Patil V

Rationale: Understand the survival outcomes of black and white Veterans with metastatic castration-resistant prostate cancer (mCRPC).

Background: Black men have a higher incidence of prostate cancer and are more likely to be diagnosed at an earlier age, have a more aggressive disease at presentation and experience worse clinical outcome than white men. Evidence has shown that at diagnosis race is associated with disease progression, however, few studies have examined whether race is associated with survival in men once they reach an advanced stage of the disease. This study examines the survival outcomes among black and white men with mCRPC treated in the Veterans Health Administration (VHA).

Methods: Patient information from the Veterans Affairs (VA) Central Cancer Registry and the VA Corporate Data Warehouse was used to identify patients who were diagnosed with prostate cancer and later developed mCRPC, defined as: (1) Radiologic evidence of metastasis obtained from radiology reports using a natural language processing algorithm; (2) Evidence of rising prostate-specific antigen (PSA); and (3) Evidence of ongoing androgen deprivation consisting of a serum testosterone level of 50 ng/dL. Patient demographics, disease characteristics and treatment practices, and survival outcomes were extracted.

Results: From 2006 to 2015, 120,374 patients were diagnosed and treated with prostate cancer in the VHA; with 3,637 developing mCRPC. At diagnosis 2,429 (67%) were white, 1,066 (29%) were black, and 142 (4%) were reported as other. Compared to white men, black men were younger (66 vs 69 years) and had a higher PSA (92 vs 41 ng/mL), although there were no differences in disease characteristics
(Gleason score and stage) and early treatments (radiation prostatectomy, surgical orchiectomy, castration by agonists, castration by agonists/androgen deprivation). There were no significant differences between black and white men with mCRPC and their overall survival on both univariable (HR, .95; P = .203) or multivariable (HR, 1.0; P = .971) analyses.

Conclusions: Consistent with prior reports, black men are more likely to develop mCRPC than white men, although once black men progress to advanced disease, a multivariable analysis suggests that race is not associated with overall survival.

Rationale: Understand the survival outcomes of black and white Veterans with metastatic castration-resistant prostate cancer (mCRPC).

Background: Black men have a higher incidence of prostate cancer and are more likely to be diagnosed at an earlier age, have a more aggressive disease at presentation and experience worse clinical outcome than white men. Evidence has shown that at diagnosis race is associated with disease progression, however, few studies have examined whether race is associated with survival in men once they reach an advanced stage of the disease. This study examines the survival outcomes among black and white men with mCRPC treated in the Veterans Health Administration (VHA).

Methods: Patient information from the Veterans Affairs (VA) Central Cancer Registry and the VA Corporate Data Warehouse was used to identify patients who were diagnosed with prostate cancer and later developed mCRPC, defined as: (1) Radiologic evidence of metastasis obtained from radiology reports using a natural language processing algorithm; (2) Evidence of rising prostate-specific antigen (PSA); and (3) Evidence of ongoing androgen deprivation consisting of a serum testosterone level of 50 ng/dL. Patient demographics, disease characteristics and treatment practices, and survival outcomes were extracted.

Results: From 2006 to 2015, 120,374 patients were diagnosed and treated with prostate cancer in the VHA; with 3,637 developing mCRPC. At diagnosis 2,429 (67%) were white, 1,066 (29%) were black, and 142 (4%) were reported as other. Compared to white men, black men were younger (66 vs 69 years) and had a higher PSA (92 vs 41 ng/mL), although there were no differences in disease characteristics
(Gleason score and stage) and early treatments (radiation prostatectomy, surgical orchiectomy, castration by agonists, castration by agonists/androgen deprivation). There were no significant differences between black and white men with mCRPC and their overall survival on both univariable (HR, .95; P = .203) or multivariable (HR, 1.0; P = .971) analyses.

Conclusions: Consistent with prior reports, black men are more likely to develop mCRPC than white men, although once black men progress to advanced disease, a multivariable analysis suggests that race is not associated with overall survival.

Rationale: Understand the survival outcomes of black and white Veterans with metastatic castration-resistant prostate cancer (mCRPC).

Background: Black men have a higher incidence of prostate cancer and are more likely to be diagnosed at an earlier age, have a more aggressive disease at presentation and experience worse clinical outcome than white men. Evidence has shown that at diagnosis race is associated with disease progression, however, few studies have examined whether race is associated with survival in men once they reach an advanced stage of the disease. This study examines the survival outcomes among black and white men with mCRPC treated in the Veterans Health Administration (VHA).

Methods: Patient information from the Veterans Affairs (VA) Central Cancer Registry and the VA Corporate Data Warehouse was used to identify patients who were diagnosed with prostate cancer and later developed mCRPC, defined as: (1) Radiologic evidence of metastasis obtained from radiology reports using a natural language processing algorithm; (2) Evidence of rising prostate-specific antigen (PSA); and (3) Evidence of ongoing androgen deprivation consisting of a serum testosterone level of 50 ng/dL. Patient demographics, disease characteristics and treatment practices, and survival outcomes were extracted.

Results: From 2006 to 2015, 120,374 patients were diagnosed and treated with prostate cancer in the VHA; with 3,637 developing mCRPC. At diagnosis 2,429 (67%) were white, 1,066 (29%) were black, and 142 (4%) were reported as other. Compared to white men, black men were younger (66 vs 69 years) and had a higher PSA (92 vs 41 ng/mL), although there were no differences in disease characteristics
(Gleason score and stage) and early treatments (radiation prostatectomy, surgical orchiectomy, castration by agonists, castration by agonists/androgen deprivation). There were no significant differences between black and white men with mCRPC and their overall survival on both univariable (HR, .95; P = .203) or multivariable (HR, 1.0; P = .971) analyses.

Conclusions: Consistent with prior reports, black men are more likely to develop mCRPC than white men, although once black men progress to advanced disease, a multivariable analysis suggests that race is not associated with overall survival.

Rationale: Successfully extract, identify, and validate therapeutics lines used in the treatment of Veterans with follicular lymphoma.

Background: With the adoption of electronic health record (EHR) systems, leveraging this data is becoming increasingly important for clinical and observational research, especially in oncology, where precision oncology has become central to the Cancer Moonshot Initiative. One of the greatest challenges in using EHR data is extracting a cancer patient’s treatment history. The difficulty lies in identifying treatment “lines,” which may include one or more drugs, with each drug dispensation often recorded in an unstructured format within the EHR. Our objective was to conceptualize, develop, and validate an algorithm that reconstructs a cancer treatment line history using single-agent EHR pharmacy data in a cohort of follicular lymphoma patients treated in the Veterans Health Administration (VHA).

Methods: The CANCER CARE algorithm recreates and formalizes the heuristic a clinician uses to identify treatment lines dispensed using two inputs: (1) National Comprehensive Cancer Network treatment guidelines and the recommended chemotherapy lines and their comprising
antineoplastic agents that are used in the treatment of the cancer of interest; and (2) Single-agent dispensation information retrieved from the VA Corporate Data Warehouse. The algorithm uses rules to map concordant dispensation agents to a treatment line while taking into account common
practice variations such as omitted agents during the start or middle of a treatment line. It also identifies the initiation of a new line based on a change in agents received or time gaps between treatments. The algorithm was validated by comparing a set of 100 treatment lines that were independently annotated by a clinician in a cohort of patients with follicular lymphoma to the algorithm output. Accuracy, sensitivity, and precision were measured.

Results: CANCER CARE had an accuracy of 96%. Accuracy, sensitivity and precision for most prevalent lines were: 98%, 97% and 100% (rituximab), respectively; and 99%, 100%, and 95% (RCHOP), respectively. Accuracy, sensitivity, and precision for RCVP and BR were all 100%.

Conclusions: Cancer treatment line identification from EHR pharmacy dispensation data using a rule-based approach is feasible with high accuracy and can be used in real-world studies of cancer patient treatment practices and outcomes.

Rationale: Successfully extract, identify, and validate therapeutics lines used in the treatment of Veterans with follicular lymphoma.

Background: With the adoption of electronic health record (EHR) systems, leveraging this data is becoming increasingly important for clinical and observational research, especially in oncology, where precision oncology has become central to the Cancer Moonshot Initiative. One of the greatest challenges in using EHR data is extracting a cancer patient’s treatment history. The difficulty lies in identifying treatment “lines,” which may include one or more drugs, with each drug dispensation often recorded in an unstructured format within the EHR. Our objective was to conceptualize, develop, and validate an algorithm that reconstructs a cancer treatment line history using single-agent EHR pharmacy data in a cohort of follicular lymphoma patients treated in the Veterans Health Administration (VHA).

Methods: The CANCER CARE algorithm recreates and formalizes the heuristic a clinician uses to identify treatment lines dispensed using two inputs: (1) National Comprehensive Cancer Network treatment guidelines and the recommended chemotherapy lines and their comprising
antineoplastic agents that are used in the treatment of the cancer of interest; and (2) Single-agent dispensation information retrieved from the VA Corporate Data Warehouse. The algorithm uses rules to map concordant dispensation agents to a treatment line while taking into account common
practice variations such as omitted agents during the start or middle of a treatment line. It also identifies the initiation of a new line based on a change in agents received or time gaps between treatments. The algorithm was validated by comparing a set of 100 treatment lines that were independently annotated by a clinician in a cohort of patients with follicular lymphoma to the algorithm output. Accuracy, sensitivity, and precision were measured.

Results: CANCER CARE had an accuracy of 96%. Accuracy, sensitivity and precision for most prevalent lines were: 98%, 97% and 100% (rituximab), respectively; and 99%, 100%, and 95% (RCHOP), respectively. Accuracy, sensitivity, and precision for RCVP and BR were all 100%.

Conclusions: Cancer treatment line identification from EHR pharmacy dispensation data using a rule-based approach is feasible with high accuracy and can be used in real-world studies of cancer patient treatment practices and outcomes.

Rationale: Successfully extract, identify, and validate therapeutics lines used in the treatment of Veterans with follicular lymphoma.

Background: With the adoption of electronic health record (EHR) systems, leveraging this data is becoming increasingly important for clinical and observational research, especially in oncology, where precision oncology has become central to the Cancer Moonshot Initiative. One of the greatest challenges in using EHR data is extracting a cancer patient’s treatment history. The difficulty lies in identifying treatment “lines,” which may include one or more drugs, with each drug dispensation often recorded in an unstructured format within the EHR. Our objective was to conceptualize, develop, and validate an algorithm that reconstructs a cancer treatment line history using single-agent EHR pharmacy data in a cohort of follicular lymphoma patients treated in the Veterans Health Administration (VHA).

Methods: The CANCER CARE algorithm recreates and formalizes the heuristic a clinician uses to identify treatment lines dispensed using two inputs: (1) National Comprehensive Cancer Network treatment guidelines and the recommended chemotherapy lines and their comprising
antineoplastic agents that are used in the treatment of the cancer of interest; and (2) Single-agent dispensation information retrieved from the VA Corporate Data Warehouse. The algorithm uses rules to map concordant dispensation agents to a treatment line while taking into account common
practice variations such as omitted agents during the start or middle of a treatment line. It also identifies the initiation of a new line based on a change in agents received or time gaps between treatments. The algorithm was validated by comparing a set of 100 treatment lines that were independently annotated by a clinician in a cohort of patients with follicular lymphoma to the algorithm output. Accuracy, sensitivity, and precision were measured.

Results: CANCER CARE had an accuracy of 96%. Accuracy, sensitivity and precision for most prevalent lines were: 98%, 97% and 100% (rituximab), respectively; and 99%, 100%, and 95% (RCHOP), respectively. Accuracy, sensitivity, and precision for RCVP and BR were all 100%.

Conclusions: Cancer treatment line identification from EHR pharmacy dispensation data using a rule-based approach is feasible with high accuracy and can be used in real-world studies of cancer patient treatment practices and outcomes.

Purpose: Symptom assessment in cancer patients is associated with improved quality of life and prolonged survival; we sought to evaluate the use of a systematic symptom assessment tool in VA.

Background: Veterans Affairs (VA) Symptom Assessment Scale (VSAS) is a clinical tool for VA nurses and providers to capture symptom burden in patients with cancer. It includes 10 physical factors (pain, tiredness, anorexia, nausea, vomiting, diarrhea, constipation, shortness of breath at rest and with exertion, and drowsiness) and 3 emotional factors (depression, anxiety, and distress). Each symptom is scored on a scale of 0 (absence) to 10 (worst possible symptom). Here, we report symptom prevalence, VSAS reliability and internal consistency.

Methods: VSAS data were collected from the VA Corporate Data Warehouse. Symptom prevalence at baseline (initial hematology or oncology visit) and at subsequent follow-up is described. Reliability was assessed using factor-level test-retest correlation within a one week time period. Internal consistency and reliability of “physical” and “emotional” factors were assessed using Cronbach’s alpha.

Results: From January 2015 through June 2018, 5,995 patients were administered 21,761 VSAS assessments in two VA medical centers. At baseline, patients were most likely to report tiredness (68%), shortness of breath with exertion (49%), and pain (45%). Severe symptoms (scores 7-10) included tiredness (23%), pain (17%), and shortness of breath with exertion (13%). The most common symptoms recorded on follow-up were tiredness (70%; 21% severe), shortness of breath with exertion (51%; 17% severe), and pain (45%; 11% severe). Factor correlation upon retesting within one week was moderate, ranging from 0.40 to 0.62. Internal consistency across all factors was high with a Cronbach alpha of 0.86. Internal reliability of physical and emotional symptoms was also high at 0.81 and 0.87, respectively.

Conclusions: Cancer patients treated in the VA have a high symptom burden. The most prevalent symptoms were pain, tiredness, and shortness of breath. We evaluated reliability and consistency of VSAS factors, validating this method of measuring and documenting cancer-related symptoms. This preliminary report establishes VSAS as a tool that can be implemented widely within the VA with the goal of improving quality of care in VA oncology patients.

Purpose: Symptom assessment in cancer patients is associated with improved quality of life and prolonged survival; we sought to evaluate the use of a systematic symptom assessment tool in VA.

Background: Veterans Affairs (VA) Symptom Assessment Scale (VSAS) is a clinical tool for VA nurses and providers to capture symptom burden in patients with cancer. It includes 10 physical factors (pain, tiredness, anorexia, nausea, vomiting, diarrhea, constipation, shortness of breath at rest and with exertion, and drowsiness) and 3 emotional factors (depression, anxiety, and distress). Each symptom is scored on a scale of 0 (absence) to 10 (worst possible symptom). Here, we report symptom prevalence, VSAS reliability and internal consistency.

Methods: VSAS data were collected from the VA Corporate Data Warehouse. Symptom prevalence at baseline (initial hematology or oncology visit) and at subsequent follow-up is described. Reliability was assessed using factor-level test-retest correlation within a one week time period. Internal consistency and reliability of “physical” and “emotional” factors were assessed using Cronbach’s alpha.

Results: From January 2015 through June 2018, 5,995 patients were administered 21,761 VSAS assessments in two VA medical centers. At baseline, patients were most likely to report tiredness (68%), shortness of breath with exertion (49%), and pain (45%). Severe symptoms (scores 7-10) included tiredness (23%), pain (17%), and shortness of breath with exertion (13%). The most common symptoms recorded on follow-up were tiredness (70%; 21% severe), shortness of breath with exertion (51%; 17% severe), and pain (45%; 11% severe). Factor correlation upon retesting within one week was moderate, ranging from 0.40 to 0.62. Internal consistency across all factors was high with a Cronbach alpha of 0.86. Internal reliability of physical and emotional symptoms was also high at 0.81 and 0.87, respectively.

Conclusions: Cancer patients treated in the VA have a high symptom burden. The most prevalent symptoms were pain, tiredness, and shortness of breath. We evaluated reliability and consistency of VSAS factors, validating this method of measuring and documenting cancer-related symptoms. This preliminary report establishes VSAS as a tool that can be implemented widely within the VA with the goal of improving quality of care in VA oncology patients.

Purpose: Symptom assessment in cancer patients is associated with improved quality of life and prolonged survival; we sought to evaluate the use of a systematic symptom assessment tool in VA.

Background: Veterans Affairs (VA) Symptom Assessment Scale (VSAS) is a clinical tool for VA nurses and providers to capture symptom burden in patients with cancer. It includes 10 physical factors (pain, tiredness, anorexia, nausea, vomiting, diarrhea, constipation, shortness of breath at rest and with exertion, and drowsiness) and 3 emotional factors (depression, anxiety, and distress). Each symptom is scored on a scale of 0 (absence) to 10 (worst possible symptom). Here, we report symptom prevalence, VSAS reliability and internal consistency.

Methods: VSAS data were collected from the VA Corporate Data Warehouse. Symptom prevalence at baseline (initial hematology or oncology visit) and at subsequent follow-up is described. Reliability was assessed using factor-level test-retest correlation within a one week time period. Internal consistency and reliability of “physical” and “emotional” factors were assessed using Cronbach’s alpha.

Results: From January 2015 through June 2018, 5,995 patients were administered 21,761 VSAS assessments in two VA medical centers. At baseline, patients were most likely to report tiredness (68%), shortness of breath with exertion (49%), and pain (45%). Severe symptoms (scores 7-10) included tiredness (23%), pain (17%), and shortness of breath with exertion (13%). The most common symptoms recorded on follow-up were tiredness (70%; 21% severe), shortness of breath with exertion (51%; 17% severe), and pain (45%; 11% severe). Factor correlation upon retesting within one week was moderate, ranging from 0.40 to 0.62. Internal consistency across all factors was high with a Cronbach alpha of 0.86. Internal reliability of physical and emotional symptoms was also high at 0.81 and 0.87, respectively.

Conclusions: Cancer patients treated in the VA have a high symptom burden. The most prevalent symptoms were pain, tiredness, and shortness of breath. We evaluated reliability and consistency of VSAS factors, validating this method of measuring and documenting cancer-related symptoms. This preliminary report establishes VSAS as a tool that can be implemented widely within the VA with the goal of improving quality of care in VA oncology patients.

Background: Cancer care in academically affiliated settings such as teaching hospitals has been associated with improved clinical outcomes. Historically, Veterans Affairs (VA) medical centers are partnered with academic affiliates; however, there have been few studies examining how this partnership affects clinical care in the Veterans Health Administration (VHA). We therefore examined the variation of first line therapy (1L) in patients with metastatic castrate resistant prostate cancer (mCRPC) in the VHA by degree of academic affiliation.

Methods: Information from the VA Central Cancer Registry was linked to clinical data from the VA Corporate Data Warehouse to identify incident cases of mCRPC, defined as first incidence of radiologic evidence of metastasis and castrate resistance in patients with prostate cancer. Patient demographics, disease characteristics and treatment practices were extracted. The degree of academic affiliation of the treating facility was calculated using the Herfindahl-Hirschman Index (HHI), which reflects how dispersed medical residents are among different specialties and how many specialties are available within a given VA facility.

Results: From 2006 to 2015, 3,637 patients received an mCRPC diagnosis and were treated in 123 VA facilities. Median HHI for treating facilities was 0.374. Of these patients, 1,723 (47%) were treated in a facility with higher academic affiliation (HAA; HHI ≥ 0.374) and 1,914 (53%) were treated in a facility with lower academic affiliation (LAA; HHI ≤ 0.373). There was no difference in patient or disease characteristics by academic affiliation; patients with HAA and LAA had comparable Gleason scores, stage of disease at diagnosis, primary local therapy, age and median PSA levels at time of diagnosis. Patients with mCRPC at HAA facilities were more likely to receive 1L (59% vs 55%, P = .015). Regimens frequently used for 1L were comparable: HAA, docetaxel (29%), abiraterone (22%), and enzalutamide (6%); LAA: docetaxel (25%), abiraterone (21%), and enzalutamide (7%).

Conclusions: Patients with mCRPC had a small but significant increase in likelihood of receiving 1L if treated in HAA vs LAA facilities. Further study will focus on identifying patient, prescriber and facility factors that are associated with the likelihood of initiating 1L and the choice of 1L regimen.

Background: Cancer care in academically affiliated settings such as teaching hospitals has been associated with improved clinical outcomes. Historically, Veterans Affairs (VA) medical centers are partnered with academic affiliates; however, there have been few studies examining how this partnership affects clinical care in the Veterans Health Administration (VHA). We therefore examined the variation of first line therapy (1L) in patients with metastatic castrate resistant prostate cancer (mCRPC) in the VHA by degree of academic affiliation.

Methods: Information from the VA Central Cancer Registry was linked to clinical data from the VA Corporate Data Warehouse to identify incident cases of mCRPC, defined as first incidence of radiologic evidence of metastasis and castrate resistance in patients with prostate cancer. Patient demographics, disease characteristics and treatment practices were extracted. The degree of academic affiliation of the treating facility was calculated using the Herfindahl-Hirschman Index (HHI), which reflects how dispersed medical residents are among different specialties and how many specialties are available within a given VA facility.

Results: From 2006 to 2015, 3,637 patients received an mCRPC diagnosis and were treated in 123 VA facilities. Median HHI for treating facilities was 0.374. Of these patients, 1,723 (47%) were treated in a facility with higher academic affiliation (HAA; HHI ≥ 0.374) and 1,914 (53%) were treated in a facility with lower academic affiliation (LAA; HHI ≤ 0.373). There was no difference in patient or disease characteristics by academic affiliation; patients with HAA and LAA had comparable Gleason scores, stage of disease at diagnosis, primary local therapy, age and median PSA levels at time of diagnosis. Patients with mCRPC at HAA facilities were more likely to receive 1L (59% vs 55%, P = .015). Regimens frequently used for 1L were comparable: HAA, docetaxel (29%), abiraterone (22%), and enzalutamide (6%); LAA: docetaxel (25%), abiraterone (21%), and enzalutamide (7%).

Conclusions: Patients with mCRPC had a small but significant increase in likelihood of receiving 1L if treated in HAA vs LAA facilities. Further study will focus on identifying patient, prescriber and facility factors that are associated with the likelihood of initiating 1L and the choice of 1L regimen.

Background: Cancer care in academically affiliated settings such as teaching hospitals has been associated with improved clinical outcomes. Historically, Veterans Affairs (VA) medical centers are partnered with academic affiliates; however, there have been few studies examining how this partnership affects clinical care in the Veterans Health Administration (VHA). We therefore examined the variation of first line therapy (1L) in patients with metastatic castrate resistant prostate cancer (mCRPC) in the VHA by degree of academic affiliation.

Methods: Information from the VA Central Cancer Registry was linked to clinical data from the VA Corporate Data Warehouse to identify incident cases of mCRPC, defined as first incidence of radiologic evidence of metastasis and castrate resistance in patients with prostate cancer. Patient demographics, disease characteristics and treatment practices were extracted. The degree of academic affiliation of the treating facility was calculated using the Herfindahl-Hirschman Index (HHI), which reflects how dispersed medical residents are among different specialties and how many specialties are available within a given VA facility.

Results: From 2006 to 2015, 3,637 patients received an mCRPC diagnosis and were treated in 123 VA facilities. Median HHI for treating facilities was 0.374. Of these patients, 1,723 (47%) were treated in a facility with higher academic affiliation (HAA; HHI ≥ 0.374) and 1,914 (53%) were treated in a facility with lower academic affiliation (LAA; HHI ≤ 0.373). There was no difference in patient or disease characteristics by academic affiliation; patients with HAA and LAA had comparable Gleason scores, stage of disease at diagnosis, primary local therapy, age and median PSA levels at time of diagnosis. Patients with mCRPC at HAA facilities were more likely to receive 1L (59% vs 55%, P = .015). Regimens frequently used for 1L were comparable: HAA, docetaxel (29%), abiraterone (22%), and enzalutamide (6%); LAA: docetaxel (25%), abiraterone (21%), and enzalutamide (7%).

Conclusions: Patients with mCRPC had a small but significant increase in likelihood of receiving 1L if treated in HAA vs LAA facilities. Further study will focus on identifying patient, prescriber and facility factors that are associated with the likelihood of initiating 1L and the choice of 1L regimen.

Purpose: To evaluate data extraction methods for identifying cytogenetic and fluorescence in situ hybridization (FISH) testing among chronic lymphoblastic leukemia (CLL) patients in the Veterans Health Administration (VHA).

Background: Cytogenetic/FISH testing are increasingly important for assessing risk and guiding therapy in patients with CLL. Administrative health data are frequently used to study testing practices; however, they are limited in their sensitivity and reliability. Increasing adoption of electronic health records (EHR) presents an opportunity to describe clinical practices in large patient populations. We compare three different EHR extraction methods to identify cytogenetic/ FISH testing in a cohort of CLL patients treated within the VHA.

Methods: CLL patients were identified using the VA Clinical Cancer Registry. Testing information was extracted from time of diagnosis to time of first treatment using three methods: (1) Current Procedural Terminology (CPT) codes; (2) Text mining of healthcare provider orders (HPO); (3) Clinical Lab Information Retrieval (CLIR), a previously validated conceptual framework that incorporates LOINC codes and test names that are then validated using test result information.

Results: 1,363 CLL patients were diagnosed and followed until their first line of therapy at VHA between 2008 and 2016: 635 (47%) had evidence of testing by text mining of HPO, 554 (41%) by CPT, and 399 (29%) by CLIR. Comparing CPT vs combined CLIR+HPO, CPT extraction had
a sensitivity of 52.8%, a precision of 73.1% and an F-measure of 0.613. Cytogenetic/FISH testing increased by nearly two-fold from 2008 to 2016, regardless of extraction method: HPO text mining (25% to 51%), CPT (20% to 54%), or CLIR (19% to 32%).

Conclusions: Advanced EHR extraction methods offer a more granular description of testing practices than administrative data alone as they examine multiple components of the EHR including the ordering, processing, and results of testing occurrences. Results suggest that there has been a slow increase in the number of CLL patients undergoing cytogenetic/FISH testing during the past decade, which is comparable to similar reports of testing practices outside the VHA, although approximately half of all CLL patients are not undergoing testing despite established clinical guideline recommendations.

Purpose: To evaluate data extraction methods for identifying cytogenetic and fluorescence in situ hybridization (FISH) testing among chronic lymphoblastic leukemia (CLL) patients in the Veterans Health Administration (VHA).

Background: Cytogenetic/FISH testing are increasingly important for assessing risk and guiding therapy in patients with CLL. Administrative health data are frequently used to study testing practices; however, they are limited in their sensitivity and reliability. Increasing adoption of electronic health records (EHR) presents an opportunity to describe clinical practices in large patient populations. We compare three different EHR extraction methods to identify cytogenetic/ FISH testing in a cohort of CLL patients treated within the VHA.

Methods: CLL patients were identified using the VA Clinical Cancer Registry. Testing information was extracted from time of diagnosis to time of first treatment using three methods: (1) Current Procedural Terminology (CPT) codes; (2) Text mining of healthcare provider orders (HPO); (3) Clinical Lab Information Retrieval (CLIR), a previously validated conceptual framework that incorporates LOINC codes and test names that are then validated using test result information.

Results: 1,363 CLL patients were diagnosed and followed until their first line of therapy at VHA between 2008 and 2016: 635 (47%) had evidence of testing by text mining of HPO, 554 (41%) by CPT, and 399 (29%) by CLIR. Comparing CPT vs combined CLIR+HPO, CPT extraction had
a sensitivity of 52.8%, a precision of 73.1% and an F-measure of 0.613. Cytogenetic/FISH testing increased by nearly two-fold from 2008 to 2016, regardless of extraction method: HPO text mining (25% to 51%), CPT (20% to 54%), or CLIR (19% to 32%).

Conclusions: Advanced EHR extraction methods offer a more granular description of testing practices than administrative data alone as they examine multiple components of the EHR including the ordering, processing, and results of testing occurrences. Results suggest that there has been a slow increase in the number of CLL patients undergoing cytogenetic/FISH testing during the past decade, which is comparable to similar reports of testing practices outside the VHA, although approximately half of all CLL patients are not undergoing testing despite established clinical guideline recommendations.

Purpose: To evaluate data extraction methods for identifying cytogenetic and fluorescence in situ hybridization (FISH) testing among chronic lymphoblastic leukemia (CLL) patients in the Veterans Health Administration (VHA).

Background: Cytogenetic/FISH testing are increasingly important for assessing risk and guiding therapy in patients with CLL. Administrative health data are frequently used to study testing practices; however, they are limited in their sensitivity and reliability. Increasing adoption of electronic health records (EHR) presents an opportunity to describe clinical practices in large patient populations. We compare three different EHR extraction methods to identify cytogenetic/ FISH testing in a cohort of CLL patients treated within the VHA.

Methods: CLL patients were identified using the VA Clinical Cancer Registry. Testing information was extracted from time of diagnosis to time of first treatment using three methods: (1) Current Procedural Terminology (CPT) codes; (2) Text mining of healthcare provider orders (HPO); (3) Clinical Lab Information Retrieval (CLIR), a previously validated conceptual framework that incorporates LOINC codes and test names that are then validated using test result information.

Results: 1,363 CLL patients were diagnosed and followed until their first line of therapy at VHA between 2008 and 2016: 635 (47%) had evidence of testing by text mining of HPO, 554 (41%) by CPT, and 399 (29%) by CLIR. Comparing CPT vs combined CLIR+HPO, CPT extraction had
a sensitivity of 52.8%, a precision of 73.1% and an F-measure of 0.613. Cytogenetic/FISH testing increased by nearly two-fold from 2008 to 2016, regardless of extraction method: HPO text mining (25% to 51%), CPT (20% to 54%), or CLIR (19% to 32%).

Conclusions: Advanced EHR extraction methods offer a more granular description of testing practices than administrative data alone as they examine multiple components of the EHR including the ordering, processing, and results of testing occurrences. Results suggest that there has been a slow increase in the number of CLL patients undergoing cytogenetic/FISH testing during the past decade, which is comparable to similar reports of testing practices outside the VHA, although approximately half of all CLL patients are not undergoing testing despite established clinical guideline recommendations.

Background: Radiographic imaging is important for the diagnosis and management of cancer. Radiology reports contain a wealth of information, but are typically formatted as unstructured text, making large scale information extraction challenging. We validated a natural language processing (NLP) algorithm to identify the presence of metastatic disease in radiographic imaging reports.

Methods: Using VA Clinical Cancer Registry and Corporate Data Warehouse, we identified approximately 3 million radiology reports for 120,374 patients receiving care for prostate cancer in the VA from 2006-2015. We focused on the impression section of CT, PET/CT, X-ray, bone scan, and MRI reports. We expanded on Chapman et al. “ConText” algorithm to identify the presence of metastatic disease: (1) Using UMLS, we identified terms compatible with “metastasis”; (2) Report impressions were preprocessed and tokenized at the sentence level and as part of the sentence; (3) Positive and negative trigger phrases were implemented as a series of regular expressions, which were refined over a number of iterations using training data from 2 batches of 600 reports, allowing us to extend trigger identification to a larger set of phrases. The final algorithm was validated using an independent sample of 2,000 reports annotated by a domain expert.

Results: The first training set of 600 of radiology reports achieved an accuracy of: 94% for reports with no mention of metastasis, 85% for negated mention of metastasis, and 74% mentions of metastasis without negation. Errors were reviewed resulting in vocabulary expansion and improved implementation of regular expressions to capture the expanded trigger phrases. Performance of the modified algorithm was tested on a new set of 600 reports and resulted in an increased accuracy of 96% for no mention of metastasis, 90% for negated mention of metastasis, and 89% mentions of metastasis without negation. After additional modifications were made, the revised algorithm was validated using an independent sample of 2,000 reports. The accuracy was 96% (Cohen’s kappa ~1), with precision of 98%, and a sensitivity of 98%.

Conclusions: Detecting presence of metastatic disease from radiographic notes is feasible with NLP.

References: (1) Sarkar S, Das S. A review of imaging methods for prostate cancer detection. Biomed Eng Comput Biol. 2016;7(Suppl 1):1-15. (2) Chapman WW, Bridewell W, Hanbury P, Cooper GF, Buchanan BG. A simple algorithm for identifying negated findings and diseases in discharge summaries. J Biomed Inform. 2001;34(5):301- 310. (3) Harkema H, Dowling JN, Thornblade T. Con-Text: An algorithm for determining negation, experiencer, and temporal status from clinical reports. J Biomed Inform. 2009;42(5):839-851.

Background: Radiographic imaging is important for the diagnosis and management of cancer. Radiology reports contain a wealth of information, but are typically formatted as unstructured text, making large scale information extraction challenging. We validated a natural language processing (NLP) algorithm to identify the presence of metastatic disease in radiographic imaging reports.

Methods: Using VA Clinical Cancer Registry and Corporate Data Warehouse, we identified approximately 3 million radiology reports for 120,374 patients receiving care for prostate cancer in the VA from 2006-2015. We focused on the impression section of CT, PET/CT, X-ray, bone scan, and MRI reports. We expanded on Chapman et al. “ConText” algorithm to identify the presence of metastatic disease: (1) Using UMLS, we identified terms compatible with “metastasis”; (2) Report impressions were preprocessed and tokenized at the sentence level and as part of the sentence; (3) Positive and negative trigger phrases were implemented as a series of regular expressions, which were refined over a number of iterations using training data from 2 batches of 600 reports, allowing us to extend trigger identification to a larger set of phrases. The final algorithm was validated using an independent sample of 2,000 reports annotated by a domain expert.

Results: The first training set of 600 of radiology reports achieved an accuracy of: 94% for reports with no mention of metastasis, 85% for negated mention of metastasis, and 74% mentions of metastasis without negation. Errors were reviewed resulting in vocabulary expansion and improved implementation of regular expressions to capture the expanded trigger phrases. Performance of the modified algorithm was tested on a new set of 600 reports and resulted in an increased accuracy of 96% for no mention of metastasis, 90% for negated mention of metastasis, and 89% mentions of metastasis without negation. After additional modifications were made, the revised algorithm was validated using an independent sample of 2,000 reports. The accuracy was 96% (Cohen’s kappa ~1), with precision of 98%, and a sensitivity of 98%.

Conclusions: Detecting presence of metastatic disease from radiographic notes is feasible with NLP.

References: (1) Sarkar S, Das S. A review of imaging methods for prostate cancer detection. Biomed Eng Comput Biol. 2016;7(Suppl 1):1-15. (2) Chapman WW, Bridewell W, Hanbury P, Cooper GF, Buchanan BG. A simple algorithm for identifying negated findings and diseases in discharge summaries. J Biomed Inform. 2001;34(5):301- 310. (3) Harkema H, Dowling JN, Thornblade T. Con-Text: An algorithm for determining negation, experiencer, and temporal status from clinical reports. J Biomed Inform. 2009;42(5):839-851.

Background: Radiographic imaging is important for the diagnosis and management of cancer. Radiology reports contain a wealth of information, but are typically formatted as unstructured text, making large scale information extraction challenging. We validated a natural language processing (NLP) algorithm to identify the presence of metastatic disease in radiographic imaging reports.

Methods: Using VA Clinical Cancer Registry and Corporate Data Warehouse, we identified approximately 3 million radiology reports for 120,374 patients receiving care for prostate cancer in the VA from 2006-2015. We focused on the impression section of CT, PET/CT, X-ray, bone scan, and MRI reports. We expanded on Chapman et al. “ConText” algorithm to identify the presence of metastatic disease: (1) Using UMLS, we identified terms compatible with “metastasis”; (2) Report impressions were preprocessed and tokenized at the sentence level and as part of the sentence; (3) Positive and negative trigger phrases were implemented as a series of regular expressions, which were refined over a number of iterations using training data from 2 batches of 600 reports, allowing us to extend trigger identification to a larger set of phrases. The final algorithm was validated using an independent sample of 2,000 reports annotated by a domain expert.

Results: The first training set of 600 of radiology reports achieved an accuracy of: 94% for reports with no mention of metastasis, 85% for negated mention of metastasis, and 74% mentions of metastasis without negation. Errors were reviewed resulting in vocabulary expansion and improved implementation of regular expressions to capture the expanded trigger phrases. Performance of the modified algorithm was tested on a new set of 600 reports and resulted in an increased accuracy of 96% for no mention of metastasis, 90% for negated mention of metastasis, and 89% mentions of metastasis without negation. After additional modifications were made, the revised algorithm was validated using an independent sample of 2,000 reports. The accuracy was 96% (Cohen’s kappa ~1), with precision of 98%, and a sensitivity of 98%.

Conclusions: Detecting presence of metastatic disease from radiographic notes is feasible with NLP.

References: (1) Sarkar S, Das S. A review of imaging methods for prostate cancer detection. Biomed Eng Comput Biol. 2016;7(Suppl 1):1-15. (2) Chapman WW, Bridewell W, Hanbury P, Cooper GF, Buchanan BG. A simple algorithm for identifying negated findings and diseases in discharge summaries. J Biomed Inform. 2001;34(5):301- 310. (3) Harkema H, Dowling JN, Thornblade T. Con-Text: An algorithm for determining negation, experiencer, and temporal status from clinical reports. J Biomed Inform. 2009;42(5):839-851.