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The modified Story Memory Technique (mSMT), a behavioral intervention aimed at improving new learning and memory in patients with multiple sclerosis, may help with processing speed and other cognitive markers, according to the double-blind, placebo-controlled, MEMREHAB trial of patients with clinically definite multiple sclerosis.
Participants were randomized to either mSMT or a placebo group, and underwent baseline and follow-up neuropsychological assessment. Compared to the control group, the treatment group showed significant improvements on California Verbal Learning Test (CVLT).
Investigators also note that performance on the Symbol Digit Modalities Test (SDMT) was a significant predictor of benefit from mSMT therapy, suggesting SDMT scores may serve as a proxy for overall cognitive impairment.
Citation: Chiaravalloti ND, DeLuca J. The influence of cognitive dysfunction on benefit from learning and memory rehabilitation in MS: a sub-analysis of the MEMREHAB trial. Mult Scler. 2015. pii: 1352458514567726.
The modified Story Memory Technique (mSMT), a behavioral intervention aimed at improving new learning and memory in patients with multiple sclerosis, may help with processing speed and other cognitive markers, according to the double-blind, placebo-controlled, MEMREHAB trial of patients with clinically definite multiple sclerosis.
Participants were randomized to either mSMT or a placebo group, and underwent baseline and follow-up neuropsychological assessment. Compared to the control group, the treatment group showed significant improvements on California Verbal Learning Test (CVLT).
Investigators also note that performance on the Symbol Digit Modalities Test (SDMT) was a significant predictor of benefit from mSMT therapy, suggesting SDMT scores may serve as a proxy for overall cognitive impairment.
Citation: Chiaravalloti ND, DeLuca J. The influence of cognitive dysfunction on benefit from learning and memory rehabilitation in MS: a sub-analysis of the MEMREHAB trial. Mult Scler. 2015. pii: 1352458514567726.
The modified Story Memory Technique (mSMT), a behavioral intervention aimed at improving new learning and memory in patients with multiple sclerosis, may help with processing speed and other cognitive markers, according to the double-blind, placebo-controlled, MEMREHAB trial of patients with clinically definite multiple sclerosis.
Participants were randomized to either mSMT or a placebo group, and underwent baseline and follow-up neuropsychological assessment. Compared to the control group, the treatment group showed significant improvements on California Verbal Learning Test (CVLT).
Investigators also note that performance on the Symbol Digit Modalities Test (SDMT) was a significant predictor of benefit from mSMT therapy, suggesting SDMT scores may serve as a proxy for overall cognitive impairment.
Citation: Chiaravalloti ND, DeLuca J. The influence of cognitive dysfunction on benefit from learning and memory rehabilitation in MS: a sub-analysis of the MEMREHAB trial. Mult Scler. 2015. pii: 1352458514567726.