicking on this link: usatinemedia.com

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Transgender patients: Providing sensitive care

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PRACTICE RECOMMENDATIONS

› Refer transgender patients to a mental health provider with experience in treating this patient population for diagnosis of gender dysphoria. B
› Confirm patients’ eligibility for hormone therapy and obtain informed consent before initiating it. B
› Treat minor adverse effects of hormone therapy whenever possible, as discontinuing the hormones may be detrimental to the well-being of patients in the process of transitioning. B
› Continue recommended screenings based on the sex the patient was assigned at birth, unless the organ or tissue in question has been surgically removed. A

Strength of recommendation (SOR)

A Good-quality patient-oriented evidence
B Inconsistent or limited-quality patient-oriented evidence
C Consensus, usual practice, opinion, disease-oriented evidence, case series

 

Civil rights for the lesbian, gay, bisexual, and transgender population have advanced markedly in the past decade, and the medical community has gradually begun to address more of their health concerns. More recently, media attention to transgender individuals—although focused primarily on the “appropriate” use of restrooms—has encouraged many more to openly seek care.1,2

It is estimated that anywhere from 0.3% to 5% of the US population identifies as transgender.1-3 While awareness of this population has slowly increased, there is a paucity of research on the hormone treatment that is often essential to patients’ well-being. Studies of surgical options for transgender patients have been minimal, as well.

Family physicians are uniquely positioned to coordinate medical services and ensure continuity of care for transgender patients as they strive to become their authentic selves. Our goal in writing this article is to equip you with the tools to provide this patient population with sensitive, high-quality care (TABLE 1).4-7 Our focus is on the diagnosis of gender dysphoria (GD) and its medical and hormonal management—the realm of primary care providers. We briefly discuss surgical management of GD, as well.

 

 

Understanding and diagnosing gender dysphoria

Two classification systems are used for diagnoses related to GD: the Diagnostic and Statistical Manual of Mental Disorders, Fifth Ed. (DSM-5)8 and the International Classification of Diseases, 10th Rev. (ICD-10).9

The transitioning process is a complex and individualized journey that can include inward or outward change, or both.

ICD-10 criteria use the term “gender identity disorder;” DSM-5 refers to “gender dysphoria” instead. It is important to emphasize that these classification systems represent an attempt to categorize a group of signs and symptoms that lead to distress for the patient, and are not meant to suggest that being transgender is pathological. In fact, in DSM-5—released in 2013—the American Psychiatric Association revised the terminology to emphasize that such individuals are not “disordered” by the nature of their identity, but rather by the distress that being transgender causes.8

For a diagnosis of GD in children, DSM-5 criteria include characteristics perceived to be incongruent between the child’s sex at birth and the self-identified gender based on preferred activities or dislike of his or her own sexual anatomy. The child must meet 6 or more of the following for at least 6 months:

  • a repeatedly stated desire to be, or insistence that he or she is, of the other gender
  • in boys, a preference for cross-dressing or simulating female attire; in girls, insistence on wearing only stereotypical masculine clothing
  • strong and persistent preferences for cross-gender roles in make-believe play or fantasy
  • a strong rejection of toys/games typically associated with the child’s sex
  • intense desire to participate in stereotypical games and pastimes of the other gender
  • strong preference for playmates of the other gender
  • a strong dislike of one’s sexual anatomy
  • a strong desire for the primary (eg, penis or vagina) or secondary (eg, menstruation) sex characteristics of the other gender.8

Adolescents and adults must meet 2 or more of the following for at least 6 months:

  • a noticeable incongruence between the gender that the patient sees themselves as and their sex characteristics
  • an intense need to do away with (or prevent) his or her primary or secondary sex features
  • an intense desire to have the primary and/or secondary sex features of the other gender
  • a deep desire to transform into another gender
  • a profound need for society to treat them as someone of the other gender
  • a powerful assurance of having the characteristic feelings and responses of the other gender.8

For children as well as adolescents and adults, the condition should cause the patient significant distress or significantly affect him or her socially, at work or school, and in other important areas of life.8

Is the patient a candidate for hormone therapy?

Two primary sources—Standards of Care for the Health of Transsexual, Transgender, and Gender-Nonconforming People, Version 7, issued by the World Professional Association for Transgender Health (WPATH)10 and Endocrine Treatment of Transsexual Persons11 by the Endocrine Society—offer clinical practice guidance based on evidence and expert opinion.

WPATH recommends that a mental health professional (MHP) experienced in transgender care diagnose GD to ensure that it is not mistaken for a psychiatric condition manifesting as altered gender identity. However, if no one with such experience is available or accessible in the region, it is reasonable for a primary care physician to make the diagnosis and consider initiating hormone therapy without a mental health referral,12 as the expected benefits outweigh the risks of nontreatment.13

Whether or not a MHP confirms a diagnosis of GD, it is still up to the treating physician to confirm the patient’s eligibility and readiness for hormone therapy: He or she should meet DSM-5 or ICD-10 criteria for GD, have no psychiatric comorbidity (eg, schizophrenia, body dysmorphic disorder, or uncontrolled bipolar disorder) likely to interfere with treatment, understand the expected outcomes and the social benefits and risks, and have indicated a willingness to take the hormones responsibly.

Historically, patients were required to have a documented Real-Life Experience (RLE), defined as having fully adopted the new gender role in everyday life for at least 3 months.10,11 This model has fallen out of favor, however, as it is unsupported by evidence and may place transgender individuals at physical and emotional risk.. Instead, readiness is confirmed by obtaining informed consent.12

Puberty may be suppressed with a gonadotropin-releasing hormone (GnRH) agonist in adolescents who have a GD diagnosis and are at Tanner stage 2 to 3 of puberty until age 16. At that point, hormone therapy consistent with their gender identification may be initiated.11 (See “How to help transgender teens.”11,14-20)

 

 

SIDEBAR
How to help transgender teens

Gender exploration is a normal part of childhood. Changes that occur during puberty cause many adolescents to question their ideas of gender and sexuality, but those with persistent gender nonconformity or extreme body dysphoria should receive medical and mental health care as early as possible.

A mental health professional (MHP) can help families create a safe, unconditionally accepting, and supportive environment in which their child can develop into his or her authentic self. A specialist in adolescent gender dysphoria (GD) should be consulted before initiating hormone therapy. Family physicians are well positioned to provide follow-up and ongoing care.

Initiating hormone suppression for adolescents with GD early in puberty can greatly reduce the emotional trauma, as well as the need for surgery related to unwanted secondary sex characteristics. Hormone suppression also gives adolescents more time to explore their gender nonconformity and developmental needs. Treatment with a gonadotropin-releasing hormone agonist such as leuprolide or histrelin can be initiated for adolescents in Tanner Stage 2, assessed by hormone levels, as well as breast, testicle, and pubic hair development (childgrowthfoundation.org/CMS/FILES/Puberty_and_the_Tanner_Stages.pdf), to suppress ongoing puberty.11,14

The effects of puberty blockers are reversible. If preferred, however, medication management can allow teens to progress directly from hormone suppression to the puberty of their self-identified gender once initiation of adult transgender hormone therapy is started—typically around the age of 16.11

Some adolescents may seek medical care well after puberty has begun. It is possible to use hormone suppression therapy after a teen has started to develop unwanted secondary sex characteristics. However, such patients may get less benefit from puberty blockers and often derive more benefit from initiation of cross-gender hormones.

Safety—a broader perspective. Regardless of medical treatment or the age at which treatment is begun, parents and patients need to be reminded that gender transition is about more than hormones. It is crucial that either the MHP or primary care physician, or both, address safety issues and work with the transgender individual to create a comprehensive plan for his or her health, safety, and social well-being.

Psychosocial concerns for transgender youth are vast, often encompassing rejection by peers and potentially, by family and authority figures; harassment; physical, emotional, and sexual abuse; inadequate housing; legal problems; lack of financial support; and educational difficulties.15 School is a particular source of concern. A survey by the Gay, Lesbian and Straight Education Network found, for instance, that nearly 9 in 10 transgender youth had been verbally harassed at school because of their gender expression. More than half also reported being physically harassed (eg, pushed or shoved).15

Bathroom use in schools is a major issue, as well, with transgender youth often prevented from using the restroom or locker room that coincides with their gender identity. In May, 11 states filed a lawsuit against the Obama administration for directing schools to allow such students to do so or risk the loss of federal funds.16

Tools and support. In 2006, the Vancouver Coastal Health, Transcend Transgender Support & Education Society, and the Canadian Rainbow Health Coalition published guidelines for the care of transgender adolescents, including a modification of the HEEADSSS tool (used to assess teens’ psychosocial well-being) specific to transgender youth.17 (See http://www.amsa.org/wp-content/uploads/2015/04/CaringForTransgenderAdolescents.pdf.) The tool can help you identify possible areas of concern and intervene, as needed.

If a patient reports feeling especially vulnerable at school, for example, encourage him or her to identify supportive friends, family members, teachers, or school counselors who can help create safe networks. Suggest that a teen who feels threatened travel in groups whenever possible. Stress to family members that their acceptance is key to nurturing positive feelings in youth with GD. And refer patients and parents to organizations that provide information and support.

Chief among them are Trans Youth Family Allies18 (www.imatyfa.org), which provides resources for parents, educators, and health care practitioners; the Human Rights Campaign, which has created a survival guide for gay and transgender youth who are forced to seek independent living19 (available at hrc-assets.s3-website-us-east-1.amazonaws.com//files/assets/resources/HRC-OnOurOwn-LGBTQYouth.pdf), and the Gay, Lesbian, Bisexual, and Transgender National Help Center, which hosts a GLBT national hotline (888-843-4564) and a weekly Trans Teen Online Talk Group.20 For more information about the online talk group, go to glbthotline.org and click on “transteens.”

 

 

Beginning the transition

The transitioning process is a complex and individualized journey that can include inward or outward change, or both.

For patients interested in medical interventions, possible therapies include cross-sex hormone administration and gender-affirming surgery. Both are aimed at making the physical and the psychological more congruent. Hormone treatment (TABLE 2)10,11,21 is often essential to reduce the distress of individuals with GD and to help them feel comfortable in their own body. Psychological conditions, such as depression, tend to improve as the transitioning process gets underway.22

 

 

 

Female-to-male transition

CASE 1

Jennie R, a 55-year-old postmenopausal patient, comes to your office for an annual exam. Although you’ve been her primary care physician for several years, she confides for the first time that she has never been comfortable as a woman. “I’ve always felt that my body didn’t belong to me,” the patient admits, and goes on to say that for the last several years she has been living as a man. Jennie R says she is ready to start hormone therapy to assist with the gender transition and asks about the process, the benefits and risks, and how quickly she can expect to achieve the desired results.

If Jennie R were your patient, how would you respond?

Masculinizing hormone treatment

As you would explain to a patient like Jennie R, the goal of hormone therapy is to suppress the effects of the sex assigned at birth and replace them with those of the desired gender. In the case of a female transitioning to a male (known as a transman), masculinizing hormones would promote growth of facial and body hair, cessation of menses, increased muscle mass, deepening of the voice, and clitoral enlargement.11,23,24

Physical changes induced by masculinizing hormone therapy have an expected onset of one to 6 months and achieve maximum effect in approximately 2 to 5 years.10,11 Although there have been no controlled clinical trials evaluating the safety or efficacy of any transitional hormone regimen, WPATH and the Center of Excellence for Transgender Health at the University of California, San Francisco, suggest initiating intramuscular or transdermal testosterone at increasing doses until normal physiologic male testosterone levels between 350 and 700 ng/dL are achieved, or until cessation of menses.13,25-28 The dose at which either, or both, occur should be continued as long-term maintenance therapy. Medroxyprogesterone can be added, if necessary for menstrual cessation, and a GnRH agonist or endometrial ablation can be used for refractory uterine bleeding.29,30

Psychological conditions such as depression tend to improve when a transgender individual begins the transitioning process.

Testosterone is not a contraceptive. It is important to emphasize to transmen like Jennie that they remain at risk of pregnancy if they are having sex with fertile males. Caution patients not to assume that the possibility of pregnancy ends when menses stop.

Treat minor adverse effects. Adverse effects of masculinizing hormones include vaginal atrophy, fat redistribution and weight gain, polycythemia, acne, scalp hair loss, sleep apnea, elevated liver enzymes, hyperlipidemia, cardiovascular disease, diabetes, and bone density loss. Increased risk of cancer of the female organs has not been proven.10,11 It is reasonable to treat minor adverse effects after reviewing the risks vs benefits of doing so, as discontinuing hormone therapy could be detrimental to the well-being of transitioning patients.11

There are absolute contraindications to masculinizing hormone therapy, however, including pregnancy, unstable coronary artery disease, and untreated polycythemia with a hematocrit >55%.10

Monitoring is essential. Patients receiving masculinizing hormone therapy should be monitored every 3 months during the first year and once or twice a year thereafter, with a focused history (including mood symptoms), physical exam (including weight and blood pressure), and labs (including complete blood count, liver function, renal function, and lipids) at each visit.11,23 Some clinicians also check estradiol levels until they fall below 50 pg/mL,23,27 while others take the cessation of uterine bleeding for >6 months as an indicator of estrogen suppression.

Remind patients of the need for contraception, pointing out that a male transitioning to a female may still impregnate a female partner and a female transitioning to a male may still conceive.

Preventive health measures continue. Routine screening should continue, based on the patient’s assigned sex at birth. Thus, a transman who has not had a hysterectomy still needs Pap smears, mammograms if the patient has not had a double mastectomy, and bone mineral density (BMD) testing to screen for osteoporosis.31,32 Some experts recommend starting to test BMD at age 50 for patients receiving masculinizing hormones, given the unknown effect of testosterone on bone density.11,31,32

CASE 1

The first question for a transgender patient is about his or her current gender identity, but Jennie R has already reported living as a man. So you start by asking “What name do you prefer to use?” and “Do you prefer to be referred to with male or female pronouns?”

The patient tells you that he sees himself as a man, he wants to be called Jeff, and he prefers male pronouns. You explain that you believe he has gender dysphoria and would benefit from hormone therapy, but it is important to confirm this diagnosis with a MHP. You explain that testosterone can be prescribed for masculinizing effects, and describe the expected effects—more facial and body hair, a deeper voice and greater muscle mass, among others—and review the likely time frame

You also discuss the risks of masculinizing hormones (hyperlipidemia, cardiovascular disease, diabetes, and loss of bone density) that will need to be monitored. Before he leaves, you give him the name of a MHP who is experienced in transgender care and tell him to make a follow-up appointment with you after he has seen her. At the conclusion of the visit, you make a note of the patient’s name and gender identity in the chart and inform the staff of the changes.

 

 

Male-to-female transition

CASE 2

Before heading into your office to talk to a new patient named Carl S, you glance at his chart and see that he is a healthy 21-year-old who has come in for a routine physical. When you enter the room, you find Carl wearing a dress, heels, and make-up. After confirming that you have the right patient, you ask, “What is your current gender identity?” “Female,” says Carl, who indicates that she now goes by Carol. The patient has no medical problems, surgical history, or significant family history, but reports that she has been taking spironolactone and estrogen for the past 3 years. Carol also says she has a new female partner and is having unprotected sexual activity.

Feminizing hormone treatment

The desired effects of feminizing hormones include voice change, decreased hair growth, breast growth, body fat redistribution, decreased muscle mass, skin softening, decreased oiliness of skin and hair, and a decrease in spontaneous erections, testicular volume, and sperm production.10,11 The onset of feminizing effects ranges from one month to one year and the expected maximum effect occurs anywhere between 3 months and 5 years.10,11 Regimens usually include anti-androgen agents and estrogen.13,26-28

The medications that have been most studied with anti-androgenic effects include spironolactone and 5-alpha reductase inhibitors (5-ARIs) such as finasteride. Spironolactone inhibits testosterone secretion and inhibits androgen binding to androgen receptors; 5-ARIs block the conversion of testosterone to 5-alpha-dihydrotestosterone, the more active form.

Males transitioning to females should undergo breast cancer screening beginning at 40 to 50 years of age if they remain on hormone therapy.

Estrogen can be administered via oral, sublingual, transdermal, or intramuscular route, but parenteral formulations are preferred to avoid first-pass metabolism. The serum estradiol target is similar to the mean daily level of premenopausal women (<200 pg/mL) and the level of testosterone should be in the normal female range (<55 ng/dL).13,26-28

The selection of medications should be individualized for each patient. Comorbidities must be considered, as well as the risk of adverse effects, which include venous thromboembolism, elevated liver enzymes, breast cancer, cardiovascular disease, diabetes, hyperprolactinemia, weight gain, gallstones, cerebrovascular disease, and severe migraine headaches.10,11 Estrogen therapy is not reported to induce hypertrophy or premalignant changes in the prostate.33 As is the case for masculinizing hormones, feminizing hormone therapy should be continued indefinitely for long-term effects.

Frequent monitoring is recommended. Patients on feminizing hormones (transwomen) should be seen every 2 to 3 months in the first year and monitored once or twice a year thereafter. Serum testosterone and estradiol levels should initially be monitored every 3 months; serum electrolytes, specifically potassium, should be monitored every 2 to 3 months in the first year until stable.

CASE 2

You recommend that Carol S be screened annually for sexually transmitted diseases, as you would for any 21-year-old patient. You point out, too, that while estrogen and androgen-suppressing therapy decrease sperm production, there is a possibility that the patient could impregnate a female partner and recommend that contraception be used if the couple is not trying to conceive.

You also discuss the risks and benefits of hormone therapy and reasonable expectations of continued treatment. You ask Carol to schedule a follow-up visit in 6 months, as her hormone regimen is stable. Finally, if the patient remains on hormone therapy, you mention that the only screening unique to men transitioning to women is for breast cancer, which should begin at 40 to 50 years of age (as it is for all women).

Gender-affirming surgical options

Nearly 9 in 10 transgender youth report being verbally harassed at school because of their gender expression. More than half report being physically harassed.

Surgical management of transgender patients is not within the scope of family medicine. But it is essential to know what procedures are available as you may have occasion to advocate for patients during the surgical referral process and possibly to provide postoperative care.

For transmen, surgical options include chest reconstruction, hysterectomy/oophorectomy, metoidioplasty (using the clitoris to surgically approximate a penis), phalloplasty, scrotoplasty, urethroplasty, and vaginectomy.10,34 The surgeries available for transwomen are orchiectomy, vaginoplasty, penectomy, breast augmentation, thyroid chondroplasty and voice surgery, and facial feminization.10,34 Keep in mind that not all transgender individuals desire surgery as part of the transitioning process.

CORRESPONDENCE
Abbas Hyderi, MD, MPH, 1919 West Taylor Street, M/C 663, Chicago, IL 60612; ahyder2@uic.edu.

The authors would like to acknowledge the assistance of Michelle Forcier, MD, MPH, and Karen S. Bernstein, MD, MPH, in the preparation of this manuscript. 

References

1. Pew Research Center. A survey of LGBT Americans: attitudes, experiences and values in changing times. Available at: http://www.pewsocialtrends.org/2013/06/13/a-survey-of-lgbt-americans. Accessed June 24, 2015.

2. Gates GJ. How many people are lesbian, gay, bisexual and transgender? Available at: http://williamsinstitute.law.ucla.edu/wp-content/uploads/Gates-How-Many-People-LGBT-Apr-2011.pdf. Accessed May 25, 2016.

3. van Kesteren PJ, Gooren LJ, Megens JA. An epidemiological and demographic study of transsexuals in The Netherlands. Arch Sex Behav. 1996;25:589-600.

4. Bhola S. An ally’s guide to terminology: talking about LGBT people & equality. Available at: http://www.glaad.org/2011/07/28/an-allys-guide-to-terminology-talking-about-lgbt-people-equality. Accessed June 24, 2015.

5. University of California, San Francisco. Transgender terminology. UCSF Center of Excellence for Transgender Health. Available at: http://transhealth.ucsf.edu/tcoe?page=protocol-terminology. Accessed June 24, 2015.

6. Istar A. How queer! the development of gender identity and sexual orientation in LGBTQ-headed families. Fam Process. 2010;49:268-290.

7. Goins ES, Pye D. Check the box that best describes you: reflexively managing theory and praxis in LGBTQ health communication research. Health Commun. 2013;28:397-407.

8. American Psychiatric Association. Gender dysphoria. Diagnostic and Statistical Manual of Mental Disorders, 5th ed. Washington, DC: American Psychiatric Association. 2013:451-459.

9. World Health Organization. The International Classification of Diseases, 10th rev. Classification of mental and behavioural disorders: clinical descriptions and diagnostic guidelines. 1992; Geneva.

10. Coleman E, Bockting W, Botzer M, et al; World Professional Association for Transgender Health. Standards of Care for the Health of Transsexual, Transgender, and Gender-Nonconforming People, Version 7. Int J Transgender. 2011;13:165–232.

11. Hembree WC, Cohen-Kettenis P, Delemarre-van de Waal HA, et al. Endocrine Treatment of transsexual persons: an Endocrine Society Clinical Practice Guideline. J Clin Endo Metabol. 2009;94:3132–3154.

12. University of California, San Francisco. Assessing readiness for hormones. UCSF Center of Excellence for Transgender Health. Available at: http://transhealth.ucsf.edu/tcoe?page=protocol-hormone-ready. Accessed June 24, 2015.

13. Gooren L. Hormone treatment of the adult transsexual patient. Horm Res. 2005;64(suppl 2):S31-S614.

14. Hembree WC. Guidelines for pubertal suspension and gender reassignment for transgender adolescents. Child Adolesc Psychiatr Clin N Am. 2011;20:725-732.

15. Gay, Lesbian, and Straight Education Network (GLSEN). Harsh realities. The experiences of transgender youth in our nation’s schools. Available at: https://www.glsen.org/sites/default/files/Harsh%20Realities.pdf. Accessed May 29, 2016.

16. Berman M, Balingit M. Eleven states sue Obama administration over bathroom guidance for transgender students. May 25, 2016. Washington Post. Available at: https://www.washingtonpost.com/news/post-nation/wp/2016/05/25/texas-governor-says-state-will-sue-obama-administration-over-bathroom-directive/. Accessed May 31, 2016.

17. de Vries AL, Cohen-Kettenis PT, Delemarre-van de Waal H. Clinical management of gender dysphoria in adolescents. 2006. Vancouver Coastal Health - Transgender Health Program. Available at: http://www.amsa.org/wp-content/uploads/2015/04/CaringForTransgenderAdolescents.pdf. Accessed May 26, 2016.

18. TransYouth Family Allies. Empowering transgender youth & families. Available at: http://www.imatyfa.org/. Accessed May 26, 2016.

19. Human Rights Campaign. On our own: a survival guide for independent LGBTQ youth. Available at: https://www.hrc.org/resources/on-our-own-a-survival-guide-for-independent-lgbtq-youth. Accessed May 26, 2016.

20. Gay, Lesbian, Bisexual, and Transgender National Help Center. Available at: www.glbthotline.org. Accessed May 31, 2016.

21. University of California, San Francisco. Hormone administration. UCSF Center of Excellence for Transgender Health. Available at: http://transhealth.ucsf.edu/trans?page=protocol-hormones.  Accessed December 12, 2015.

22. Gorin-Lazard A, Baumstarck K, Boyer L, et al. Hormonal therapy is associated with better self-esteem, mood, and quality of life in transsexuals. J Nerv Ment Dis. 2013;201:996-1000.

23. Bhasin S, Cunningham GR, Hayes FJ, et al. Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2006;91:1995-2010.

24. Boloña ER, Uraga MV, Haddad RM, et al. Testosterone use in men with sexual dysfunction: a systematic review and meta-analysis of randomized placebo-controlled trials. Mayo Clin Proc. 2007;82:20-28.

25. Gooren LJ, Giltay EJ. Review of studies of androgen treatment of female-to-male transsexuals: effects and risks of administration of androgens to females. J Sex Med. 2008;5:765-776.

26. Levy A, Crown A, Reid R. Endocrine intervention for transsexuals. Clin Endocrinol (Oxf). 2003;59:409-418.

27. Moore E, Wisniewski A, Dobs A. Endocrine treatment of transsexual people: a review of treatment regimens, outcomes, and adverse effects. J Clin Endocrinol Metab. 2003;88:3467-3473.

28. Tangpricha V, Ducharme SH, Barber TW, et al. Endocrinologic treatment of gender identity disorders. Endocr Pract. 2003;9:12-21.

29. Dickersin K, Munro MG, Clark M, et al.  Hysterectomy compared with endometrial ablation for dysfunctional uterine bleeding: a randomized control trial. Obstet Gynecol. 2007;110:1279-1289.

30. Prasad P, Powell MC. Prospective observational study of thermablate endometrial ablation system as an outpatient procedure. J Minim Invasive Gynecol. 2008;15:476-479.

31. University of California, San Francisco. General prevention and screening. UCSF Center of Excellence for Transgender Health. Available at: http://transhealth.ucsf.edu/trans?page=protocol-screening. Accessed June 24, 2015.

32. Ganly I, Taylor EW. Breast cancer in a trans-sexual man receiving hormone replacement therapy. Br J Surg. 1995;82:341.

33. Meriggiola MC, Gava G. Endocrine care of transpeople part II: a review of cross-sex hormonal treatments, outcomes and adverse effects in transwomen. Clin Endocrinol (Oxf). 2015;83:607-615.

34. University of California, San Francisco. Surgical options. UCSF Center of Excellence for Transgender Health. Available at: http://transhealth.ucsf.edu/trans?page=protocol-surgery. Accessed December 12, 2015.

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Abbas Hyderi, MD, MPH
Joseph Angel, MD
Morgan Madison, MD
L. Amanda Perry, MD
Leila Hagshenas, MD

University of Illinois at Chicago
ahyder2@uic.edu

The authors reported no potential conflict of interest relevant to this article.

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transgender, WPATH, World Professional Association for Transgender Health, female-to-male transition, male-to-female transition, LGBTQ, men's health, women's health, practice management, Abbas Hyderi, Joseph Angel, Morgan Madison, L. Amanda Perry, Leila Hagshenas
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Joseph Angel, MD
Morgan Madison, MD
L. Amanda Perry, MD
Leila Hagshenas, MD

University of Illinois at Chicago
ahyder2@uic.edu

The authors reported no potential conflict of interest relevant to this article.

Author and Disclosure Information

Abbas Hyderi, MD, MPH
Joseph Angel, MD
Morgan Madison, MD
L. Amanda Perry, MD
Leila Hagshenas, MD

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ahyder2@uic.edu

The authors reported no potential conflict of interest relevant to this article.

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PRACTICE RECOMMENDATIONS

› Refer transgender patients to a mental health provider with experience in treating this patient population for diagnosis of gender dysphoria. B
› Confirm patients’ eligibility for hormone therapy and obtain informed consent before initiating it. B
› Treat minor adverse effects of hormone therapy whenever possible, as discontinuing the hormones may be detrimental to the well-being of patients in the process of transitioning. B
› Continue recommended screenings based on the sex the patient was assigned at birth, unless the organ or tissue in question has been surgically removed. A

Strength of recommendation (SOR)

A Good-quality patient-oriented evidence
B Inconsistent or limited-quality patient-oriented evidence
C Consensus, usual practice, opinion, disease-oriented evidence, case series

 

Civil rights for the lesbian, gay, bisexual, and transgender population have advanced markedly in the past decade, and the medical community has gradually begun to address more of their health concerns. More recently, media attention to transgender individuals—although focused primarily on the “appropriate” use of restrooms—has encouraged many more to openly seek care.1,2

It is estimated that anywhere from 0.3% to 5% of the US population identifies as transgender.1-3 While awareness of this population has slowly increased, there is a paucity of research on the hormone treatment that is often essential to patients’ well-being. Studies of surgical options for transgender patients have been minimal, as well.

Family physicians are uniquely positioned to coordinate medical services and ensure continuity of care for transgender patients as they strive to become their authentic selves. Our goal in writing this article is to equip you with the tools to provide this patient population with sensitive, high-quality care (TABLE 1).4-7 Our focus is on the diagnosis of gender dysphoria (GD) and its medical and hormonal management—the realm of primary care providers. We briefly discuss surgical management of GD, as well.

 

 

Understanding and diagnosing gender dysphoria

Two classification systems are used for diagnoses related to GD: the Diagnostic and Statistical Manual of Mental Disorders, Fifth Ed. (DSM-5)8 and the International Classification of Diseases, 10th Rev. (ICD-10).9

The transitioning process is a complex and individualized journey that can include inward or outward change, or both.

ICD-10 criteria use the term “gender identity disorder;” DSM-5 refers to “gender dysphoria” instead. It is important to emphasize that these classification systems represent an attempt to categorize a group of signs and symptoms that lead to distress for the patient, and are not meant to suggest that being transgender is pathological. In fact, in DSM-5—released in 2013—the American Psychiatric Association revised the terminology to emphasize that such individuals are not “disordered” by the nature of their identity, but rather by the distress that being transgender causes.8

For a diagnosis of GD in children, DSM-5 criteria include characteristics perceived to be incongruent between the child’s sex at birth and the self-identified gender based on preferred activities or dislike of his or her own sexual anatomy. The child must meet 6 or more of the following for at least 6 months:

  • a repeatedly stated desire to be, or insistence that he or she is, of the other gender
  • in boys, a preference for cross-dressing or simulating female attire; in girls, insistence on wearing only stereotypical masculine clothing
  • strong and persistent preferences for cross-gender roles in make-believe play or fantasy
  • a strong rejection of toys/games typically associated with the child’s sex
  • intense desire to participate in stereotypical games and pastimes of the other gender
  • strong preference for playmates of the other gender
  • a strong dislike of one’s sexual anatomy
  • a strong desire for the primary (eg, penis or vagina) or secondary (eg, menstruation) sex characteristics of the other gender.8

Adolescents and adults must meet 2 or more of the following for at least 6 months:

  • a noticeable incongruence between the gender that the patient sees themselves as and their sex characteristics
  • an intense need to do away with (or prevent) his or her primary or secondary sex features
  • an intense desire to have the primary and/or secondary sex features of the other gender
  • a deep desire to transform into another gender
  • a profound need for society to treat them as someone of the other gender
  • a powerful assurance of having the characteristic feelings and responses of the other gender.8

For children as well as adolescents and adults, the condition should cause the patient significant distress or significantly affect him or her socially, at work or school, and in other important areas of life.8

Is the patient a candidate for hormone therapy?

Two primary sources—Standards of Care for the Health of Transsexual, Transgender, and Gender-Nonconforming People, Version 7, issued by the World Professional Association for Transgender Health (WPATH)10 and Endocrine Treatment of Transsexual Persons11 by the Endocrine Society—offer clinical practice guidance based on evidence and expert opinion.

WPATH recommends that a mental health professional (MHP) experienced in transgender care diagnose GD to ensure that it is not mistaken for a psychiatric condition manifesting as altered gender identity. However, if no one with such experience is available or accessible in the region, it is reasonable for a primary care physician to make the diagnosis and consider initiating hormone therapy without a mental health referral,12 as the expected benefits outweigh the risks of nontreatment.13

Whether or not a MHP confirms a diagnosis of GD, it is still up to the treating physician to confirm the patient’s eligibility and readiness for hormone therapy: He or she should meet DSM-5 or ICD-10 criteria for GD, have no psychiatric comorbidity (eg, schizophrenia, body dysmorphic disorder, or uncontrolled bipolar disorder) likely to interfere with treatment, understand the expected outcomes and the social benefits and risks, and have indicated a willingness to take the hormones responsibly.

Historically, patients were required to have a documented Real-Life Experience (RLE), defined as having fully adopted the new gender role in everyday life for at least 3 months.10,11 This model has fallen out of favor, however, as it is unsupported by evidence and may place transgender individuals at physical and emotional risk.. Instead, readiness is confirmed by obtaining informed consent.12

Puberty may be suppressed with a gonadotropin-releasing hormone (GnRH) agonist in adolescents who have a GD diagnosis and are at Tanner stage 2 to 3 of puberty until age 16. At that point, hormone therapy consistent with their gender identification may be initiated.11 (See “How to help transgender teens.”11,14-20)

 

 

SIDEBAR
How to help transgender teens

Gender exploration is a normal part of childhood. Changes that occur during puberty cause many adolescents to question their ideas of gender and sexuality, but those with persistent gender nonconformity or extreme body dysphoria should receive medical and mental health care as early as possible.

A mental health professional (MHP) can help families create a safe, unconditionally accepting, and supportive environment in which their child can develop into his or her authentic self. A specialist in adolescent gender dysphoria (GD) should be consulted before initiating hormone therapy. Family physicians are well positioned to provide follow-up and ongoing care.

Initiating hormone suppression for adolescents with GD early in puberty can greatly reduce the emotional trauma, as well as the need for surgery related to unwanted secondary sex characteristics. Hormone suppression also gives adolescents more time to explore their gender nonconformity and developmental needs. Treatment with a gonadotropin-releasing hormone agonist such as leuprolide or histrelin can be initiated for adolescents in Tanner Stage 2, assessed by hormone levels, as well as breast, testicle, and pubic hair development (childgrowthfoundation.org/CMS/FILES/Puberty_and_the_Tanner_Stages.pdf), to suppress ongoing puberty.11,14

The effects of puberty blockers are reversible. If preferred, however, medication management can allow teens to progress directly from hormone suppression to the puberty of their self-identified gender once initiation of adult transgender hormone therapy is started—typically around the age of 16.11

Some adolescents may seek medical care well after puberty has begun. It is possible to use hormone suppression therapy after a teen has started to develop unwanted secondary sex characteristics. However, such patients may get less benefit from puberty blockers and often derive more benefit from initiation of cross-gender hormones.

Safety—a broader perspective. Regardless of medical treatment or the age at which treatment is begun, parents and patients need to be reminded that gender transition is about more than hormones. It is crucial that either the MHP or primary care physician, or both, address safety issues and work with the transgender individual to create a comprehensive plan for his or her health, safety, and social well-being.

Psychosocial concerns for transgender youth are vast, often encompassing rejection by peers and potentially, by family and authority figures; harassment; physical, emotional, and sexual abuse; inadequate housing; legal problems; lack of financial support; and educational difficulties.15 School is a particular source of concern. A survey by the Gay, Lesbian and Straight Education Network found, for instance, that nearly 9 in 10 transgender youth had been verbally harassed at school because of their gender expression. More than half also reported being physically harassed (eg, pushed or shoved).15

Bathroom use in schools is a major issue, as well, with transgender youth often prevented from using the restroom or locker room that coincides with their gender identity. In May, 11 states filed a lawsuit against the Obama administration for directing schools to allow such students to do so or risk the loss of federal funds.16

Tools and support. In 2006, the Vancouver Coastal Health, Transcend Transgender Support & Education Society, and the Canadian Rainbow Health Coalition published guidelines for the care of transgender adolescents, including a modification of the HEEADSSS tool (used to assess teens’ psychosocial well-being) specific to transgender youth.17 (See http://www.amsa.org/wp-content/uploads/2015/04/CaringForTransgenderAdolescents.pdf.) The tool can help you identify possible areas of concern and intervene, as needed.

If a patient reports feeling especially vulnerable at school, for example, encourage him or her to identify supportive friends, family members, teachers, or school counselors who can help create safe networks. Suggest that a teen who feels threatened travel in groups whenever possible. Stress to family members that their acceptance is key to nurturing positive feelings in youth with GD. And refer patients and parents to organizations that provide information and support.

Chief among them are Trans Youth Family Allies18 (www.imatyfa.org), which provides resources for parents, educators, and health care practitioners; the Human Rights Campaign, which has created a survival guide for gay and transgender youth who are forced to seek independent living19 (available at hrc-assets.s3-website-us-east-1.amazonaws.com//files/assets/resources/HRC-OnOurOwn-LGBTQYouth.pdf), and the Gay, Lesbian, Bisexual, and Transgender National Help Center, which hosts a GLBT national hotline (888-843-4564) and a weekly Trans Teen Online Talk Group.20 For more information about the online talk group, go to glbthotline.org and click on “transteens.”

 

 

Beginning the transition

The transitioning process is a complex and individualized journey that can include inward or outward change, or both.

For patients interested in medical interventions, possible therapies include cross-sex hormone administration and gender-affirming surgery. Both are aimed at making the physical and the psychological more congruent. Hormone treatment (TABLE 2)10,11,21 is often essential to reduce the distress of individuals with GD and to help them feel comfortable in their own body. Psychological conditions, such as depression, tend to improve as the transitioning process gets underway.22

 

 

 

Female-to-male transition

CASE 1

Jennie R, a 55-year-old postmenopausal patient, comes to your office for an annual exam. Although you’ve been her primary care physician for several years, she confides for the first time that she has never been comfortable as a woman. “I’ve always felt that my body didn’t belong to me,” the patient admits, and goes on to say that for the last several years she has been living as a man. Jennie R says she is ready to start hormone therapy to assist with the gender transition and asks about the process, the benefits and risks, and how quickly she can expect to achieve the desired results.

If Jennie R were your patient, how would you respond?

Masculinizing hormone treatment

As you would explain to a patient like Jennie R, the goal of hormone therapy is to suppress the effects of the sex assigned at birth and replace them with those of the desired gender. In the case of a female transitioning to a male (known as a transman), masculinizing hormones would promote growth of facial and body hair, cessation of menses, increased muscle mass, deepening of the voice, and clitoral enlargement.11,23,24

Physical changes induced by masculinizing hormone therapy have an expected onset of one to 6 months and achieve maximum effect in approximately 2 to 5 years.10,11 Although there have been no controlled clinical trials evaluating the safety or efficacy of any transitional hormone regimen, WPATH and the Center of Excellence for Transgender Health at the University of California, San Francisco, suggest initiating intramuscular or transdermal testosterone at increasing doses until normal physiologic male testosterone levels between 350 and 700 ng/dL are achieved, or until cessation of menses.13,25-28 The dose at which either, or both, occur should be continued as long-term maintenance therapy. Medroxyprogesterone can be added, if necessary for menstrual cessation, and a GnRH agonist or endometrial ablation can be used for refractory uterine bleeding.29,30

Psychological conditions such as depression tend to improve when a transgender individual begins the transitioning process.

Testosterone is not a contraceptive. It is important to emphasize to transmen like Jennie that they remain at risk of pregnancy if they are having sex with fertile males. Caution patients not to assume that the possibility of pregnancy ends when menses stop.

Treat minor adverse effects. Adverse effects of masculinizing hormones include vaginal atrophy, fat redistribution and weight gain, polycythemia, acne, scalp hair loss, sleep apnea, elevated liver enzymes, hyperlipidemia, cardiovascular disease, diabetes, and bone density loss. Increased risk of cancer of the female organs has not been proven.10,11 It is reasonable to treat minor adverse effects after reviewing the risks vs benefits of doing so, as discontinuing hormone therapy could be detrimental to the well-being of transitioning patients.11

There are absolute contraindications to masculinizing hormone therapy, however, including pregnancy, unstable coronary artery disease, and untreated polycythemia with a hematocrit >55%.10

Monitoring is essential. Patients receiving masculinizing hormone therapy should be monitored every 3 months during the first year and once or twice a year thereafter, with a focused history (including mood symptoms), physical exam (including weight and blood pressure), and labs (including complete blood count, liver function, renal function, and lipids) at each visit.11,23 Some clinicians also check estradiol levels until they fall below 50 pg/mL,23,27 while others take the cessation of uterine bleeding for >6 months as an indicator of estrogen suppression.

Remind patients of the need for contraception, pointing out that a male transitioning to a female may still impregnate a female partner and a female transitioning to a male may still conceive.

Preventive health measures continue. Routine screening should continue, based on the patient’s assigned sex at birth. Thus, a transman who has not had a hysterectomy still needs Pap smears, mammograms if the patient has not had a double mastectomy, and bone mineral density (BMD) testing to screen for osteoporosis.31,32 Some experts recommend starting to test BMD at age 50 for patients receiving masculinizing hormones, given the unknown effect of testosterone on bone density.11,31,32

CASE 1

The first question for a transgender patient is about his or her current gender identity, but Jennie R has already reported living as a man. So you start by asking “What name do you prefer to use?” and “Do you prefer to be referred to with male or female pronouns?”

The patient tells you that he sees himself as a man, he wants to be called Jeff, and he prefers male pronouns. You explain that you believe he has gender dysphoria and would benefit from hormone therapy, but it is important to confirm this diagnosis with a MHP. You explain that testosterone can be prescribed for masculinizing effects, and describe the expected effects—more facial and body hair, a deeper voice and greater muscle mass, among others—and review the likely time frame

You also discuss the risks of masculinizing hormones (hyperlipidemia, cardiovascular disease, diabetes, and loss of bone density) that will need to be monitored. Before he leaves, you give him the name of a MHP who is experienced in transgender care and tell him to make a follow-up appointment with you after he has seen her. At the conclusion of the visit, you make a note of the patient’s name and gender identity in the chart and inform the staff of the changes.

 

 

Male-to-female transition

CASE 2

Before heading into your office to talk to a new patient named Carl S, you glance at his chart and see that he is a healthy 21-year-old who has come in for a routine physical. When you enter the room, you find Carl wearing a dress, heels, and make-up. After confirming that you have the right patient, you ask, “What is your current gender identity?” “Female,” says Carl, who indicates that she now goes by Carol. The patient has no medical problems, surgical history, or significant family history, but reports that she has been taking spironolactone and estrogen for the past 3 years. Carol also says she has a new female partner and is having unprotected sexual activity.

Feminizing hormone treatment

The desired effects of feminizing hormones include voice change, decreased hair growth, breast growth, body fat redistribution, decreased muscle mass, skin softening, decreased oiliness of skin and hair, and a decrease in spontaneous erections, testicular volume, and sperm production.10,11 The onset of feminizing effects ranges from one month to one year and the expected maximum effect occurs anywhere between 3 months and 5 years.10,11 Regimens usually include anti-androgen agents and estrogen.13,26-28

The medications that have been most studied with anti-androgenic effects include spironolactone and 5-alpha reductase inhibitors (5-ARIs) such as finasteride. Spironolactone inhibits testosterone secretion and inhibits androgen binding to androgen receptors; 5-ARIs block the conversion of testosterone to 5-alpha-dihydrotestosterone, the more active form.

Males transitioning to females should undergo breast cancer screening beginning at 40 to 50 years of age if they remain on hormone therapy.

Estrogen can be administered via oral, sublingual, transdermal, or intramuscular route, but parenteral formulations are preferred to avoid first-pass metabolism. The serum estradiol target is similar to the mean daily level of premenopausal women (<200 pg/mL) and the level of testosterone should be in the normal female range (<55 ng/dL).13,26-28

The selection of medications should be individualized for each patient. Comorbidities must be considered, as well as the risk of adverse effects, which include venous thromboembolism, elevated liver enzymes, breast cancer, cardiovascular disease, diabetes, hyperprolactinemia, weight gain, gallstones, cerebrovascular disease, and severe migraine headaches.10,11 Estrogen therapy is not reported to induce hypertrophy or premalignant changes in the prostate.33 As is the case for masculinizing hormones, feminizing hormone therapy should be continued indefinitely for long-term effects.

Frequent monitoring is recommended. Patients on feminizing hormones (transwomen) should be seen every 2 to 3 months in the first year and monitored once or twice a year thereafter. Serum testosterone and estradiol levels should initially be monitored every 3 months; serum electrolytes, specifically potassium, should be monitored every 2 to 3 months in the first year until stable.

CASE 2

You recommend that Carol S be screened annually for sexually transmitted diseases, as you would for any 21-year-old patient. You point out, too, that while estrogen and androgen-suppressing therapy decrease sperm production, there is a possibility that the patient could impregnate a female partner and recommend that contraception be used if the couple is not trying to conceive.

You also discuss the risks and benefits of hormone therapy and reasonable expectations of continued treatment. You ask Carol to schedule a follow-up visit in 6 months, as her hormone regimen is stable. Finally, if the patient remains on hormone therapy, you mention that the only screening unique to men transitioning to women is for breast cancer, which should begin at 40 to 50 years of age (as it is for all women).

Gender-affirming surgical options

Nearly 9 in 10 transgender youth report being verbally harassed at school because of their gender expression. More than half report being physically harassed.

Surgical management of transgender patients is not within the scope of family medicine. But it is essential to know what procedures are available as you may have occasion to advocate for patients during the surgical referral process and possibly to provide postoperative care.

For transmen, surgical options include chest reconstruction, hysterectomy/oophorectomy, metoidioplasty (using the clitoris to surgically approximate a penis), phalloplasty, scrotoplasty, urethroplasty, and vaginectomy.10,34 The surgeries available for transwomen are orchiectomy, vaginoplasty, penectomy, breast augmentation, thyroid chondroplasty and voice surgery, and facial feminization.10,34 Keep in mind that not all transgender individuals desire surgery as part of the transitioning process.

CORRESPONDENCE
Abbas Hyderi, MD, MPH, 1919 West Taylor Street, M/C 663, Chicago, IL 60612; ahyder2@uic.edu.

The authors would like to acknowledge the assistance of Michelle Forcier, MD, MPH, and Karen S. Bernstein, MD, MPH, in the preparation of this manuscript. 

PRACTICE RECOMMENDATIONS

› Refer transgender patients to a mental health provider with experience in treating this patient population for diagnosis of gender dysphoria. B
› Confirm patients’ eligibility for hormone therapy and obtain informed consent before initiating it. B
› Treat minor adverse effects of hormone therapy whenever possible, as discontinuing the hormones may be detrimental to the well-being of patients in the process of transitioning. B
› Continue recommended screenings based on the sex the patient was assigned at birth, unless the organ or tissue in question has been surgically removed. A

Strength of recommendation (SOR)

A Good-quality patient-oriented evidence
B Inconsistent or limited-quality patient-oriented evidence
C Consensus, usual practice, opinion, disease-oriented evidence, case series

 

Civil rights for the lesbian, gay, bisexual, and transgender population have advanced markedly in the past decade, and the medical community has gradually begun to address more of their health concerns. More recently, media attention to transgender individuals—although focused primarily on the “appropriate” use of restrooms—has encouraged many more to openly seek care.1,2

It is estimated that anywhere from 0.3% to 5% of the US population identifies as transgender.1-3 While awareness of this population has slowly increased, there is a paucity of research on the hormone treatment that is often essential to patients’ well-being. Studies of surgical options for transgender patients have been minimal, as well.

Family physicians are uniquely positioned to coordinate medical services and ensure continuity of care for transgender patients as they strive to become their authentic selves. Our goal in writing this article is to equip you with the tools to provide this patient population with sensitive, high-quality care (TABLE 1).4-7 Our focus is on the diagnosis of gender dysphoria (GD) and its medical and hormonal management—the realm of primary care providers. We briefly discuss surgical management of GD, as well.

 

 

Understanding and diagnosing gender dysphoria

Two classification systems are used for diagnoses related to GD: the Diagnostic and Statistical Manual of Mental Disorders, Fifth Ed. (DSM-5)8 and the International Classification of Diseases, 10th Rev. (ICD-10).9

The transitioning process is a complex and individualized journey that can include inward or outward change, or both.

ICD-10 criteria use the term “gender identity disorder;” DSM-5 refers to “gender dysphoria” instead. It is important to emphasize that these classification systems represent an attempt to categorize a group of signs and symptoms that lead to distress for the patient, and are not meant to suggest that being transgender is pathological. In fact, in DSM-5—released in 2013—the American Psychiatric Association revised the terminology to emphasize that such individuals are not “disordered” by the nature of their identity, but rather by the distress that being transgender causes.8

For a diagnosis of GD in children, DSM-5 criteria include characteristics perceived to be incongruent between the child’s sex at birth and the self-identified gender based on preferred activities or dislike of his or her own sexual anatomy. The child must meet 6 or more of the following for at least 6 months:

  • a repeatedly stated desire to be, or insistence that he or she is, of the other gender
  • in boys, a preference for cross-dressing or simulating female attire; in girls, insistence on wearing only stereotypical masculine clothing
  • strong and persistent preferences for cross-gender roles in make-believe play or fantasy
  • a strong rejection of toys/games typically associated with the child’s sex
  • intense desire to participate in stereotypical games and pastimes of the other gender
  • strong preference for playmates of the other gender
  • a strong dislike of one’s sexual anatomy
  • a strong desire for the primary (eg, penis or vagina) or secondary (eg, menstruation) sex characteristics of the other gender.8

Adolescents and adults must meet 2 or more of the following for at least 6 months:

  • a noticeable incongruence between the gender that the patient sees themselves as and their sex characteristics
  • an intense need to do away with (or prevent) his or her primary or secondary sex features
  • an intense desire to have the primary and/or secondary sex features of the other gender
  • a deep desire to transform into another gender
  • a profound need for society to treat them as someone of the other gender
  • a powerful assurance of having the characteristic feelings and responses of the other gender.8

For children as well as adolescents and adults, the condition should cause the patient significant distress or significantly affect him or her socially, at work or school, and in other important areas of life.8

Is the patient a candidate for hormone therapy?

Two primary sources—Standards of Care for the Health of Transsexual, Transgender, and Gender-Nonconforming People, Version 7, issued by the World Professional Association for Transgender Health (WPATH)10 and Endocrine Treatment of Transsexual Persons11 by the Endocrine Society—offer clinical practice guidance based on evidence and expert opinion.

WPATH recommends that a mental health professional (MHP) experienced in transgender care diagnose GD to ensure that it is not mistaken for a psychiatric condition manifesting as altered gender identity. However, if no one with such experience is available or accessible in the region, it is reasonable for a primary care physician to make the diagnosis and consider initiating hormone therapy without a mental health referral,12 as the expected benefits outweigh the risks of nontreatment.13

Whether or not a MHP confirms a diagnosis of GD, it is still up to the treating physician to confirm the patient’s eligibility and readiness for hormone therapy: He or she should meet DSM-5 or ICD-10 criteria for GD, have no psychiatric comorbidity (eg, schizophrenia, body dysmorphic disorder, or uncontrolled bipolar disorder) likely to interfere with treatment, understand the expected outcomes and the social benefits and risks, and have indicated a willingness to take the hormones responsibly.

Historically, patients were required to have a documented Real-Life Experience (RLE), defined as having fully adopted the new gender role in everyday life for at least 3 months.10,11 This model has fallen out of favor, however, as it is unsupported by evidence and may place transgender individuals at physical and emotional risk.. Instead, readiness is confirmed by obtaining informed consent.12

Puberty may be suppressed with a gonadotropin-releasing hormone (GnRH) agonist in adolescents who have a GD diagnosis and are at Tanner stage 2 to 3 of puberty until age 16. At that point, hormone therapy consistent with their gender identification may be initiated.11 (See “How to help transgender teens.”11,14-20)

 

 

SIDEBAR
How to help transgender teens

Gender exploration is a normal part of childhood. Changes that occur during puberty cause many adolescents to question their ideas of gender and sexuality, but those with persistent gender nonconformity or extreme body dysphoria should receive medical and mental health care as early as possible.

A mental health professional (MHP) can help families create a safe, unconditionally accepting, and supportive environment in which their child can develop into his or her authentic self. A specialist in adolescent gender dysphoria (GD) should be consulted before initiating hormone therapy. Family physicians are well positioned to provide follow-up and ongoing care.

Initiating hormone suppression for adolescents with GD early in puberty can greatly reduce the emotional trauma, as well as the need for surgery related to unwanted secondary sex characteristics. Hormone suppression also gives adolescents more time to explore their gender nonconformity and developmental needs. Treatment with a gonadotropin-releasing hormone agonist such as leuprolide or histrelin can be initiated for adolescents in Tanner Stage 2, assessed by hormone levels, as well as breast, testicle, and pubic hair development (childgrowthfoundation.org/CMS/FILES/Puberty_and_the_Tanner_Stages.pdf), to suppress ongoing puberty.11,14

The effects of puberty blockers are reversible. If preferred, however, medication management can allow teens to progress directly from hormone suppression to the puberty of their self-identified gender once initiation of adult transgender hormone therapy is started—typically around the age of 16.11

Some adolescents may seek medical care well after puberty has begun. It is possible to use hormone suppression therapy after a teen has started to develop unwanted secondary sex characteristics. However, such patients may get less benefit from puberty blockers and often derive more benefit from initiation of cross-gender hormones.

Safety—a broader perspective. Regardless of medical treatment or the age at which treatment is begun, parents and patients need to be reminded that gender transition is about more than hormones. It is crucial that either the MHP or primary care physician, or both, address safety issues and work with the transgender individual to create a comprehensive plan for his or her health, safety, and social well-being.

Psychosocial concerns for transgender youth are vast, often encompassing rejection by peers and potentially, by family and authority figures; harassment; physical, emotional, and sexual abuse; inadequate housing; legal problems; lack of financial support; and educational difficulties.15 School is a particular source of concern. A survey by the Gay, Lesbian and Straight Education Network found, for instance, that nearly 9 in 10 transgender youth had been verbally harassed at school because of their gender expression. More than half also reported being physically harassed (eg, pushed or shoved).15

Bathroom use in schools is a major issue, as well, with transgender youth often prevented from using the restroom or locker room that coincides with their gender identity. In May, 11 states filed a lawsuit against the Obama administration for directing schools to allow such students to do so or risk the loss of federal funds.16

Tools and support. In 2006, the Vancouver Coastal Health, Transcend Transgender Support & Education Society, and the Canadian Rainbow Health Coalition published guidelines for the care of transgender adolescents, including a modification of the HEEADSSS tool (used to assess teens’ psychosocial well-being) specific to transgender youth.17 (See http://www.amsa.org/wp-content/uploads/2015/04/CaringForTransgenderAdolescents.pdf.) The tool can help you identify possible areas of concern and intervene, as needed.

If a patient reports feeling especially vulnerable at school, for example, encourage him or her to identify supportive friends, family members, teachers, or school counselors who can help create safe networks. Suggest that a teen who feels threatened travel in groups whenever possible. Stress to family members that their acceptance is key to nurturing positive feelings in youth with GD. And refer patients and parents to organizations that provide information and support.

Chief among them are Trans Youth Family Allies18 (www.imatyfa.org), which provides resources for parents, educators, and health care practitioners; the Human Rights Campaign, which has created a survival guide for gay and transgender youth who are forced to seek independent living19 (available at hrc-assets.s3-website-us-east-1.amazonaws.com//files/assets/resources/HRC-OnOurOwn-LGBTQYouth.pdf), and the Gay, Lesbian, Bisexual, and Transgender National Help Center, which hosts a GLBT national hotline (888-843-4564) and a weekly Trans Teen Online Talk Group.20 For more information about the online talk group, go to glbthotline.org and click on “transteens.”

 

 

Beginning the transition

The transitioning process is a complex and individualized journey that can include inward or outward change, or both.

For patients interested in medical interventions, possible therapies include cross-sex hormone administration and gender-affirming surgery. Both are aimed at making the physical and the psychological more congruent. Hormone treatment (TABLE 2)10,11,21 is often essential to reduce the distress of individuals with GD and to help them feel comfortable in their own body. Psychological conditions, such as depression, tend to improve as the transitioning process gets underway.22

 

 

 

Female-to-male transition

CASE 1

Jennie R, a 55-year-old postmenopausal patient, comes to your office for an annual exam. Although you’ve been her primary care physician for several years, she confides for the first time that she has never been comfortable as a woman. “I’ve always felt that my body didn’t belong to me,” the patient admits, and goes on to say that for the last several years she has been living as a man. Jennie R says she is ready to start hormone therapy to assist with the gender transition and asks about the process, the benefits and risks, and how quickly she can expect to achieve the desired results.

If Jennie R were your patient, how would you respond?

Masculinizing hormone treatment

As you would explain to a patient like Jennie R, the goal of hormone therapy is to suppress the effects of the sex assigned at birth and replace them with those of the desired gender. In the case of a female transitioning to a male (known as a transman), masculinizing hormones would promote growth of facial and body hair, cessation of menses, increased muscle mass, deepening of the voice, and clitoral enlargement.11,23,24

Physical changes induced by masculinizing hormone therapy have an expected onset of one to 6 months and achieve maximum effect in approximately 2 to 5 years.10,11 Although there have been no controlled clinical trials evaluating the safety or efficacy of any transitional hormone regimen, WPATH and the Center of Excellence for Transgender Health at the University of California, San Francisco, suggest initiating intramuscular or transdermal testosterone at increasing doses until normal physiologic male testosterone levels between 350 and 700 ng/dL are achieved, or until cessation of menses.13,25-28 The dose at which either, or both, occur should be continued as long-term maintenance therapy. Medroxyprogesterone can be added, if necessary for menstrual cessation, and a GnRH agonist or endometrial ablation can be used for refractory uterine bleeding.29,30

Psychological conditions such as depression tend to improve when a transgender individual begins the transitioning process.

Testosterone is not a contraceptive. It is important to emphasize to transmen like Jennie that they remain at risk of pregnancy if they are having sex with fertile males. Caution patients not to assume that the possibility of pregnancy ends when menses stop.

Treat minor adverse effects. Adverse effects of masculinizing hormones include vaginal atrophy, fat redistribution and weight gain, polycythemia, acne, scalp hair loss, sleep apnea, elevated liver enzymes, hyperlipidemia, cardiovascular disease, diabetes, and bone density loss. Increased risk of cancer of the female organs has not been proven.10,11 It is reasonable to treat minor adverse effects after reviewing the risks vs benefits of doing so, as discontinuing hormone therapy could be detrimental to the well-being of transitioning patients.11

There are absolute contraindications to masculinizing hormone therapy, however, including pregnancy, unstable coronary artery disease, and untreated polycythemia with a hematocrit >55%.10

Monitoring is essential. Patients receiving masculinizing hormone therapy should be monitored every 3 months during the first year and once or twice a year thereafter, with a focused history (including mood symptoms), physical exam (including weight and blood pressure), and labs (including complete blood count, liver function, renal function, and lipids) at each visit.11,23 Some clinicians also check estradiol levels until they fall below 50 pg/mL,23,27 while others take the cessation of uterine bleeding for >6 months as an indicator of estrogen suppression.

Remind patients of the need for contraception, pointing out that a male transitioning to a female may still impregnate a female partner and a female transitioning to a male may still conceive.

Preventive health measures continue. Routine screening should continue, based on the patient’s assigned sex at birth. Thus, a transman who has not had a hysterectomy still needs Pap smears, mammograms if the patient has not had a double mastectomy, and bone mineral density (BMD) testing to screen for osteoporosis.31,32 Some experts recommend starting to test BMD at age 50 for patients receiving masculinizing hormones, given the unknown effect of testosterone on bone density.11,31,32

CASE 1

The first question for a transgender patient is about his or her current gender identity, but Jennie R has already reported living as a man. So you start by asking “What name do you prefer to use?” and “Do you prefer to be referred to with male or female pronouns?”

The patient tells you that he sees himself as a man, he wants to be called Jeff, and he prefers male pronouns. You explain that you believe he has gender dysphoria and would benefit from hormone therapy, but it is important to confirm this diagnosis with a MHP. You explain that testosterone can be prescribed for masculinizing effects, and describe the expected effects—more facial and body hair, a deeper voice and greater muscle mass, among others—and review the likely time frame

You also discuss the risks of masculinizing hormones (hyperlipidemia, cardiovascular disease, diabetes, and loss of bone density) that will need to be monitored. Before he leaves, you give him the name of a MHP who is experienced in transgender care and tell him to make a follow-up appointment with you after he has seen her. At the conclusion of the visit, you make a note of the patient’s name and gender identity in the chart and inform the staff of the changes.

 

 

Male-to-female transition

CASE 2

Before heading into your office to talk to a new patient named Carl S, you glance at his chart and see that he is a healthy 21-year-old who has come in for a routine physical. When you enter the room, you find Carl wearing a dress, heels, and make-up. After confirming that you have the right patient, you ask, “What is your current gender identity?” “Female,” says Carl, who indicates that she now goes by Carol. The patient has no medical problems, surgical history, or significant family history, but reports that she has been taking spironolactone and estrogen for the past 3 years. Carol also says she has a new female partner and is having unprotected sexual activity.

Feminizing hormone treatment

The desired effects of feminizing hormones include voice change, decreased hair growth, breast growth, body fat redistribution, decreased muscle mass, skin softening, decreased oiliness of skin and hair, and a decrease in spontaneous erections, testicular volume, and sperm production.10,11 The onset of feminizing effects ranges from one month to one year and the expected maximum effect occurs anywhere between 3 months and 5 years.10,11 Regimens usually include anti-androgen agents and estrogen.13,26-28

The medications that have been most studied with anti-androgenic effects include spironolactone and 5-alpha reductase inhibitors (5-ARIs) such as finasteride. Spironolactone inhibits testosterone secretion and inhibits androgen binding to androgen receptors; 5-ARIs block the conversion of testosterone to 5-alpha-dihydrotestosterone, the more active form.

Males transitioning to females should undergo breast cancer screening beginning at 40 to 50 years of age if they remain on hormone therapy.

Estrogen can be administered via oral, sublingual, transdermal, or intramuscular route, but parenteral formulations are preferred to avoid first-pass metabolism. The serum estradiol target is similar to the mean daily level of premenopausal women (<200 pg/mL) and the level of testosterone should be in the normal female range (<55 ng/dL).13,26-28

The selection of medications should be individualized for each patient. Comorbidities must be considered, as well as the risk of adverse effects, which include venous thromboembolism, elevated liver enzymes, breast cancer, cardiovascular disease, diabetes, hyperprolactinemia, weight gain, gallstones, cerebrovascular disease, and severe migraine headaches.10,11 Estrogen therapy is not reported to induce hypertrophy or premalignant changes in the prostate.33 As is the case for masculinizing hormones, feminizing hormone therapy should be continued indefinitely for long-term effects.

Frequent monitoring is recommended. Patients on feminizing hormones (transwomen) should be seen every 2 to 3 months in the first year and monitored once or twice a year thereafter. Serum testosterone and estradiol levels should initially be monitored every 3 months; serum electrolytes, specifically potassium, should be monitored every 2 to 3 months in the first year until stable.

CASE 2

You recommend that Carol S be screened annually for sexually transmitted diseases, as you would for any 21-year-old patient. You point out, too, that while estrogen and androgen-suppressing therapy decrease sperm production, there is a possibility that the patient could impregnate a female partner and recommend that contraception be used if the couple is not trying to conceive.

You also discuss the risks and benefits of hormone therapy and reasonable expectations of continued treatment. You ask Carol to schedule a follow-up visit in 6 months, as her hormone regimen is stable. Finally, if the patient remains on hormone therapy, you mention that the only screening unique to men transitioning to women is for breast cancer, which should begin at 40 to 50 years of age (as it is for all women).

Gender-affirming surgical options

Nearly 9 in 10 transgender youth report being verbally harassed at school because of their gender expression. More than half report being physically harassed.

Surgical management of transgender patients is not within the scope of family medicine. But it is essential to know what procedures are available as you may have occasion to advocate for patients during the surgical referral process and possibly to provide postoperative care.

For transmen, surgical options include chest reconstruction, hysterectomy/oophorectomy, metoidioplasty (using the clitoris to surgically approximate a penis), phalloplasty, scrotoplasty, urethroplasty, and vaginectomy.10,34 The surgeries available for transwomen are orchiectomy, vaginoplasty, penectomy, breast augmentation, thyroid chondroplasty and voice surgery, and facial feminization.10,34 Keep in mind that not all transgender individuals desire surgery as part of the transitioning process.

CORRESPONDENCE
Abbas Hyderi, MD, MPH, 1919 West Taylor Street, M/C 663, Chicago, IL 60612; ahyder2@uic.edu.

The authors would like to acknowledge the assistance of Michelle Forcier, MD, MPH, and Karen S. Bernstein, MD, MPH, in the preparation of this manuscript. 

References

1. Pew Research Center. A survey of LGBT Americans: attitudes, experiences and values in changing times. Available at: http://www.pewsocialtrends.org/2013/06/13/a-survey-of-lgbt-americans. Accessed June 24, 2015.

2. Gates GJ. How many people are lesbian, gay, bisexual and transgender? Available at: http://williamsinstitute.law.ucla.edu/wp-content/uploads/Gates-How-Many-People-LGBT-Apr-2011.pdf. Accessed May 25, 2016.

3. van Kesteren PJ, Gooren LJ, Megens JA. An epidemiological and demographic study of transsexuals in The Netherlands. Arch Sex Behav. 1996;25:589-600.

4. Bhola S. An ally’s guide to terminology: talking about LGBT people & equality. Available at: http://www.glaad.org/2011/07/28/an-allys-guide-to-terminology-talking-about-lgbt-people-equality. Accessed June 24, 2015.

5. University of California, San Francisco. Transgender terminology. UCSF Center of Excellence for Transgender Health. Available at: http://transhealth.ucsf.edu/tcoe?page=protocol-terminology. Accessed June 24, 2015.

6. Istar A. How queer! the development of gender identity and sexual orientation in LGBTQ-headed families. Fam Process. 2010;49:268-290.

7. Goins ES, Pye D. Check the box that best describes you: reflexively managing theory and praxis in LGBTQ health communication research. Health Commun. 2013;28:397-407.

8. American Psychiatric Association. Gender dysphoria. Diagnostic and Statistical Manual of Mental Disorders, 5th ed. Washington, DC: American Psychiatric Association. 2013:451-459.

9. World Health Organization. The International Classification of Diseases, 10th rev. Classification of mental and behavioural disorders: clinical descriptions and diagnostic guidelines. 1992; Geneva.

10. Coleman E, Bockting W, Botzer M, et al; World Professional Association for Transgender Health. Standards of Care for the Health of Transsexual, Transgender, and Gender-Nonconforming People, Version 7. Int J Transgender. 2011;13:165–232.

11. Hembree WC, Cohen-Kettenis P, Delemarre-van de Waal HA, et al. Endocrine Treatment of transsexual persons: an Endocrine Society Clinical Practice Guideline. J Clin Endo Metabol. 2009;94:3132–3154.

12. University of California, San Francisco. Assessing readiness for hormones. UCSF Center of Excellence for Transgender Health. Available at: http://transhealth.ucsf.edu/tcoe?page=protocol-hormone-ready. Accessed June 24, 2015.

13. Gooren L. Hormone treatment of the adult transsexual patient. Horm Res. 2005;64(suppl 2):S31-S614.

14. Hembree WC. Guidelines for pubertal suspension and gender reassignment for transgender adolescents. Child Adolesc Psychiatr Clin N Am. 2011;20:725-732.

15. Gay, Lesbian, and Straight Education Network (GLSEN). Harsh realities. The experiences of transgender youth in our nation’s schools. Available at: https://www.glsen.org/sites/default/files/Harsh%20Realities.pdf. Accessed May 29, 2016.

16. Berman M, Balingit M. Eleven states sue Obama administration over bathroom guidance for transgender students. May 25, 2016. Washington Post. Available at: https://www.washingtonpost.com/news/post-nation/wp/2016/05/25/texas-governor-says-state-will-sue-obama-administration-over-bathroom-directive/. Accessed May 31, 2016.

17. de Vries AL, Cohen-Kettenis PT, Delemarre-van de Waal H. Clinical management of gender dysphoria in adolescents. 2006. Vancouver Coastal Health - Transgender Health Program. Available at: http://www.amsa.org/wp-content/uploads/2015/04/CaringForTransgenderAdolescents.pdf. Accessed May 26, 2016.

18. TransYouth Family Allies. Empowering transgender youth & families. Available at: http://www.imatyfa.org/. Accessed May 26, 2016.

19. Human Rights Campaign. On our own: a survival guide for independent LGBTQ youth. Available at: https://www.hrc.org/resources/on-our-own-a-survival-guide-for-independent-lgbtq-youth. Accessed May 26, 2016.

20. Gay, Lesbian, Bisexual, and Transgender National Help Center. Available at: www.glbthotline.org. Accessed May 31, 2016.

21. University of California, San Francisco. Hormone administration. UCSF Center of Excellence for Transgender Health. Available at: http://transhealth.ucsf.edu/trans?page=protocol-hormones.  Accessed December 12, 2015.

22. Gorin-Lazard A, Baumstarck K, Boyer L, et al. Hormonal therapy is associated with better self-esteem, mood, and quality of life in transsexuals. J Nerv Ment Dis. 2013;201:996-1000.

23. Bhasin S, Cunningham GR, Hayes FJ, et al. Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2006;91:1995-2010.

24. Boloña ER, Uraga MV, Haddad RM, et al. Testosterone use in men with sexual dysfunction: a systematic review and meta-analysis of randomized placebo-controlled trials. Mayo Clin Proc. 2007;82:20-28.

25. Gooren LJ, Giltay EJ. Review of studies of androgen treatment of female-to-male transsexuals: effects and risks of administration of androgens to females. J Sex Med. 2008;5:765-776.

26. Levy A, Crown A, Reid R. Endocrine intervention for transsexuals. Clin Endocrinol (Oxf). 2003;59:409-418.

27. Moore E, Wisniewski A, Dobs A. Endocrine treatment of transsexual people: a review of treatment regimens, outcomes, and adverse effects. J Clin Endocrinol Metab. 2003;88:3467-3473.

28. Tangpricha V, Ducharme SH, Barber TW, et al. Endocrinologic treatment of gender identity disorders. Endocr Pract. 2003;9:12-21.

29. Dickersin K, Munro MG, Clark M, et al.  Hysterectomy compared with endometrial ablation for dysfunctional uterine bleeding: a randomized control trial. Obstet Gynecol. 2007;110:1279-1289.

30. Prasad P, Powell MC. Prospective observational study of thermablate endometrial ablation system as an outpatient procedure. J Minim Invasive Gynecol. 2008;15:476-479.

31. University of California, San Francisco. General prevention and screening. UCSF Center of Excellence for Transgender Health. Available at: http://transhealth.ucsf.edu/trans?page=protocol-screening. Accessed June 24, 2015.

32. Ganly I, Taylor EW. Breast cancer in a trans-sexual man receiving hormone replacement therapy. Br J Surg. 1995;82:341.

33. Meriggiola MC, Gava G. Endocrine care of transpeople part II: a review of cross-sex hormonal treatments, outcomes and adverse effects in transwomen. Clin Endocrinol (Oxf). 2015;83:607-615.

34. University of California, San Francisco. Surgical options. UCSF Center of Excellence for Transgender Health. Available at: http://transhealth.ucsf.edu/trans?page=protocol-surgery. Accessed December 12, 2015.

References

1. Pew Research Center. A survey of LGBT Americans: attitudes, experiences and values in changing times. Available at: http://www.pewsocialtrends.org/2013/06/13/a-survey-of-lgbt-americans. Accessed June 24, 2015.

2. Gates GJ. How many people are lesbian, gay, bisexual and transgender? Available at: http://williamsinstitute.law.ucla.edu/wp-content/uploads/Gates-How-Many-People-LGBT-Apr-2011.pdf. Accessed May 25, 2016.

3. van Kesteren PJ, Gooren LJ, Megens JA. An epidemiological and demographic study of transsexuals in The Netherlands. Arch Sex Behav. 1996;25:589-600.

4. Bhola S. An ally’s guide to terminology: talking about LGBT people & equality. Available at: http://www.glaad.org/2011/07/28/an-allys-guide-to-terminology-talking-about-lgbt-people-equality. Accessed June 24, 2015.

5. University of California, San Francisco. Transgender terminology. UCSF Center of Excellence for Transgender Health. Available at: http://transhealth.ucsf.edu/tcoe?page=protocol-terminology. Accessed June 24, 2015.

6. Istar A. How queer! the development of gender identity and sexual orientation in LGBTQ-headed families. Fam Process. 2010;49:268-290.

7. Goins ES, Pye D. Check the box that best describes you: reflexively managing theory and praxis in LGBTQ health communication research. Health Commun. 2013;28:397-407.

8. American Psychiatric Association. Gender dysphoria. Diagnostic and Statistical Manual of Mental Disorders, 5th ed. Washington, DC: American Psychiatric Association. 2013:451-459.

9. World Health Organization. The International Classification of Diseases, 10th rev. Classification of mental and behavioural disorders: clinical descriptions and diagnostic guidelines. 1992; Geneva.

10. Coleman E, Bockting W, Botzer M, et al; World Professional Association for Transgender Health. Standards of Care for the Health of Transsexual, Transgender, and Gender-Nonconforming People, Version 7. Int J Transgender. 2011;13:165–232.

11. Hembree WC, Cohen-Kettenis P, Delemarre-van de Waal HA, et al. Endocrine Treatment of transsexual persons: an Endocrine Society Clinical Practice Guideline. J Clin Endo Metabol. 2009;94:3132–3154.

12. University of California, San Francisco. Assessing readiness for hormones. UCSF Center of Excellence for Transgender Health. Available at: http://transhealth.ucsf.edu/tcoe?page=protocol-hormone-ready. Accessed June 24, 2015.

13. Gooren L. Hormone treatment of the adult transsexual patient. Horm Res. 2005;64(suppl 2):S31-S614.

14. Hembree WC. Guidelines for pubertal suspension and gender reassignment for transgender adolescents. Child Adolesc Psychiatr Clin N Am. 2011;20:725-732.

15. Gay, Lesbian, and Straight Education Network (GLSEN). Harsh realities. The experiences of transgender youth in our nation’s schools. Available at: https://www.glsen.org/sites/default/files/Harsh%20Realities.pdf. Accessed May 29, 2016.

16. Berman M, Balingit M. Eleven states sue Obama administration over bathroom guidance for transgender students. May 25, 2016. Washington Post. Available at: https://www.washingtonpost.com/news/post-nation/wp/2016/05/25/texas-governor-says-state-will-sue-obama-administration-over-bathroom-directive/. Accessed May 31, 2016.

17. de Vries AL, Cohen-Kettenis PT, Delemarre-van de Waal H. Clinical management of gender dysphoria in adolescents. 2006. Vancouver Coastal Health - Transgender Health Program. Available at: http://www.amsa.org/wp-content/uploads/2015/04/CaringForTransgenderAdolescents.pdf. Accessed May 26, 2016.

18. TransYouth Family Allies. Empowering transgender youth & families. Available at: http://www.imatyfa.org/. Accessed May 26, 2016.

19. Human Rights Campaign. On our own: a survival guide for independent LGBTQ youth. Available at: https://www.hrc.org/resources/on-our-own-a-survival-guide-for-independent-lgbtq-youth. Accessed May 26, 2016.

20. Gay, Lesbian, Bisexual, and Transgender National Help Center. Available at: www.glbthotline.org. Accessed May 31, 2016.

21. University of California, San Francisco. Hormone administration. UCSF Center of Excellence for Transgender Health. Available at: http://transhealth.ucsf.edu/trans?page=protocol-hormones.  Accessed December 12, 2015.

22. Gorin-Lazard A, Baumstarck K, Boyer L, et al. Hormonal therapy is associated with better self-esteem, mood, and quality of life in transsexuals. J Nerv Ment Dis. 2013;201:996-1000.

23. Bhasin S, Cunningham GR, Hayes FJ, et al. Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2006;91:1995-2010.

24. Boloña ER, Uraga MV, Haddad RM, et al. Testosterone use in men with sexual dysfunction: a systematic review and meta-analysis of randomized placebo-controlled trials. Mayo Clin Proc. 2007;82:20-28.

25. Gooren LJ, Giltay EJ. Review of studies of androgen treatment of female-to-male transsexuals: effects and risks of administration of androgens to females. J Sex Med. 2008;5:765-776.

26. Levy A, Crown A, Reid R. Endocrine intervention for transsexuals. Clin Endocrinol (Oxf). 2003;59:409-418.

27. Moore E, Wisniewski A, Dobs A. Endocrine treatment of transsexual people: a review of treatment regimens, outcomes, and adverse effects. J Clin Endocrinol Metab. 2003;88:3467-3473.

28. Tangpricha V, Ducharme SH, Barber TW, et al. Endocrinologic treatment of gender identity disorders. Endocr Pract. 2003;9:12-21.

29. Dickersin K, Munro MG, Clark M, et al.  Hysterectomy compared with endometrial ablation for dysfunctional uterine bleeding: a randomized control trial. Obstet Gynecol. 2007;110:1279-1289.

30. Prasad P, Powell MC. Prospective observational study of thermablate endometrial ablation system as an outpatient procedure. J Minim Invasive Gynecol. 2008;15:476-479.

31. University of California, San Francisco. General prevention and screening. UCSF Center of Excellence for Transgender Health. Available at: http://transhealth.ucsf.edu/trans?page=protocol-screening. Accessed June 24, 2015.

32. Ganly I, Taylor EW. Breast cancer in a trans-sexual man receiving hormone replacement therapy. Br J Surg. 1995;82:341.

33. Meriggiola MC, Gava G. Endocrine care of transpeople part II: a review of cross-sex hormonal treatments, outcomes and adverse effects in transwomen. Clin Endocrinol (Oxf). 2015;83:607-615.

34. University of California, San Francisco. Surgical options. UCSF Center of Excellence for Transgender Health. Available at: http://transhealth.ucsf.edu/trans?page=protocol-surgery. Accessed December 12, 2015.

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Account for all medications, even if they’re banned

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I recently saw a 73-year-old Hispanic woman in the emergency department who said (through her daughter, who was translating) that she was experiencing mild headache, shortness of breath, and throat swelling. She had previously sought care for these complaints, but her condition had not improved. Her past medical and surgical history was otherwise unremarkable.

On examination, her voice was hoarse and she had bilateral 1+ pitting edema of her lower extremities. Her vital signs were stable, her lungs were clear, her throat appeared normal, and she didn’t have any skin rashes. However, her lab results included a white blood cell count of 2100/mcL, platelet count of 73,000/mcL, and an absolute neutrophil count of 1000/mm3. Her b-type natriuretic peptide, cardiac marker, and thyroid-stimulating hormone levels were normal.

The diagnosis was clear—neutropenia and agranulocytosis—although the cause was not. That is, until we learned about a drug the patient had obtained in Mexico.

The diagnosis was clear—neutropenia and agranulocytosis—although the cause was not.

I gathered a more detailed history and learned that the patient had been living in the United States for years, but she occasionally returned to Mexico for visits and routine medical care. During one of these trips, she’d obtained metamizole—a drug banned in the United States—and was taking it for her headaches.

A Web search revealed rare adverse effects of agranulocytosis, neutropenia, and anaphylaxis from metamizole. It is highly probable that the metamizole caused my patient’s symptoms and abnormal labs findings. I advised her of my suspicions and recommended that she stop taking the medication. A hospitalist then took over her care.

The key takeaway from this case is to account for all medications when gathering a patient’s history, including those that may be obtained outside of the United States.

Nick Ly, DO
Lillington, NC

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I recently saw a 73-year-old Hispanic woman in the emergency department who said (through her daughter, who was translating) that she was experiencing mild headache, shortness of breath, and throat swelling. She had previously sought care for these complaints, but her condition had not improved. Her past medical and surgical history was otherwise unremarkable.

On examination, her voice was hoarse and she had bilateral 1+ pitting edema of her lower extremities. Her vital signs were stable, her lungs were clear, her throat appeared normal, and she didn’t have any skin rashes. However, her lab results included a white blood cell count of 2100/mcL, platelet count of 73,000/mcL, and an absolute neutrophil count of 1000/mm3. Her b-type natriuretic peptide, cardiac marker, and thyroid-stimulating hormone levels were normal.

The diagnosis was clear—neutropenia and agranulocytosis—although the cause was not. That is, until we learned about a drug the patient had obtained in Mexico.

The diagnosis was clear—neutropenia and agranulocytosis—although the cause was not.

I gathered a more detailed history and learned that the patient had been living in the United States for years, but she occasionally returned to Mexico for visits and routine medical care. During one of these trips, she’d obtained metamizole—a drug banned in the United States—and was taking it for her headaches.

A Web search revealed rare adverse effects of agranulocytosis, neutropenia, and anaphylaxis from metamizole. It is highly probable that the metamizole caused my patient’s symptoms and abnormal labs findings. I advised her of my suspicions and recommended that she stop taking the medication. A hospitalist then took over her care.

The key takeaway from this case is to account for all medications when gathering a patient’s history, including those that may be obtained outside of the United States.

Nick Ly, DO
Lillington, NC

I recently saw a 73-year-old Hispanic woman in the emergency department who said (through her daughter, who was translating) that she was experiencing mild headache, shortness of breath, and throat swelling. She had previously sought care for these complaints, but her condition had not improved. Her past medical and surgical history was otherwise unremarkable.

On examination, her voice was hoarse and she had bilateral 1+ pitting edema of her lower extremities. Her vital signs were stable, her lungs were clear, her throat appeared normal, and she didn’t have any skin rashes. However, her lab results included a white blood cell count of 2100/mcL, platelet count of 73,000/mcL, and an absolute neutrophil count of 1000/mm3. Her b-type natriuretic peptide, cardiac marker, and thyroid-stimulating hormone levels were normal.

The diagnosis was clear—neutropenia and agranulocytosis—although the cause was not. That is, until we learned about a drug the patient had obtained in Mexico.

The diagnosis was clear—neutropenia and agranulocytosis—although the cause was not.

I gathered a more detailed history and learned that the patient had been living in the United States for years, but she occasionally returned to Mexico for visits and routine medical care. During one of these trips, she’d obtained metamizole—a drug banned in the United States—and was taking it for her headaches.

A Web search revealed rare adverse effects of agranulocytosis, neutropenia, and anaphylaxis from metamizole. It is highly probable that the metamizole caused my patient’s symptoms and abnormal labs findings. I advised her of my suspicions and recommended that she stop taking the medication. A hospitalist then took over her care.

The key takeaway from this case is to account for all medications when gathering a patient’s history, including those that may be obtained outside of the United States.

Nick Ly, DO
Lillington, NC

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As a scribe and accepted future medical student, I was quite interested in the article, “Medical scribes: How do their notes stack up?” by Misra-Hebert, et al (J Fam Pract. 2016;65:155-159) and the editorial, “Working with scribes—the good, the surprising” (J Fam Pract. 2016;65:154,176) in the March issue. I was struck, however, that both pieces implied that only medical assistants (MAs) are scribes.

I am familiar with practices where MAs assume a “documentation support” function in addition to their traditional role, and I currently work in a practice with professional scribes. Professional scribes are often recent college graduates who are working before beginning their studies to become a physician or physician assistant.

In my experience, MAs want to do the work they were hired and trained to do and are not enthusiastic about extensive charting. However, professional scribes apply to the position expecting to do this very task, with the goals of learning from the doctor-patient interaction, deepening their medical knowledge, and becoming comfortable in a clinical setting.

Although I am glad to see that MAs improve documentation quality per the original research mentioned above, it would be beneficial to compare the outcomes of professional scribes to those of cross-trained MAs or to traditional providers who do their own note-writing.

D. Brendan Johnson, BA
Minneapolis, Minn

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As a scribe and accepted future medical student, I was quite interested in the article, “Medical scribes: How do their notes stack up?” by Misra-Hebert, et al (J Fam Pract. 2016;65:155-159) and the editorial, “Working with scribes—the good, the surprising” (J Fam Pract. 2016;65:154,176) in the March issue. I was struck, however, that both pieces implied that only medical assistants (MAs) are scribes.

I am familiar with practices where MAs assume a “documentation support” function in addition to their traditional role, and I currently work in a practice with professional scribes. Professional scribes are often recent college graduates who are working before beginning their studies to become a physician or physician assistant.

In my experience, MAs want to do the work they were hired and trained to do and are not enthusiastic about extensive charting. However, professional scribes apply to the position expecting to do this very task, with the goals of learning from the doctor-patient interaction, deepening their medical knowledge, and becoming comfortable in a clinical setting.

Although I am glad to see that MAs improve documentation quality per the original research mentioned above, it would be beneficial to compare the outcomes of professional scribes to those of cross-trained MAs or to traditional providers who do their own note-writing.

D. Brendan Johnson, BA
Minneapolis, Minn

As a scribe and accepted future medical student, I was quite interested in the article, “Medical scribes: How do their notes stack up?” by Misra-Hebert, et al (J Fam Pract. 2016;65:155-159) and the editorial, “Working with scribes—the good, the surprising” (J Fam Pract. 2016;65:154,176) in the March issue. I was struck, however, that both pieces implied that only medical assistants (MAs) are scribes.

I am familiar with practices where MAs assume a “documentation support” function in addition to their traditional role, and I currently work in a practice with professional scribes. Professional scribes are often recent college graduates who are working before beginning their studies to become a physician or physician assistant.

In my experience, MAs want to do the work they were hired and trained to do and are not enthusiastic about extensive charting. However, professional scribes apply to the position expecting to do this very task, with the goals of learning from the doctor-patient interaction, deepening their medical knowledge, and becoming comfortable in a clinical setting.

Although I am glad to see that MAs improve documentation quality per the original research mentioned above, it would be beneficial to compare the outcomes of professional scribes to those of cross-trained MAs or to traditional providers who do their own note-writing.

D. Brendan Johnson, BA
Minneapolis, Minn

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Gun violence, the LGBT community, and terrorism. Who would have imagined these 3 entities tragically colliding in Orlando last month, in the shadow of “the happiest place on earth”? The tragedy was all too real for the victims—mostly gay young Hispanic men—their families and friends, and all those who responded with urgent help. Our hearts go out to the victims and their loved ones, and our hats go off to those who rushed in to help—especially the dedicated law enforcement and medical personnel who saved many lives.

We respond as a nation and as individuals with great sadness and anger to an event like this. But are there lessons embedded in the sorrow for us as family physicians and primary care clinicians? I believe there are.

1. Ask yourself: Am I doing all I can to provide compassionate care? Although I think of myself as a caring, compassionate family physician who treats all patients equally, I realize that I must continue to educate myself about the culture and health needs of specific segments of my patient population to ensure that I provide truly excellent care. Traditionally, cultural sensitivity training has focused on knowledge of races, ethnicities, and cultures, but it must also include training about sexual orientation. Asking patients about their sexual orientation must be a routine part of the medical history.

Violence and discrimination, like chronic disease, seem to be permanent fixtures on the human landscape. What can we do to prevent and mitigate these evils?

One of the minority groups we know least about is transgender individuals, who have unique medical and psychological issues. It is tragically ironic that we had planned an article about caring for transgender patients—a group that experiences disproportionate discrimination and violence1—for this issue of JFP long before the Orlando shooting. We still have much to learn about the most appropriate way of caring for transgender individuals because there has been so little research.

2. Treat gun violence like an infectious disease. Another lesson from the Orlando tragedy is to approach the issue of gun violence—which is always highly politicized and charged in this country—as a public health problem. One of the best examples of this approach in action is an organization called Cure Violence (cureviolence.org) led by Gary Slutkin, MD, a former Centers for Disease Control and Prevention infectious disease specialist and epidemiologist. The organization proposes that the best way to stop violence is by using the methods and strategies associated with disease control. The group claims to have made great strides in reducing violence in the communities in which it works by treating violence as an epidemic.

Violence and discrimination, like chronic disease, seem to be permanent fixtures on the human landscape. We all must do our small, but important, part as health professionals to prevent and mitigate these evils.

References

1. Pew Research Center. A survey of LGBT Americans: attitudes, experiences and values in changing times. Available at: http://www.pewsocialtrends.org/2013/06/13/a-survey-of-lgbt-americans. Accessed June 15, 2016.

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Gun violence, the LGBT community, and terrorism. Who would have imagined these 3 entities tragically colliding in Orlando last month, in the shadow of “the happiest place on earth”? The tragedy was all too real for the victims—mostly gay young Hispanic men—their families and friends, and all those who responded with urgent help. Our hearts go out to the victims and their loved ones, and our hats go off to those who rushed in to help—especially the dedicated law enforcement and medical personnel who saved many lives.

We respond as a nation and as individuals with great sadness and anger to an event like this. But are there lessons embedded in the sorrow for us as family physicians and primary care clinicians? I believe there are.

1. Ask yourself: Am I doing all I can to provide compassionate care? Although I think of myself as a caring, compassionate family physician who treats all patients equally, I realize that I must continue to educate myself about the culture and health needs of specific segments of my patient population to ensure that I provide truly excellent care. Traditionally, cultural sensitivity training has focused on knowledge of races, ethnicities, and cultures, but it must also include training about sexual orientation. Asking patients about their sexual orientation must be a routine part of the medical history.

Violence and discrimination, like chronic disease, seem to be permanent fixtures on the human landscape. What can we do to prevent and mitigate these evils?

One of the minority groups we know least about is transgender individuals, who have unique medical and psychological issues. It is tragically ironic that we had planned an article about caring for transgender patients—a group that experiences disproportionate discrimination and violence1—for this issue of JFP long before the Orlando shooting. We still have much to learn about the most appropriate way of caring for transgender individuals because there has been so little research.

2. Treat gun violence like an infectious disease. Another lesson from the Orlando tragedy is to approach the issue of gun violence—which is always highly politicized and charged in this country—as a public health problem. One of the best examples of this approach in action is an organization called Cure Violence (cureviolence.org) led by Gary Slutkin, MD, a former Centers for Disease Control and Prevention infectious disease specialist and epidemiologist. The organization proposes that the best way to stop violence is by using the methods and strategies associated with disease control. The group claims to have made great strides in reducing violence in the communities in which it works by treating violence as an epidemic.

Violence and discrimination, like chronic disease, seem to be permanent fixtures on the human landscape. We all must do our small, but important, part as health professionals to prevent and mitigate these evils.

Gun violence, the LGBT community, and terrorism. Who would have imagined these 3 entities tragically colliding in Orlando last month, in the shadow of “the happiest place on earth”? The tragedy was all too real for the victims—mostly gay young Hispanic men—their families and friends, and all those who responded with urgent help. Our hearts go out to the victims and their loved ones, and our hats go off to those who rushed in to help—especially the dedicated law enforcement and medical personnel who saved many lives.

We respond as a nation and as individuals with great sadness and anger to an event like this. But are there lessons embedded in the sorrow for us as family physicians and primary care clinicians? I believe there are.

1. Ask yourself: Am I doing all I can to provide compassionate care? Although I think of myself as a caring, compassionate family physician who treats all patients equally, I realize that I must continue to educate myself about the culture and health needs of specific segments of my patient population to ensure that I provide truly excellent care. Traditionally, cultural sensitivity training has focused on knowledge of races, ethnicities, and cultures, but it must also include training about sexual orientation. Asking patients about their sexual orientation must be a routine part of the medical history.

Violence and discrimination, like chronic disease, seem to be permanent fixtures on the human landscape. What can we do to prevent and mitigate these evils?

One of the minority groups we know least about is transgender individuals, who have unique medical and psychological issues. It is tragically ironic that we had planned an article about caring for transgender patients—a group that experiences disproportionate discrimination and violence1—for this issue of JFP long before the Orlando shooting. We still have much to learn about the most appropriate way of caring for transgender individuals because there has been so little research.

2. Treat gun violence like an infectious disease. Another lesson from the Orlando tragedy is to approach the issue of gun violence—which is always highly politicized and charged in this country—as a public health problem. One of the best examples of this approach in action is an organization called Cure Violence (cureviolence.org) led by Gary Slutkin, MD, a former Centers for Disease Control and Prevention infectious disease specialist and epidemiologist. The organization proposes that the best way to stop violence is by using the methods and strategies associated with disease control. The group claims to have made great strides in reducing violence in the communities in which it works by treating violence as an epidemic.

Violence and discrimination, like chronic disease, seem to be permanent fixtures on the human landscape. We all must do our small, but important, part as health professionals to prevent and mitigate these evils.

References

1. Pew Research Center. A survey of LGBT Americans: attitudes, experiences and values in changing times. Available at: http://www.pewsocialtrends.org/2013/06/13/a-survey-of-lgbt-americans. Accessed June 15, 2016.

References

1. Pew Research Center. A survey of LGBT Americans: attitudes, experiences and values in changing times. Available at: http://www.pewsocialtrends.org/2013/06/13/a-survey-of-lgbt-americans. Accessed June 15, 2016.

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Tonsillectomy for this 35-year-old patient?

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THE CASE

A 35-year-old woman sought care for a fever and sore throat that she’d had for 4 days. She denied symptoms of cough, rhinorrhea, or sputum production.

The patient’s medical history included severe recurrent streptococcal pharyngitis as a child and teenager. At the age of 17, she developed a fever of 105° F with associated delirium, dysphagia, nausea, and vomiting, and missed several days of school. She also lost 82 pounds, developed oral thrush, and continued to feel fatigued for approximately a year. After her primary care physician noted a heart murmur on physical exam, she was sent for echocardiography and diagnosed with rheumatic fever secondary to streptococcal pharyngitis.

Eighteen years (and numerous streptococcal infections) later, the patient was at our facility and we were ordering a rapid antigen detection test (RADT) for her current illness. The throat specimen was positive for group A ß-hemolytic streptococcus (GAS). The patient’s 8-year-old daughter also had a sore throat, fever, and positive RADT; her symptoms resolved with oral amoxicillin for 10 days. The patient’s husband was also treated successfully with oral amoxicillin/clavulanate for 10 days for similar symptoms. The patient herself, however, was unsuccessfully treated with oral amoxicillin 500 mg twice daily for 7 days.

She was then given oral amoxicillin/clavulanate 875 mg twice daily for 14 days, but received no relief. Even after receiving clindamycin 600 mg twice daily for 10 days, she had minimal relief and remained positive for GAS on repeat RADT. It was at this point that tonsillectomy was considered as a possible treatment modality for her refractory GAS pharyngitis.

The patient consented to the procedure and underwent a tonsillectomy. She has remained asymptomatic for 2 years and there have been no reported outbreaks of GAS infection in her household.

DISCUSSION

Streptococcal pharyngitis is an infection of the oropharynx and/or nasopharynx that is caused by Streptococcus pyogenes (also known as GAS). It is one of the most frequent illnesses encountered by primary care physicians, and primarily occurs in children ages 5 to 15 years.1,2 The signs and symptoms of GAS pharyngitis include an abrupt onset of a sore throat, tonsillar exudate, tender cervical adenopathy, and fever. (The classic presentation of GAS pharyngitis in a different patient can be seen in the FIGURE.)

Throat cultures are the gold standard for the diagnosis of GAS pharyngitis, but results take 24 to 48 hours, which can delay appropriate treatment. Therefore, the use of the RADT is often preferred clinically.1 RADT is not recommended for children and adults who show clinical symptoms that are highly suggestive of a viral illness, such as cough, rhinorrhea, hoarseness, or oral ulcers. A negative RADT in children and adolescents necessitates a throat culture to confirm the diagnosis.2

The antibiotics of choice are either penicillin 50 mg/kg/d in 4 divided doses or amoxicillin 40 mg/kg/d in 3 divided doses (maximum for both is 2000 mg/d) for 10 days. Options for patients with penicillin allergies include clindamycin or clarithromycin for 10 days or azithromycin for 5 days.2

The Infectious Diseases Society of America (IDSA) does not recommend routine testing or empiric treatment of asymptomatic carriers. However, it does recommend treatment of GAS carriers in certain situations, such as when: 2

  • the carrier has acute rheumatic fever
  • there is a family or personal history of acute rheumatic fever
  • there is a post-streptococcal glomerulonephritis outbreak
  • a family has excessive anxiety about GAS infections
  • a tonsillectomy is being considered.

When—and for whom—is tonsillectomy beneficial?

Tonsillectomy is a treatment option for patients with recurrent episodes of GAS pharyngitis. Indications include patients with 7 GAS infections in a year, 5 episodes in 2 years, or 3 episodes in 3 years.3,4 In select patient populations, tonsillectomy has been shown to decrease missed work days and medical expenses caused by recurrent pharyngitis.5,6

Alho et al demonstrated that adults with recurrent episodes of GAS pharyngitis benefit from tonsillectomy in terms of fewer repeat infections and more days without throat pain.7 A randomized controlled trial conducted by Koskenkorva et al found that the overall rates of pharyngitis, throat pain, rhinitis, and cough were significantly lower in adults who received a tonsillectomy vs those who did not.5 Still, whether tonsillectomy is worthwhile in adults is debatable; Burton et al found no evidence that tonsillectomy is effective for chronic or recurrent acute tonsillitis in adults.8

Our patient has not missed work or visited her primary care physician because of a GAS infection since her tonsillectomy.

Overall meta-analysis results indicate that tonsillectomy results in a 43% reduction in the incidence of pharyngitis in children between the ages of 4 and 16.8,9 One study found that children without tonsillectomy were 3.1 times more likely to develop subsequent GAS pharyngitis than children who underwent tonsillectomy.9 Another study found that children who received tonsillectomy demonstrated a decrease in sore throat episodes by 1.2 episodes per year and a decrease in school absenteeism by 2.8 days per year.6 Tonsillectomy does carry a risk of intraoperative and postoperative bleeding in children and adults, which may make it a less desirable option for some patients.6

 

 

THE TAKEAWAY

Recurrent GAS pharyngitis poses a significant challenge for clinicians. When episodes recur, it may be prudent to treat asymptomatic carriers in the patient’s household. Tonsillectomy should be considered in refractory cases since recurrent GAS pharyngitis directly impacts the wellness and productivity of patients. Our patient certainly benefited from the surgery: She has not missed any work days or had to visit her primary care physician because of a GAS infection since her tonsillectomy.

References

1. Gurol Y, Akan H, Izbirak G, et al. The sensitivity and the specificity of rapid antigen test in streptococcal upper respiratory tract infections. Int J Pediatr Otorhinolaryngol. 2010;74:591-593.

2. Shulman ST, Bisno AL, Clegg HW, et al. Clinical practice guideline for the diagnosis and management of group A streptococcal pharyngitis: 2012 update by the Infectious Diseases Society of America. Clin Infect Dis. 2012;55:1279-1282.

3. Stuck BA, Götte K, Windfuhr JP, et al. Tonsillectomy in children. Dtsch Arztebl Int. 2008;105:852-860.

4. Baugh RF, Archer SM, Mitchell RB, et al; American Academy of Otolaryngology-Head and Neck Surgery Foundation. Clinical practice guideline: tonsillectomy in children. Otolaryngol Head Neck Surg. 2011;144:S1-S30.

5. Koskenkorva T, Koivunen P, Koskela M, et al. Short-term outcomes of tonsillectomy in adult patients with recurrent pharyngitis: a randomized controlled trial. CMAJ. 2013;185:E331-E336.

6. van Staaij BK, van den Akker EH, van der Heijden GJ, et al. Adenotonsillectomy for upper respiratory infections: evidence based? Arch Dis Child. 2005;90:19-25.

7. Alho OP, Koivunen P, Penna T, et al. Tonsillectomy versus watchful waiting in recurrent streptococcal pharyngitis in adults: randomised controlled trial. BMJ. 2007;334:939.

8. Burton MJ, Towler B, Glasziou P. Tonsillectomy versus non-surgical treatment for chronic/recurrent acute tonsillitis. Cochrane Database Syst Rev. 2000;(2):CD001802.

9. Orvidas LJ, St Sauver JL, Weaver AL. Efficacy of tonsillectomy in treatment of recurrent group A beta-hemolytic streptococcal pharyngitis. Laryngoscope. 2006;116:1946-1950.

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Aysha Ahmed, MS
Abraham T. Yacoub, MD
Arun Ponnuru, MD
Smitha Pabbathi, MD, FACP
Sowmya Nanjappa, MD
Albert L. Vincent, PhD
John Greene, MD, FACP

Lake Erie College of Osteopathic Medicine, Bradenton Campus, Fla (Ms. Ahmed); H. Lee Mofitt Cancer Center and Research Institute (Drs. Yacoub, Ponnuru, Pabbathi, Nanjappa, and Greene) and Department of Internal Medicine (Dr. Vincent), University of South Florida Morsani College of Medicine, Tampa
john.greene@moffitt.org

The authors reported no potential conflict of interest relevant to this article.

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Aysha Ahmed, MS
Abraham T. Yacoub, MD
Arun Ponnuru, MD
Smitha Pabbathi, MD, FACP
Sowmya Nanjappa, MD
Albert L. Vincent, PhD
John Greene, MD, FACP

Lake Erie College of Osteopathic Medicine, Bradenton Campus, Fla (Ms. Ahmed); H. Lee Mofitt Cancer Center and Research Institute (Drs. Yacoub, Ponnuru, Pabbathi, Nanjappa, and Greene) and Department of Internal Medicine (Dr. Vincent), University of South Florida Morsani College of Medicine, Tampa
john.greene@moffitt.org

The authors reported no potential conflict of interest relevant to this article.

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Aysha Ahmed, MS
Abraham T. Yacoub, MD
Arun Ponnuru, MD
Smitha Pabbathi, MD, FACP
Sowmya Nanjappa, MD
Albert L. Vincent, PhD
John Greene, MD, FACP

Lake Erie College of Osteopathic Medicine, Bradenton Campus, Fla (Ms. Ahmed); H. Lee Mofitt Cancer Center and Research Institute (Drs. Yacoub, Ponnuru, Pabbathi, Nanjappa, and Greene) and Department of Internal Medicine (Dr. Vincent), University of South Florida Morsani College of Medicine, Tampa
john.greene@moffitt.org

The authors reported no potential conflict of interest relevant to this article.

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THE CASE

A 35-year-old woman sought care for a fever and sore throat that she’d had for 4 days. She denied symptoms of cough, rhinorrhea, or sputum production.

The patient’s medical history included severe recurrent streptococcal pharyngitis as a child and teenager. At the age of 17, she developed a fever of 105° F with associated delirium, dysphagia, nausea, and vomiting, and missed several days of school. She also lost 82 pounds, developed oral thrush, and continued to feel fatigued for approximately a year. After her primary care physician noted a heart murmur on physical exam, she was sent for echocardiography and diagnosed with rheumatic fever secondary to streptococcal pharyngitis.

Eighteen years (and numerous streptococcal infections) later, the patient was at our facility and we were ordering a rapid antigen detection test (RADT) for her current illness. The throat specimen was positive for group A ß-hemolytic streptococcus (GAS). The patient’s 8-year-old daughter also had a sore throat, fever, and positive RADT; her symptoms resolved with oral amoxicillin for 10 days. The patient’s husband was also treated successfully with oral amoxicillin/clavulanate for 10 days for similar symptoms. The patient herself, however, was unsuccessfully treated with oral amoxicillin 500 mg twice daily for 7 days.

She was then given oral amoxicillin/clavulanate 875 mg twice daily for 14 days, but received no relief. Even after receiving clindamycin 600 mg twice daily for 10 days, she had minimal relief and remained positive for GAS on repeat RADT. It was at this point that tonsillectomy was considered as a possible treatment modality for her refractory GAS pharyngitis.

The patient consented to the procedure and underwent a tonsillectomy. She has remained asymptomatic for 2 years and there have been no reported outbreaks of GAS infection in her household.

DISCUSSION

Streptococcal pharyngitis is an infection of the oropharynx and/or nasopharynx that is caused by Streptococcus pyogenes (also known as GAS). It is one of the most frequent illnesses encountered by primary care physicians, and primarily occurs in children ages 5 to 15 years.1,2 The signs and symptoms of GAS pharyngitis include an abrupt onset of a sore throat, tonsillar exudate, tender cervical adenopathy, and fever. (The classic presentation of GAS pharyngitis in a different patient can be seen in the FIGURE.)

Throat cultures are the gold standard for the diagnosis of GAS pharyngitis, but results take 24 to 48 hours, which can delay appropriate treatment. Therefore, the use of the RADT is often preferred clinically.1 RADT is not recommended for children and adults who show clinical symptoms that are highly suggestive of a viral illness, such as cough, rhinorrhea, hoarseness, or oral ulcers. A negative RADT in children and adolescents necessitates a throat culture to confirm the diagnosis.2

The antibiotics of choice are either penicillin 50 mg/kg/d in 4 divided doses or amoxicillin 40 mg/kg/d in 3 divided doses (maximum for both is 2000 mg/d) for 10 days. Options for patients with penicillin allergies include clindamycin or clarithromycin for 10 days or azithromycin for 5 days.2

The Infectious Diseases Society of America (IDSA) does not recommend routine testing or empiric treatment of asymptomatic carriers. However, it does recommend treatment of GAS carriers in certain situations, such as when: 2

  • the carrier has acute rheumatic fever
  • there is a family or personal history of acute rheumatic fever
  • there is a post-streptococcal glomerulonephritis outbreak
  • a family has excessive anxiety about GAS infections
  • a tonsillectomy is being considered.

When—and for whom—is tonsillectomy beneficial?

Tonsillectomy is a treatment option for patients with recurrent episodes of GAS pharyngitis. Indications include patients with 7 GAS infections in a year, 5 episodes in 2 years, or 3 episodes in 3 years.3,4 In select patient populations, tonsillectomy has been shown to decrease missed work days and medical expenses caused by recurrent pharyngitis.5,6

Alho et al demonstrated that adults with recurrent episodes of GAS pharyngitis benefit from tonsillectomy in terms of fewer repeat infections and more days without throat pain.7 A randomized controlled trial conducted by Koskenkorva et al found that the overall rates of pharyngitis, throat pain, rhinitis, and cough were significantly lower in adults who received a tonsillectomy vs those who did not.5 Still, whether tonsillectomy is worthwhile in adults is debatable; Burton et al found no evidence that tonsillectomy is effective for chronic or recurrent acute tonsillitis in adults.8

Our patient has not missed work or visited her primary care physician because of a GAS infection since her tonsillectomy.

Overall meta-analysis results indicate that tonsillectomy results in a 43% reduction in the incidence of pharyngitis in children between the ages of 4 and 16.8,9 One study found that children without tonsillectomy were 3.1 times more likely to develop subsequent GAS pharyngitis than children who underwent tonsillectomy.9 Another study found that children who received tonsillectomy demonstrated a decrease in sore throat episodes by 1.2 episodes per year and a decrease in school absenteeism by 2.8 days per year.6 Tonsillectomy does carry a risk of intraoperative and postoperative bleeding in children and adults, which may make it a less desirable option for some patients.6

 

 

THE TAKEAWAY

Recurrent GAS pharyngitis poses a significant challenge for clinicians. When episodes recur, it may be prudent to treat asymptomatic carriers in the patient’s household. Tonsillectomy should be considered in refractory cases since recurrent GAS pharyngitis directly impacts the wellness and productivity of patients. Our patient certainly benefited from the surgery: She has not missed any work days or had to visit her primary care physician because of a GAS infection since her tonsillectomy.

THE CASE

A 35-year-old woman sought care for a fever and sore throat that she’d had for 4 days. She denied symptoms of cough, rhinorrhea, or sputum production.

The patient’s medical history included severe recurrent streptococcal pharyngitis as a child and teenager. At the age of 17, she developed a fever of 105° F with associated delirium, dysphagia, nausea, and vomiting, and missed several days of school. She also lost 82 pounds, developed oral thrush, and continued to feel fatigued for approximately a year. After her primary care physician noted a heart murmur on physical exam, she was sent for echocardiography and diagnosed with rheumatic fever secondary to streptococcal pharyngitis.

Eighteen years (and numerous streptococcal infections) later, the patient was at our facility and we were ordering a rapid antigen detection test (RADT) for her current illness. The throat specimen was positive for group A ß-hemolytic streptococcus (GAS). The patient’s 8-year-old daughter also had a sore throat, fever, and positive RADT; her symptoms resolved with oral amoxicillin for 10 days. The patient’s husband was also treated successfully with oral amoxicillin/clavulanate for 10 days for similar symptoms. The patient herself, however, was unsuccessfully treated with oral amoxicillin 500 mg twice daily for 7 days.

She was then given oral amoxicillin/clavulanate 875 mg twice daily for 14 days, but received no relief. Even after receiving clindamycin 600 mg twice daily for 10 days, she had minimal relief and remained positive for GAS on repeat RADT. It was at this point that tonsillectomy was considered as a possible treatment modality for her refractory GAS pharyngitis.

The patient consented to the procedure and underwent a tonsillectomy. She has remained asymptomatic for 2 years and there have been no reported outbreaks of GAS infection in her household.

DISCUSSION

Streptococcal pharyngitis is an infection of the oropharynx and/or nasopharynx that is caused by Streptococcus pyogenes (also known as GAS). It is one of the most frequent illnesses encountered by primary care physicians, and primarily occurs in children ages 5 to 15 years.1,2 The signs and symptoms of GAS pharyngitis include an abrupt onset of a sore throat, tonsillar exudate, tender cervical adenopathy, and fever. (The classic presentation of GAS pharyngitis in a different patient can be seen in the FIGURE.)

Throat cultures are the gold standard for the diagnosis of GAS pharyngitis, but results take 24 to 48 hours, which can delay appropriate treatment. Therefore, the use of the RADT is often preferred clinically.1 RADT is not recommended for children and adults who show clinical symptoms that are highly suggestive of a viral illness, such as cough, rhinorrhea, hoarseness, or oral ulcers. A negative RADT in children and adolescents necessitates a throat culture to confirm the diagnosis.2

The antibiotics of choice are either penicillin 50 mg/kg/d in 4 divided doses or amoxicillin 40 mg/kg/d in 3 divided doses (maximum for both is 2000 mg/d) for 10 days. Options for patients with penicillin allergies include clindamycin or clarithromycin for 10 days or azithromycin for 5 days.2

The Infectious Diseases Society of America (IDSA) does not recommend routine testing or empiric treatment of asymptomatic carriers. However, it does recommend treatment of GAS carriers in certain situations, such as when: 2

  • the carrier has acute rheumatic fever
  • there is a family or personal history of acute rheumatic fever
  • there is a post-streptococcal glomerulonephritis outbreak
  • a family has excessive anxiety about GAS infections
  • a tonsillectomy is being considered.

When—and for whom—is tonsillectomy beneficial?

Tonsillectomy is a treatment option for patients with recurrent episodes of GAS pharyngitis. Indications include patients with 7 GAS infections in a year, 5 episodes in 2 years, or 3 episodes in 3 years.3,4 In select patient populations, tonsillectomy has been shown to decrease missed work days and medical expenses caused by recurrent pharyngitis.5,6

Alho et al demonstrated that adults with recurrent episodes of GAS pharyngitis benefit from tonsillectomy in terms of fewer repeat infections and more days without throat pain.7 A randomized controlled trial conducted by Koskenkorva et al found that the overall rates of pharyngitis, throat pain, rhinitis, and cough were significantly lower in adults who received a tonsillectomy vs those who did not.5 Still, whether tonsillectomy is worthwhile in adults is debatable; Burton et al found no evidence that tonsillectomy is effective for chronic or recurrent acute tonsillitis in adults.8

Our patient has not missed work or visited her primary care physician because of a GAS infection since her tonsillectomy.

Overall meta-analysis results indicate that tonsillectomy results in a 43% reduction in the incidence of pharyngitis in children between the ages of 4 and 16.8,9 One study found that children without tonsillectomy were 3.1 times more likely to develop subsequent GAS pharyngitis than children who underwent tonsillectomy.9 Another study found that children who received tonsillectomy demonstrated a decrease in sore throat episodes by 1.2 episodes per year and a decrease in school absenteeism by 2.8 days per year.6 Tonsillectomy does carry a risk of intraoperative and postoperative bleeding in children and adults, which may make it a less desirable option for some patients.6

 

 

THE TAKEAWAY

Recurrent GAS pharyngitis poses a significant challenge for clinicians. When episodes recur, it may be prudent to treat asymptomatic carriers in the patient’s household. Tonsillectomy should be considered in refractory cases since recurrent GAS pharyngitis directly impacts the wellness and productivity of patients. Our patient certainly benefited from the surgery: She has not missed any work days or had to visit her primary care physician because of a GAS infection since her tonsillectomy.

References

1. Gurol Y, Akan H, Izbirak G, et al. The sensitivity and the specificity of rapid antigen test in streptococcal upper respiratory tract infections. Int J Pediatr Otorhinolaryngol. 2010;74:591-593.

2. Shulman ST, Bisno AL, Clegg HW, et al. Clinical practice guideline for the diagnosis and management of group A streptococcal pharyngitis: 2012 update by the Infectious Diseases Society of America. Clin Infect Dis. 2012;55:1279-1282.

3. Stuck BA, Götte K, Windfuhr JP, et al. Tonsillectomy in children. Dtsch Arztebl Int. 2008;105:852-860.

4. Baugh RF, Archer SM, Mitchell RB, et al; American Academy of Otolaryngology-Head and Neck Surgery Foundation. Clinical practice guideline: tonsillectomy in children. Otolaryngol Head Neck Surg. 2011;144:S1-S30.

5. Koskenkorva T, Koivunen P, Koskela M, et al. Short-term outcomes of tonsillectomy in adult patients with recurrent pharyngitis: a randomized controlled trial. CMAJ. 2013;185:E331-E336.

6. van Staaij BK, van den Akker EH, van der Heijden GJ, et al. Adenotonsillectomy for upper respiratory infections: evidence based? Arch Dis Child. 2005;90:19-25.

7. Alho OP, Koivunen P, Penna T, et al. Tonsillectomy versus watchful waiting in recurrent streptococcal pharyngitis in adults: randomised controlled trial. BMJ. 2007;334:939.

8. Burton MJ, Towler B, Glasziou P. Tonsillectomy versus non-surgical treatment for chronic/recurrent acute tonsillitis. Cochrane Database Syst Rev. 2000;(2):CD001802.

9. Orvidas LJ, St Sauver JL, Weaver AL. Efficacy of tonsillectomy in treatment of recurrent group A beta-hemolytic streptococcal pharyngitis. Laryngoscope. 2006;116:1946-1950.

References

1. Gurol Y, Akan H, Izbirak G, et al. The sensitivity and the specificity of rapid antigen test in streptococcal upper respiratory tract infections. Int J Pediatr Otorhinolaryngol. 2010;74:591-593.

2. Shulman ST, Bisno AL, Clegg HW, et al. Clinical practice guideline for the diagnosis and management of group A streptococcal pharyngitis: 2012 update by the Infectious Diseases Society of America. Clin Infect Dis. 2012;55:1279-1282.

3. Stuck BA, Götte K, Windfuhr JP, et al. Tonsillectomy in children. Dtsch Arztebl Int. 2008;105:852-860.

4. Baugh RF, Archer SM, Mitchell RB, et al; American Academy of Otolaryngology-Head and Neck Surgery Foundation. Clinical practice guideline: tonsillectomy in children. Otolaryngol Head Neck Surg. 2011;144:S1-S30.

5. Koskenkorva T, Koivunen P, Koskela M, et al. Short-term outcomes of tonsillectomy in adult patients with recurrent pharyngitis: a randomized controlled trial. CMAJ. 2013;185:E331-E336.

6. van Staaij BK, van den Akker EH, van der Heijden GJ, et al. Adenotonsillectomy for upper respiratory infections: evidence based? Arch Dis Child. 2005;90:19-25.

7. Alho OP, Koivunen P, Penna T, et al. Tonsillectomy versus watchful waiting in recurrent streptococcal pharyngitis in adults: randomised controlled trial. BMJ. 2007;334:939.

8. Burton MJ, Towler B, Glasziou P. Tonsillectomy versus non-surgical treatment for chronic/recurrent acute tonsillitis. Cochrane Database Syst Rev. 2000;(2):CD001802.

9. Orvidas LJ, St Sauver JL, Weaver AL. Efficacy of tonsillectomy in treatment of recurrent group A beta-hemolytic streptococcal pharyngitis. Laryngoscope. 2006;116:1946-1950.

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Children’s environmental health: An updated resource

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In 1996, 2 exposure incidents sparked a movement to better understand children’s environmental health. In both incidents, children were exposed to significant toxicants in unexpected ways. In one, the organophosphate insecticide methyl parathion was applied illegally in indoor settings.1 In another, elemental mercury residue was detected in apartments converted from a fluorescent bulb facility.2 These incidents, and others like them, alerted physicians and government agencies to the collective lack of training and experience in the field of pediatric environmental health.

To address the situation, the Agency for Toxic Substances and Disease Registry and the Environmental Protection Agency created the Pediatric Environmental Health Specialty Unit (PEHSU) program. The program, which is now jointly operated by the American College of Medical Toxicology and the American Academy of Pediatrics, maintains sites in 10 regions3 and seeks to enhance education and promote consultation and referral related to reproductive and children’s environmental health.

This past fall, PEHSU updated its Web site at www.pehsu.net, which provides information, training, and resources for health professionals and the general public. The Web site provides news, fact sheets, and online education regarding environment-related pediatric and reproductive health issues. It also provides a tool for finding a local expert in the PEHSU national network, should a family physician need to refer a patient for more extensive assistance.

We believe that family physicians will find the PEHSU program resources informative, educational, and relevant to their practice.

Carl R. Baum, MD, FAAP, FACMT, Medical Director
Dana Turner, MPH, CHES
Amanda Allen, MS

PEHSU Program
National Office—West
Phoenix, Ariz

References

1. Esteban E, Rubin C, Hill R, et al. Association between indoor residential contamination with methyl parathion and urinary para-nitrophenol. J Expo Anal Environ Epidemiol. 1996;6:375-387.

2. Centers for Disease Control and Prevention (CDC). Mercury exposure among residents of a building formerly used for industrial purposes—New Jersey, 1995. MMWR Morb Mortal Wkly Rep. 1996;45:422-424.

3. Wilborne-Davis P, Kirkland KH, Mulloy KB. A model for physician education and consultation in pediatric environmental health—the Pediatric Environmental Health Specialty Units (PEHSU) program. Pediatr Clin North Am. 2007;54:1-13.

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In 1996, 2 exposure incidents sparked a movement to better understand children’s environmental health. In both incidents, children were exposed to significant toxicants in unexpected ways. In one, the organophosphate insecticide methyl parathion was applied illegally in indoor settings.1 In another, elemental mercury residue was detected in apartments converted from a fluorescent bulb facility.2 These incidents, and others like them, alerted physicians and government agencies to the collective lack of training and experience in the field of pediatric environmental health.

To address the situation, the Agency for Toxic Substances and Disease Registry and the Environmental Protection Agency created the Pediatric Environmental Health Specialty Unit (PEHSU) program. The program, which is now jointly operated by the American College of Medical Toxicology and the American Academy of Pediatrics, maintains sites in 10 regions3 and seeks to enhance education and promote consultation and referral related to reproductive and children’s environmental health.

This past fall, PEHSU updated its Web site at www.pehsu.net, which provides information, training, and resources for health professionals and the general public. The Web site provides news, fact sheets, and online education regarding environment-related pediatric and reproductive health issues. It also provides a tool for finding a local expert in the PEHSU national network, should a family physician need to refer a patient for more extensive assistance.

We believe that family physicians will find the PEHSU program resources informative, educational, and relevant to their practice.

Carl R. Baum, MD, FAAP, FACMT, Medical Director
Dana Turner, MPH, CHES
Amanda Allen, MS

PEHSU Program
National Office—West
Phoenix, Ariz

References

1. Esteban E, Rubin C, Hill R, et al. Association between indoor residential contamination with methyl parathion and urinary para-nitrophenol. J Expo Anal Environ Epidemiol. 1996;6:375-387.

2. Centers for Disease Control and Prevention (CDC). Mercury exposure among residents of a building formerly used for industrial purposes—New Jersey, 1995. MMWR Morb Mortal Wkly Rep. 1996;45:422-424.

3. Wilborne-Davis P, Kirkland KH, Mulloy KB. A model for physician education and consultation in pediatric environmental health—the Pediatric Environmental Health Specialty Units (PEHSU) program. Pediatr Clin North Am. 2007;54:1-13.

In 1996, 2 exposure incidents sparked a movement to better understand children’s environmental health. In both incidents, children were exposed to significant toxicants in unexpected ways. In one, the organophosphate insecticide methyl parathion was applied illegally in indoor settings.1 In another, elemental mercury residue was detected in apartments converted from a fluorescent bulb facility.2 These incidents, and others like them, alerted physicians and government agencies to the collective lack of training and experience in the field of pediatric environmental health.

To address the situation, the Agency for Toxic Substances and Disease Registry and the Environmental Protection Agency created the Pediatric Environmental Health Specialty Unit (PEHSU) program. The program, which is now jointly operated by the American College of Medical Toxicology and the American Academy of Pediatrics, maintains sites in 10 regions3 and seeks to enhance education and promote consultation and referral related to reproductive and children’s environmental health.

This past fall, PEHSU updated its Web site at www.pehsu.net, which provides information, training, and resources for health professionals and the general public. The Web site provides news, fact sheets, and online education regarding environment-related pediatric and reproductive health issues. It also provides a tool for finding a local expert in the PEHSU national network, should a family physician need to refer a patient for more extensive assistance.

We believe that family physicians will find the PEHSU program resources informative, educational, and relevant to their practice.

Carl R. Baum, MD, FAAP, FACMT, Medical Director
Dana Turner, MPH, CHES
Amanda Allen, MS

PEHSU Program
National Office—West
Phoenix, Ariz

References

1. Esteban E, Rubin C, Hill R, et al. Association between indoor residential contamination with methyl parathion and urinary para-nitrophenol. J Expo Anal Environ Epidemiol. 1996;6:375-387.

2. Centers for Disease Control and Prevention (CDC). Mercury exposure among residents of a building formerly used for industrial purposes—New Jersey, 1995. MMWR Morb Mortal Wkly Rep. 1996;45:422-424.

3. Wilborne-Davis P, Kirkland KH, Mulloy KB. A model for physician education and consultation in pediatric environmental health—the Pediatric Environmental Health Specialty Units (PEHSU) program. Pediatr Clin North Am. 2007;54:1-13.

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