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Pyoderma Gangrenosum Following Patellar Tendon Repair: A Case Report and Review of the Literature
A Complex Injury of the Distal Ulnar Physis: A Case Report and Brief Review of the Literature
When Is a Medial Epicondyle Fracture a Medial Condyle Fracture?
Use of an Absorbable Plate in the Management of a Clavicle Fracture in an Adolescent
Hip Hemiarthroplasty Periprosthetic Loosening Caused by Papillary Ovarian Carcinoma Metastasis in a 78-Year-Old Woman: A Rare Presentation and a Literature Review
Posterior reversible encephalopathy syndrome: a potential side effect of gemcitabine
A 50-year-old woman presented to her primary care physician with abdominal pain and jaundice. Computed tomographic (CT) scan of the abdomen revealed a pancreatic head mass. Exploratory laparotomy showed a tumor obstructing the duodenum and encasing the portal vein and superior mesenteric artery, deeming it unresectable. Biopsies confirmed it to be an adenocarcinoma with mucinous differentiation...
Click on the PDF icon at the top of this introduction to read the full article.
A 50-year-old woman presented to her primary care physician with abdominal pain and jaundice. Computed tomographic (CT) scan of the abdomen revealed a pancreatic head mass. Exploratory laparotomy showed a tumor obstructing the duodenum and encasing the portal vein and superior mesenteric artery, deeming it unresectable. Biopsies confirmed it to be an adenocarcinoma with mucinous differentiation...
Click on the PDF icon at the top of this introduction to read the full article.
A 50-year-old woman presented to her primary care physician with abdominal pain and jaundice. Computed tomographic (CT) scan of the abdomen revealed a pancreatic head mass. Exploratory laparotomy showed a tumor obstructing the duodenum and encasing the portal vein and superior mesenteric artery, deeming it unresectable. Biopsies confirmed it to be an adenocarcinoma with mucinous differentiation...
Click on the PDF icon at the top of this introduction to read the full article.
Severe and rapid cardiac toxicity from sunitinib therapy in a patient with metastatic renal cell carcinoma
A 67-year-old man with a history of leftsided renal cell carcinoma status after undergoing a radical nephrectomy presented to the oncology clinic after sustaining a pathologic fracture of the left humerus. Computed tomography revealed a right suprarenal mass with invasion into the inferior vena cava and right atrium, confirmed to be poorly differentiated RCC on biopsy. Transthoracic echocardiogram showed tumor thrombus occluding the IVC lumen; the tumor also extended into the right atrium, measuring 8 cm in circumference. Despite this direct invasion, cardiac function remained normal; there was no evidence of valvular or wall motion abnormalities, and left ventricular ejection fraction was preserved at 67%. Therapy for metastatic RCC was initiated with the tyrosine kinase inhibitor sunitinib at 50 mg daily. Body mass index at this time was 24.8. Within 12 days of starting therapy, however, the patient exhibited symptoms of New York Heart Association class IV heart failure and was referred to the emergency department.
Click on the PDF icon at the top of this introduction to read the full article.
A 67-year-old man with a history of leftsided renal cell carcinoma status after undergoing a radical nephrectomy presented to the oncology clinic after sustaining a pathologic fracture of the left humerus. Computed tomography revealed a right suprarenal mass with invasion into the inferior vena cava and right atrium, confirmed to be poorly differentiated RCC on biopsy. Transthoracic echocardiogram showed tumor thrombus occluding the IVC lumen; the tumor also extended into the right atrium, measuring 8 cm in circumference. Despite this direct invasion, cardiac function remained normal; there was no evidence of valvular or wall motion abnormalities, and left ventricular ejection fraction was preserved at 67%. Therapy for metastatic RCC was initiated with the tyrosine kinase inhibitor sunitinib at 50 mg daily. Body mass index at this time was 24.8. Within 12 days of starting therapy, however, the patient exhibited symptoms of New York Heart Association class IV heart failure and was referred to the emergency department.
Click on the PDF icon at the top of this introduction to read the full article.
A 67-year-old man with a history of leftsided renal cell carcinoma status after undergoing a radical nephrectomy presented to the oncology clinic after sustaining a pathologic fracture of the left humerus. Computed tomography revealed a right suprarenal mass with invasion into the inferior vena cava and right atrium, confirmed to be poorly differentiated RCC on biopsy. Transthoracic echocardiogram showed tumor thrombus occluding the IVC lumen; the tumor also extended into the right atrium, measuring 8 cm in circumference. Despite this direct invasion, cardiac function remained normal; there was no evidence of valvular or wall motion abnormalities, and left ventricular ejection fraction was preserved at 67%. Therapy for metastatic RCC was initiated with the tyrosine kinase inhibitor sunitinib at 50 mg daily. Body mass index at this time was 24.8. Within 12 days of starting therapy, however, the patient exhibited symptoms of New York Heart Association class IV heart failure and was referred to the emergency department.
Click on the PDF icon at the top of this introduction to read the full article.