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Key clinical point: Cimetropium, drotaverine, and acupuncture were more effective in improving abdominal pain than placebo in patients with irritable bowel syndrome (IBS), with acupuncture being more effective than pinaverium in relieving global IBS symptoms and causing fewer adverse events than other antispasmodics.
Major finding: Cimetropium (standardized mean difference [SMD] −3.00; 95% CI −4.47 to −1.53) was the most effective for relieving abdominal pain, with drotaverine, acupuncture, and pinaverium being superior to placebo. Acupuncture vs pinaverium more effectively relieved global IBS symptoms (SMD −1.11; 95% CI −1.94 to −0.28). The adverse event rate was lower with acupuncture vs most antispasmodics.
Study details: The data come from an adjusted indirect treatment comparison meta-analysis of 35 randomized control trials including 5190 participants.
Disclosures: This study was supported by the National Key Research and Development Program of the Ministry of Science and Technology of the People’s Republic of China and others. The authors declared no conflicts of interest.
Source: Shi YZ et al. Acupuncture vs antispasmodics in the treatment of irritable bowel syndrome: An adjusted indirect treatment comparison meta-analysis. Front Physiol. 2022; 13:1001978 (Oct 6). Doi: 10.3389/fphys.2022.1001978
Key clinical point: Cimetropium, drotaverine, and acupuncture were more effective in improving abdominal pain than placebo in patients with irritable bowel syndrome (IBS), with acupuncture being more effective than pinaverium in relieving global IBS symptoms and causing fewer adverse events than other antispasmodics.
Major finding: Cimetropium (standardized mean difference [SMD] −3.00; 95% CI −4.47 to −1.53) was the most effective for relieving abdominal pain, with drotaverine, acupuncture, and pinaverium being superior to placebo. Acupuncture vs pinaverium more effectively relieved global IBS symptoms (SMD −1.11; 95% CI −1.94 to −0.28). The adverse event rate was lower with acupuncture vs most antispasmodics.
Study details: The data come from an adjusted indirect treatment comparison meta-analysis of 35 randomized control trials including 5190 participants.
Disclosures: This study was supported by the National Key Research and Development Program of the Ministry of Science and Technology of the People’s Republic of China and others. The authors declared no conflicts of interest.
Source: Shi YZ et al. Acupuncture vs antispasmodics in the treatment of irritable bowel syndrome: An adjusted indirect treatment comparison meta-analysis. Front Physiol. 2022; 13:1001978 (Oct 6). Doi: 10.3389/fphys.2022.1001978
Key clinical point: Cimetropium, drotaverine, and acupuncture were more effective in improving abdominal pain than placebo in patients with irritable bowel syndrome (IBS), with acupuncture being more effective than pinaverium in relieving global IBS symptoms and causing fewer adverse events than other antispasmodics.
Major finding: Cimetropium (standardized mean difference [SMD] −3.00; 95% CI −4.47 to −1.53) was the most effective for relieving abdominal pain, with drotaverine, acupuncture, and pinaverium being superior to placebo. Acupuncture vs pinaverium more effectively relieved global IBS symptoms (SMD −1.11; 95% CI −1.94 to −0.28). The adverse event rate was lower with acupuncture vs most antispasmodics.
Study details: The data come from an adjusted indirect treatment comparison meta-analysis of 35 randomized control trials including 5190 participants.
Disclosures: This study was supported by the National Key Research and Development Program of the Ministry of Science and Technology of the People’s Republic of China and others. The authors declared no conflicts of interest.
Source: Shi YZ et al. Acupuncture vs antispasmodics in the treatment of irritable bowel syndrome: An adjusted indirect treatment comparison meta-analysis. Front Physiol. 2022; 13:1001978 (Oct 6). Doi: 10.3389/fphys.2022.1001978