Computerized Test Predicted Acute Coronary Syndrome in the ED

CHICAGO — A computerized pretest probability device accurately predicted acute coronary syndrome in low-risk chest pain patients and significantly reduced unneeded exposure to thoracic imaging as well as return visits to the emergency department in a randomized controlled trial of 400 patients.

The Web-based software device (PRETestConsultACS) produces a point estimate of ACS based on eight predictor variables: age, sex, race, history of coronary artery disease, chest wall tenderness to palpation that reproduces chest pain, diaphoresis, ST depression greater than 0.5 mm in two leads, and T-wave inversion greater than 0.5 mm in two leads.

The variables are entered into a personal computer or personal digital assistant that searches a large database for evaluated patients who share the same profile. The percentage of matched patients who have ACS equals the pretest probability. ACS included myocardial infarction; coronary stenosis greater than 60% prompting new medical management or revascularization; ventricular arrhythmia; cardiogenic shock; or bradycardia requiring therapeutic intervention.

After obtaining a clinician's estimate of pretest probability of an ACS, 400 patients (mean age, 46 years) and their emergency clinicians were randomized to receive a written printout from the computer, or not. In all, 31 patients were excluded.

Pretest probability estimates of an ACS generated by the emergency clinician (mean, 4) correlated significantly with estimates from the software device (mean, 4), according to a poster at the annual meeting of the American College of Emergency Physicians.

A significant cardiovascular diagnosis was made in 36 (19.4%) of the 185 controls and 35 (19%) of the 184 intervention-group patients.

Researchers discovered one case of a missed or delayed diagnosis of ACS within 45 days, the study's primary safety end point, in a control-group patient, said lead investigator Dr. Jeffrey Kline and his colleagues in the department of emergency medicine, Carolinas Medical Center, Charlotte, N.C. The patient was diagnosed with unstable angina that was treated with a percutaneous intracoronary stent device 21 days after enrollment.

The rate of hospital admission of patients who had no significant cardiovascular diagnosis within 45 days was significantly higher among controls (11%) than in the intervention group (5%).

The rate of exposure to a thoracic imaging test that imparted greater than 5 mSv and had a negative result was significantly greater among controls (19.4%) than in the intervention group (8.6%). The lifetime risk of malignancy is thought to increase significantly after a dose of radiation that exceeds 5 mSv.

“If the results of this study are independently validated in a larger and different sample of patients, then clinicians will have evidence to justify the use of quantitative pretest probability, together with their own clinical instincts, to reduce excessive diagnostic testing in low-risk patients with chest pain,” Dr. Kline said in an interview.

Median length of stay in the emergency department was not significantly different between the control (11.4 hours) and intervention (9.2 hours) groups.

Based on telephone follow-up, patients in the intervention group were less likely than were those in the control group to be readmitted within 7 days of their emergency visit (4% vs. 11%), according to the investigators, who reported no relevant conflicts.

CHICAGO — A computerized pretest probability device accurately predicted acute coronary syndrome in low-risk chest pain patients and significantly reduced unneeded exposure to thoracic imaging as well as return visits to the emergency department in a randomized controlled trial of 400 patients.

The Web-based software device (PRETestConsultACS) produces a point estimate of ACS based on eight predictor variables: age, sex, race, history of coronary artery disease, chest wall tenderness to palpation that reproduces chest pain, diaphoresis, ST depression greater than 0.5 mm in two leads, and T-wave inversion greater than 0.5 mm in two leads.

The variables are entered into a personal computer or personal digital assistant that searches a large database for evaluated patients who share the same profile. The percentage of matched patients who have ACS equals the pretest probability. ACS included myocardial infarction; coronary stenosis greater than 60% prompting new medical management or revascularization; ventricular arrhythmia; cardiogenic shock; or bradycardia requiring therapeutic intervention.

After obtaining a clinician's estimate of pretest probability of an ACS, 400 patients (mean age, 46 years) and their emergency clinicians were randomized to receive a written printout from the computer, or not. In all, 31 patients were excluded.

Pretest probability estimates of an ACS generated by the emergency clinician (mean, 4) correlated significantly with estimates from the software device (mean, 4), according to a poster at the annual meeting of the American College of Emergency Physicians.

A significant cardiovascular diagnosis was made in 36 (19.4%) of the 185 controls and 35 (19%) of the 184 intervention-group patients.

Researchers discovered one case of a missed or delayed diagnosis of ACS within 45 days, the study's primary safety end point, in a control-group patient, said lead investigator Dr. Jeffrey Kline and his colleagues in the department of emergency medicine, Carolinas Medical Center, Charlotte, N.C. The patient was diagnosed with unstable angina that was treated with a percutaneous intracoronary stent device 21 days after enrollment.

The rate of hospital admission of patients who had no significant cardiovascular diagnosis within 45 days was significantly higher among controls (11%) than in the intervention group (5%).

The rate of exposure to a thoracic imaging test that imparted greater than 5 mSv and had a negative result was significantly greater among controls (19.4%) than in the intervention group (8.6%). The lifetime risk of malignancy is thought to increase significantly after a dose of radiation that exceeds 5 mSv.

“If the results of this study are independently validated in a larger and different sample of patients, then clinicians will have evidence to justify the use of quantitative pretest probability, together with their own clinical instincts, to reduce excessive diagnostic testing in low-risk patients with chest pain,” Dr. Kline said in an interview.

Median length of stay in the emergency department was not significantly different between the control (11.4 hours) and intervention (9.2 hours) groups.

Based on telephone follow-up, patients in the intervention group were less likely than were those in the control group to be readmitted within 7 days of their emergency visit (4% vs. 11%), according to the investigators, who reported no relevant conflicts.

CHICAGO — A computerized pretest probability device accurately predicted acute coronary syndrome in low-risk chest pain patients and significantly reduced unneeded exposure to thoracic imaging as well as return visits to the emergency department in a randomized controlled trial of 400 patients.

The Web-based software device (PRETestConsultACS) produces a point estimate of ACS based on eight predictor variables: age, sex, race, history of coronary artery disease, chest wall tenderness to palpation that reproduces chest pain, diaphoresis, ST depression greater than 0.5 mm in two leads, and T-wave inversion greater than 0.5 mm in two leads.

The variables are entered into a personal computer or personal digital assistant that searches a large database for evaluated patients who share the same profile. The percentage of matched patients who have ACS equals the pretest probability. ACS included myocardial infarction; coronary stenosis greater than 60% prompting new medical management or revascularization; ventricular arrhythmia; cardiogenic shock; or bradycardia requiring therapeutic intervention.

After obtaining a clinician's estimate of pretest probability of an ACS, 400 patients (mean age, 46 years) and their emergency clinicians were randomized to receive a written printout from the computer, or not. In all, 31 patients were excluded.

Pretest probability estimates of an ACS generated by the emergency clinician (mean, 4) correlated significantly with estimates from the software device (mean, 4), according to a poster at the annual meeting of the American College of Emergency Physicians.

A significant cardiovascular diagnosis was made in 36 (19.4%) of the 185 controls and 35 (19%) of the 184 intervention-group patients.

Researchers discovered one case of a missed or delayed diagnosis of ACS within 45 days, the study's primary safety end point, in a control-group patient, said lead investigator Dr. Jeffrey Kline and his colleagues in the department of emergency medicine, Carolinas Medical Center, Charlotte, N.C. The patient was diagnosed with unstable angina that was treated with a percutaneous intracoronary stent device 21 days after enrollment.

The rate of hospital admission of patients who had no significant cardiovascular diagnosis within 45 days was significantly higher among controls (11%) than in the intervention group (5%).

The rate of exposure to a thoracic imaging test that imparted greater than 5 mSv and had a negative result was significantly greater among controls (19.4%) than in the intervention group (8.6%). The lifetime risk of malignancy is thought to increase significantly after a dose of radiation that exceeds 5 mSv.

“If the results of this study are independently validated in a larger and different sample of patients, then clinicians will have evidence to justify the use of quantitative pretest probability, together with their own clinical instincts, to reduce excessive diagnostic testing in low-risk patients with chest pain,” Dr. Kline said in an interview.

Median length of stay in the emergency department was not significantly different between the control (11.4 hours) and intervention (9.2 hours) groups.

Based on telephone follow-up, patients in the intervention group were less likely than were those in the control group to be readmitted within 7 days of their emergency visit (4% vs. 11%), according to the investigators, who reported no relevant conflicts.