Diffuse dermal angiomatosis (DDA) is a rare acquired, cutaneous, reactive, vascular disorder that was originally thought to be a variant of cutaneous reactive angiomatosis (CREA) but is now considered to be on the spectrum of CREA. This article will focus on DDA and review the literature of prior case reports with brief descriptions of the differential diagnosis.

Case Report

A 43-year-old Haitian man presented to the clinic with a lesion on the left buttock that had developed over the last 6 years. The patient stated the lesion had been enlarging over the last several months. Upon examination, there was a large (15-cm diameter), indurated, hyperpigmented plaque covering the left buttock (Figure 1). The patient reported no medical or contributory family history. Upon review of systems, he described a burning sensation sometimes in the area of the lesion that would develop randomly throughout the year.

Three biopsies were performed, which revealed a collection of slightly dilated blood vessels with normal-appearing endothelial cells occupying the mid dermis and deep dermis (Figure 2). Immunohistochemical stains with antibodies were directed against human herpesvirus 8 (HHV-8), CD31, CD34, the cell surface glycoprotein podoplanin, Ki-67, and smooth muscle actin antigens, with appropriate controls. The vessel walls were positive for CD31, CD34, and smooth muscle actin, and negative for HHV-8 and podoplanin; Ki-67 was not increased. These histologic findings were consistent with a diagnosis of DDA. A detailed history was taken. The cause of DDA in our patient was uncertain.

Comment

Classification and Epidemiology
Diffuse dermal angiomatosis is a rare acquired, cutaneous, reactive, vascular disorder first described by Krell et al¹ in 1994. Diffuse dermal angiomatosis is benign and is classified in the group of cutaneous reactive angiomatoses,² which are benign vascular disorders marked by intravascular and extravascular hyperplasia of endothelial cells that may or may not include pericytes.² Diffuse dermal angiomatosis was originally described as a variant of CREA, which is characterized by hyperplasia of endothelial dermal cells and intravascular proliferation.³ However, DDA has more recently been identified as a distinct disorder on the spectrum of CREA rather than as a variant of CREA.² Given the recent reclassification, not all physicians make this distinction. However, as more case reports of DDA are published, physicians continue to support this change.⁴ Nevertheless, DDA has been an established disorder since 1994.¹

Vascular proliferation in DDA is hypothesized to stem from ischemia or inflammation.⁵ Peripheral vascular atherosclerosis has been associated with DDA.⁶ The epidemiology of DDA is not well known because of the rarity of the disease. We performed a more specific review of the literature by limiting the PubMed search of articles indexed for MEDLINE to the term diffuse dermal angiomatosis rather than a broader search including all reactive angioendotheliomatoses. Only 31 case reports have been published^1,3-32; of them, only adults were affected. Most reported cases were in middle-aged females. A summary of the demographics of DDA is provided in the Table.^1,3-32

Etiology
Diffuse dermal angiomatosis is a rare complication of ischemia that may be secondary to atherosclerosis, arteriovenous fistula, or macromastia.^9-11 In DDA of the breasts, ulcerations of fatty tissue occur due to trauma in these patients who have large pendulous breasts, causing angiogenesis resembling DDA histologically.² One case of DDA was reported secondary to relative ischemia from cutis marmorata telangiectatica congenita,¹² whereas another case highlighted Wegener granulomatosis as the cause of ischemia.⁷ There also have been reported cases associated with calciphylaxis and anticardiolipin antibiodies.¹³ In general, any medical condition that can lead to ischemia can cause DDA. Comorbid conditions for DDA include cardiovascular disease, hypertension, diabetes mellitus, and most often severe peripheral vascular disease. Many patients also have a history of smoking.¹⁴ Diffuse dermal angiomatosis rarely presents without underlying comorbidity, with only 1 case report of unknown cause (Table).

Presentation, Histopathology, and Differential Diagnosis
Cutaneous reactive angiomatosis disorders present the same clinically, with multiple erythematous to violaceous purpuric patches and plaques that can progress to necrosis and ulceration. Lesions are widely distributed but are predisposed to the upper and lower extremities.² The differential diagnosis of DDA includes CREA, acroangiodermatitis (pseudo–Kaposi sarcoma), or vascular malignancies such as Kaposi sarcoma and low-grade angiosarcoma.⁷

In DDA, lesions may be painful and sometimes have a central ulceration.¹⁵ They often are associated with notable peripheral vascular atherosclerotic disease and are mainly found on the lower extremities.^12,16 Histologically, DDA presents as a diffuse proliferation of endothelial cells between collagen bundles. The endothelial cells are distributed throughout the papillary and reticular dermis and develop into vascular lumina.¹⁷ Furthermore, the proliferating endothelial cells are spindle shaped and contain vacuolated cytoplasm.¹⁴

Acroangiodermatitis, or pseudo–Kaposi sarcoma, presents as slow-growing, erythematous to violaceous, brown, or dusky macules, papules, or plaques of the legs.¹⁴ Histologically, acroangiodermatitis presents with relatively less proliferation of endothelial cells found intravascularly rather than extravascularly, as in DDA, forming new thick-walled vessels in a lobular pattern in the papillary dermis.¹⁴

Vascular malignancies, such as Kaposi sarcoma and angiosarcoma, may present similarly to DDA. Kaposi sarcoma, for example, presents as erythematous to violaceous patches, plaques, or nodules found mostly on the extremities.⁷ Histologically, spindle cells and vascular structures also are found but in a clefting pattern representative of Kaposi sarcoma (so-called vascular slits).⁷ Diffuse dermal angiomatosis and vascular malignancies can further be distinguished based on atypia of the proliferations and staining for HHV-8.^7,14 Lastly, DDA differs from vascular tumors in that vascular tumors are reactive to locations of occluded vessels, with vascular proliferation ceasing once the underlying cause of hypoxia is removed.²

Treatment
There is no standard treatment of DDA.⁷ Treatment of the underlying cause of ischemia is the primary goal, which will cause the DDA to resolve in most cases. Stenting, removal of an arteriovenous fistula, or other forms of revascularization may be warranted.^{1,5,6,10,17,29,30}

Reported medical therapies for DDA include systemic or topical corticosteroids used for their antiangiogenic properties with varying results.⁷ Isotretinoin also has been used, which has been found to be effective in several cases of DDA of the breast, though 1 study reported a subsequent elevated lipid profile, requiring a decrease in dosage.^14,15,27,31

Most interestingly, a study by Sanz-Motilva et al¹⁶ demonstrated that control of comorbidities, especially smoking cessation, led to improvement, which highlights the importance of incorporating nonpharmacotherapy rather than initiating treatment solely with medication. The Table summarizes treatments used and their efficacy.

Conclusion

Diffuse dermal angiomatosis is associated with medical conditions that predispose an individual to ischemia. Although rare, DDA can present as painful and visibly disturbing lesions that can affect the daily life of afflicted patients. By reporting the few cases that do arise and reviewing prior cases and their treatments, physicians can consider DDA within the differential diagnosis and identify which treatment is most efficient for a given patient. For all DDA patients, strict control of comorbidities, especially smoking cessation, should be incorporated into the treatment plan. When DDA affects the breasts, isotretinoin appears to provide the best relief. Otherwise, treatment of the underlying cause, revascularization, withdrawal of the offending agent, or steroids seem to be the best treatment options.

Diffuse dermal angiomatosis (DDA) is a rare acquired, cutaneous, reactive, vascular disorder that was originally thought to be a variant of cutaneous reactive angiomatosis (CREA) but is now considered to be on the spectrum of CREA. This article will focus on DDA and review the literature of prior case reports with brief descriptions of the differential diagnosis.

Case Report

A 43-year-old Haitian man presented to the clinic with a lesion on the left buttock that had developed over the last 6 years. The patient stated the lesion had been enlarging over the last several months. Upon examination, there was a large (15-cm diameter), indurated, hyperpigmented plaque covering the left buttock (Figure 1). The patient reported no medical or contributory family history. Upon review of systems, he described a burning sensation sometimes in the area of the lesion that would develop randomly throughout the year.

Three biopsies were performed, which revealed a collection of slightly dilated blood vessels with normal-appearing endothelial cells occupying the mid dermis and deep dermis (Figure 2). Immunohistochemical stains with antibodies were directed against human herpesvirus 8 (HHV-8), CD31, CD34, the cell surface glycoprotein podoplanin, Ki-67, and smooth muscle actin antigens, with appropriate controls. The vessel walls were positive for CD31, CD34, and smooth muscle actin, and negative for HHV-8 and podoplanin; Ki-67 was not increased. These histologic findings were consistent with a diagnosis of DDA. A detailed history was taken. The cause of DDA in our patient was uncertain.

Comment

Classification and Epidemiology
Diffuse dermal angiomatosis is a rare acquired, cutaneous, reactive, vascular disorder first described by Krell et al¹ in 1994. Diffuse dermal angiomatosis is benign and is classified in the group of cutaneous reactive angiomatoses,² which are benign vascular disorders marked by intravascular and extravascular hyperplasia of endothelial cells that may or may not include pericytes.² Diffuse dermal angiomatosis was originally described as a variant of CREA, which is characterized by hyperplasia of endothelial dermal cells and intravascular proliferation.³ However, DDA has more recently been identified as a distinct disorder on the spectrum of CREA rather than as a variant of CREA.² Given the recent reclassification, not all physicians make this distinction. However, as more case reports of DDA are published, physicians continue to support this change.⁴ Nevertheless, DDA has been an established disorder since 1994.¹

Vascular proliferation in DDA is hypothesized to stem from ischemia or inflammation.⁵ Peripheral vascular atherosclerosis has been associated with DDA.⁶ The epidemiology of DDA is not well known because of the rarity of the disease. We performed a more specific review of the literature by limiting the PubMed search of articles indexed for MEDLINE to the term diffuse dermal angiomatosis rather than a broader search including all reactive angioendotheliomatoses. Only 31 case reports have been published^1,3-32; of them, only adults were affected. Most reported cases were in middle-aged females. A summary of the demographics of DDA is provided in the Table.^1,3-32

Etiology
Diffuse dermal angiomatosis is a rare complication of ischemia that may be secondary to atherosclerosis, arteriovenous fistula, or macromastia.^9-11 In DDA of the breasts, ulcerations of fatty tissue occur due to trauma in these patients who have large pendulous breasts, causing angiogenesis resembling DDA histologically.² One case of DDA was reported secondary to relative ischemia from cutis marmorata telangiectatica congenita,¹² whereas another case highlighted Wegener granulomatosis as the cause of ischemia.⁷ There also have been reported cases associated with calciphylaxis and anticardiolipin antibiodies.¹³ In general, any medical condition that can lead to ischemia can cause DDA. Comorbid conditions for DDA include cardiovascular disease, hypertension, diabetes mellitus, and most often severe peripheral vascular disease. Many patients also have a history of smoking.¹⁴ Diffuse dermal angiomatosis rarely presents without underlying comorbidity, with only 1 case report of unknown cause (Table).

Presentation, Histopathology, and Differential Diagnosis
Cutaneous reactive angiomatosis disorders present the same clinically, with multiple erythematous to violaceous purpuric patches and plaques that can progress to necrosis and ulceration. Lesions are widely distributed but are predisposed to the upper and lower extremities.² The differential diagnosis of DDA includes CREA, acroangiodermatitis (pseudo–Kaposi sarcoma), or vascular malignancies such as Kaposi sarcoma and low-grade angiosarcoma.⁷

In DDA, lesions may be painful and sometimes have a central ulceration.¹⁵ They often are associated with notable peripheral vascular atherosclerotic disease and are mainly found on the lower extremities.^12,16 Histologically, DDA presents as a diffuse proliferation of endothelial cells between collagen bundles. The endothelial cells are distributed throughout the papillary and reticular dermis and develop into vascular lumina.¹⁷ Furthermore, the proliferating endothelial cells are spindle shaped and contain vacuolated cytoplasm.¹⁴

Acroangiodermatitis, or pseudo–Kaposi sarcoma, presents as slow-growing, erythematous to violaceous, brown, or dusky macules, papules, or plaques of the legs.¹⁴ Histologically, acroangiodermatitis presents with relatively less proliferation of endothelial cells found intravascularly rather than extravascularly, as in DDA, forming new thick-walled vessels in a lobular pattern in the papillary dermis.¹⁴

Vascular malignancies, such as Kaposi sarcoma and angiosarcoma, may present similarly to DDA. Kaposi sarcoma, for example, presents as erythematous to violaceous patches, plaques, or nodules found mostly on the extremities.⁷ Histologically, spindle cells and vascular structures also are found but in a clefting pattern representative of Kaposi sarcoma (so-called vascular slits).⁷ Diffuse dermal angiomatosis and vascular malignancies can further be distinguished based on atypia of the proliferations and staining for HHV-8.^7,14 Lastly, DDA differs from vascular tumors in that vascular tumors are reactive to locations of occluded vessels, with vascular proliferation ceasing once the underlying cause of hypoxia is removed.²

Treatment
There is no standard treatment of DDA.⁷ Treatment of the underlying cause of ischemia is the primary goal, which will cause the DDA to resolve in most cases. Stenting, removal of an arteriovenous fistula, or other forms of revascularization may be warranted.^{1,5,6,10,17,29,30}

Reported medical therapies for DDA include systemic or topical corticosteroids used for their antiangiogenic properties with varying results.⁷ Isotretinoin also has been used, which has been found to be effective in several cases of DDA of the breast, though 1 study reported a subsequent elevated lipid profile, requiring a decrease in dosage.^14,15,27,31

Most interestingly, a study by Sanz-Motilva et al¹⁶ demonstrated that control of comorbidities, especially smoking cessation, led to improvement, which highlights the importance of incorporating nonpharmacotherapy rather than initiating treatment solely with medication. The Table summarizes treatments used and their efficacy.

Conclusion

Diffuse dermal angiomatosis is associated with medical conditions that predispose an individual to ischemia. Although rare, DDA can present as painful and visibly disturbing lesions that can affect the daily life of afflicted patients. By reporting the few cases that do arise and reviewing prior cases and their treatments, physicians can consider DDA within the differential diagnosis and identify which treatment is most efficient for a given patient. For all DDA patients, strict control of comorbidities, especially smoking cessation, should be incorporated into the treatment plan. When DDA affects the breasts, isotretinoin appears to provide the best relief. Otherwise, treatment of the underlying cause, revascularization, withdrawal of the offending agent, or steroids seem to be the best treatment options.

Diffuse dermal angiomatosis (DDA) is a rare acquired, cutaneous, reactive, vascular disorder that was originally thought to be a variant of cutaneous reactive angiomatosis (CREA) but is now considered to be on the spectrum of CREA. This article will focus on DDA and review the literature of prior case reports with brief descriptions of the differential diagnosis.

Case Report

A 43-year-old Haitian man presented to the clinic with a lesion on the left buttock that had developed over the last 6 years. The patient stated the lesion had been enlarging over the last several months. Upon examination, there was a large (15-cm diameter), indurated, hyperpigmented plaque covering the left buttock (Figure 1). The patient reported no medical or contributory family history. Upon review of systems, he described a burning sensation sometimes in the area of the lesion that would develop randomly throughout the year.

Three biopsies were performed, which revealed a collection of slightly dilated blood vessels with normal-appearing endothelial cells occupying the mid dermis and deep dermis (Figure 2). Immunohistochemical stains with antibodies were directed against human herpesvirus 8 (HHV-8), CD31, CD34, the cell surface glycoprotein podoplanin, Ki-67, and smooth muscle actin antigens, with appropriate controls. The vessel walls were positive for CD31, CD34, and smooth muscle actin, and negative for HHV-8 and podoplanin; Ki-67 was not increased. These histologic findings were consistent with a diagnosis of DDA. A detailed history was taken. The cause of DDA in our patient was uncertain.

Comment

Classification and Epidemiology
Diffuse dermal angiomatosis is a rare acquired, cutaneous, reactive, vascular disorder first described by Krell et al¹ in 1994. Diffuse dermal angiomatosis is benign and is classified in the group of cutaneous reactive angiomatoses,² which are benign vascular disorders marked by intravascular and extravascular hyperplasia of endothelial cells that may or may not include pericytes.² Diffuse dermal angiomatosis was originally described as a variant of CREA, which is characterized by hyperplasia of endothelial dermal cells and intravascular proliferation.³ However, DDA has more recently been identified as a distinct disorder on the spectrum of CREA rather than as a variant of CREA.² Given the recent reclassification, not all physicians make this distinction. However, as more case reports of DDA are published, physicians continue to support this change.⁴ Nevertheless, DDA has been an established disorder since 1994.¹

Vascular proliferation in DDA is hypothesized to stem from ischemia or inflammation.⁵ Peripheral vascular atherosclerosis has been associated with DDA.⁶ The epidemiology of DDA is not well known because of the rarity of the disease. We performed a more specific review of the literature by limiting the PubMed search of articles indexed for MEDLINE to the term diffuse dermal angiomatosis rather than a broader search including all reactive angioendotheliomatoses. Only 31 case reports have been published^1,3-32; of them, only adults were affected. Most reported cases were in middle-aged females. A summary of the demographics of DDA is provided in the Table.^1,3-32

Etiology
Diffuse dermal angiomatosis is a rare complication of ischemia that may be secondary to atherosclerosis, arteriovenous fistula, or macromastia.^9-11 In DDA of the breasts, ulcerations of fatty tissue occur due to trauma in these patients who have large pendulous breasts, causing angiogenesis resembling DDA histologically.² One case of DDA was reported secondary to relative ischemia from cutis marmorata telangiectatica congenita,¹² whereas another case highlighted Wegener granulomatosis as the cause of ischemia.⁷ There also have been reported cases associated with calciphylaxis and anticardiolipin antibiodies.¹³ In general, any medical condition that can lead to ischemia can cause DDA. Comorbid conditions for DDA include cardiovascular disease, hypertension, diabetes mellitus, and most often severe peripheral vascular disease. Many patients also have a history of smoking.¹⁴ Diffuse dermal angiomatosis rarely presents without underlying comorbidity, with only 1 case report of unknown cause (Table).

Presentation, Histopathology, and Differential Diagnosis
Cutaneous reactive angiomatosis disorders present the same clinically, with multiple erythematous to violaceous purpuric patches and plaques that can progress to necrosis and ulceration. Lesions are widely distributed but are predisposed to the upper and lower extremities.² The differential diagnosis of DDA includes CREA, acroangiodermatitis (pseudo–Kaposi sarcoma), or vascular malignancies such as Kaposi sarcoma and low-grade angiosarcoma.⁷

In DDA, lesions may be painful and sometimes have a central ulceration.¹⁵ They often are associated with notable peripheral vascular atherosclerotic disease and are mainly found on the lower extremities.^12,16 Histologically, DDA presents as a diffuse proliferation of endothelial cells between collagen bundles. The endothelial cells are distributed throughout the papillary and reticular dermis and develop into vascular lumina.¹⁷ Furthermore, the proliferating endothelial cells are spindle shaped and contain vacuolated cytoplasm.¹⁴

Acroangiodermatitis, or pseudo–Kaposi sarcoma, presents as slow-growing, erythematous to violaceous, brown, or dusky macules, papules, or plaques of the legs.¹⁴ Histologically, acroangiodermatitis presents with relatively less proliferation of endothelial cells found intravascularly rather than extravascularly, as in DDA, forming new thick-walled vessels in a lobular pattern in the papillary dermis.¹⁴

Vascular malignancies, such as Kaposi sarcoma and angiosarcoma, may present similarly to DDA. Kaposi sarcoma, for example, presents as erythematous to violaceous patches, plaques, or nodules found mostly on the extremities.⁷ Histologically, spindle cells and vascular structures also are found but in a clefting pattern representative of Kaposi sarcoma (so-called vascular slits).⁷ Diffuse dermal angiomatosis and vascular malignancies can further be distinguished based on atypia of the proliferations and staining for HHV-8.^7,14 Lastly, DDA differs from vascular tumors in that vascular tumors are reactive to locations of occluded vessels, with vascular proliferation ceasing once the underlying cause of hypoxia is removed.²

Treatment
There is no standard treatment of DDA.⁷ Treatment of the underlying cause of ischemia is the primary goal, which will cause the DDA to resolve in most cases. Stenting, removal of an arteriovenous fistula, or other forms of revascularization may be warranted.^{1,5,6,10,17,29,30}

Reported medical therapies for DDA include systemic or topical corticosteroids used for their antiangiogenic properties with varying results.⁷ Isotretinoin also has been used, which has been found to be effective in several cases of DDA of the breast, though 1 study reported a subsequent elevated lipid profile, requiring a decrease in dosage.^14,15,27,31

Most interestingly, a study by Sanz-Motilva et al¹⁶ demonstrated that control of comorbidities, especially smoking cessation, led to improvement, which highlights the importance of incorporating nonpharmacotherapy rather than initiating treatment solely with medication. The Table summarizes treatments used and their efficacy.

Conclusion

Diffuse dermal angiomatosis is associated with medical conditions that predispose an individual to ischemia. Although rare, DDA can present as painful and visibly disturbing lesions that can affect the daily life of afflicted patients. By reporting the few cases that do arise and reviewing prior cases and their treatments, physicians can consider DDA within the differential diagnosis and identify which treatment is most efficient for a given patient. For all DDA patients, strict control of comorbidities, especially smoking cessation, should be incorporated into the treatment plan. When DDA affects the breasts, isotretinoin appears to provide the best relief. Otherwise, treatment of the underlying cause, revascularization, withdrawal of the offending agent, or steroids seem to be the best treatment options.

Robotic stereoelectroencephalography for the localization of seizures in epilepsy is associated with less procedural morbidity, such as infection and hemorrhage, and better outcomes, compared with subdural electrode implantation.

A paper published in JAMA Neurology detailed the results of a retrospective cohort study of the outcomes of 239 patients with medically intractable epilepsy, 121 of whom underwent stereoelectroencephalography (SEEG) and 139 underwent subdural electrode (SDE) implantation.

The authors noted a significant difference between the two groups in complication rates. There were seven symptomatic hemorrhagic sequelae and three infections related to SDE implantation, and in one of these cases the patient suffered long-term neurologic consequences.

In contrast, there were no symptomatic complications in the SEEG cohort, although two patients were found to have small asymptomatic subdural hematomas that were spotted on CT scans.

Patients in the implantation group also received significantly more narcotics and had a much higher rate of perioperative blood transfusions (13.7% vs. 0.8%, P less than .001), compared with those in the SEEG group.

The study also looked at epilepsy outcomes in the two groups. Significantly more of the patients who had subdural electrodes underwent resection or ablative surgery with laser interstitial thermal therapy, compared with the patients who had SEEG (91.4% vs. 74.4%, P less than .001).

“Thus, the SEEG and SDE cohorts were significantly different in the proportions of cases that were lesional, suggesting that these modalities were used to evaluate somewhat different populations, although the same group of physicians at the same center managed and referred these cases,” wrote Nitin Tandon, MD, from the University of Texas, Houston, and his coauthors. “However, this shift in the patient pool would be expected to bias outcomes against SEEG, because these patients generally have less favorable outcomes.”

Yet the authors saw that a significantly greater proportion of the SEEG patients were free of disabling seizures, compared with the SDE implant group at 6 months (83.9% vs. 66.1%) and 1 year (76% vs. 54.6%) after resection.

To account for the difference between the two groups in the proportion of cases that were lesional, the authors conducted a subgroup analysis of patients with abnormalities on imaging. Again, they saw that a significantly greater proportion of the SEEG patients achieved good outcomes at 6 months and 1 year, compared with the electrode group.

While subdural electrodes have long been the standard approach for delineating epileptogenic zones, the authors wrote that SEEG offers improved coverage and precise targeting of deeper structures. “In addition, the ability of the SEEG method to map distributed epileptic networks involved in epileptic activity has been hypothesized to be responsible for improved outcomes in patients with epilepsy that is difficult to localize.”

They also commented that, in their institution, they saw much greater patient tolerance for SEEG and slightly better outcomes in those patients who underwent resection or ablation.

One author reported a position with a company specializing in outpatient clinical neurophysiological testing services. No other conflicts of interest were reported.

SOURCE: Tandon N et al. JAMA Neurol. 2019 Mar 4. doi: 10.1001/jamaneurol.2019.0098.
 

Robotic stereoelectroencephalography for the localization of seizures in epilepsy is associated with less procedural morbidity, such as infection and hemorrhage, and better outcomes, compared with subdural electrode implantation.

A paper published in JAMA Neurology detailed the results of a retrospective cohort study of the outcomes of 239 patients with medically intractable epilepsy, 121 of whom underwent stereoelectroencephalography (SEEG) and 139 underwent subdural electrode (SDE) implantation.

The authors noted a significant difference between the two groups in complication rates. There were seven symptomatic hemorrhagic sequelae and three infections related to SDE implantation, and in one of these cases the patient suffered long-term neurologic consequences.

In contrast, there were no symptomatic complications in the SEEG cohort, although two patients were found to have small asymptomatic subdural hematomas that were spotted on CT scans.

Patients in the implantation group also received significantly more narcotics and had a much higher rate of perioperative blood transfusions (13.7% vs. 0.8%, P less than .001), compared with those in the SEEG group.

The study also looked at epilepsy outcomes in the two groups. Significantly more of the patients who had subdural electrodes underwent resection or ablative surgery with laser interstitial thermal therapy, compared with the patients who had SEEG (91.4% vs. 74.4%, P less than .001).

“Thus, the SEEG and SDE cohorts were significantly different in the proportions of cases that were lesional, suggesting that these modalities were used to evaluate somewhat different populations, although the same group of physicians at the same center managed and referred these cases,” wrote Nitin Tandon, MD, from the University of Texas, Houston, and his coauthors. “However, this shift in the patient pool would be expected to bias outcomes against SEEG, because these patients generally have less favorable outcomes.”

Yet the authors saw that a significantly greater proportion of the SEEG patients were free of disabling seizures, compared with the SDE implant group at 6 months (83.9% vs. 66.1%) and 1 year (76% vs. 54.6%) after resection.

To account for the difference between the two groups in the proportion of cases that were lesional, the authors conducted a subgroup analysis of patients with abnormalities on imaging. Again, they saw that a significantly greater proportion of the SEEG patients achieved good outcomes at 6 months and 1 year, compared with the electrode group.

While subdural electrodes have long been the standard approach for delineating epileptogenic zones, the authors wrote that SEEG offers improved coverage and precise targeting of deeper structures. “In addition, the ability of the SEEG method to map distributed epileptic networks involved in epileptic activity has been hypothesized to be responsible for improved outcomes in patients with epilepsy that is difficult to localize.”

They also commented that, in their institution, they saw much greater patient tolerance for SEEG and slightly better outcomes in those patients who underwent resection or ablation.

One author reported a position with a company specializing in outpatient clinical neurophysiological testing services. No other conflicts of interest were reported.

SOURCE: Tandon N et al. JAMA Neurol. 2019 Mar 4. doi: 10.1001/jamaneurol.2019.0098.
 

Robotic stereoelectroencephalography for the localization of seizures in epilepsy is associated with less procedural morbidity, such as infection and hemorrhage, and better outcomes, compared with subdural electrode implantation.

A paper published in JAMA Neurology detailed the results of a retrospective cohort study of the outcomes of 239 patients with medically intractable epilepsy, 121 of whom underwent stereoelectroencephalography (SEEG) and 139 underwent subdural electrode (SDE) implantation.

The authors noted a significant difference between the two groups in complication rates. There were seven symptomatic hemorrhagic sequelae and three infections related to SDE implantation, and in one of these cases the patient suffered long-term neurologic consequences.

In contrast, there were no symptomatic complications in the SEEG cohort, although two patients were found to have small asymptomatic subdural hematomas that were spotted on CT scans.

Patients in the implantation group also received significantly more narcotics and had a much higher rate of perioperative blood transfusions (13.7% vs. 0.8%, P less than .001), compared with those in the SEEG group.

The study also looked at epilepsy outcomes in the two groups. Significantly more of the patients who had subdural electrodes underwent resection or ablative surgery with laser interstitial thermal therapy, compared with the patients who had SEEG (91.4% vs. 74.4%, P less than .001).

“Thus, the SEEG and SDE cohorts were significantly different in the proportions of cases that were lesional, suggesting that these modalities were used to evaluate somewhat different populations, although the same group of physicians at the same center managed and referred these cases,” wrote Nitin Tandon, MD, from the University of Texas, Houston, and his coauthors. “However, this shift in the patient pool would be expected to bias outcomes against SEEG, because these patients generally have less favorable outcomes.”

Yet the authors saw that a significantly greater proportion of the SEEG patients were free of disabling seizures, compared with the SDE implant group at 6 months (83.9% vs. 66.1%) and 1 year (76% vs. 54.6%) after resection.

To account for the difference between the two groups in the proportion of cases that were lesional, the authors conducted a subgroup analysis of patients with abnormalities on imaging. Again, they saw that a significantly greater proportion of the SEEG patients achieved good outcomes at 6 months and 1 year, compared with the electrode group.

While subdural electrodes have long been the standard approach for delineating epileptogenic zones, the authors wrote that SEEG offers improved coverage and precise targeting of deeper structures. “In addition, the ability of the SEEG method to map distributed epileptic networks involved in epileptic activity has been hypothesized to be responsible for improved outcomes in patients with epilepsy that is difficult to localize.”

They also commented that, in their institution, they saw much greater patient tolerance for SEEG and slightly better outcomes in those patients who underwent resection or ablation.

One author reported a position with a company specializing in outpatient clinical neurophysiological testing services. No other conflicts of interest were reported.

SOURCE: Tandon N et al. JAMA Neurol. 2019 Mar 4. doi: 10.1001/jamaneurol.2019.0098.
 

The experience of recovering from addiction can look different in different people, according to a Washington Post article. Some patients hit “rock bottom” and are able to climb back after connecting with a therapist. Others maintain sobriety by working with sponsors through 12-step programs. Still others are able to attain sobriety and maintain it by carefully vetting social invitations and bypassing situations in which drugs or lots of alcohol are involved. Medications that manage cravings are another intervention used by some of the 22 million Americans reportedly in recovery from drugs and alcohol. A major milestone for those seeking recovery is reaching the 3- to 5-year mark, said Robert D. Ashford, MSW, of the Substance Use Disorders Institute at the University of Pennsylvania, Philadelphia. “That benchmark can signal a reduced risk of returning to substance use because the person with addiction has had the time to develop effective coping skills, social connections, and a renewed sense of self.” The Washington Post.

University life can be rewarding, but stress is a reality – and for some, that stress can either exacerbate or trigger mental health challenges. More universities have recognized the mental toll that campus life can exact and have put supports in place. At the University of California, Los Angeles, Internet-based screenings and online mental health treatment are offered with one-on-one personal contact with “resilience peers.” The latter are not licensed counselors, but they are trained to listen and provide an outlet for stressed students. The online help teaches skills that are useful in combating anxiety and depression. The goal is to help as many students as fast as possible. “This program fundamentally changed who I am and how I approach my life,” said UCLA student Nivi Ahlawat. “I may not remember the structures of all the intermediates of the glycolysis pathway I learned in biochemistry class. But I’ll remember what I’ve learned about active listening, motivational interviewing, and mindfulness intervention for the rest of my life.” Meanwhile, Kent (Ohio) State University has provided mental health training to more than 700 students, faculty, and staff. And at Jefferson Community College in Watertown, N.Y., mental health help includes a “wraparound” model that provides aid to economically disadvantaged students whose stress includes putting food on the table for their children. The New York Times.

Sen. Richard Briggs, MD, has proposed a resolution that seeks to loosen the purses of insurance companies in Tennessee, with the aim of better coverage for those with mental health or substance use issues who are seeking treatment. In introducing the resolution, Dr. Briggs noted that, despite the opioid crisis in his state, there is an “undeniable difference in coverage for mental health and substance abuse services for Tennesseans suffering from substance use disorder or opioid use disorder,” compared with the way other traditional diseases are covered and insured. “Mental illness is an illness just like any other medical illness, and should be treated and reimbursed to physicians in the same manner,” said Dr. Briggs, a heart and lung surgeon who served combat tours in Iraq and Afghanistan. NewsChannel 5 in Nashville.

“When I tell you I moved down to Miami for the weather, I really mean I moved to South Florida to escape my depression,” wrote Minhae Shim Roth. But for some, other factors get in the way. “The problem is that the heat and humidity can be so oppressive that people are forced indoors, negating the positive benefits of the sunshine,” said Daniel E. Jimenez, PhD, an assistant professor of psychiatry and behavioral sciences at the University of Miami. Last year, more than 560,000 Floridians – or 3.5% of the state’s adults – reportedly contemplated suicide, statistics show. Those stats are comparable with those of New York state. One difference, however, is that people in Miami are less willing to talk about mental health challenges, Ms. Roth suggested. “It’s easy to believe living in the Magic City is like a booze-, drug-, and fun-filled party that never stops. This pervasive hedonistic reputation makes it unpopular and shameful to admit you’re depressed. Everyone’s having fun, so why aren’t you?” Ms. Roth wrote. Those who seek help face an understaffed and underfunded system where an appointment with a psychiatrist can take months to secure. Help needs to come in other forms, according to Ms. Roth, and include “compassion and empathy, public initiatives aimed at combating the stigma of mental illness, greater accessibility to mental health services, and readily available intervention tools.” Miami New Times.

Seven in 10 U.S. teens see anxiety and depression as major problems among their peers. The concerns cut across gender, racial and socioeconomic lines, according to a survey of 920 teens aged 13-17 years. The major reason for the anxiety and depression is school, with 61% of the respondents feeling pressure to excel academically. Girls were far more likely than boys to say they planned to attend a 4-year college (68% vs. 51%). About half of the teens surveyed viewed drug addiction and alcohol consumption as major problems among people their age. Pew Research Center.

The experience of recovering from addiction can look different in different people, according to a Washington Post article. Some patients hit “rock bottom” and are able to climb back after connecting with a therapist. Others maintain sobriety by working with sponsors through 12-step programs. Still others are able to attain sobriety and maintain it by carefully vetting social invitations and bypassing situations in which drugs or lots of alcohol are involved. Medications that manage cravings are another intervention used by some of the 22 million Americans reportedly in recovery from drugs and alcohol. A major milestone for those seeking recovery is reaching the 3- to 5-year mark, said Robert D. Ashford, MSW, of the Substance Use Disorders Institute at the University of Pennsylvania, Philadelphia. “That benchmark can signal a reduced risk of returning to substance use because the person with addiction has had the time to develop effective coping skills, social connections, and a renewed sense of self.” The Washington Post.

University life can be rewarding, but stress is a reality – and for some, that stress can either exacerbate or trigger mental health challenges. More universities have recognized the mental toll that campus life can exact and have put supports in place. At the University of California, Los Angeles, Internet-based screenings and online mental health treatment are offered with one-on-one personal contact with “resilience peers.” The latter are not licensed counselors, but they are trained to listen and provide an outlet for stressed students. The online help teaches skills that are useful in combating anxiety and depression. The goal is to help as many students as fast as possible. “This program fundamentally changed who I am and how I approach my life,” said UCLA student Nivi Ahlawat. “I may not remember the structures of all the intermediates of the glycolysis pathway I learned in biochemistry class. But I’ll remember what I’ve learned about active listening, motivational interviewing, and mindfulness intervention for the rest of my life.” Meanwhile, Kent (Ohio) State University has provided mental health training to more than 700 students, faculty, and staff. And at Jefferson Community College in Watertown, N.Y., mental health help includes a “wraparound” model that provides aid to economically disadvantaged students whose stress includes putting food on the table for their children. The New York Times.

Sen. Richard Briggs, MD, has proposed a resolution that seeks to loosen the purses of insurance companies in Tennessee, with the aim of better coverage for those with mental health or substance use issues who are seeking treatment. In introducing the resolution, Dr. Briggs noted that, despite the opioid crisis in his state, there is an “undeniable difference in coverage for mental health and substance abuse services for Tennesseans suffering from substance use disorder or opioid use disorder,” compared with the way other traditional diseases are covered and insured. “Mental illness is an illness just like any other medical illness, and should be treated and reimbursed to physicians in the same manner,” said Dr. Briggs, a heart and lung surgeon who served combat tours in Iraq and Afghanistan. NewsChannel 5 in Nashville.

“When I tell you I moved down to Miami for the weather, I really mean I moved to South Florida to escape my depression,” wrote Minhae Shim Roth. But for some, other factors get in the way. “The problem is that the heat and humidity can be so oppressive that people are forced indoors, negating the positive benefits of the sunshine,” said Daniel E. Jimenez, PhD, an assistant professor of psychiatry and behavioral sciences at the University of Miami. Last year, more than 560,000 Floridians – or 3.5% of the state’s adults – reportedly contemplated suicide, statistics show. Those stats are comparable with those of New York state. One difference, however, is that people in Miami are less willing to talk about mental health challenges, Ms. Roth suggested. “It’s easy to believe living in the Magic City is like a booze-, drug-, and fun-filled party that never stops. This pervasive hedonistic reputation makes it unpopular and shameful to admit you’re depressed. Everyone’s having fun, so why aren’t you?” Ms. Roth wrote. Those who seek help face an understaffed and underfunded system where an appointment with a psychiatrist can take months to secure. Help needs to come in other forms, according to Ms. Roth, and include “compassion and empathy, public initiatives aimed at combating the stigma of mental illness, greater accessibility to mental health services, and readily available intervention tools.” Miami New Times.

Seven in 10 U.S. teens see anxiety and depression as major problems among their peers. The concerns cut across gender, racial and socioeconomic lines, according to a survey of 920 teens aged 13-17 years. The major reason for the anxiety and depression is school, with 61% of the respondents feeling pressure to excel academically. Girls were far more likely than boys to say they planned to attend a 4-year college (68% vs. 51%). About half of the teens surveyed viewed drug addiction and alcohol consumption as major problems among people their age. Pew Research Center.

The experience of recovering from addiction can look different in different people, according to a Washington Post article. Some patients hit “rock bottom” and are able to climb back after connecting with a therapist. Others maintain sobriety by working with sponsors through 12-step programs. Still others are able to attain sobriety and maintain it by carefully vetting social invitations and bypassing situations in which drugs or lots of alcohol are involved. Medications that manage cravings are another intervention used by some of the 22 million Americans reportedly in recovery from drugs and alcohol. A major milestone for those seeking recovery is reaching the 3- to 5-year mark, said Robert D. Ashford, MSW, of the Substance Use Disorders Institute at the University of Pennsylvania, Philadelphia. “That benchmark can signal a reduced risk of returning to substance use because the person with addiction has had the time to develop effective coping skills, social connections, and a renewed sense of self.” The Washington Post.

University life can be rewarding, but stress is a reality – and for some, that stress can either exacerbate or trigger mental health challenges. More universities have recognized the mental toll that campus life can exact and have put supports in place. At the University of California, Los Angeles, Internet-based screenings and online mental health treatment are offered with one-on-one personal contact with “resilience peers.” The latter are not licensed counselors, but they are trained to listen and provide an outlet for stressed students. The online help teaches skills that are useful in combating anxiety and depression. The goal is to help as many students as fast as possible. “This program fundamentally changed who I am and how I approach my life,” said UCLA student Nivi Ahlawat. “I may not remember the structures of all the intermediates of the glycolysis pathway I learned in biochemistry class. But I’ll remember what I’ve learned about active listening, motivational interviewing, and mindfulness intervention for the rest of my life.” Meanwhile, Kent (Ohio) State University has provided mental health training to more than 700 students, faculty, and staff. And at Jefferson Community College in Watertown, N.Y., mental health help includes a “wraparound” model that provides aid to economically disadvantaged students whose stress includes putting food on the table for their children. The New York Times.

Sen. Richard Briggs, MD, has proposed a resolution that seeks to loosen the purses of insurance companies in Tennessee, with the aim of better coverage for those with mental health or substance use issues who are seeking treatment. In introducing the resolution, Dr. Briggs noted that, despite the opioid crisis in his state, there is an “undeniable difference in coverage for mental health and substance abuse services for Tennesseans suffering from substance use disorder or opioid use disorder,” compared with the way other traditional diseases are covered and insured. “Mental illness is an illness just like any other medical illness, and should be treated and reimbursed to physicians in the same manner,” said Dr. Briggs, a heart and lung surgeon who served combat tours in Iraq and Afghanistan. NewsChannel 5 in Nashville.

“When I tell you I moved down to Miami for the weather, I really mean I moved to South Florida to escape my depression,” wrote Minhae Shim Roth. But for some, other factors get in the way. “The problem is that the heat and humidity can be so oppressive that people are forced indoors, negating the positive benefits of the sunshine,” said Daniel E. Jimenez, PhD, an assistant professor of psychiatry and behavioral sciences at the University of Miami. Last year, more than 560,000 Floridians – or 3.5% of the state’s adults – reportedly contemplated suicide, statistics show. Those stats are comparable with those of New York state. One difference, however, is that people in Miami are less willing to talk about mental health challenges, Ms. Roth suggested. “It’s easy to believe living in the Magic City is like a booze-, drug-, and fun-filled party that never stops. This pervasive hedonistic reputation makes it unpopular and shameful to admit you’re depressed. Everyone’s having fun, so why aren’t you?” Ms. Roth wrote. Those who seek help face an understaffed and underfunded system where an appointment with a psychiatrist can take months to secure. Help needs to come in other forms, according to Ms. Roth, and include “compassion and empathy, public initiatives aimed at combating the stigma of mental illness, greater accessibility to mental health services, and readily available intervention tools.” Miami New Times.

Seven in 10 U.S. teens see anxiety and depression as major problems among their peers. The concerns cut across gender, racial and socioeconomic lines, according to a survey of 920 teens aged 13-17 years. The major reason for the anxiety and depression is school, with 61% of the respondents feeling pressure to excel academically. Girls were far more likely than boys to say they planned to attend a 4-year college (68% vs. 51%). About half of the teens surveyed viewed drug addiction and alcohol consumption as major problems among people their age. Pew Research Center.

Conceiving within 1 year of a stillbirth was not associated with adverse outcomes in the subsequent pregnancy, according to authors of a large, international observational study.

There was no significantly increased risk of stillbirth, preterm birth, or small-for-gestational-age birth in the next pregnancy for women who conceived in that 12-month time period, according to results of the study, which was based on birth records for nearly 14,500 women in Finland, Norway, and Australia.

“We hope that our findings can provide reassurance to women who wish to become pregnant or unexpectedly become pregnant shortly after a stillbirth,” study author Annette K. Regan, PhD, of Curtin University, Perth, Australia, said in a statement on the study, which appears in The Lancet.

Judette Marie Louis, MD, MPH, said that while data are conflicting on optimal interpregnancy interval following stillbirth, large population-based studies such as this one may provide an indication of the relative safety of an interval of 12 months or less. (She was not involved in this study.)

“This paper is good news for a lot of women,” Dr. Louis, associate professor of obstetrics and gynecology at the University of South Florida, Tampa, said in an interview. “After a stillbirth, it’s such a traumatic experience that some do want to move on, and these findings suggest that, yes, you don’t have to wait that long to have a successful pregnancy.”

These results are for women living in relatively high-income countries, so the findings might not apply to every population, she added. Dr. Louis was the first author of a recent interpregnancy care consensus statement by the American College of Obstetricians and Gynecologists and the Society of Maternal-Fetal Medicine, and was asked to comment on this study.

The World Health Organization recommends interpregnancy intervals of 2 years or more after live births and 6 months or more after miscarriage, but currently has no specific recommendations on the optimal interpregnancy interval after a stillbirth, according to Dr. Regan and her colleagues.

“Because length of gestation might affect nutrient concentrations and health status in women, it is plausible that the optimal interval after stillbirth is somewhere between the optimal interval after miscarriage and live birth,” they said in their report.

Researchers for two previous studies also have reported on the link between the interpregnancy interval after stillbirth and birth outcomes in the next pregnancy, but neither was specifically designed to evaluate that outcome, they added.

Dr. Regan and her coauthors used birth record data spanning several decades from three high-income countries to identify 14,452 women who had stillbirths. Of those, 63% conceived within the next 12 months, and for 37%, it was as early as 6 months.

Overall, 2% of the subsequent pregnancies ended in stillbirth, while 9% were small-for-gestational-age and 18% were preterm, according to the report.

In analyses adjusted for variables such as age, smoking, and education level, there was no association between short interpregnancy intervals and subsequent stillbirths, compared with longer intervals (24-59 months), with odds ratios of 1.09 for an interval shorter than 6 months and 0.90 for 6-11 months.

Likewise, there was no link between shorter intervals and subsequent small-for-gestational-age birth, with odds ratios of 0.66 for less than 6 months and 0.64 for 6-11 months, and no link between interval and subsequent preterm births, with odds ratios of 0.91 for both short-interval groups.

That data could be useful to health care providers who do postpartum counseling after stillbirths, and could potentially inform future recommendations on pregnancy spacing, Dr. Regan and her coauthors said.

“These results apply to a large proportion of women conceiving after a stillbirth,” they noted.

This study included countries with access to universal health care, with populations that are mostly white, so the results may not apply to low- or middle-income countries without universal health care or with significant ethnic minority populations, they added.

Dr. Regan and her colleagues declared no competing interests related to the study, which was funded the National Health and Medical Research Council of Australia, among other sources.

SOURCE: Regan AK et al. Lancet. 2019 Feb 28. doi: 10.1016/S0140-6736(18)32266-9.

Conceiving within 1 year of a stillbirth was not associated with adverse outcomes in the subsequent pregnancy, according to authors of a large, international observational study.

There was no significantly increased risk of stillbirth, preterm birth, or small-for-gestational-age birth in the next pregnancy for women who conceived in that 12-month time period, according to results of the study, which was based on birth records for nearly 14,500 women in Finland, Norway, and Australia.

“We hope that our findings can provide reassurance to women who wish to become pregnant or unexpectedly become pregnant shortly after a stillbirth,” study author Annette K. Regan, PhD, of Curtin University, Perth, Australia, said in a statement on the study, which appears in The Lancet.

Judette Marie Louis, MD, MPH, said that while data are conflicting on optimal interpregnancy interval following stillbirth, large population-based studies such as this one may provide an indication of the relative safety of an interval of 12 months or less. (She was not involved in this study.)

“This paper is good news for a lot of women,” Dr. Louis, associate professor of obstetrics and gynecology at the University of South Florida, Tampa, said in an interview. “After a stillbirth, it’s such a traumatic experience that some do want to move on, and these findings suggest that, yes, you don’t have to wait that long to have a successful pregnancy.”

These results are for women living in relatively high-income countries, so the findings might not apply to every population, she added. Dr. Louis was the first author of a recent interpregnancy care consensus statement by the American College of Obstetricians and Gynecologists and the Society of Maternal-Fetal Medicine, and was asked to comment on this study.

The World Health Organization recommends interpregnancy intervals of 2 years or more after live births and 6 months or more after miscarriage, but currently has no specific recommendations on the optimal interpregnancy interval after a stillbirth, according to Dr. Regan and her colleagues.

“Because length of gestation might affect nutrient concentrations and health status in women, it is plausible that the optimal interval after stillbirth is somewhere between the optimal interval after miscarriage and live birth,” they said in their report.

Researchers for two previous studies also have reported on the link between the interpregnancy interval after stillbirth and birth outcomes in the next pregnancy, but neither was specifically designed to evaluate that outcome, they added.

Dr. Regan and her coauthors used birth record data spanning several decades from three high-income countries to identify 14,452 women who had stillbirths. Of those, 63% conceived within the next 12 months, and for 37%, it was as early as 6 months.

Overall, 2% of the subsequent pregnancies ended in stillbirth, while 9% were small-for-gestational-age and 18% were preterm, according to the report.

In analyses adjusted for variables such as age, smoking, and education level, there was no association between short interpregnancy intervals and subsequent stillbirths, compared with longer intervals (24-59 months), with odds ratios of 1.09 for an interval shorter than 6 months and 0.90 for 6-11 months.

Likewise, there was no link between shorter intervals and subsequent small-for-gestational-age birth, with odds ratios of 0.66 for less than 6 months and 0.64 for 6-11 months, and no link between interval and subsequent preterm births, with odds ratios of 0.91 for both short-interval groups.

That data could be useful to health care providers who do postpartum counseling after stillbirths, and could potentially inform future recommendations on pregnancy spacing, Dr. Regan and her coauthors said.

“These results apply to a large proportion of women conceiving after a stillbirth,” they noted.

This study included countries with access to universal health care, with populations that are mostly white, so the results may not apply to low- or middle-income countries without universal health care or with significant ethnic minority populations, they added.

Dr. Regan and her colleagues declared no competing interests related to the study, which was funded the National Health and Medical Research Council of Australia, among other sources.

SOURCE: Regan AK et al. Lancet. 2019 Feb 28. doi: 10.1016/S0140-6736(18)32266-9.

Conceiving within 1 year of a stillbirth was not associated with adverse outcomes in the subsequent pregnancy, according to authors of a large, international observational study.

There was no significantly increased risk of stillbirth, preterm birth, or small-for-gestational-age birth in the next pregnancy for women who conceived in that 12-month time period, according to results of the study, which was based on birth records for nearly 14,500 women in Finland, Norway, and Australia.

“We hope that our findings can provide reassurance to women who wish to become pregnant or unexpectedly become pregnant shortly after a stillbirth,” study author Annette K. Regan, PhD, of Curtin University, Perth, Australia, said in a statement on the study, which appears in The Lancet.

Judette Marie Louis, MD, MPH, said that while data are conflicting on optimal interpregnancy interval following stillbirth, large population-based studies such as this one may provide an indication of the relative safety of an interval of 12 months or less. (She was not involved in this study.)

“This paper is good news for a lot of women,” Dr. Louis, associate professor of obstetrics and gynecology at the University of South Florida, Tampa, said in an interview. “After a stillbirth, it’s such a traumatic experience that some do want to move on, and these findings suggest that, yes, you don’t have to wait that long to have a successful pregnancy.”

These results are for women living in relatively high-income countries, so the findings might not apply to every population, she added. Dr. Louis was the first author of a recent interpregnancy care consensus statement by the American College of Obstetricians and Gynecologists and the Society of Maternal-Fetal Medicine, and was asked to comment on this study.

The World Health Organization recommends interpregnancy intervals of 2 years or more after live births and 6 months or more after miscarriage, but currently has no specific recommendations on the optimal interpregnancy interval after a stillbirth, according to Dr. Regan and her colleagues.

“Because length of gestation might affect nutrient concentrations and health status in women, it is plausible that the optimal interval after stillbirth is somewhere between the optimal interval after miscarriage and live birth,” they said in their report.

Researchers for two previous studies also have reported on the link between the interpregnancy interval after stillbirth and birth outcomes in the next pregnancy, but neither was specifically designed to evaluate that outcome, they added.

Dr. Regan and her coauthors used birth record data spanning several decades from three high-income countries to identify 14,452 women who had stillbirths. Of those, 63% conceived within the next 12 months, and for 37%, it was as early as 6 months.

Overall, 2% of the subsequent pregnancies ended in stillbirth, while 9% were small-for-gestational-age and 18% were preterm, according to the report.

In analyses adjusted for variables such as age, smoking, and education level, there was no association between short interpregnancy intervals and subsequent stillbirths, compared with longer intervals (24-59 months), with odds ratios of 1.09 for an interval shorter than 6 months and 0.90 for 6-11 months.

Likewise, there was no link between shorter intervals and subsequent small-for-gestational-age birth, with odds ratios of 0.66 for less than 6 months and 0.64 for 6-11 months, and no link between interval and subsequent preterm births, with odds ratios of 0.91 for both short-interval groups.

That data could be useful to health care providers who do postpartum counseling after stillbirths, and could potentially inform future recommendations on pregnancy spacing, Dr. Regan and her coauthors said.

“These results apply to a large proportion of women conceiving after a stillbirth,” they noted.

This study included countries with access to universal health care, with populations that are mostly white, so the results may not apply to low- or middle-income countries without universal health care or with significant ethnic minority populations, they added.

Dr. Regan and her colleagues declared no competing interests related to the study, which was funded the National Health and Medical Research Council of Australia, among other sources.

SOURCE: Regan AK et al. Lancet. 2019 Feb 28. doi: 10.1016/S0140-6736(18)32266-9.

The SVS has recently re-vamped its newsletters geared towards future vascular surgeons. These provide residents, students and vascular trainees with up-to-date information on upcoming events, awards and scholarships, open positions and more. These are sent on a bi-weekly and monthly basis, depending on what content you are interested in. Learn more and subscribe here. They will also be posted on the SVS future vascular surgeon’s Twitter and Facebook.

The SVS has recently re-vamped its newsletters geared towards future vascular surgeons. These provide residents, students and vascular trainees with up-to-date information on upcoming events, awards and scholarships, open positions and more. These are sent on a bi-weekly and monthly basis, depending on what content you are interested in. Learn more and subscribe here. They will also be posted on the SVS future vascular surgeon’s Twitter and Facebook.

The SVS has recently re-vamped its newsletters geared towards future vascular surgeons. These provide residents, students and vascular trainees with up-to-date information on upcoming events, awards and scholarships, open positions and more. These are sent on a bi-weekly and monthly basis, depending on what content you are interested in. Learn more and subscribe here. They will also be posted on the SVS future vascular surgeon’s Twitter and Facebook.

We’re still a few months away from the Vascular Spectacular Gala at VAM, but excitement is growing concurrently with the list of items contributed to the event's live and silent auctions. You’ll definitely leave VAM with new professional connections and inspiration, but perhaps you’ll also take home a one-week stay in Camden, Maine. Or maybe you’ll be anticipating a new charbroiled oyster kit, vouchers to one of the nation's best botanical gardens, jewelry or free registration for next year’s VAM. These are just a few of the items our generous donors have added to our growing list. If you can't make it to the gala or VAM, you can still join in on the fun by donating an item or bidding online. All gala proceeds benefit the SVS Foundation.

We’re still a few months away from the Vascular Spectacular Gala at VAM, but excitement is growing concurrently with the list of items contributed to the event's live and silent auctions. You’ll definitely leave VAM with new professional connections and inspiration, but perhaps you’ll also take home a one-week stay in Camden, Maine. Or maybe you’ll be anticipating a new charbroiled oyster kit, vouchers to one of the nation's best botanical gardens, jewelry or free registration for next year’s VAM. These are just a few of the items our generous donors have added to our growing list. If you can't make it to the gala or VAM, you can still join in on the fun by donating an item or bidding online. All gala proceeds benefit the SVS Foundation.

We’re still a few months away from the Vascular Spectacular Gala at VAM, but excitement is growing concurrently with the list of items contributed to the event's live and silent auctions. You’ll definitely leave VAM with new professional connections and inspiration, but perhaps you’ll also take home a one-week stay in Camden, Maine. Or maybe you’ll be anticipating a new charbroiled oyster kit, vouchers to one of the nation's best botanical gardens, jewelry or free registration for next year’s VAM. These are just a few of the items our generous donors have added to our growing list. If you can't make it to the gala or VAM, you can still join in on the fun by donating an item or bidding online. All gala proceeds benefit the SVS Foundation.

You can now log in to SVSConnect conveniently from your phone and tablet. This gives you easy access to field-related discussions, resources from other users and the SVS member directory. You can do everything on the app that you can on your desktop and it only takes a few minutes to set up. Follow the steps in this flier to download. If you encounter difficulties, email communications@vascularsociety.org or call 312-334-2300.

You can now log in to SVSConnect conveniently from your phone and tablet. This gives you easy access to field-related discussions, resources from other users and the SVS member directory. You can do everything on the app that you can on your desktop and it only takes a few minutes to set up. Follow the steps in this flier to download. If you encounter difficulties, email communications@vascularsociety.org or call 312-334-2300.

You can now log in to SVSConnect conveniently from your phone and tablet. This gives you easy access to field-related discussions, resources from other users and the SVS member directory. You can do everything on the app that you can on your desktop and it only takes a few minutes to set up. Follow the steps in this flier to download. If you encounter difficulties, email communications@vascularsociety.org or call 312-334-2300.

The time has almost come to register for the 2019 Vascular Annual Meeting. This month, you’ll be able to register for the can’t-miss event of the year for vascular care professionals. This year’s event will be held on June 12-15 in National Harbor, Md., (near Washington, D.C.) As always, attendees will learn about cutting-edge vascular research, attend innovative education sessions, have the opportunity to network with other thought leaders in the field and do much more. Reservations for VAM housing open at the same time. For more information about VAM registration and housing, visit our meeting website.

The time has almost come to register for the 2019 Vascular Annual Meeting. This month, you’ll be able to register for the can’t-miss event of the year for vascular care professionals. This year’s event will be held on June 12-15 in National Harbor, Md., (near Washington, D.C.) As always, attendees will learn about cutting-edge vascular research, attend innovative education sessions, have the opportunity to network with other thought leaders in the field and do much more. Reservations for VAM housing open at the same time. For more information about VAM registration and housing, visit our meeting website.

The time has almost come to register for the 2019 Vascular Annual Meeting. This month, you’ll be able to register for the can’t-miss event of the year for vascular care professionals. This year’s event will be held on June 12-15 in National Harbor, Md., (near Washington, D.C.) As always, attendees will learn about cutting-edge vascular research, attend innovative education sessions, have the opportunity to network with other thought leaders in the field and do much more. Reservations for VAM housing open at the same time. For more information about VAM registration and housing, visit our meeting website.

Delaying antibiotics in elderly patients with urinary tract infections is linked to higher sepsis, death rates. A pilot study of smartphone-based visual tests shows promise in multiple sclerosis. Myeloma therapies raise cardiovascular risks. And sperm counts are largely stable after adjuvant treatment of early testicular cancer.

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Spotify

Delaying antibiotics in elderly patients with urinary tract infections is linked to higher sepsis, death rates. A pilot study of smartphone-based visual tests shows promise in multiple sclerosis. Myeloma therapies raise cardiovascular risks. And sperm counts are largely stable after adjuvant treatment of early testicular cancer.

Amazon Alexa

Apple Podcasts

Google Podcasts

Spotify

Delaying antibiotics in elderly patients with urinary tract infections is linked to higher sepsis, death rates. A pilot study of smartphone-based visual tests shows promise in multiple sclerosis. Myeloma therapies raise cardiovascular risks. And sperm counts are largely stable after adjuvant treatment of early testicular cancer.

Amazon Alexa

Apple Podcasts

Google Podcasts

Spotify

Per- and polyfluoroalkyl substances (PFAS) are manmade chemicals used in industry and consumer products, such as nonstick cookware, water-repellent clothing, and stain-resistant fabrics. Studies have shown that exposure to PFAS can—among other things—affect growth, learning, and behavior of infants and children; reduce a woman’s chance of getting pregnant; affect the immune system; and increase the risk of cancer.

The 2018 National Defense Authorization Act allowed the CDC and the Agency for Toxic Substances and Disease Registry (ATSDR) to look at PFAS exposure in communities near current or former military bases that are known to have had PFAS in the drinking water. In a pilot study, researchers conducted assessments in Bucks and Montgomery counties in Pennsylvania (near Horsham Air Guard Station and former Naval Air Warfare Center), and in Westhampton, New York (near Gabreski Air National Guard Base).

Now, CDC/ATSDR have expanded the assessments to 8 other communities:

• Berkeley County (WV) near Shepherd Field Air National Guard Base
• El Paso County (CO) near Peterson Air Force Base
• Fairbanks North Star Borough (AK) near Eielson Air Force Base
• Hampden County (MA) near Barnes Air National Guard Base
• Lubbock County (TX) near Reese Technology Center
• Orange County (NY) near Stewart Air National Guard Base
• New Castle County (DE) near New Castle Air National Guard Base
• Spokane County (WA) near Fairchild Air Force Base

The researchers will randomly select people in each community to participate by having their PFAS levels checked in blood and urine samples. The sampling results will provide researchers and public health professionals with information about community-level exposure but also be used to help communities understand the level of risk and how to reduce PFAS exposure.

The assessments, expected to begin this year and continue through 2020, will also “lay the groundwork,” the CDC says, for a multisite health study that will examine the relationship between PFAS exposure and health outcomes.

For more information about PFAS and the Exposure Assessment, visit https://www.atsdr.cdc.gov/pfas/index.html.

Per- and polyfluoroalkyl substances (PFAS) are manmade chemicals used in industry and consumer products, such as nonstick cookware, water-repellent clothing, and stain-resistant fabrics. Studies have shown that exposure to PFAS can—among other things—affect growth, learning, and behavior of infants and children; reduce a woman’s chance of getting pregnant; affect the immune system; and increase the risk of cancer.

The 2018 National Defense Authorization Act allowed the CDC and the Agency for Toxic Substances and Disease Registry (ATSDR) to look at PFAS exposure in communities near current or former military bases that are known to have had PFAS in the drinking water. In a pilot study, researchers conducted assessments in Bucks and Montgomery counties in Pennsylvania (near Horsham Air Guard Station and former Naval Air Warfare Center), and in Westhampton, New York (near Gabreski Air National Guard Base).

Now, CDC/ATSDR have expanded the assessments to 8 other communities:

• Berkeley County (WV) near Shepherd Field Air National Guard Base
• El Paso County (CO) near Peterson Air Force Base
• Fairbanks North Star Borough (AK) near Eielson Air Force Base
• Hampden County (MA) near Barnes Air National Guard Base
• Lubbock County (TX) near Reese Technology Center
• Orange County (NY) near Stewart Air National Guard Base
• New Castle County (DE) near New Castle Air National Guard Base
• Spokane County (WA) near Fairchild Air Force Base

The researchers will randomly select people in each community to participate by having their PFAS levels checked in blood and urine samples. The sampling results will provide researchers and public health professionals with information about community-level exposure but also be used to help communities understand the level of risk and how to reduce PFAS exposure.

The assessments, expected to begin this year and continue through 2020, will also “lay the groundwork,” the CDC says, for a multisite health study that will examine the relationship between PFAS exposure and health outcomes.

For more information about PFAS and the Exposure Assessment, visit https://www.atsdr.cdc.gov/pfas/index.html.

Per- and polyfluoroalkyl substances (PFAS) are manmade chemicals used in industry and consumer products, such as nonstick cookware, water-repellent clothing, and stain-resistant fabrics. Studies have shown that exposure to PFAS can—among other things—affect growth, learning, and behavior of infants and children; reduce a woman’s chance of getting pregnant; affect the immune system; and increase the risk of cancer.

The 2018 National Defense Authorization Act allowed the CDC and the Agency for Toxic Substances and Disease Registry (ATSDR) to look at PFAS exposure in communities near current or former military bases that are known to have had PFAS in the drinking water. In a pilot study, researchers conducted assessments in Bucks and Montgomery counties in Pennsylvania (near Horsham Air Guard Station and former Naval Air Warfare Center), and in Westhampton, New York (near Gabreski Air National Guard Base).

Now, CDC/ATSDR have expanded the assessments to 8 other communities:

• Berkeley County (WV) near Shepherd Field Air National Guard Base
• El Paso County (CO) near Peterson Air Force Base
• Fairbanks North Star Borough (AK) near Eielson Air Force Base
• Hampden County (MA) near Barnes Air National Guard Base
• Lubbock County (TX) near Reese Technology Center
• Orange County (NY) near Stewart Air National Guard Base
• New Castle County (DE) near New Castle Air National Guard Base
• Spokane County (WA) near Fairchild Air Force Base

The researchers will randomly select people in each community to participate by having their PFAS levels checked in blood and urine samples. The sampling results will provide researchers and public health professionals with information about community-level exposure but also be used to help communities understand the level of risk and how to reduce PFAS exposure.

The assessments, expected to begin this year and continue through 2020, will also “lay the groundwork,” the CDC says, for a multisite health study that will examine the relationship between PFAS exposure and health outcomes.

For more information about PFAS and the Exposure Assessment, visit https://www.atsdr.cdc.gov/pfas/index.html.