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Key clinical point: Breath gas patterns are linked to distinct gut microtypes in diarrhea-predominant irritable bowel syndrome (IBS-D) and constipation-predominant IBS (IBS-C).
Major finding: Patients with IBS-D vs IBS-C had a higher area under the curve (AUC) for hydrogen (P = .02) and hydrogen sulfide (P = .002), whereas those with IBS-C vs IBS-D had a higher AUC for methane (P = .002). Higher breath methane in IBS-C correlated with higher breath microbial diversity, whereas higher breath hydrogen and hydrogen sulfide in IBS-D correlated with lower microbial diversity and higher relative abundance of hydrogen sulfide-producing bacteria, respectively.
Study details: The data come from two randomized controlled trials including patients with IBS-C (n = 124) and IBS-D (n = 47).
Disclosures: This study was partly funded by the Monica Lester Charitable Trust; Elias, Genevieve, and Georgianna Atol Charitable Trust; and others. Some authors declared receiving research grants or serving as consultants or speakers for various sources.
Source: Villanueva-Millan MJ et al. Methanogens and hydrogen sulfide producing bacteria guide distinct gut microbe profiles and irritable bowel syndrome subtypes. Am J Gastroenterol. 2022 (Sep 6). Doi: 10.14309/ajg.0000000000001997
Key clinical point: Breath gas patterns are linked to distinct gut microtypes in diarrhea-predominant irritable bowel syndrome (IBS-D) and constipation-predominant IBS (IBS-C).
Major finding: Patients with IBS-D vs IBS-C had a higher area under the curve (AUC) for hydrogen (P = .02) and hydrogen sulfide (P = .002), whereas those with IBS-C vs IBS-D had a higher AUC for methane (P = .002). Higher breath methane in IBS-C correlated with higher breath microbial diversity, whereas higher breath hydrogen and hydrogen sulfide in IBS-D correlated with lower microbial diversity and higher relative abundance of hydrogen sulfide-producing bacteria, respectively.
Study details: The data come from two randomized controlled trials including patients with IBS-C (n = 124) and IBS-D (n = 47).
Disclosures: This study was partly funded by the Monica Lester Charitable Trust; Elias, Genevieve, and Georgianna Atol Charitable Trust; and others. Some authors declared receiving research grants or serving as consultants or speakers for various sources.
Source: Villanueva-Millan MJ et al. Methanogens and hydrogen sulfide producing bacteria guide distinct gut microbe profiles and irritable bowel syndrome subtypes. Am J Gastroenterol. 2022 (Sep 6). Doi: 10.14309/ajg.0000000000001997
Key clinical point: Breath gas patterns are linked to distinct gut microtypes in diarrhea-predominant irritable bowel syndrome (IBS-D) and constipation-predominant IBS (IBS-C).
Major finding: Patients with IBS-D vs IBS-C had a higher area under the curve (AUC) for hydrogen (P = .02) and hydrogen sulfide (P = .002), whereas those with IBS-C vs IBS-D had a higher AUC for methane (P = .002). Higher breath methane in IBS-C correlated with higher breath microbial diversity, whereas higher breath hydrogen and hydrogen sulfide in IBS-D correlated with lower microbial diversity and higher relative abundance of hydrogen sulfide-producing bacteria, respectively.
Study details: The data come from two randomized controlled trials including patients with IBS-C (n = 124) and IBS-D (n = 47).
Disclosures: This study was partly funded by the Monica Lester Charitable Trust; Elias, Genevieve, and Georgianna Atol Charitable Trust; and others. Some authors declared receiving research grants or serving as consultants or speakers for various sources.
Source: Villanueva-Millan MJ et al. Methanogens and hydrogen sulfide producing bacteria guide distinct gut microbe profiles and irritable bowel syndrome subtypes. Am J Gastroenterol. 2022 (Sep 6). Doi: 10.14309/ajg.0000000000001997