Maureen Donohue

Patients with type 1 diabetes and central obesity had a significantly increased risk of developing microalbuminuria in a study of 1,105 patients.

Investigators found that each 10-cm (4-inch) increase in waist circumference increased the risk of microalbuminuria by 34%. After almost 6 years of follow-up, the relationship remained significant after adjustment for other risk factors, including intensive insulin therapy, Dr. Ian H. de Boer and his colleagues at the University of Washington in Seattle reported.

They evaluated microalbuminuria levels of 1,105 patients with type 1 diabetes who had normal albumin secretion at baseline who were a part of the Diabetes Control and Complications Trial (DCCT) and were followed in the Epidemiology of Diabetes Interventions and Complications (EDIC) study, (J. Am. Soc. Nephrol. 2006 Dec. 6 [Epub doi:10.1681/ASN.2006040394]). DCCT was designed to study intensive insulin therapy versus conventional insulin therapy in patients with type 1 diabetes. At the end of that trial, all participants were invited to join the observational EDIC study.

During a median of 5.8 years of follow-up, 93 patients (8.4%) developed microalbuminuria. Incidence of microalbuminuria increased with waist circumference, and was greater in men than in women (10.7% vs. 5.8%) and in those who had been assigned in DCCT to conventional insulin therapy rather than intensive therapy (12.8% vs. 4.5%). At a median 8-year follow-up, creatinine clearance had declined by a mean of 0.34 mL/min per 1.73 m2. Waist circumference and change in creatinine clearance were not associated in unadjusted or adjusted analyses.

The investigators said further study is needed to corroborate the hypothesis that losing weight might help cut the risk of microalbuminuria in type 1 diabetics.

Patients with type 1 diabetes and central obesity had a significantly increased risk of developing microalbuminuria in a study of 1,105 patients.

Investigators found that each 10-cm (4-inch) increase in waist circumference increased the risk of microalbuminuria by 34%. After almost 6 years of follow-up, the relationship remained significant after adjustment for other risk factors, including intensive insulin therapy, Dr. Ian H. de Boer and his colleagues at the University of Washington in Seattle reported.

They evaluated microalbuminuria levels of 1,105 patients with type 1 diabetes who had normal albumin secretion at baseline who were a part of the Diabetes Control and Complications Trial (DCCT) and were followed in the Epidemiology of Diabetes Interventions and Complications (EDIC) study, (J. Am. Soc. Nephrol. 2006 Dec. 6 [Epub doi:10.1681/ASN.2006040394]). DCCT was designed to study intensive insulin therapy versus conventional insulin therapy in patients with type 1 diabetes. At the end of that trial, all participants were invited to join the observational EDIC study.

During a median of 5.8 years of follow-up, 93 patients (8.4%) developed microalbuminuria. Incidence of microalbuminuria increased with waist circumference, and was greater in men than in women (10.7% vs. 5.8%) and in those who had been assigned in DCCT to conventional insulin therapy rather than intensive therapy (12.8% vs. 4.5%). At a median 8-year follow-up, creatinine clearance had declined by a mean of 0.34 mL/min per 1.73 m2. Waist circumference and change in creatinine clearance were not associated in unadjusted or adjusted analyses.

The investigators said further study is needed to corroborate the hypothesis that losing weight might help cut the risk of microalbuminuria in type 1 diabetics.

Patients with type 1 diabetes and central obesity had a significantly increased risk of developing microalbuminuria in a study of 1,105 patients.

Investigators found that each 10-cm (4-inch) increase in waist circumference increased the risk of microalbuminuria by 34%. After almost 6 years of follow-up, the relationship remained significant after adjustment for other risk factors, including intensive insulin therapy, Dr. Ian H. de Boer and his colleagues at the University of Washington in Seattle reported.

They evaluated microalbuminuria levels of 1,105 patients with type 1 diabetes who had normal albumin secretion at baseline who were a part of the Diabetes Control and Complications Trial (DCCT) and were followed in the Epidemiology of Diabetes Interventions and Complications (EDIC) study, (J. Am. Soc. Nephrol. 2006 Dec. 6 [Epub doi:10.1681/ASN.2006040394]). DCCT was designed to study intensive insulin therapy versus conventional insulin therapy in patients with type 1 diabetes. At the end of that trial, all participants were invited to join the observational EDIC study.

During a median of 5.8 years of follow-up, 93 patients (8.4%) developed microalbuminuria. Incidence of microalbuminuria increased with waist circumference, and was greater in men than in women (10.7% vs. 5.8%) and in those who had been assigned in DCCT to conventional insulin therapy rather than intensive therapy (12.8% vs. 4.5%). At a median 8-year follow-up, creatinine clearance had declined by a mean of 0.34 mL/min per 1.73 m2. Waist circumference and change in creatinine clearance were not associated in unadjusted or adjusted analyses.

The investigators said further study is needed to corroborate the hypothesis that losing weight might help cut the risk of microalbuminuria in type 1 diabetics.

Patients with type 1 diabetes and central obesity had a significantly increased risk of developing microalbuminuria in a study of 1,105 patients.

Investigators found that each 10-cm (4-inch) increase in waist circumference increased the risk of microalbuminuria by 34%. After almost 6 years of follow-up, the relationship remained significant after adjustment for other risk factors, including intensive insulin therapy, Dr. Ian H. de Boer and his colleagues at the University of Washington in Seattle reported.

The investigators evaluated microalbuminuria levels of 1,105 patients with type 1 diabetes who were a part of the Diabetes Control and Complications Trial (DCCT) and were followed in the Epidemiology of Diabetes Interventions and Complications (EDIC) study, and who had normal albumin secretion at baseline (J. Am. Soc. Nephrol. 2006 Dec. 6 [Epub doi:10.1681/ASN.2006040394]).

DCCT was designed to study intensive insulin therapy versus conventional insulin therapy in patients with type 1 diabetes. At the end of that trial, all participants were invited to join the observational EDIC study.

During a median of 5.8 years of follow-up, 93 patients (8.4%) developed microalbuminuria. The incidence of microalbuminuria increased with waist circumference, and was greater in men than in women (10.7% versus 5.8%) and in those who had been assigned in DCCT to conventional insulin therapy rather than intensive therapy (12.8% versus 4.5%).

Patients with type 1 diabetes and central obesity had a significantly increased risk of developing microalbuminuria in a study of 1,105 patients.

Investigators found that each 10-cm (4-inch) increase in waist circumference increased the risk of microalbuminuria by 34%. After almost 6 years of follow-up, the relationship remained significant after adjustment for other risk factors, including intensive insulin therapy, Dr. Ian H. de Boer and his colleagues at the University of Washington in Seattle reported.

The investigators evaluated microalbuminuria levels of 1,105 patients with type 1 diabetes who were a part of the Diabetes Control and Complications Trial (DCCT) and were followed in the Epidemiology of Diabetes Interventions and Complications (EDIC) study, and who had normal albumin secretion at baseline (J. Am. Soc. Nephrol. 2006 Dec. 6 [Epub doi:10.1681/ASN.2006040394]).

DCCT was designed to study intensive insulin therapy versus conventional insulin therapy in patients with type 1 diabetes. At the end of that trial, all participants were invited to join the observational EDIC study.

During a median of 5.8 years of follow-up, 93 patients (8.4%) developed microalbuminuria. The incidence of microalbuminuria increased with waist circumference, and was greater in men than in women (10.7% versus 5.8%) and in those who had been assigned in DCCT to conventional insulin therapy rather than intensive therapy (12.8% versus 4.5%).

Patients with type 1 diabetes and central obesity had a significantly increased risk of developing microalbuminuria in a study of 1,105 patients.

Investigators found that each 10-cm (4-inch) increase in waist circumference increased the risk of microalbuminuria by 34%. After almost 6 years of follow-up, the relationship remained significant after adjustment for other risk factors, including intensive insulin therapy, Dr. Ian H. de Boer and his colleagues at the University of Washington in Seattle reported.

The investigators evaluated microalbuminuria levels of 1,105 patients with type 1 diabetes who were a part of the Diabetes Control and Complications Trial (DCCT) and were followed in the Epidemiology of Diabetes Interventions and Complications (EDIC) study, and who had normal albumin secretion at baseline (J. Am. Soc. Nephrol. 2006 Dec. 6 [Epub doi:10.1681/ASN.2006040394]).

DCCT was designed to study intensive insulin therapy versus conventional insulin therapy in patients with type 1 diabetes. At the end of that trial, all participants were invited to join the observational EDIC study.

During a median of 5.8 years of follow-up, 93 patients (8.4%) developed microalbuminuria. The incidence of microalbuminuria increased with waist circumference, and was greater in men than in women (10.7% versus 5.8%) and in those who had been assigned in DCCT to conventional insulin therapy rather than intensive therapy (12.8% versus 4.5%).

A high-sucrose diet may not play as significant a role in the development of insulin sensitivity in healthy, nondiabetic subjects as previously thought, a study suggests.

These findings suggested that factors other than sucrose—including caloric overload, a sedentary lifestyle, and weight gain—may be more important than carbohydrate type in determining the eventual development of type 2 diabetes.

Investigators in the study, which was supported by an unrestricted research grant from the U.K. Sugar Bureau and Suikerstichting Nederland (the Dutch sugar foundation), randomized nearly identical eucaloric diets containing either 25% or 10% sucrose (as a percentage of total energy intake) in 13 healthy men with a mean body mass index (kg/m

Women were excluded from the study to prevent the effects of the menstrual cycle from affecting the end points of the study, reported R. Neil A. Black of the Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast (Northern Ireland), and associates (Diabetes 2006;55:3566–72).

Insulin resistance was assessed using a two-step euglycemic clamp. Glycemic profiles were evaluated by a continuous glucose monitoring system, and vascular compliance was evaluated by pulse wave analysis.

Neither fasting hepatic glucose production nor suppression during low-dose insulin infusion was altered by dietary sucrose content, suggesting no abnormality of hepatic insulin action. There was also no difference in peripheral insulin resistance between the two dietary periods.

The results did indicate a trend toward an increase in insulin sensitivity with the high-sucrose diet, although this finding was not statistically significant and is likely the result of chance, the authors noted.

They also cautioned that the results of this study cannot be extrapolated to type 2 diabetes, and said that “further information regarding the impact of severe restriction of sucrose intake in low-carbohydrate weight-reduction diets is also needed.”

A high-sucrose diet may not play as significant a role in the development of insulin sensitivity in healthy, nondiabetic subjects as previously thought, a study suggests.

These findings suggested that factors other than sucrose—including caloric overload, a sedentary lifestyle, and weight gain—may be more important than carbohydrate type in determining the eventual development of type 2 diabetes.

Investigators in the study, which was supported by an unrestricted research grant from the U.K. Sugar Bureau and Suikerstichting Nederland (the Dutch sugar foundation), randomized nearly identical eucaloric diets containing either 25% or 10% sucrose (as a percentage of total energy intake) in 13 healthy men with a mean body mass index (kg/m

Women were excluded from the study to prevent the effects of the menstrual cycle from affecting the end points of the study, reported R. Neil A. Black of the Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast (Northern Ireland), and associates (Diabetes 2006;55:3566–72).

Insulin resistance was assessed using a two-step euglycemic clamp. Glycemic profiles were evaluated by a continuous glucose monitoring system, and vascular compliance was evaluated by pulse wave analysis.

Neither fasting hepatic glucose production nor suppression during low-dose insulin infusion was altered by dietary sucrose content, suggesting no abnormality of hepatic insulin action. There was also no difference in peripheral insulin resistance between the two dietary periods.

The results did indicate a trend toward an increase in insulin sensitivity with the high-sucrose diet, although this finding was not statistically significant and is likely the result of chance, the authors noted.

They also cautioned that the results of this study cannot be extrapolated to type 2 diabetes, and said that “further information regarding the impact of severe restriction of sucrose intake in low-carbohydrate weight-reduction diets is also needed.”

A high-sucrose diet may not play as significant a role in the development of insulin sensitivity in healthy, nondiabetic subjects as previously thought, a study suggests.

These findings suggested that factors other than sucrose—including caloric overload, a sedentary lifestyle, and weight gain—may be more important than carbohydrate type in determining the eventual development of type 2 diabetes.

Investigators in the study, which was supported by an unrestricted research grant from the U.K. Sugar Bureau and Suikerstichting Nederland (the Dutch sugar foundation), randomized nearly identical eucaloric diets containing either 25% or 10% sucrose (as a percentage of total energy intake) in 13 healthy men with a mean body mass index (kg/m

Women were excluded from the study to prevent the effects of the menstrual cycle from affecting the end points of the study, reported R. Neil A. Black of the Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast (Northern Ireland), and associates (Diabetes 2006;55:3566–72).

Insulin resistance was assessed using a two-step euglycemic clamp. Glycemic profiles were evaluated by a continuous glucose monitoring system, and vascular compliance was evaluated by pulse wave analysis.

Neither fasting hepatic glucose production nor suppression during low-dose insulin infusion was altered by dietary sucrose content, suggesting no abnormality of hepatic insulin action. There was also no difference in peripheral insulin resistance between the two dietary periods.

The results did indicate a trend toward an increase in insulin sensitivity with the high-sucrose diet, although this finding was not statistically significant and is likely the result of chance, the authors noted.

They also cautioned that the results of this study cannot be extrapolated to type 2 diabetes, and said that “further information regarding the impact of severe restriction of sucrose intake in low-carbohydrate weight-reduction diets is also needed.”