A 6-metabolite panel may help EPI diagnosis in chronic pancreatitis

Key clinical point: Blood specimens from patients with chronic pancreatitis (CP) yielded a panel of 6 metabolites that showed differential expression with the presence or absence of exocrine pancreatic insufficiency (EPI; fecal elastase < 200 mg/g). Findings highlight the usefulness of metabolic studies to identify novel biomarkers for EPI diagnosis in CP.

Major finding: A 6-metabolite panel including arginine-proline-threonine tripeptide, 1 phosphatidylcholine, pentasine, and 3 phosphatidylserines was effective in discriminating between the presence and absence of EPI in patients with CP (area under the receiver operator characteristic curve, 0.79; 95% CI 0.62-0.92).

Study details: This metabolic study included 53 patients with CP with (60.4%) or without (39.6%) EPI.

Disclosures: This study was funded by grants from the Junta de Andalucia and the Instituto de Salud Carlos III. The authors declared no conflict of interests.

Source: Díaz C et al. Medicina. 2021 Aug 26. doi: 10.3390/medicina57090876.

Key clinical point: Blood specimens from patients with chronic pancreatitis (CP) yielded a panel of 6 metabolites that showed differential expression with the presence or absence of exocrine pancreatic insufficiency (EPI; fecal elastase < 200 mg/g). Findings highlight the usefulness of metabolic studies to identify novel biomarkers for EPI diagnosis in CP.

Major finding: A 6-metabolite panel including arginine-proline-threonine tripeptide, 1 phosphatidylcholine, pentasine, and 3 phosphatidylserines was effective in discriminating between the presence and absence of EPI in patients with CP (area under the receiver operator characteristic curve, 0.79; 95% CI 0.62-0.92).

Study details: This metabolic study included 53 patients with CP with (60.4%) or without (39.6%) EPI.

Disclosures: This study was funded by grants from the Junta de Andalucia and the Instituto de Salud Carlos III. The authors declared no conflict of interests.

Source: Díaz C et al. Medicina. 2021 Aug 26. doi: 10.3390/medicina57090876.

Key clinical point: Blood specimens from patients with chronic pancreatitis (CP) yielded a panel of 6 metabolites that showed differential expression with the presence or absence of exocrine pancreatic insufficiency (EPI; fecal elastase < 200 mg/g). Findings highlight the usefulness of metabolic studies to identify novel biomarkers for EPI diagnosis in CP.

Major finding: A 6-metabolite panel including arginine-proline-threonine tripeptide, 1 phosphatidylcholine, pentasine, and 3 phosphatidylserines was effective in discriminating between the presence and absence of EPI in patients with CP (area under the receiver operator characteristic curve, 0.79; 95% CI 0.62-0.92).

Study details: This metabolic study included 53 patients with CP with (60.4%) or without (39.6%) EPI.

Disclosures: This study was funded by grants from the Junta de Andalucia and the Instituto de Salud Carlos III. The authors declared no conflict of interests.

Source: Díaz C et al. Medicina. 2021 Aug 26. doi: 10.3390/medicina57090876.