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Conversion from clinically isolated syndrome (CIS) to clinically definite multiple sclerosis (CDMS) can be predicted from oglioclonal bands (OCBs), MRI lesion load, and age at CIS, according to a multicenter study of 1,047 CIS cases.
Investigators followed subjects for an average of 4.3 years, during which time 623 CIS cases converted to CDMS. Predictors associated with conversion included:
• OCB (HR, 2.18)
• 2 to 9 T2 lesions compared to 1 or less lesions (HR, 1.97)
• more than 9 lesions (HR, 2.74)
• age at CIS (HR per year inversely increase, 0.98)
Lower serum vitamin D levels were associated with CDMS in univariable analysis, but not in the multivariable model.
Citation: Ciccarelli O, Toosy AT. Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study. Mult Scler. 2015;21(8):967-968. doi: 10.1177/1352458515588583.
Conversion from clinically isolated syndrome (CIS) to clinically definite multiple sclerosis (CDMS) can be predicted from oglioclonal bands (OCBs), MRI lesion load, and age at CIS, according to a multicenter study of 1,047 CIS cases.
Investigators followed subjects for an average of 4.3 years, during which time 623 CIS cases converted to CDMS. Predictors associated with conversion included:
• OCB (HR, 2.18)
• 2 to 9 T2 lesions compared to 1 or less lesions (HR, 1.97)
• more than 9 lesions (HR, 2.74)
• age at CIS (HR per year inversely increase, 0.98)
Lower serum vitamin D levels were associated with CDMS in univariable analysis, but not in the multivariable model.
Citation: Ciccarelli O, Toosy AT. Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study. Mult Scler. 2015;21(8):967-968. doi: 10.1177/1352458515588583.
Conversion from clinically isolated syndrome (CIS) to clinically definite multiple sclerosis (CDMS) can be predicted from oglioclonal bands (OCBs), MRI lesion load, and age at CIS, according to a multicenter study of 1,047 CIS cases.
Investigators followed subjects for an average of 4.3 years, during which time 623 CIS cases converted to CDMS. Predictors associated with conversion included:
• OCB (HR, 2.18)
• 2 to 9 T2 lesions compared to 1 or less lesions (HR, 1.97)
• more than 9 lesions (HR, 2.74)
• age at CIS (HR per year inversely increase, 0.98)
Lower serum vitamin D levels were associated with CDMS in univariable analysis, but not in the multivariable model.
Citation: Ciccarelli O, Toosy AT. Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study. Mult Scler. 2015;21(8):967-968. doi: 10.1177/1352458515588583.