Terry Rudd has covered clinical news and health policy as a reporter and editor since 1994.

Human hair’s super strength and boiled diabetes

Article Type
Changed
Thu, 01/16/2020 - 12:22

 

Stop us if you’ve heard this one

Dean Bertoncelj/iStockphoto
Hair salon

An elephant, a capybara, and a horse walk into a bar …

What? You’ve heard it? Really? … No, not really? You were just pulling our leg. Very funny.

Can we go on now? You’re sure? Because if there’s one thing we love, it’s reader participation.

Anyway, there’s this bar, and a bunch of researchers from the University of California’s San Diego and Berkeley campuses are hanging out with a bear, a boar, a javelina (looks and sounds like a pig, about the size of a border collie), and a giraffe when the aforementioned trio shows up.

They see all these mammals together and get an idea. Why not compare the tensile strength of their hair with that of a human adult and child? The next day, after sobering up, they started collecting hair samples.[Legal note: The situation at the bar is a literary device. At no time did the investigators conduct any of their work in such a place.]

Once that was done, uniaxial tension tests were conducted, as you would expect, using an Instron 3342 universal testing system equipped with a 500-N load cell at a strain rate of 10–2s–1.

The results, however, were not expected. Thin hairs are stronger than thick hairs. Hair from a human, with an average diameter of about 60 mcm, is stronger than hair from a boar (average diameter, 235 mcm) or a horse (average diameter, 200 mcm), and the weakest hair of all came from an elephant (diameter of 345 mcm) and a giraffe (diameter of 370 mcm). Also, the hair from the 9-year-old child is stronger than the thicker hair of the 30-year-old adult.

The results show that the inherent strength of human hair’s hierarchical structure – an outer layer, or cuticle, “wraps around an inner cortex made of many small fibers linked by chemical bonds” – makes it resistant to deformation, the investigators explained. They hope that synthetic materials with a similar structure could become lighter and stronger in the future.

Now what? The punchline? All this valuable hair information isn’t enough? Fine.

The shocked bartender, who’s already got the makings of a small zoo in his establishment, points a finger in alarm at the latest arrivals and yells, “Hey!” The horse says, “You read my mind, buddy.”


 

Boiled type 2 diabetes

amenic181/Getty Images

Ah, coffee. Is there anything it can’t do? From speeding up delivery of this tardy column (if not boosting its comedy quotient) to reducing the risk of type 2 diabetes, the magic bean seems nearly omnipotent. But java’s magical metabolic properties may be entirely dependent on how you brew your brown elixir.

Coffee-fueled Scandinavians have determined that the stimulating liquid’s antidiabetes effect is only possible when you don’t boil your beans. For those eager to ward off type 2 diabetes, filtered coffee – not boiled coffee – is the ticket to lower insulin resistance.

Researchers at Chalmers University of Technology in Gothenburg, Sweden, and Umeå (Sweden) University identified biomarkers that distinguished the consumption of filtered coffee from its boiled cousin. They found that people who drank two to three cups of filtered coffee a day enjoyed a 60% lower risk of type 2 diabetes than did those who subsisted on less than one cup of filtered coffee per day. But drinking boiled coffee did nothing to dent drinkers’ diabetes risk.

Why the difference? The coffee-sipping Swedish investigators say boiled coffee contains diterpenes, which don’t make it past a coffee filter. Other studies have shown diterpenes inflate the risk of heart and vascular diseases. And the researchers say those unfiltered diterpenes may sap your morning cuppa joe’s antidiabetes powers.

We know what you’re thinking: Who boils powdered coffee? Is Sanka even a thing anymore? It’s an approach that’s unfamiliar to most Mr. Coffee–owning Scandinavians and American java junkies alike. But before you, like us, take another smug sip from that cup you just made in the Keurig machine, know this: Coffee pod machines deal out hot, unfiltered brew.

Maybe just add two sugar packets next time. Your beta cells will thank you.
 

 

 

Let my people poop!

Panama7/iStock/Getty Images Plus

This is the way the world ends, this is the way the world ends: Not with a bang, but a tilted toilet.

The latest piece of late-stage capitalistic horror comes from Great Britain, and has lovingly been called the “StandardToilet.” No dystopian overtones there, absolutely not. The toilet’s “genius” lies in the seat’s 13-degree downward slope, which increases strain on the legs just like a squat thrust would. Sit on one for more than 5 minutes, and the pain becomes too much to handle.

The inventor of the StandardToilet claims that his product will cut time employees spend on the toilet by 25%, saving businesses as much as 4.8 billion pounds sterling a year. Not only that, he suggests that there are numerous health benefits, such as reduced hemorrhoid risk and a reduction of musculoskeletal disorders.

Critics were quick to point out that people with disabilities would likely have accessibility issues (and let’s not forget people with GI diseases), and a bathroom space expert (yes, that’s a thing) suggested that, if employees are spending too much time on the toilet, the issue is likely not laziness but the poor state of affairs in the workplace itself.

As purveyors of quality toilet- and poop-themed humor, we here at Livin’ on the MDedge world headquarters think it would be a shame if the giant corporations of the world took away normal toilets. So we say to the downtrodden proletariat: Workers of the world, unite! You have nothing to lose but your toilets!
 

Livin’ on the MDedge will be taking a holiday break, but we’ll be back to advance medical science in January!

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Stop us if you’ve heard this one

Dean Bertoncelj/iStockphoto
Hair salon

An elephant, a capybara, and a horse walk into a bar …

What? You’ve heard it? Really? … No, not really? You were just pulling our leg. Very funny.

Can we go on now? You’re sure? Because if there’s one thing we love, it’s reader participation.

Anyway, there’s this bar, and a bunch of researchers from the University of California’s San Diego and Berkeley campuses are hanging out with a bear, a boar, a javelina (looks and sounds like a pig, about the size of a border collie), and a giraffe when the aforementioned trio shows up.

They see all these mammals together and get an idea. Why not compare the tensile strength of their hair with that of a human adult and child? The next day, after sobering up, they started collecting hair samples.[Legal note: The situation at the bar is a literary device. At no time did the investigators conduct any of their work in such a place.]

Once that was done, uniaxial tension tests were conducted, as you would expect, using an Instron 3342 universal testing system equipped with a 500-N load cell at a strain rate of 10–2s–1.

The results, however, were not expected. Thin hairs are stronger than thick hairs. Hair from a human, with an average diameter of about 60 mcm, is stronger than hair from a boar (average diameter, 235 mcm) or a horse (average diameter, 200 mcm), and the weakest hair of all came from an elephant (diameter of 345 mcm) and a giraffe (diameter of 370 mcm). Also, the hair from the 9-year-old child is stronger than the thicker hair of the 30-year-old adult.

The results show that the inherent strength of human hair’s hierarchical structure – an outer layer, or cuticle, “wraps around an inner cortex made of many small fibers linked by chemical bonds” – makes it resistant to deformation, the investigators explained. They hope that synthetic materials with a similar structure could become lighter and stronger in the future.

Now what? The punchline? All this valuable hair information isn’t enough? Fine.

The shocked bartender, who’s already got the makings of a small zoo in his establishment, points a finger in alarm at the latest arrivals and yells, “Hey!” The horse says, “You read my mind, buddy.”


 

Boiled type 2 diabetes

amenic181/Getty Images

Ah, coffee. Is there anything it can’t do? From speeding up delivery of this tardy column (if not boosting its comedy quotient) to reducing the risk of type 2 diabetes, the magic bean seems nearly omnipotent. But java’s magical metabolic properties may be entirely dependent on how you brew your brown elixir.

Coffee-fueled Scandinavians have determined that the stimulating liquid’s antidiabetes effect is only possible when you don’t boil your beans. For those eager to ward off type 2 diabetes, filtered coffee – not boiled coffee – is the ticket to lower insulin resistance.

Researchers at Chalmers University of Technology in Gothenburg, Sweden, and Umeå (Sweden) University identified biomarkers that distinguished the consumption of filtered coffee from its boiled cousin. They found that people who drank two to three cups of filtered coffee a day enjoyed a 60% lower risk of type 2 diabetes than did those who subsisted on less than one cup of filtered coffee per day. But drinking boiled coffee did nothing to dent drinkers’ diabetes risk.

Why the difference? The coffee-sipping Swedish investigators say boiled coffee contains diterpenes, which don’t make it past a coffee filter. Other studies have shown diterpenes inflate the risk of heart and vascular diseases. And the researchers say those unfiltered diterpenes may sap your morning cuppa joe’s antidiabetes powers.

We know what you’re thinking: Who boils powdered coffee? Is Sanka even a thing anymore? It’s an approach that’s unfamiliar to most Mr. Coffee–owning Scandinavians and American java junkies alike. But before you, like us, take another smug sip from that cup you just made in the Keurig machine, know this: Coffee pod machines deal out hot, unfiltered brew.

Maybe just add two sugar packets next time. Your beta cells will thank you.
 

 

 

Let my people poop!

Panama7/iStock/Getty Images Plus

This is the way the world ends, this is the way the world ends: Not with a bang, but a tilted toilet.

The latest piece of late-stage capitalistic horror comes from Great Britain, and has lovingly been called the “StandardToilet.” No dystopian overtones there, absolutely not. The toilet’s “genius” lies in the seat’s 13-degree downward slope, which increases strain on the legs just like a squat thrust would. Sit on one for more than 5 minutes, and the pain becomes too much to handle.

The inventor of the StandardToilet claims that his product will cut time employees spend on the toilet by 25%, saving businesses as much as 4.8 billion pounds sterling a year. Not only that, he suggests that there are numerous health benefits, such as reduced hemorrhoid risk and a reduction of musculoskeletal disorders.

Critics were quick to point out that people with disabilities would likely have accessibility issues (and let’s not forget people with GI diseases), and a bathroom space expert (yes, that’s a thing) suggested that, if employees are spending too much time on the toilet, the issue is likely not laziness but the poor state of affairs in the workplace itself.

As purveyors of quality toilet- and poop-themed humor, we here at Livin’ on the MDedge world headquarters think it would be a shame if the giant corporations of the world took away normal toilets. So we say to the downtrodden proletariat: Workers of the world, unite! You have nothing to lose but your toilets!
 

Livin’ on the MDedge will be taking a holiday break, but we’ll be back to advance medical science in January!

 

Stop us if you’ve heard this one

Dean Bertoncelj/iStockphoto
Hair salon

An elephant, a capybara, and a horse walk into a bar …

What? You’ve heard it? Really? … No, not really? You were just pulling our leg. Very funny.

Can we go on now? You’re sure? Because if there’s one thing we love, it’s reader participation.

Anyway, there’s this bar, and a bunch of researchers from the University of California’s San Diego and Berkeley campuses are hanging out with a bear, a boar, a javelina (looks and sounds like a pig, about the size of a border collie), and a giraffe when the aforementioned trio shows up.

They see all these mammals together and get an idea. Why not compare the tensile strength of their hair with that of a human adult and child? The next day, after sobering up, they started collecting hair samples.[Legal note: The situation at the bar is a literary device. At no time did the investigators conduct any of their work in such a place.]

Once that was done, uniaxial tension tests were conducted, as you would expect, using an Instron 3342 universal testing system equipped with a 500-N load cell at a strain rate of 10–2s–1.

The results, however, were not expected. Thin hairs are stronger than thick hairs. Hair from a human, with an average diameter of about 60 mcm, is stronger than hair from a boar (average diameter, 235 mcm) or a horse (average diameter, 200 mcm), and the weakest hair of all came from an elephant (diameter of 345 mcm) and a giraffe (diameter of 370 mcm). Also, the hair from the 9-year-old child is stronger than the thicker hair of the 30-year-old adult.

The results show that the inherent strength of human hair’s hierarchical structure – an outer layer, or cuticle, “wraps around an inner cortex made of many small fibers linked by chemical bonds” – makes it resistant to deformation, the investigators explained. They hope that synthetic materials with a similar structure could become lighter and stronger in the future.

Now what? The punchline? All this valuable hair information isn’t enough? Fine.

The shocked bartender, who’s already got the makings of a small zoo in his establishment, points a finger in alarm at the latest arrivals and yells, “Hey!” The horse says, “You read my mind, buddy.”


 

Boiled type 2 diabetes

amenic181/Getty Images

Ah, coffee. Is there anything it can’t do? From speeding up delivery of this tardy column (if not boosting its comedy quotient) to reducing the risk of type 2 diabetes, the magic bean seems nearly omnipotent. But java’s magical metabolic properties may be entirely dependent on how you brew your brown elixir.

Coffee-fueled Scandinavians have determined that the stimulating liquid’s antidiabetes effect is only possible when you don’t boil your beans. For those eager to ward off type 2 diabetes, filtered coffee – not boiled coffee – is the ticket to lower insulin resistance.

Researchers at Chalmers University of Technology in Gothenburg, Sweden, and Umeå (Sweden) University identified biomarkers that distinguished the consumption of filtered coffee from its boiled cousin. They found that people who drank two to three cups of filtered coffee a day enjoyed a 60% lower risk of type 2 diabetes than did those who subsisted on less than one cup of filtered coffee per day. But drinking boiled coffee did nothing to dent drinkers’ diabetes risk.

Why the difference? The coffee-sipping Swedish investigators say boiled coffee contains diterpenes, which don’t make it past a coffee filter. Other studies have shown diterpenes inflate the risk of heart and vascular diseases. And the researchers say those unfiltered diterpenes may sap your morning cuppa joe’s antidiabetes powers.

We know what you’re thinking: Who boils powdered coffee? Is Sanka even a thing anymore? It’s an approach that’s unfamiliar to most Mr. Coffee–owning Scandinavians and American java junkies alike. But before you, like us, take another smug sip from that cup you just made in the Keurig machine, know this: Coffee pod machines deal out hot, unfiltered brew.

Maybe just add two sugar packets next time. Your beta cells will thank you.
 

 

 

Let my people poop!

Panama7/iStock/Getty Images Plus

This is the way the world ends, this is the way the world ends: Not with a bang, but a tilted toilet.

The latest piece of late-stage capitalistic horror comes from Great Britain, and has lovingly been called the “StandardToilet.” No dystopian overtones there, absolutely not. The toilet’s “genius” lies in the seat’s 13-degree downward slope, which increases strain on the legs just like a squat thrust would. Sit on one for more than 5 minutes, and the pain becomes too much to handle.

The inventor of the StandardToilet claims that his product will cut time employees spend on the toilet by 25%, saving businesses as much as 4.8 billion pounds sterling a year. Not only that, he suggests that there are numerous health benefits, such as reduced hemorrhoid risk and a reduction of musculoskeletal disorders.

Critics were quick to point out that people with disabilities would likely have accessibility issues (and let’s not forget people with GI diseases), and a bathroom space expert (yes, that’s a thing) suggested that, if employees are spending too much time on the toilet, the issue is likely not laziness but the poor state of affairs in the workplace itself.

As purveyors of quality toilet- and poop-themed humor, we here at Livin’ on the MDedge world headquarters think it would be a shame if the giant corporations of the world took away normal toilets. So we say to the downtrodden proletariat: Workers of the world, unite! You have nothing to lose but your toilets!
 

Livin’ on the MDedge will be taking a holiday break, but we’ll be back to advance medical science in January!

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Tales of nasal terror, and dental hoverboarding

Article Type
Changed
Thu, 01/16/2020 - 12:22

 

A cure for nosiness

Christmas may be just around the corner, but is there ever really a wrong time to huddle around a campfire and swap scary stories? So bundle up, get the fire going, and prepare yourselves for a pair of nasal-based horror stories that will frighten your Jingle Bells off!

RusN/iStock/Getty Images Plus

Our first tale of nostril terror comes all the way from southern India, where a 13-year-old boy jumped into a water well to cool off. Hey, southern India gets hot, even in November. But like something out of a bad sci-fi movie, his peaceful swim was interrupted when something swam up his nose, causing him extreme pain. After a 30-minute procedure, the doctor pulled out the culprit: A horrific alien parasite! Okay, we’re lying; it was a fish. But we had you going, didn’t we?

Well, maybe that didn’t get you frightened. But we have more rhinal dread to share! A young girl in Las Vegas stuck a pair of plastic doll shoes up her nose, one in each nostril. Her mother removed one shoe, but neither she nor urgent care could reach the second. A trip to the hospital was in order, and once there, the doctors were able to remove the foreign object in seconds.

But as with all things in U.S. medicine, a reckoning would soon come. You feel it now, the dread in this woman’s heart when the hospital bill came.

She takes the envelope, and opens it slowly.

The paper unfolds, rough and heavy in her hands.

Her eyes scan the page, looking for the number, where is it, where is it? It must be here, it must be ...

$3,000.

That’s right, for this simple procedure, performed with a pair of fancy tweezers, the hospital saw fit to charge the hapless mother $3,000! AHHHHHHHHHHHH!

Some say that the mother’s high-deductible insurance policy reduced the cost to $1,700. But we ask you, does that make the story any less spooky? We think not.
 

Hoverboarding down the root canal

Time spent in the dentist’s chair is among the most anxiety-inducing in anyone’s life. The needles. The grinding. The drilling. The rinsing. The spitting. The throbbing copays.

RobertoDavid/iStock/Getty Images Plus

But you know what might inject a few cc’s of fun into your oral hygiene visits?

Did you guess ... a hoverboard?

If you did, well, you’re probably dentist Steve Martin in “Little Shop of Horrors.” Or perhaps Alaska dentist Seth Lookhart, who authorities say performed a tooth extraction on a sedated patient while Dr. Lookhart also rode a hoverboard. There are also charges of felony Medicaid fraud and reckless endangerment. And allegations of hefty theft from his practice partners. Oh, and a state board apparently suspended Dr. Lookhart’s dental license in 2017.

But hey, pulling teeth while taming a hoverboard? Photos or it didn’t happen, right?

Unfortunately for the well-balanced dentist, there are photos. Actually, there’s an entire video. And when prosecutors showed it to Dr. Lookhart’s unwitting and horrified costar, she was about as happy as the impacted wisdom teeth your teen kid’s still toting around.

Dr. Lookhart denied the felony fraud charges. But he did cop to the hoverboard. Which puts him one up on his cinematic “Wild and Crazy Guy” doppelganger. Even as a neurosurgeon in “The Man With Two Brains,” Mr. Martin never attempted to hoverboard while performing double “cranial screw-top” brain surgeries.
 

 

 

CSI: Quebec

They may live in that eternally polite land on the other side of our northern border, but they know where the bodies are buried. Lots of bodies. Some of them in shallow graves. Some of them in vehicles.

MicroStockHub/iStock/Getty Images Plus

No, we are not talking about Gil Grissom and the gang at CSI. We’re talking about the Secure Site for Research in Thanatology, also known as the “body farm,” which is scheduled to open this spring in Becancour, Quebec.

It’s the first such outdoor forensic facility in Canada and the first in the world – there are also body farms in the United States, Australia, and the Netherlands – to be located in a northern climate.

“We’re particularly interested in understanding what happens when a body is in subzero temperatures, when there’s a lot of snow on the ground, and how that freeze and then the thaw process might actually change the rate of decomposition,” Shari Forbes, the farm’s director, told CTV News recently.

The science team will be out on the farm every day, meticulously checking each body – talk about making a list and checking it twice – for all the important CSI stuff: how long fingerprints and DNA evidence last, the effects of insect feeding and egg-laying, and the ability of dogs to detect scents.

The decomposition process in a cold climate will be a strange and wondrous journey, and the body farm’s work can, perhaps, best be summed up by none other than Mr. Grissom, who once said that getting to the evidence means having to destroy the evidence.

Then again, he also said that “dead men don’t ride roller coasters,” so the analogy only goes so far.

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A cure for nosiness

Christmas may be just around the corner, but is there ever really a wrong time to huddle around a campfire and swap scary stories? So bundle up, get the fire going, and prepare yourselves for a pair of nasal-based horror stories that will frighten your Jingle Bells off!

RusN/iStock/Getty Images Plus

Our first tale of nostril terror comes all the way from southern India, where a 13-year-old boy jumped into a water well to cool off. Hey, southern India gets hot, even in November. But like something out of a bad sci-fi movie, his peaceful swim was interrupted when something swam up his nose, causing him extreme pain. After a 30-minute procedure, the doctor pulled out the culprit: A horrific alien parasite! Okay, we’re lying; it was a fish. But we had you going, didn’t we?

Well, maybe that didn’t get you frightened. But we have more rhinal dread to share! A young girl in Las Vegas stuck a pair of plastic doll shoes up her nose, one in each nostril. Her mother removed one shoe, but neither she nor urgent care could reach the second. A trip to the hospital was in order, and once there, the doctors were able to remove the foreign object in seconds.

But as with all things in U.S. medicine, a reckoning would soon come. You feel it now, the dread in this woman’s heart when the hospital bill came.

She takes the envelope, and opens it slowly.

The paper unfolds, rough and heavy in her hands.

Her eyes scan the page, looking for the number, where is it, where is it? It must be here, it must be ...

$3,000.

That’s right, for this simple procedure, performed with a pair of fancy tweezers, the hospital saw fit to charge the hapless mother $3,000! AHHHHHHHHHHHH!

Some say that the mother’s high-deductible insurance policy reduced the cost to $1,700. But we ask you, does that make the story any less spooky? We think not.
 

Hoverboarding down the root canal

Time spent in the dentist’s chair is among the most anxiety-inducing in anyone’s life. The needles. The grinding. The drilling. The rinsing. The spitting. The throbbing copays.

RobertoDavid/iStock/Getty Images Plus

But you know what might inject a few cc’s of fun into your oral hygiene visits?

Did you guess ... a hoverboard?

If you did, well, you’re probably dentist Steve Martin in “Little Shop of Horrors.” Or perhaps Alaska dentist Seth Lookhart, who authorities say performed a tooth extraction on a sedated patient while Dr. Lookhart also rode a hoverboard. There are also charges of felony Medicaid fraud and reckless endangerment. And allegations of hefty theft from his practice partners. Oh, and a state board apparently suspended Dr. Lookhart’s dental license in 2017.

But hey, pulling teeth while taming a hoverboard? Photos or it didn’t happen, right?

Unfortunately for the well-balanced dentist, there are photos. Actually, there’s an entire video. And when prosecutors showed it to Dr. Lookhart’s unwitting and horrified costar, she was about as happy as the impacted wisdom teeth your teen kid’s still toting around.

Dr. Lookhart denied the felony fraud charges. But he did cop to the hoverboard. Which puts him one up on his cinematic “Wild and Crazy Guy” doppelganger. Even as a neurosurgeon in “The Man With Two Brains,” Mr. Martin never attempted to hoverboard while performing double “cranial screw-top” brain surgeries.
 

 

 

CSI: Quebec

They may live in that eternally polite land on the other side of our northern border, but they know where the bodies are buried. Lots of bodies. Some of them in shallow graves. Some of them in vehicles.

MicroStockHub/iStock/Getty Images Plus

No, we are not talking about Gil Grissom and the gang at CSI. We’re talking about the Secure Site for Research in Thanatology, also known as the “body farm,” which is scheduled to open this spring in Becancour, Quebec.

It’s the first such outdoor forensic facility in Canada and the first in the world – there are also body farms in the United States, Australia, and the Netherlands – to be located in a northern climate.

“We’re particularly interested in understanding what happens when a body is in subzero temperatures, when there’s a lot of snow on the ground, and how that freeze and then the thaw process might actually change the rate of decomposition,” Shari Forbes, the farm’s director, told CTV News recently.

The science team will be out on the farm every day, meticulously checking each body – talk about making a list and checking it twice – for all the important CSI stuff: how long fingerprints and DNA evidence last, the effects of insect feeding and egg-laying, and the ability of dogs to detect scents.

The decomposition process in a cold climate will be a strange and wondrous journey, and the body farm’s work can, perhaps, best be summed up by none other than Mr. Grissom, who once said that getting to the evidence means having to destroy the evidence.

Then again, he also said that “dead men don’t ride roller coasters,” so the analogy only goes so far.

 

A cure for nosiness

Christmas may be just around the corner, but is there ever really a wrong time to huddle around a campfire and swap scary stories? So bundle up, get the fire going, and prepare yourselves for a pair of nasal-based horror stories that will frighten your Jingle Bells off!

RusN/iStock/Getty Images Plus

Our first tale of nostril terror comes all the way from southern India, where a 13-year-old boy jumped into a water well to cool off. Hey, southern India gets hot, even in November. But like something out of a bad sci-fi movie, his peaceful swim was interrupted when something swam up his nose, causing him extreme pain. After a 30-minute procedure, the doctor pulled out the culprit: A horrific alien parasite! Okay, we’re lying; it was a fish. But we had you going, didn’t we?

Well, maybe that didn’t get you frightened. But we have more rhinal dread to share! A young girl in Las Vegas stuck a pair of plastic doll shoes up her nose, one in each nostril. Her mother removed one shoe, but neither she nor urgent care could reach the second. A trip to the hospital was in order, and once there, the doctors were able to remove the foreign object in seconds.

But as with all things in U.S. medicine, a reckoning would soon come. You feel it now, the dread in this woman’s heart when the hospital bill came.

She takes the envelope, and opens it slowly.

The paper unfolds, rough and heavy in her hands.

Her eyes scan the page, looking for the number, where is it, where is it? It must be here, it must be ...

$3,000.

That’s right, for this simple procedure, performed with a pair of fancy tweezers, the hospital saw fit to charge the hapless mother $3,000! AHHHHHHHHHHHH!

Some say that the mother’s high-deductible insurance policy reduced the cost to $1,700. But we ask you, does that make the story any less spooky? We think not.
 

Hoverboarding down the root canal

Time spent in the dentist’s chair is among the most anxiety-inducing in anyone’s life. The needles. The grinding. The drilling. The rinsing. The spitting. The throbbing copays.

RobertoDavid/iStock/Getty Images Plus

But you know what might inject a few cc’s of fun into your oral hygiene visits?

Did you guess ... a hoverboard?

If you did, well, you’re probably dentist Steve Martin in “Little Shop of Horrors.” Or perhaps Alaska dentist Seth Lookhart, who authorities say performed a tooth extraction on a sedated patient while Dr. Lookhart also rode a hoverboard. There are also charges of felony Medicaid fraud and reckless endangerment. And allegations of hefty theft from his practice partners. Oh, and a state board apparently suspended Dr. Lookhart’s dental license in 2017.

But hey, pulling teeth while taming a hoverboard? Photos or it didn’t happen, right?

Unfortunately for the well-balanced dentist, there are photos. Actually, there’s an entire video. And when prosecutors showed it to Dr. Lookhart’s unwitting and horrified costar, she was about as happy as the impacted wisdom teeth your teen kid’s still toting around.

Dr. Lookhart denied the felony fraud charges. But he did cop to the hoverboard. Which puts him one up on his cinematic “Wild and Crazy Guy” doppelganger. Even as a neurosurgeon in “The Man With Two Brains,” Mr. Martin never attempted to hoverboard while performing double “cranial screw-top” brain surgeries.
 

 

 

CSI: Quebec

They may live in that eternally polite land on the other side of our northern border, but they know where the bodies are buried. Lots of bodies. Some of them in shallow graves. Some of them in vehicles.

MicroStockHub/iStock/Getty Images Plus

No, we are not talking about Gil Grissom and the gang at CSI. We’re talking about the Secure Site for Research in Thanatology, also known as the “body farm,” which is scheduled to open this spring in Becancour, Quebec.

It’s the first such outdoor forensic facility in Canada and the first in the world – there are also body farms in the United States, Australia, and the Netherlands – to be located in a northern climate.

“We’re particularly interested in understanding what happens when a body is in subzero temperatures, when there’s a lot of snow on the ground, and how that freeze and then the thaw process might actually change the rate of decomposition,” Shari Forbes, the farm’s director, told CTV News recently.

The science team will be out on the farm every day, meticulously checking each body – talk about making a list and checking it twice – for all the important CSI stuff: how long fingerprints and DNA evidence last, the effects of insect feeding and egg-laying, and the ability of dogs to detect scents.

The decomposition process in a cold climate will be a strange and wondrous journey, and the body farm’s work can, perhaps, best be summed up by none other than Mr. Grissom, who once said that getting to the evidence means having to destroy the evidence.

Then again, he also said that “dead men don’t ride roller coasters,” so the analogy only goes so far.

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Childproofing your protocols, and what’s the deal with airline water?

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Thu, 12/05/2019 - 13:35

 

Childproof your study protocols

Childproof caps on medicine bottles. Like a bank vault lock to third-rate thieves, they’re an impregnable line of defense between inquisitive little hands and heavy-duty pharmaceuticals.

miflippo/Getty Images

So, you can imagine the delight with which parents learned that their children’s education at an Illinois elementary school included a test of their ability to spring drugs from their fortress-like bottling.

In a quest to advance scientific understanding, a junior high student recruited some of the school’s kindergartners and first graders as participants in a science fair experiment. The hypothesis: “Childproof” medicine bottles were anything but.

The junior high scientist collected data on how quickly the study subjects could defeat assorted bottles. And, being a kindly soul, the adolescent researcher demonstrated techniques for achieving a state of, ahem, pharmaceutical openness.

While teachers were present during the experiment, parental permission slips were not. As any principal or institutional review board knows, informed consent is kind of a big deal.

Surprised parents learned of the experiment only when their kids deftly demonstrated their newfound pill skills. One shocked parent even shared a video of his daughter defeating a childproof lid.

Pharmacies, of course, would remind us all that their bottles are at best “child resistant,” not childproof. It’s a distinction lost on us here at the Bureau of LOTME, however. We’re desperately viewing that how-to video for tips on liberating our statins from the “child resistant” bottle our millennial pharmacist clearly superglued the cap onto.

What’s the deal with airline food?

You probably thought Jerry Seinfeld’s immortal query was rhetorical. No one actually knows what the deal is with airline food, right?

ThamKC/Getty Images

Enter Charles Platkin, PhD, JD, MPH, executive director of the Hunter College NYC Food Policy Center, and editor of DietDetective.com. Not only does he know the deal, he publishes a study detailing the healthiness of the food offered by 11 airlines every year, based on criteria such as healthy nutrients and calorie levels of meals, level of transparency, improvement and maintenance of healthy offerings, and water health.

For the 2018-2019 edition, there’s a tie at the top between Alaska Airlines and Air Canada, both scoring 4 out of 5 on Dr. Platkin’s “Health Score,” both well ahead of Delta and JetBlue in second place with a score of 2.9.

At the bottom? Southwest Airlines, with a paltry 1.7, edging out Spirit and Hawaiian Airlines.

Our personal favorite tidbit from the study has to be the poor scores in water health. Spirit managed to score a measly 1 out of 5 in the water health subscore, and several airlines were below 2. An actual quote from the study: “The quality of drinking water varies by airline, and many have provided passengers with unhealthy water. In general, it’s probably best to avoid drinking coffee and tea on board since they are made with galley water.”

While Hawaiian can take some comfort because they didn’t finish dead last, Dr. Platkin did award them his special “Shame on You” award for not providing all their nutritional information. You can try to hide, Hawaiian Airlines, but Dr. Platkin will find you.

 

 

Use the Force, Jack Nicklaus

We here at LOTME usually strive to provide an insightful and up-to-date wrap-up of the latest news on cutting-edge research, clinical breakthroughs, and impolite bodily functions. But right now, we want to talk about something really important: your golf game.

jacoblund/Getty Images

There’s an old saying in golf: Drive for show, putt for dough. That cliché may need a bit of updating, though, now that investigators in Ireland (where they are pretty serious about their golf) have brought science to the party.

Their research indicates that it may be possible for golfers to improve their putting without practicing. Without physically practicing, that is. Without going to the golf course. Just think about it: Golfers can putt better by, you know … just thinking about it.

Imagining the feel of an action without actually performing it is known as kinesthetic imagery ability, and it just might have an effect on putting, researchers from the physical education and sports sciences department at the University of Limerick and Lero, the Science Foundation Ireland Research Centre for Software, reported in Psychology of Sport and Exercise.

In a group of 44 skilled golfers, half watched video of an expert golfer putting in a lab environment “while listening to a motor imagery script consisting of short sentences describing key visual and kinesthetic feelings associated with performing the putting.” Then all the golfers took 40 putts from 15 feet in the lab.

The good kinesthetic imagers in the bunch improved their putting consistency more than subjects with poorer kinesthetic imagery ability and subjects from the nonintervention group.

So, here’s the new and improved old saying for golfers: Drive for show, use your kinesthetic imagery ability for dough. Yup, that’ll definitely catch on.


 

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Childproof your study protocols

Childproof caps on medicine bottles. Like a bank vault lock to third-rate thieves, they’re an impregnable line of defense between inquisitive little hands and heavy-duty pharmaceuticals.

miflippo/Getty Images

So, you can imagine the delight with which parents learned that their children’s education at an Illinois elementary school included a test of their ability to spring drugs from their fortress-like bottling.

In a quest to advance scientific understanding, a junior high student recruited some of the school’s kindergartners and first graders as participants in a science fair experiment. The hypothesis: “Childproof” medicine bottles were anything but.

The junior high scientist collected data on how quickly the study subjects could defeat assorted bottles. And, being a kindly soul, the adolescent researcher demonstrated techniques for achieving a state of, ahem, pharmaceutical openness.

While teachers were present during the experiment, parental permission slips were not. As any principal or institutional review board knows, informed consent is kind of a big deal.

Surprised parents learned of the experiment only when their kids deftly demonstrated their newfound pill skills. One shocked parent even shared a video of his daughter defeating a childproof lid.

Pharmacies, of course, would remind us all that their bottles are at best “child resistant,” not childproof. It’s a distinction lost on us here at the Bureau of LOTME, however. We’re desperately viewing that how-to video for tips on liberating our statins from the “child resistant” bottle our millennial pharmacist clearly superglued the cap onto.

What’s the deal with airline food?

You probably thought Jerry Seinfeld’s immortal query was rhetorical. No one actually knows what the deal is with airline food, right?

ThamKC/Getty Images

Enter Charles Platkin, PhD, JD, MPH, executive director of the Hunter College NYC Food Policy Center, and editor of DietDetective.com. Not only does he know the deal, he publishes a study detailing the healthiness of the food offered by 11 airlines every year, based on criteria such as healthy nutrients and calorie levels of meals, level of transparency, improvement and maintenance of healthy offerings, and water health.

For the 2018-2019 edition, there’s a tie at the top between Alaska Airlines and Air Canada, both scoring 4 out of 5 on Dr. Platkin’s “Health Score,” both well ahead of Delta and JetBlue in second place with a score of 2.9.

At the bottom? Southwest Airlines, with a paltry 1.7, edging out Spirit and Hawaiian Airlines.

Our personal favorite tidbit from the study has to be the poor scores in water health. Spirit managed to score a measly 1 out of 5 in the water health subscore, and several airlines were below 2. An actual quote from the study: “The quality of drinking water varies by airline, and many have provided passengers with unhealthy water. In general, it’s probably best to avoid drinking coffee and tea on board since they are made with galley water.”

While Hawaiian can take some comfort because they didn’t finish dead last, Dr. Platkin did award them his special “Shame on You” award for not providing all their nutritional information. You can try to hide, Hawaiian Airlines, but Dr. Platkin will find you.

 

 

Use the Force, Jack Nicklaus

We here at LOTME usually strive to provide an insightful and up-to-date wrap-up of the latest news on cutting-edge research, clinical breakthroughs, and impolite bodily functions. But right now, we want to talk about something really important: your golf game.

jacoblund/Getty Images

There’s an old saying in golf: Drive for show, putt for dough. That cliché may need a bit of updating, though, now that investigators in Ireland (where they are pretty serious about their golf) have brought science to the party.

Their research indicates that it may be possible for golfers to improve their putting without practicing. Without physically practicing, that is. Without going to the golf course. Just think about it: Golfers can putt better by, you know … just thinking about it.

Imagining the feel of an action without actually performing it is known as kinesthetic imagery ability, and it just might have an effect on putting, researchers from the physical education and sports sciences department at the University of Limerick and Lero, the Science Foundation Ireland Research Centre for Software, reported in Psychology of Sport and Exercise.

In a group of 44 skilled golfers, half watched video of an expert golfer putting in a lab environment “while listening to a motor imagery script consisting of short sentences describing key visual and kinesthetic feelings associated with performing the putting.” Then all the golfers took 40 putts from 15 feet in the lab.

The good kinesthetic imagers in the bunch improved their putting consistency more than subjects with poorer kinesthetic imagery ability and subjects from the nonintervention group.

So, here’s the new and improved old saying for golfers: Drive for show, use your kinesthetic imagery ability for dough. Yup, that’ll definitely catch on.


 

 

Childproof your study protocols

Childproof caps on medicine bottles. Like a bank vault lock to third-rate thieves, they’re an impregnable line of defense between inquisitive little hands and heavy-duty pharmaceuticals.

miflippo/Getty Images

So, you can imagine the delight with which parents learned that their children’s education at an Illinois elementary school included a test of their ability to spring drugs from their fortress-like bottling.

In a quest to advance scientific understanding, a junior high student recruited some of the school’s kindergartners and first graders as participants in a science fair experiment. The hypothesis: “Childproof” medicine bottles were anything but.

The junior high scientist collected data on how quickly the study subjects could defeat assorted bottles. And, being a kindly soul, the adolescent researcher demonstrated techniques for achieving a state of, ahem, pharmaceutical openness.

While teachers were present during the experiment, parental permission slips were not. As any principal or institutional review board knows, informed consent is kind of a big deal.

Surprised parents learned of the experiment only when their kids deftly demonstrated their newfound pill skills. One shocked parent even shared a video of his daughter defeating a childproof lid.

Pharmacies, of course, would remind us all that their bottles are at best “child resistant,” not childproof. It’s a distinction lost on us here at the Bureau of LOTME, however. We’re desperately viewing that how-to video for tips on liberating our statins from the “child resistant” bottle our millennial pharmacist clearly superglued the cap onto.

What’s the deal with airline food?

You probably thought Jerry Seinfeld’s immortal query was rhetorical. No one actually knows what the deal is with airline food, right?

ThamKC/Getty Images

Enter Charles Platkin, PhD, JD, MPH, executive director of the Hunter College NYC Food Policy Center, and editor of DietDetective.com. Not only does he know the deal, he publishes a study detailing the healthiness of the food offered by 11 airlines every year, based on criteria such as healthy nutrients and calorie levels of meals, level of transparency, improvement and maintenance of healthy offerings, and water health.

For the 2018-2019 edition, there’s a tie at the top between Alaska Airlines and Air Canada, both scoring 4 out of 5 on Dr. Platkin’s “Health Score,” both well ahead of Delta and JetBlue in second place with a score of 2.9.

At the bottom? Southwest Airlines, with a paltry 1.7, edging out Spirit and Hawaiian Airlines.

Our personal favorite tidbit from the study has to be the poor scores in water health. Spirit managed to score a measly 1 out of 5 in the water health subscore, and several airlines were below 2. An actual quote from the study: “The quality of drinking water varies by airline, and many have provided passengers with unhealthy water. In general, it’s probably best to avoid drinking coffee and tea on board since they are made with galley water.”

While Hawaiian can take some comfort because they didn’t finish dead last, Dr. Platkin did award them his special “Shame on You” award for not providing all their nutritional information. You can try to hide, Hawaiian Airlines, but Dr. Platkin will find you.

 

 

Use the Force, Jack Nicklaus

We here at LOTME usually strive to provide an insightful and up-to-date wrap-up of the latest news on cutting-edge research, clinical breakthroughs, and impolite bodily functions. But right now, we want to talk about something really important: your golf game.

jacoblund/Getty Images

There’s an old saying in golf: Drive for show, putt for dough. That cliché may need a bit of updating, though, now that investigators in Ireland (where they are pretty serious about their golf) have brought science to the party.

Their research indicates that it may be possible for golfers to improve their putting without practicing. Without physically practicing, that is. Without going to the golf course. Just think about it: Golfers can putt better by, you know … just thinking about it.

Imagining the feel of an action without actually performing it is known as kinesthetic imagery ability, and it just might have an effect on putting, researchers from the physical education and sports sciences department at the University of Limerick and Lero, the Science Foundation Ireland Research Centre for Software, reported in Psychology of Sport and Exercise.

In a group of 44 skilled golfers, half watched video of an expert golfer putting in a lab environment “while listening to a motor imagery script consisting of short sentences describing key visual and kinesthetic feelings associated with performing the putting.” Then all the golfers took 40 putts from 15 feet in the lab.

The good kinesthetic imagers in the bunch improved their putting consistency more than subjects with poorer kinesthetic imagery ability and subjects from the nonintervention group.

So, here’s the new and improved old saying for golfers: Drive for show, use your kinesthetic imagery ability for dough. Yup, that’ll definitely catch on.


 

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Part 1: The ABCs of managing COPD exacerbations

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Wed, 11/20/2019 - 09:27
How to use antibiotics and bronchodilators.
Vidyard Video

Do you know the ABCs of medication management for chronic obstructive pulmonary disease exacerbations?

Understanding how to effectively use the ABCs – antibiotics, bronchodilators, and corticosteroids – in COPD exacerbations can reduce morbidity and improve patient outcomes.

In the first episode of a two-part interview, Robert A. Wise, MD, outlines the evidence and best practices for treating patients with antibiotics and bronchodilators.

Dr. Wise is a professor of medicine at Johns Hopkins University, Baltimore. He is the coauthor of a review of medication regimens to manage COPD exacerbations (Respir Care. 2018 Jun;63[6]:773-82).

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How to use antibiotics and bronchodilators.
How to use antibiotics and bronchodilators.
Vidyard Video

Do you know the ABCs of medication management for chronic obstructive pulmonary disease exacerbations?

Understanding how to effectively use the ABCs – antibiotics, bronchodilators, and corticosteroids – in COPD exacerbations can reduce morbidity and improve patient outcomes.

In the first episode of a two-part interview, Robert A. Wise, MD, outlines the evidence and best practices for treating patients with antibiotics and bronchodilators.

Dr. Wise is a professor of medicine at Johns Hopkins University, Baltimore. He is the coauthor of a review of medication regimens to manage COPD exacerbations (Respir Care. 2018 Jun;63[6]:773-82).

Vidyard Video

Do you know the ABCs of medication management for chronic obstructive pulmonary disease exacerbations?

Understanding how to effectively use the ABCs – antibiotics, bronchodilators, and corticosteroids – in COPD exacerbations can reduce morbidity and improve patient outcomes.

In the first episode of a two-part interview, Robert A. Wise, MD, outlines the evidence and best practices for treating patients with antibiotics and bronchodilators.

Dr. Wise is a professor of medicine at Johns Hopkins University, Baltimore. He is the coauthor of a review of medication regimens to manage COPD exacerbations (Respir Care. 2018 Jun;63[6]:773-82).

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Sleep vs. Netflix, and grape juice BPAP

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Fri, 11/08/2019 - 15:19

 

Sleep vs. Netflix: the eternal struggle

Ladies and gentlemen, welcome to Livin’ on the MDedge World Championship Boxing! Tonight, we bring you a classic match-up in the endless battle for your valuable time.

jackscoldsweat/Getty Images

In the red corner, weighing in at a muscular 8 hours, is the defending champion: a good night’s sleep! And now for the challenger in the blue corner, coming in at a strong “just one more episode, I promise,” it’s binge watching!

Oh, sleep opens the match strong: According to a survey from the American Academy of Sleep Medicine, U.S. adults rank sleep as their second-most important priority, with only family beating it out. My goodness, that is a strong opening offensive.

But wait, binge watching is countering! According to the very same survey, 88% of Americans have admitted that they’d lost sleep because they’d stayed up late to watch extra episodes of a TV show or streaming series, a rate that rises to 95% in people aged 18-44 years. Oh dear, sleep looks like it’s in trouble.

Hang on, what’s binge watching doing? It’s unleashing a quick barrage of attacks: 72% of men aged 18-34 reported delaying sleep for video games, two-thirds of U.S. adults reported losing sleep to read a book, and nearly 60% of adults delayed sleep to watch sports. We feel slightly conflicted about our metaphor choice now.

And with a final haymaker from “guess I’ll watch ‘The Office’ for a sixth time,” binge watching has defeated the defending champion! Be sure to tune in next week, when alcohol takes on common sense. A true fight for the ages there.
 

Lead us not into temptation

Can anyone resist the temptation of binge watching? Can no one swim against the sleep-depriving, show-streaming current? Is resistance to an “Orange Is the New Black” bender futile?

spaxiax/Getty Images

University of Wyoming researchers say there’s hope. Those who would sleep svelte and sound in a world of streaming services and Krispy Kreme must plan ahead to tame temptation.

Proactive temptation management begins long before those chocolate iced glazed with sprinkles appear at the nurses’ station. Planning your response ahead of time increases the odds that the first episode of “Stranger Things” is also the evening’s last episode.

Using psychology’s human lab mice – undergraduate students – the researchers tested five temptation-proofing self-control strategies.

The first strategy: situation selection. If “Game of Thrones” is on in the den, avoid the room as if it were an unmucked House Lannister horse stall. Second: situation modification. Is your spouse hotboxing GoT on an iPad next to you in the bed? Politely suggest that GoT is even better when viewed on the living room sofa.

The third strategy: distraction. Enjoy the wholesome snap of a Finn Crisp while your coworkers destroy those Krispy Kremes like Daenerys leveling King’s Landing. Fourth: reappraisal. Tell yourself that season 2 of “Ozark” can’t surpass season 1, and will simply swindle you of your precious time. And fifth, the Nancy-Reagan, temptation-resistance classic: response inhibition. When offered the narcotic that is “Breaking Bad,” just say no!

Which temptation strategies worked best?

Planning ahead with one through four led fewer Cowboy State undergrads into temptation.

As for responding in the moment? Well, the Krispy Kremes would’ve never lasted past season 2 of “The Great British Baking Show.”
 

 

 

Stuck between a tongue and a hard place

There once was a 7-year-old boy who loved grape juice. He loved grape juice so much that he didn’t want to waste any after drinking a bottle of the stuff.

Shablon/Getty Images

To get every last drop, he tried to use his tongue to lick the inside of a grape juice bottle. One particular bottle, however, was evil and had other plans. It grabbed his tongue and wouldn’t let go, even after his mother tried to help him.

She took him to the great healing wizards at Auf der Bult Children’s Hospital in Hannover, Germany – which is quite surprising, because they live in New Jersey. [Just kidding, they’re from Hannover – just checking to see if you’re paying attention.]

When their magic wands didn’t work, doctors at the hospital mildly sedated the boy with midazolam and esketamine and then advanced a 70-mm plastic button cannula between the neck of the bottle and his tongue, hoping to release the presumed vacuum. No such luck.

It was at that point that the greatest of all the wizards, Dr. Christoph Eich, a pediatric anesthesiologist at the hospital, remembered having a similar problem with a particularly villainous bottle of “grape juice” during his magical training days some 20 years earlier.

The solution then, he discovered, was to connect the cannula to a syringe and inject air into the bottle to produce positive pressure and force out the foreign object.

Dr. Eich’s reinvention of BPAP (bottle positive airway pressure) worked on the child, who, once the purple discoloration of his tongue faded after 3 days, was none the worse for wear and lived happily ever after.

We’re just wondering if the good doctor told the child’s mother that the original situation involved a bottle of wine that couldn’t be opened because no one had a corkscrew. Well, maybe she reads the European Journal of Anaesthesiology.

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Sleep vs. Netflix: the eternal struggle

Ladies and gentlemen, welcome to Livin’ on the MDedge World Championship Boxing! Tonight, we bring you a classic match-up in the endless battle for your valuable time.

jackscoldsweat/Getty Images

In the red corner, weighing in at a muscular 8 hours, is the defending champion: a good night’s sleep! And now for the challenger in the blue corner, coming in at a strong “just one more episode, I promise,” it’s binge watching!

Oh, sleep opens the match strong: According to a survey from the American Academy of Sleep Medicine, U.S. adults rank sleep as their second-most important priority, with only family beating it out. My goodness, that is a strong opening offensive.

But wait, binge watching is countering! According to the very same survey, 88% of Americans have admitted that they’d lost sleep because they’d stayed up late to watch extra episodes of a TV show or streaming series, a rate that rises to 95% in people aged 18-44 years. Oh dear, sleep looks like it’s in trouble.

Hang on, what’s binge watching doing? It’s unleashing a quick barrage of attacks: 72% of men aged 18-34 reported delaying sleep for video games, two-thirds of U.S. adults reported losing sleep to read a book, and nearly 60% of adults delayed sleep to watch sports. We feel slightly conflicted about our metaphor choice now.

And with a final haymaker from “guess I’ll watch ‘The Office’ for a sixth time,” binge watching has defeated the defending champion! Be sure to tune in next week, when alcohol takes on common sense. A true fight for the ages there.
 

Lead us not into temptation

Can anyone resist the temptation of binge watching? Can no one swim against the sleep-depriving, show-streaming current? Is resistance to an “Orange Is the New Black” bender futile?

spaxiax/Getty Images

University of Wyoming researchers say there’s hope. Those who would sleep svelte and sound in a world of streaming services and Krispy Kreme must plan ahead to tame temptation.

Proactive temptation management begins long before those chocolate iced glazed with sprinkles appear at the nurses’ station. Planning your response ahead of time increases the odds that the first episode of “Stranger Things” is also the evening’s last episode.

Using psychology’s human lab mice – undergraduate students – the researchers tested five temptation-proofing self-control strategies.

The first strategy: situation selection. If “Game of Thrones” is on in the den, avoid the room as if it were an unmucked House Lannister horse stall. Second: situation modification. Is your spouse hotboxing GoT on an iPad next to you in the bed? Politely suggest that GoT is even better when viewed on the living room sofa.

The third strategy: distraction. Enjoy the wholesome snap of a Finn Crisp while your coworkers destroy those Krispy Kremes like Daenerys leveling King’s Landing. Fourth: reappraisal. Tell yourself that season 2 of “Ozark” can’t surpass season 1, and will simply swindle you of your precious time. And fifth, the Nancy-Reagan, temptation-resistance classic: response inhibition. When offered the narcotic that is “Breaking Bad,” just say no!

Which temptation strategies worked best?

Planning ahead with one through four led fewer Cowboy State undergrads into temptation.

As for responding in the moment? Well, the Krispy Kremes would’ve never lasted past season 2 of “The Great British Baking Show.”
 

 

 

Stuck between a tongue and a hard place

There once was a 7-year-old boy who loved grape juice. He loved grape juice so much that he didn’t want to waste any after drinking a bottle of the stuff.

Shablon/Getty Images

To get every last drop, he tried to use his tongue to lick the inside of a grape juice bottle. One particular bottle, however, was evil and had other plans. It grabbed his tongue and wouldn’t let go, even after his mother tried to help him.

She took him to the great healing wizards at Auf der Bult Children’s Hospital in Hannover, Germany – which is quite surprising, because they live in New Jersey. [Just kidding, they’re from Hannover – just checking to see if you’re paying attention.]

When their magic wands didn’t work, doctors at the hospital mildly sedated the boy with midazolam and esketamine and then advanced a 70-mm plastic button cannula between the neck of the bottle and his tongue, hoping to release the presumed vacuum. No such luck.

It was at that point that the greatest of all the wizards, Dr. Christoph Eich, a pediatric anesthesiologist at the hospital, remembered having a similar problem with a particularly villainous bottle of “grape juice” during his magical training days some 20 years earlier.

The solution then, he discovered, was to connect the cannula to a syringe and inject air into the bottle to produce positive pressure and force out the foreign object.

Dr. Eich’s reinvention of BPAP (bottle positive airway pressure) worked on the child, who, once the purple discoloration of his tongue faded after 3 days, was none the worse for wear and lived happily ever after.

We’re just wondering if the good doctor told the child’s mother that the original situation involved a bottle of wine that couldn’t be opened because no one had a corkscrew. Well, maybe she reads the European Journal of Anaesthesiology.

 

Sleep vs. Netflix: the eternal struggle

Ladies and gentlemen, welcome to Livin’ on the MDedge World Championship Boxing! Tonight, we bring you a classic match-up in the endless battle for your valuable time.

jackscoldsweat/Getty Images

In the red corner, weighing in at a muscular 8 hours, is the defending champion: a good night’s sleep! And now for the challenger in the blue corner, coming in at a strong “just one more episode, I promise,” it’s binge watching!

Oh, sleep opens the match strong: According to a survey from the American Academy of Sleep Medicine, U.S. adults rank sleep as their second-most important priority, with only family beating it out. My goodness, that is a strong opening offensive.

But wait, binge watching is countering! According to the very same survey, 88% of Americans have admitted that they’d lost sleep because they’d stayed up late to watch extra episodes of a TV show or streaming series, a rate that rises to 95% in people aged 18-44 years. Oh dear, sleep looks like it’s in trouble.

Hang on, what’s binge watching doing? It’s unleashing a quick barrage of attacks: 72% of men aged 18-34 reported delaying sleep for video games, two-thirds of U.S. adults reported losing sleep to read a book, and nearly 60% of adults delayed sleep to watch sports. We feel slightly conflicted about our metaphor choice now.

And with a final haymaker from “guess I’ll watch ‘The Office’ for a sixth time,” binge watching has defeated the defending champion! Be sure to tune in next week, when alcohol takes on common sense. A true fight for the ages there.
 

Lead us not into temptation

Can anyone resist the temptation of binge watching? Can no one swim against the sleep-depriving, show-streaming current? Is resistance to an “Orange Is the New Black” bender futile?

spaxiax/Getty Images

University of Wyoming researchers say there’s hope. Those who would sleep svelte and sound in a world of streaming services and Krispy Kreme must plan ahead to tame temptation.

Proactive temptation management begins long before those chocolate iced glazed with sprinkles appear at the nurses’ station. Planning your response ahead of time increases the odds that the first episode of “Stranger Things” is also the evening’s last episode.

Using psychology’s human lab mice – undergraduate students – the researchers tested five temptation-proofing self-control strategies.

The first strategy: situation selection. If “Game of Thrones” is on in the den, avoid the room as if it were an unmucked House Lannister horse stall. Second: situation modification. Is your spouse hotboxing GoT on an iPad next to you in the bed? Politely suggest that GoT is even better when viewed on the living room sofa.

The third strategy: distraction. Enjoy the wholesome snap of a Finn Crisp while your coworkers destroy those Krispy Kremes like Daenerys leveling King’s Landing. Fourth: reappraisal. Tell yourself that season 2 of “Ozark” can’t surpass season 1, and will simply swindle you of your precious time. And fifth, the Nancy-Reagan, temptation-resistance classic: response inhibition. When offered the narcotic that is “Breaking Bad,” just say no!

Which temptation strategies worked best?

Planning ahead with one through four led fewer Cowboy State undergrads into temptation.

As for responding in the moment? Well, the Krispy Kremes would’ve never lasted past season 2 of “The Great British Baking Show.”
 

 

 

Stuck between a tongue and a hard place

There once was a 7-year-old boy who loved grape juice. He loved grape juice so much that he didn’t want to waste any after drinking a bottle of the stuff.

Shablon/Getty Images

To get every last drop, he tried to use his tongue to lick the inside of a grape juice bottle. One particular bottle, however, was evil and had other plans. It grabbed his tongue and wouldn’t let go, even after his mother tried to help him.

She took him to the great healing wizards at Auf der Bult Children’s Hospital in Hannover, Germany – which is quite surprising, because they live in New Jersey. [Just kidding, they’re from Hannover – just checking to see if you’re paying attention.]

When their magic wands didn’t work, doctors at the hospital mildly sedated the boy with midazolam and esketamine and then advanced a 70-mm plastic button cannula between the neck of the bottle and his tongue, hoping to release the presumed vacuum. No such luck.

It was at that point that the greatest of all the wizards, Dr. Christoph Eich, a pediatric anesthesiologist at the hospital, remembered having a similar problem with a particularly villainous bottle of “grape juice” during his magical training days some 20 years earlier.

The solution then, he discovered, was to connect the cannula to a syringe and inject air into the bottle to produce positive pressure and force out the foreign object.

Dr. Eich’s reinvention of BPAP (bottle positive airway pressure) worked on the child, who, once the purple discoloration of his tongue faded after 3 days, was none the worse for wear and lived happily ever after.

We’re just wondering if the good doctor told the child’s mother that the original situation involved a bottle of wine that couldn’t be opened because no one had a corkscrew. Well, maybe she reads the European Journal of Anaesthesiology.

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Werewolves of Vallejo and a haunted-house doctor’s note

Article Type
Changed
Wed, 11/06/2019 - 14:39

 

A crappy excuse of a database

Have you ever been so impressed with your bowel movement that you’ve been compelled to record the incident for posterity? No? Just us? Well, you may want to reconsider, because a pair of AI tech companies are looking for a few good poop pictures.

Andy/Getty Images

It’s all part of the “Give a S--t” (you can probably guess what we’ve censored out) campaign, a joint venture from Auggi, a gut health start-up, and Seed Health. The companies hope to use photos sent in by regular people to build an app that would help people with chronic gut problems automatically track their own bowel movements. In addition, the photo library could also be used for research into gut-related diseases such as irritable bowl syndrome.

The two companies hope to collect 100,000 photos for their library, which is an absolutely prodigious amount of poop to sort through. But hey, that’s what the AI is for. They already know the AI works, as Auggi created a proof-of-concept library of 36,000 images of faux feces made from blue Play-Doh. The AI was able to recognize consistency according to the Bristol scale basically 100% of the time.

If you’ve been inspired, you can submit your lovely poop pictures here. Seed and Auggi expect contributers to send only one image each, but multiple submissions are welcome. They’ve already received a dozen from LOTME world headquarters. We love a good bowel movement here.

Criminal moon

“The Wolf Man.” “An American Werewolf in London.” “The Howling.” “Teen Wolf.” All terrifying Hollywood tales of bloodthirsty behavior and sanguinary slaughter. (Michael J. Fox as a hirsute homicidal lycan? Okay, maybe not “Teen Wolf.”)

Vlad Gans/Getty Images

And the propellant igniting all that criminal lycanthropy? The full moon.

Any teacher will swear a full moon portends the kind of student behavior that an entire pot of teachers’ lounge coffee can’t counter. And every cop knows it’s going to be a “Training Day” shift when the lunar light shines brightest.

But is the Thin Blue Line truly stretched to snapping during a full moon? New York University’s BetaGov research team looked at the purported “lunar effect” linking crime and the full moon. A lit review revealed mixed findings for and against a criminal lunar effect. The team then collaborated with the Vallejo, Calif., police department to match the moon’s phases with the city’s crime events. They did the same with departments in Canada and Mexico.

The results? A full moon had no effect on Vallejo’s crime rate, or anywhere else in North America.

While the finding eviscerates the moon-induced mayhem hypothesis, cops walking a full-moonlit beat can at least take comfort in this fact: Unlike London, Vallejo is clearly free of American werewolves.

A doctor’s note … of terror

With Halloween upon us, here’s a veddy scary riddle: When is a sports physical not a sports physical?

CheeriesJD/Getty Images

When it’s a haunted house physical.

Specifically, when the haunted house is McKamey Manor in Summertown, Tenn. … and in Huntsville, Ala. That’s right, it can be in two places at the same time. Terrifying.

McKamey Manor is considered by many to be the most terrifying haunted house in the United States, and by some to be a “torture chamber under disguise.”

The “Surivial [we think they misspelled it on purpose to make it even scarier] Horror Challenge” is so terrifying that management requires all participants to have a “completed ‘sports physical’ and doctor’s letter stating you are physically and mentally cleared,” as well as proof of medical insurance. Each paying customer also has to “pass a portable drug test on the day of the show,” according to the McKamey Manor website.

The manor also happens to be the subject of a petition, which currently has over 58,000 signatures, asking state officials in Alabama and Tennessee to shut it down because “some people have had to seek professional psychiatric help and medical care for extensive injuries.”

Ironically, we hear that some of the most traumatized customers have been actual physicians who succumbed to the horrors of Prior Approval Asylum, the EHR Torment Room, and the River of the Damned Maintenance of Certification.


 

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A crappy excuse of a database

Have you ever been so impressed with your bowel movement that you’ve been compelled to record the incident for posterity? No? Just us? Well, you may want to reconsider, because a pair of AI tech companies are looking for a few good poop pictures.

Andy/Getty Images

It’s all part of the “Give a S--t” (you can probably guess what we’ve censored out) campaign, a joint venture from Auggi, a gut health start-up, and Seed Health. The companies hope to use photos sent in by regular people to build an app that would help people with chronic gut problems automatically track their own bowel movements. In addition, the photo library could also be used for research into gut-related diseases such as irritable bowl syndrome.

The two companies hope to collect 100,000 photos for their library, which is an absolutely prodigious amount of poop to sort through. But hey, that’s what the AI is for. They already know the AI works, as Auggi created a proof-of-concept library of 36,000 images of faux feces made from blue Play-Doh. The AI was able to recognize consistency according to the Bristol scale basically 100% of the time.

If you’ve been inspired, you can submit your lovely poop pictures here. Seed and Auggi expect contributers to send only one image each, but multiple submissions are welcome. They’ve already received a dozen from LOTME world headquarters. We love a good bowel movement here.

Criminal moon

“The Wolf Man.” “An American Werewolf in London.” “The Howling.” “Teen Wolf.” All terrifying Hollywood tales of bloodthirsty behavior and sanguinary slaughter. (Michael J. Fox as a hirsute homicidal lycan? Okay, maybe not “Teen Wolf.”)

Vlad Gans/Getty Images

And the propellant igniting all that criminal lycanthropy? The full moon.

Any teacher will swear a full moon portends the kind of student behavior that an entire pot of teachers’ lounge coffee can’t counter. And every cop knows it’s going to be a “Training Day” shift when the lunar light shines brightest.

But is the Thin Blue Line truly stretched to snapping during a full moon? New York University’s BetaGov research team looked at the purported “lunar effect” linking crime and the full moon. A lit review revealed mixed findings for and against a criminal lunar effect. The team then collaborated with the Vallejo, Calif., police department to match the moon’s phases with the city’s crime events. They did the same with departments in Canada and Mexico.

The results? A full moon had no effect on Vallejo’s crime rate, or anywhere else in North America.

While the finding eviscerates the moon-induced mayhem hypothesis, cops walking a full-moonlit beat can at least take comfort in this fact: Unlike London, Vallejo is clearly free of American werewolves.

A doctor’s note … of terror

With Halloween upon us, here’s a veddy scary riddle: When is a sports physical not a sports physical?

CheeriesJD/Getty Images

When it’s a haunted house physical.

Specifically, when the haunted house is McKamey Manor in Summertown, Tenn. … and in Huntsville, Ala. That’s right, it can be in two places at the same time. Terrifying.

McKamey Manor is considered by many to be the most terrifying haunted house in the United States, and by some to be a “torture chamber under disguise.”

The “Surivial [we think they misspelled it on purpose to make it even scarier] Horror Challenge” is so terrifying that management requires all participants to have a “completed ‘sports physical’ and doctor’s letter stating you are physically and mentally cleared,” as well as proof of medical insurance. Each paying customer also has to “pass a portable drug test on the day of the show,” according to the McKamey Manor website.

The manor also happens to be the subject of a petition, which currently has over 58,000 signatures, asking state officials in Alabama and Tennessee to shut it down because “some people have had to seek professional psychiatric help and medical care for extensive injuries.”

Ironically, we hear that some of the most traumatized customers have been actual physicians who succumbed to the horrors of Prior Approval Asylum, the EHR Torment Room, and the River of the Damned Maintenance of Certification.


 

 

A crappy excuse of a database

Have you ever been so impressed with your bowel movement that you’ve been compelled to record the incident for posterity? No? Just us? Well, you may want to reconsider, because a pair of AI tech companies are looking for a few good poop pictures.

Andy/Getty Images

It’s all part of the “Give a S--t” (you can probably guess what we’ve censored out) campaign, a joint venture from Auggi, a gut health start-up, and Seed Health. The companies hope to use photos sent in by regular people to build an app that would help people with chronic gut problems automatically track their own bowel movements. In addition, the photo library could also be used for research into gut-related diseases such as irritable bowl syndrome.

The two companies hope to collect 100,000 photos for their library, which is an absolutely prodigious amount of poop to sort through. But hey, that’s what the AI is for. They already know the AI works, as Auggi created a proof-of-concept library of 36,000 images of faux feces made from blue Play-Doh. The AI was able to recognize consistency according to the Bristol scale basically 100% of the time.

If you’ve been inspired, you can submit your lovely poop pictures here. Seed and Auggi expect contributers to send only one image each, but multiple submissions are welcome. They’ve already received a dozen from LOTME world headquarters. We love a good bowel movement here.

Criminal moon

“The Wolf Man.” “An American Werewolf in London.” “The Howling.” “Teen Wolf.” All terrifying Hollywood tales of bloodthirsty behavior and sanguinary slaughter. (Michael J. Fox as a hirsute homicidal lycan? Okay, maybe not “Teen Wolf.”)

Vlad Gans/Getty Images

And the propellant igniting all that criminal lycanthropy? The full moon.

Any teacher will swear a full moon portends the kind of student behavior that an entire pot of teachers’ lounge coffee can’t counter. And every cop knows it’s going to be a “Training Day” shift when the lunar light shines brightest.

But is the Thin Blue Line truly stretched to snapping during a full moon? New York University’s BetaGov research team looked at the purported “lunar effect” linking crime and the full moon. A lit review revealed mixed findings for and against a criminal lunar effect. The team then collaborated with the Vallejo, Calif., police department to match the moon’s phases with the city’s crime events. They did the same with departments in Canada and Mexico.

The results? A full moon had no effect on Vallejo’s crime rate, or anywhere else in North America.

While the finding eviscerates the moon-induced mayhem hypothesis, cops walking a full-moonlit beat can at least take comfort in this fact: Unlike London, Vallejo is clearly free of American werewolves.

A doctor’s note … of terror

With Halloween upon us, here’s a veddy scary riddle: When is a sports physical not a sports physical?

CheeriesJD/Getty Images

When it’s a haunted house physical.

Specifically, when the haunted house is McKamey Manor in Summertown, Tenn. … and in Huntsville, Ala. That’s right, it can be in two places at the same time. Terrifying.

McKamey Manor is considered by many to be the most terrifying haunted house in the United States, and by some to be a “torture chamber under disguise.”

The “Surivial [we think they misspelled it on purpose to make it even scarier] Horror Challenge” is so terrifying that management requires all participants to have a “completed ‘sports physical’ and doctor’s letter stating you are physically and mentally cleared,” as well as proof of medical insurance. Each paying customer also has to “pass a portable drug test on the day of the show,” according to the McKamey Manor website.

The manor also happens to be the subject of a petition, which currently has over 58,000 signatures, asking state officials in Alabama and Tennessee to shut it down because “some people have had to seek professional psychiatric help and medical care for extensive injuries.”

Ironically, we hear that some of the most traumatized customers have been actual physicians who succumbed to the horrors of Prior Approval Asylum, the EHR Torment Room, and the River of the Damned Maintenance of Certification.


 

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Electrified pathogens and urbanized mosquitoes

Article Type
Changed
Fri, 10/25/2019 - 11:19

 

Microbes won’t believe this shocking truth!

Pathogens can be tough little critters. Always getting into places they don’t belong, and when they get there, they can be difficult to get rid of, what with their ability to quickly evolve resistance to our best medications. If only there was some shocking new way to tackle those nasty and annoying infections.

alano design/Getty Images

Thanks to some engineers and researchers from the University of Pittsburgh, if you’ve got an infection centered on a metal implant, that shocking new treatment won’t be just a figure of speech. They ran a weak electrical current through metal dental implants infected with recurring Candida albicans infection, which damaged the cell membranes of the offending fungal pathogens but left the healthy tissue around the infection alone. That damage increased the pathogen's permeability, making it more susceptible to antimicrobial treatment.

The treatment, also known as electrochemical therapy, is great if you’ve got a recurrent infection. The dormant pathogens responsible for the recurrence, not normally susceptible to treatment, are affected by antifungals or antibiotics after the shock wakes them up. Even bacteria that have evolved drug resistance become vulnerable again after a session with Dr. Electricity.

Unfortunately, while the therapy could certainly be expanded beyond dental implants, shocking yourself when you’ve got a regular old infection probably won’t work. We know – Watt a disappointment.

Blast from the brewing past

What separates a rich Belgian ale from its paler, mass-produced American competitors? Is it the sudsy je ne sais quoi produced by squabbling Walloons and Flemings debating the fine points of the brewing arts over open tanks? Perhaps it’s the signature warm-fermented ways of Trappist monks? Is it possible les Belges have hired the unemployed Artesians who once made Olympia Beer a household name across the American West?

SerhiiBobyk/Getty Images

Wrong, wrong, and faux. In fact, Belgium’s finest brews are driven by hybrids. Yeast hybrids. Specifically, rare and unusual forms of hybrid yeasts.

Or, as Belgian researcher and world beer hero Dr. Jan Steensels of VIB-KU Leuven Center for Microbiology explains, “Think of lions and tigers making a super-baby.”

Fearlessly, Dr. Steensels and his intrepid colleagues went hunting for these exotic creatures. They found that the yeasts behind many of Belgium’s finest brews combine the DNA of the traditional, domesticated ale yeast, Saccharomyces cerevisiae, with genetic material from wild yeasts such as Saccharomyces kudriavzevii.

The result? The mighty fermentation strengths of normal beer yeasts are paired with the stress resistance and alluring aromas of feral yeasts that survived mankind’s Medieval brewing endeavors and somehow stumbled into the modern brewery for a drink.

Dr. Steensels’ team is now using its knowledge to craft more yeasty lion-tiger super-babies. We at the Bureau of LOTME look forward to hoisting a pint of this “liger” elixir. We’re certain the brew will bear the name of ligers’ greatest cinematic fan, Napoleon Dynamite, and feature the subtle undertones of tater tots.

 

 

How can mosquitoes be even more fun?

If you’re anything like the gang at LOTME, you’ve spent quite a bit of time wondering which cliché is the best fit for a less-affluent Baltimore neighborhood.

DamrongpanThongwat/thinkstock

The answer? When it rains, it pours.

We’ll explain. By definition, a less-affluent neighborhood is, well, less affluent, and that lack of affluence has many health consequences for the people who live in those neighborhoods. Today we’re focusing on everyone’s favorite winged disease vector, the mosquito.

It was already known that low-income urban neighborhoods have more mosquitoes than other neighborhoods, and now the Journal of Medical Entomology has published a survey of 13 residential blocks in Baltimore that shows low-income neighborhoods have larger mosquitoes as well.

Trapping took place in five socioeconomically diverse Baltimore neighborhoods during June and July of 2015-2017. (In case you were wondering, the researchers used BG-Sentinel traps baited with CO2 and a 2.0-mL Octenol Lure, which would have been our choice, too). It confirmed that lower affluence correlated with larger mosquito wing size. Wing size, the investigators said in a written statement, “is an accurate proxy for body size in mosquitoes, and body size influences traits that are important to disease transmission.”

So, it seems that larger mosquitoes are more efficient at transmitting diseases, which means more dengue fever, more Zika, more chikungunya, more eastern equine encephalitis, and more West Nile virus. To extend the original cliché a bit, when it rains in Baltimore, the poor neighborhoods get the wettest.

* Correction, 10/24/19: An earlier version of this story misstated the fungal target of the electrical therapy experiment.

Jonny Hawkins


 

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Microbes won’t believe this shocking truth!

Pathogens can be tough little critters. Always getting into places they don’t belong, and when they get there, they can be difficult to get rid of, what with their ability to quickly evolve resistance to our best medications. If only there was some shocking new way to tackle those nasty and annoying infections.

alano design/Getty Images

Thanks to some engineers and researchers from the University of Pittsburgh, if you’ve got an infection centered on a metal implant, that shocking new treatment won’t be just a figure of speech. They ran a weak electrical current through metal dental implants infected with recurring Candida albicans infection, which damaged the cell membranes of the offending fungal pathogens but left the healthy tissue around the infection alone. That damage increased the pathogen's permeability, making it more susceptible to antimicrobial treatment.

The treatment, also known as electrochemical therapy, is great if you’ve got a recurrent infection. The dormant pathogens responsible for the recurrence, not normally susceptible to treatment, are affected by antifungals or antibiotics after the shock wakes them up. Even bacteria that have evolved drug resistance become vulnerable again after a session with Dr. Electricity.

Unfortunately, while the therapy could certainly be expanded beyond dental implants, shocking yourself when you’ve got a regular old infection probably won’t work. We know – Watt a disappointment.

Blast from the brewing past

What separates a rich Belgian ale from its paler, mass-produced American competitors? Is it the sudsy je ne sais quoi produced by squabbling Walloons and Flemings debating the fine points of the brewing arts over open tanks? Perhaps it’s the signature warm-fermented ways of Trappist monks? Is it possible les Belges have hired the unemployed Artesians who once made Olympia Beer a household name across the American West?

SerhiiBobyk/Getty Images

Wrong, wrong, and faux. In fact, Belgium’s finest brews are driven by hybrids. Yeast hybrids. Specifically, rare and unusual forms of hybrid yeasts.

Or, as Belgian researcher and world beer hero Dr. Jan Steensels of VIB-KU Leuven Center for Microbiology explains, “Think of lions and tigers making a super-baby.”

Fearlessly, Dr. Steensels and his intrepid colleagues went hunting for these exotic creatures. They found that the yeasts behind many of Belgium’s finest brews combine the DNA of the traditional, domesticated ale yeast, Saccharomyces cerevisiae, with genetic material from wild yeasts such as Saccharomyces kudriavzevii.

The result? The mighty fermentation strengths of normal beer yeasts are paired with the stress resistance and alluring aromas of feral yeasts that survived mankind’s Medieval brewing endeavors and somehow stumbled into the modern brewery for a drink.

Dr. Steensels’ team is now using its knowledge to craft more yeasty lion-tiger super-babies. We at the Bureau of LOTME look forward to hoisting a pint of this “liger” elixir. We’re certain the brew will bear the name of ligers’ greatest cinematic fan, Napoleon Dynamite, and feature the subtle undertones of tater tots.

 

 

How can mosquitoes be even more fun?

If you’re anything like the gang at LOTME, you’ve spent quite a bit of time wondering which cliché is the best fit for a less-affluent Baltimore neighborhood.

DamrongpanThongwat/thinkstock

The answer? When it rains, it pours.

We’ll explain. By definition, a less-affluent neighborhood is, well, less affluent, and that lack of affluence has many health consequences for the people who live in those neighborhoods. Today we’re focusing on everyone’s favorite winged disease vector, the mosquito.

It was already known that low-income urban neighborhoods have more mosquitoes than other neighborhoods, and now the Journal of Medical Entomology has published a survey of 13 residential blocks in Baltimore that shows low-income neighborhoods have larger mosquitoes as well.

Trapping took place in five socioeconomically diverse Baltimore neighborhoods during June and July of 2015-2017. (In case you were wondering, the researchers used BG-Sentinel traps baited with CO2 and a 2.0-mL Octenol Lure, which would have been our choice, too). It confirmed that lower affluence correlated with larger mosquito wing size. Wing size, the investigators said in a written statement, “is an accurate proxy for body size in mosquitoes, and body size influences traits that are important to disease transmission.”

So, it seems that larger mosquitoes are more efficient at transmitting diseases, which means more dengue fever, more Zika, more chikungunya, more eastern equine encephalitis, and more West Nile virus. To extend the original cliché a bit, when it rains in Baltimore, the poor neighborhoods get the wettest.

* Correction, 10/24/19: An earlier version of this story misstated the fungal target of the electrical therapy experiment.

Jonny Hawkins


 

 

Microbes won’t believe this shocking truth!

Pathogens can be tough little critters. Always getting into places they don’t belong, and when they get there, they can be difficult to get rid of, what with their ability to quickly evolve resistance to our best medications. If only there was some shocking new way to tackle those nasty and annoying infections.

alano design/Getty Images

Thanks to some engineers and researchers from the University of Pittsburgh, if you’ve got an infection centered on a metal implant, that shocking new treatment won’t be just a figure of speech. They ran a weak electrical current through metal dental implants infected with recurring Candida albicans infection, which damaged the cell membranes of the offending fungal pathogens but left the healthy tissue around the infection alone. That damage increased the pathogen's permeability, making it more susceptible to antimicrobial treatment.

The treatment, also known as electrochemical therapy, is great if you’ve got a recurrent infection. The dormant pathogens responsible for the recurrence, not normally susceptible to treatment, are affected by antifungals or antibiotics after the shock wakes them up. Even bacteria that have evolved drug resistance become vulnerable again after a session with Dr. Electricity.

Unfortunately, while the therapy could certainly be expanded beyond dental implants, shocking yourself when you’ve got a regular old infection probably won’t work. We know – Watt a disappointment.

Blast from the brewing past

What separates a rich Belgian ale from its paler, mass-produced American competitors? Is it the sudsy je ne sais quoi produced by squabbling Walloons and Flemings debating the fine points of the brewing arts over open tanks? Perhaps it’s the signature warm-fermented ways of Trappist monks? Is it possible les Belges have hired the unemployed Artesians who once made Olympia Beer a household name across the American West?

SerhiiBobyk/Getty Images

Wrong, wrong, and faux. In fact, Belgium’s finest brews are driven by hybrids. Yeast hybrids. Specifically, rare and unusual forms of hybrid yeasts.

Or, as Belgian researcher and world beer hero Dr. Jan Steensels of VIB-KU Leuven Center for Microbiology explains, “Think of lions and tigers making a super-baby.”

Fearlessly, Dr. Steensels and his intrepid colleagues went hunting for these exotic creatures. They found that the yeasts behind many of Belgium’s finest brews combine the DNA of the traditional, domesticated ale yeast, Saccharomyces cerevisiae, with genetic material from wild yeasts such as Saccharomyces kudriavzevii.

The result? The mighty fermentation strengths of normal beer yeasts are paired with the stress resistance and alluring aromas of feral yeasts that survived mankind’s Medieval brewing endeavors and somehow stumbled into the modern brewery for a drink.

Dr. Steensels’ team is now using its knowledge to craft more yeasty lion-tiger super-babies. We at the Bureau of LOTME look forward to hoisting a pint of this “liger” elixir. We’re certain the brew will bear the name of ligers’ greatest cinematic fan, Napoleon Dynamite, and feature the subtle undertones of tater tots.

 

 

How can mosquitoes be even more fun?

If you’re anything like the gang at LOTME, you’ve spent quite a bit of time wondering which cliché is the best fit for a less-affluent Baltimore neighborhood.

DamrongpanThongwat/thinkstock

The answer? When it rains, it pours.

We’ll explain. By definition, a less-affluent neighborhood is, well, less affluent, and that lack of affluence has many health consequences for the people who live in those neighborhoods. Today we’re focusing on everyone’s favorite winged disease vector, the mosquito.

It was already known that low-income urban neighborhoods have more mosquitoes than other neighborhoods, and now the Journal of Medical Entomology has published a survey of 13 residential blocks in Baltimore that shows low-income neighborhoods have larger mosquitoes as well.

Trapping took place in five socioeconomically diverse Baltimore neighborhoods during June and July of 2015-2017. (In case you were wondering, the researchers used BG-Sentinel traps baited with CO2 and a 2.0-mL Octenol Lure, which would have been our choice, too). It confirmed that lower affluence correlated with larger mosquito wing size. Wing size, the investigators said in a written statement, “is an accurate proxy for body size in mosquitoes, and body size influences traits that are important to disease transmission.”

So, it seems that larger mosquitoes are more efficient at transmitting diseases, which means more dengue fever, more Zika, more chikungunya, more eastern equine encephalitis, and more West Nile virus. To extend the original cliché a bit, when it rains in Baltimore, the poor neighborhoods get the wettest.

* Correction, 10/24/19: An earlier version of this story misstated the fungal target of the electrical therapy experiment.

Jonny Hawkins


 

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America’s peas problem and freshly grated tattoos

Article Type
Changed
Fri, 10/25/2019 - 11:44

 

Hold the peas, pass the spiders

There’s an old saying – and by “old,” we mean that we just made it up – in the medical-humor business: When in doubt, find a survey.

Barcin/iStock/Getty Images Plus

Some group is always surveying somebody about something and coming up with a wacky assumption or misguided opinion held by a minority of the respondents. It’s a classic go-to move for the desperate writer.

And look, here’s one now. According to a recent survey conducted by OnePoll for VeggieTracker.com, 83% of Americans like – and this makes us feel oogie just thinking about it – peas. Blecch. Even more amazing? About a quarter of the 2,000 respondents said that they had never even eaten a vegetable. That might explain a good bit of the country’s obesity problem.

And then there’s the survey that OnePoll did for Mattress Advisor, which questioned 2,000 Americans about sleep science and myth. Among the results: 23% believe that an hour of sleep before midnight is worth more than two after, 25% think that sleeping on your left side helps digestion, and 15% said that circadian rhythm was the proper term for the body’s blood flow.

Our favorite, though, was the myth that you swallow eight spiders a year while you sleep. We’ve never heard that one, but 20% of respondents thought it was true.

We’re glad that it’s just a myth, but even spiders would be better than peas.
 

The politics of pretty

It’s an age-old political question: Did a majority of U.S. voters back Martin Van Buren in the 1836 presidential election because he pushed the popular policies of his boss, fellow Democrat Andrew Jackson? Or was it the suave sideburns of Jackson’s stylish vice president that trumped (see what we did there?) the clean-shaven Whig William Henry Harrison?

Robert Daly/OJO Images

The evidence-backed answer: Probably both.

Researchers at the University of Freiburg in Germany conducted two style-or-substance studies to determine how much political advantage a pretty face confers. The first study examined the impact attractive looks and the ability to appear competent riding atop an Abrams tank (ooooh, sorry, Dukakis fans), er, the ability to look competent in photos had in Germany’s 2017 Bundestag elections.

The study’s precise answer: 3.8 percentage points. That’s the polling advantage candidates gained by being judged more attractive than their competitors. Admittedly, the researchers also found it helped to be more than just a pretty face – the unaesthetic quality of relative competence also played a positive role.

The second study took the same approach to U.S. House of Representatives races. In that research beauty contest, America’s aesthetically attuned voters delivered up to an 11-point advantage to the prettiest person.

Now, as anyone will tell you who’s watched congressional TMZ – a.k.a. C-SPAN – beauty in politics is a relative matter. As one of our colleagues noted after visiting the Bureau of LOTME’s Washington hometown and seeing several political stars up close and personal: “Washington is Hollywood for the not so good lookin’.”
 

 

 

Grate idea, or greatest idea?

Tattoo removal is a big part of business for quite a few dermatologists out there. In 2011, more than 100,000 tattoo removal procedures were performed, according to the American Society for Dermatologic Surgery.

JoeGough/iStock/Getty Images Plus

But dermatologists beware, because an Argentinian man may have found a far cheaper method for getting rid of unwanted tattoos, one that would make all those fancy lasers obsolete.

And it all hinges on a humble kitchen utensil: the cheese grater.

The story began when our intrepid hero found out that he wouldn’t be able to work as airport police with a visible tattoo. Simultaneously, he decided that the detail on the week-old tattoo was not up to his standard. So, the man took to the Internet, searching for a cheap way to remove the offending mark. He tried a pumice stone but had no luck. So, next came the cheese grater.

And credit where credit’s due – he did get rid of the tattoo. He washed the wound, applied disinfectant, and everything was good.

Okay, he MAY have required a trip to his local emergency department because he needed a tetanus shot. And while the man isn’t sorry that he did what he did, he wouldn’t recommend the procedure to anyone else.

But consider yourselves on notice, dermatologists. There are always new ways to innovate.

Specimens cartoon for LOTME -- Oct. 17, 2019

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Hold the peas, pass the spiders

There’s an old saying – and by “old,” we mean that we just made it up – in the medical-humor business: When in doubt, find a survey.

Barcin/iStock/Getty Images Plus

Some group is always surveying somebody about something and coming up with a wacky assumption or misguided opinion held by a minority of the respondents. It’s a classic go-to move for the desperate writer.

And look, here’s one now. According to a recent survey conducted by OnePoll for VeggieTracker.com, 83% of Americans like – and this makes us feel oogie just thinking about it – peas. Blecch. Even more amazing? About a quarter of the 2,000 respondents said that they had never even eaten a vegetable. That might explain a good bit of the country’s obesity problem.

And then there’s the survey that OnePoll did for Mattress Advisor, which questioned 2,000 Americans about sleep science and myth. Among the results: 23% believe that an hour of sleep before midnight is worth more than two after, 25% think that sleeping on your left side helps digestion, and 15% said that circadian rhythm was the proper term for the body’s blood flow.

Our favorite, though, was the myth that you swallow eight spiders a year while you sleep. We’ve never heard that one, but 20% of respondents thought it was true.

We’re glad that it’s just a myth, but even spiders would be better than peas.
 

The politics of pretty

It’s an age-old political question: Did a majority of U.S. voters back Martin Van Buren in the 1836 presidential election because he pushed the popular policies of his boss, fellow Democrat Andrew Jackson? Or was it the suave sideburns of Jackson’s stylish vice president that trumped (see what we did there?) the clean-shaven Whig William Henry Harrison?

Robert Daly/OJO Images

The evidence-backed answer: Probably both.

Researchers at the University of Freiburg in Germany conducted two style-or-substance studies to determine how much political advantage a pretty face confers. The first study examined the impact attractive looks and the ability to appear competent riding atop an Abrams tank (ooooh, sorry, Dukakis fans), er, the ability to look competent in photos had in Germany’s 2017 Bundestag elections.

The study’s precise answer: 3.8 percentage points. That’s the polling advantage candidates gained by being judged more attractive than their competitors. Admittedly, the researchers also found it helped to be more than just a pretty face – the unaesthetic quality of relative competence also played a positive role.

The second study took the same approach to U.S. House of Representatives races. In that research beauty contest, America’s aesthetically attuned voters delivered up to an 11-point advantage to the prettiest person.

Now, as anyone will tell you who’s watched congressional TMZ – a.k.a. C-SPAN – beauty in politics is a relative matter. As one of our colleagues noted after visiting the Bureau of LOTME’s Washington hometown and seeing several political stars up close and personal: “Washington is Hollywood for the not so good lookin’.”
 

 

 

Grate idea, or greatest idea?

Tattoo removal is a big part of business for quite a few dermatologists out there. In 2011, more than 100,000 tattoo removal procedures were performed, according to the American Society for Dermatologic Surgery.

JoeGough/iStock/Getty Images Plus

But dermatologists beware, because an Argentinian man may have found a far cheaper method for getting rid of unwanted tattoos, one that would make all those fancy lasers obsolete.

And it all hinges on a humble kitchen utensil: the cheese grater.

The story began when our intrepid hero found out that he wouldn’t be able to work as airport police with a visible tattoo. Simultaneously, he decided that the detail on the week-old tattoo was not up to his standard. So, the man took to the Internet, searching for a cheap way to remove the offending mark. He tried a pumice stone but had no luck. So, next came the cheese grater.

And credit where credit’s due – he did get rid of the tattoo. He washed the wound, applied disinfectant, and everything was good.

Okay, he MAY have required a trip to his local emergency department because he needed a tetanus shot. And while the man isn’t sorry that he did what he did, he wouldn’t recommend the procedure to anyone else.

But consider yourselves on notice, dermatologists. There are always new ways to innovate.

Specimens cartoon for LOTME -- Oct. 17, 2019

 

Hold the peas, pass the spiders

There’s an old saying – and by “old,” we mean that we just made it up – in the medical-humor business: When in doubt, find a survey.

Barcin/iStock/Getty Images Plus

Some group is always surveying somebody about something and coming up with a wacky assumption or misguided opinion held by a minority of the respondents. It’s a classic go-to move for the desperate writer.

And look, here’s one now. According to a recent survey conducted by OnePoll for VeggieTracker.com, 83% of Americans like – and this makes us feel oogie just thinking about it – peas. Blecch. Even more amazing? About a quarter of the 2,000 respondents said that they had never even eaten a vegetable. That might explain a good bit of the country’s obesity problem.

And then there’s the survey that OnePoll did for Mattress Advisor, which questioned 2,000 Americans about sleep science and myth. Among the results: 23% believe that an hour of sleep before midnight is worth more than two after, 25% think that sleeping on your left side helps digestion, and 15% said that circadian rhythm was the proper term for the body’s blood flow.

Our favorite, though, was the myth that you swallow eight spiders a year while you sleep. We’ve never heard that one, but 20% of respondents thought it was true.

We’re glad that it’s just a myth, but even spiders would be better than peas.
 

The politics of pretty

It’s an age-old political question: Did a majority of U.S. voters back Martin Van Buren in the 1836 presidential election because he pushed the popular policies of his boss, fellow Democrat Andrew Jackson? Or was it the suave sideburns of Jackson’s stylish vice president that trumped (see what we did there?) the clean-shaven Whig William Henry Harrison?

Robert Daly/OJO Images

The evidence-backed answer: Probably both.

Researchers at the University of Freiburg in Germany conducted two style-or-substance studies to determine how much political advantage a pretty face confers. The first study examined the impact attractive looks and the ability to appear competent riding atop an Abrams tank (ooooh, sorry, Dukakis fans), er, the ability to look competent in photos had in Germany’s 2017 Bundestag elections.

The study’s precise answer: 3.8 percentage points. That’s the polling advantage candidates gained by being judged more attractive than their competitors. Admittedly, the researchers also found it helped to be more than just a pretty face – the unaesthetic quality of relative competence also played a positive role.

The second study took the same approach to U.S. House of Representatives races. In that research beauty contest, America’s aesthetically attuned voters delivered up to an 11-point advantage to the prettiest person.

Now, as anyone will tell you who’s watched congressional TMZ – a.k.a. C-SPAN – beauty in politics is a relative matter. As one of our colleagues noted after visiting the Bureau of LOTME’s Washington hometown and seeing several political stars up close and personal: “Washington is Hollywood for the not so good lookin’.”
 

 

 

Grate idea, or greatest idea?

Tattoo removal is a big part of business for quite a few dermatologists out there. In 2011, more than 100,000 tattoo removal procedures were performed, according to the American Society for Dermatologic Surgery.

JoeGough/iStock/Getty Images Plus

But dermatologists beware, because an Argentinian man may have found a far cheaper method for getting rid of unwanted tattoos, one that would make all those fancy lasers obsolete.

And it all hinges on a humble kitchen utensil: the cheese grater.

The story began when our intrepid hero found out that he wouldn’t be able to work as airport police with a visible tattoo. Simultaneously, he decided that the detail on the week-old tattoo was not up to his standard. So, the man took to the Internet, searching for a cheap way to remove the offending mark. He tried a pumice stone but had no luck. So, next came the cheese grater.

And credit where credit’s due – he did get rid of the tattoo. He washed the wound, applied disinfectant, and everything was good.

Okay, he MAY have required a trip to his local emergency department because he needed a tetanus shot. And while the man isn’t sorry that he did what he did, he wouldn’t recommend the procedure to anyone else.

But consider yourselves on notice, dermatologists. There are always new ways to innovate.

Specimens cartoon for LOTME -- Oct. 17, 2019

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Printed meat in space and diesel-pattern baldness

Article Type
Changed
Tue, 10/15/2019 - 12:33

 

If at first you don’t succeed …

Kuzmik_A/iStock/Getty Images Plus

Dozens of new drugs are approved every year, but for every promising new medication, there are far more that fail to get past the clinical trial stage. The causes can vary: The drug didn’t do enough, it caused too many adverse events, and so on.

DNA topoisomerase inhibitors have been extensively researched as an anticancer agent, but many examples failed their clinical trials. These molecules are flat and made up of neatly stacked columns of electrically conductive rings, and operate by inserting themselves into DNA to stop replication.

That molecular structure is what interested a team of researchers from the University of Illinois at Urbana-Champaign. In research published in Nature Communications, the researchers noted that DNA topoisomerase inhibitors are structured much like organic semiconductors, but with a bonus. Those columns that make up the molecule are linked by hydrogen bonds, which allow bridges to form across the entire molecule, transforming the entire thing into a semiconductor.

That property, along with their easy printability and their high-specificity interactions with biological material, make the inhibitors an excellent candidate for use in biosensors or biotransistors.

A word to the manufacturer of those topoisomerase inhibitors, though, now that we’ve gotten you all excited again: We doubt you’ll be able to charge as much for the molecule. Semiconductors are hardly as glamorous as treating cancer.
 

Houston, we have a cultivated meat product

Magone/iStock/Getty Images Plus

The Delmonico brothers didn’t do it. Ronald McDonald didn’t do it. Neil Armstrong never even tried. Same goes for Julia Child.

None of these culinary giants or astronauts ever grew beef in space. That honor belongs to Aleph Farms of Rehovot, Israel. The company, a self-proclaimed “global leader in the cultivated meat industry,” collaborated with 3D Bioprinting Solutions of Moscow and others to produce slaughter-free beef in the Russian segment of the International Space Station in September.

The actual process of growing a steak mimics natural “muscle-tissue regeneration occurring inside the cow’s body” and somehow uses a 3-D bioprinter to assemble “a small-scale muscle tissue.” We don’t really understand it, but the scientists and engineers here at LOTME Co. assure us it makes sense.

But why, you may ask, did they do it on the space station? Think of it as a stand-in for New York City. You know … if you can make it there, you can make it anywhere. We’ll let Didier Toubia, cofounder and CEO of Aleph Farms, explain: “In space, we don’t have 10,000 or 15,000 liter (3962.58 gallon) of water available to produce 1 kilogram (2.205 pounds) of beef.” It’s all about sustainable food production.

The next phase of the project, we think, is going to be even more interesting. For a proper fine dining experience in space, they’re going to grow a snooty French waiter to serve cultivated steak to the astronauts.
 

Pollution Hair Club for Men

Chmiel/iStock/Getty Images Plus

By now, most people are well aware that air pollution is linked with cancer. And chronic obstructive pulmonary disease. And asthma. And cardiovascular disease. And Germanic automotive emissions system cheating. Yawn.

 

 

But there’s a newly revealed association sure to make even the most jaded health news consumer’s hair stand on end: Exposure to pollution’s particulate matter is linked to ... hair loss.

Researchers from the Future Science Research Center in South Korea exposed cells from the base of human hair follicles to assorted concentrations of diesel and dust particulates. After 24 hours, the pollutants had suppressed production of beta-catenin, the primary protein crucial to the maintenance of George Clooney’s luxurious mane. And three other proteins supporting hair growth and hair retention also went AWOL in the presence of pollutants. Plus more particulate matter meant fewer hair-restoring proteins.

Diesel particulates and baldness? It all makes so much more sense now. Given the pollutant-rich Big Apple air in which lollipop-loving TV detective Theo Kojak’s smooth pate was steeped, is it any wonder he was famously so follicularly challenged? The Clean Air Act – who loves ya, baby?




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If at first you don’t succeed …

Kuzmik_A/iStock/Getty Images Plus

Dozens of new drugs are approved every year, but for every promising new medication, there are far more that fail to get past the clinical trial stage. The causes can vary: The drug didn’t do enough, it caused too many adverse events, and so on.

DNA topoisomerase inhibitors have been extensively researched as an anticancer agent, but many examples failed their clinical trials. These molecules are flat and made up of neatly stacked columns of electrically conductive rings, and operate by inserting themselves into DNA to stop replication.

That molecular structure is what interested a team of researchers from the University of Illinois at Urbana-Champaign. In research published in Nature Communications, the researchers noted that DNA topoisomerase inhibitors are structured much like organic semiconductors, but with a bonus. Those columns that make up the molecule are linked by hydrogen bonds, which allow bridges to form across the entire molecule, transforming the entire thing into a semiconductor.

That property, along with their easy printability and their high-specificity interactions with biological material, make the inhibitors an excellent candidate for use in biosensors or biotransistors.

A word to the manufacturer of those topoisomerase inhibitors, though, now that we’ve gotten you all excited again: We doubt you’ll be able to charge as much for the molecule. Semiconductors are hardly as glamorous as treating cancer.
 

Houston, we have a cultivated meat product

Magone/iStock/Getty Images Plus

The Delmonico brothers didn’t do it. Ronald McDonald didn’t do it. Neil Armstrong never even tried. Same goes for Julia Child.

None of these culinary giants or astronauts ever grew beef in space. That honor belongs to Aleph Farms of Rehovot, Israel. The company, a self-proclaimed “global leader in the cultivated meat industry,” collaborated with 3D Bioprinting Solutions of Moscow and others to produce slaughter-free beef in the Russian segment of the International Space Station in September.

The actual process of growing a steak mimics natural “muscle-tissue regeneration occurring inside the cow’s body” and somehow uses a 3-D bioprinter to assemble “a small-scale muscle tissue.” We don’t really understand it, but the scientists and engineers here at LOTME Co. assure us it makes sense.

But why, you may ask, did they do it on the space station? Think of it as a stand-in for New York City. You know … if you can make it there, you can make it anywhere. We’ll let Didier Toubia, cofounder and CEO of Aleph Farms, explain: “In space, we don’t have 10,000 or 15,000 liter (3962.58 gallon) of water available to produce 1 kilogram (2.205 pounds) of beef.” It’s all about sustainable food production.

The next phase of the project, we think, is going to be even more interesting. For a proper fine dining experience in space, they’re going to grow a snooty French waiter to serve cultivated steak to the astronauts.
 

Pollution Hair Club for Men

Chmiel/iStock/Getty Images Plus

By now, most people are well aware that air pollution is linked with cancer. And chronic obstructive pulmonary disease. And asthma. And cardiovascular disease. And Germanic automotive emissions system cheating. Yawn.

 

 

But there’s a newly revealed association sure to make even the most jaded health news consumer’s hair stand on end: Exposure to pollution’s particulate matter is linked to ... hair loss.

Researchers from the Future Science Research Center in South Korea exposed cells from the base of human hair follicles to assorted concentrations of diesel and dust particulates. After 24 hours, the pollutants had suppressed production of beta-catenin, the primary protein crucial to the maintenance of George Clooney’s luxurious mane. And three other proteins supporting hair growth and hair retention also went AWOL in the presence of pollutants. Plus more particulate matter meant fewer hair-restoring proteins.

Diesel particulates and baldness? It all makes so much more sense now. Given the pollutant-rich Big Apple air in which lollipop-loving TV detective Theo Kojak’s smooth pate was steeped, is it any wonder he was famously so follicularly challenged? The Clean Air Act – who loves ya, baby?




 

If at first you don’t succeed …

Kuzmik_A/iStock/Getty Images Plus

Dozens of new drugs are approved every year, but for every promising new medication, there are far more that fail to get past the clinical trial stage. The causes can vary: The drug didn’t do enough, it caused too many adverse events, and so on.

DNA topoisomerase inhibitors have been extensively researched as an anticancer agent, but many examples failed their clinical trials. These molecules are flat and made up of neatly stacked columns of electrically conductive rings, and operate by inserting themselves into DNA to stop replication.

That molecular structure is what interested a team of researchers from the University of Illinois at Urbana-Champaign. In research published in Nature Communications, the researchers noted that DNA topoisomerase inhibitors are structured much like organic semiconductors, but with a bonus. Those columns that make up the molecule are linked by hydrogen bonds, which allow bridges to form across the entire molecule, transforming the entire thing into a semiconductor.

That property, along with their easy printability and their high-specificity interactions with biological material, make the inhibitors an excellent candidate for use in biosensors or biotransistors.

A word to the manufacturer of those topoisomerase inhibitors, though, now that we’ve gotten you all excited again: We doubt you’ll be able to charge as much for the molecule. Semiconductors are hardly as glamorous as treating cancer.
 

Houston, we have a cultivated meat product

Magone/iStock/Getty Images Plus

The Delmonico brothers didn’t do it. Ronald McDonald didn’t do it. Neil Armstrong never even tried. Same goes for Julia Child.

None of these culinary giants or astronauts ever grew beef in space. That honor belongs to Aleph Farms of Rehovot, Israel. The company, a self-proclaimed “global leader in the cultivated meat industry,” collaborated with 3D Bioprinting Solutions of Moscow and others to produce slaughter-free beef in the Russian segment of the International Space Station in September.

The actual process of growing a steak mimics natural “muscle-tissue regeneration occurring inside the cow’s body” and somehow uses a 3-D bioprinter to assemble “a small-scale muscle tissue.” We don’t really understand it, but the scientists and engineers here at LOTME Co. assure us it makes sense.

But why, you may ask, did they do it on the space station? Think of it as a stand-in for New York City. You know … if you can make it there, you can make it anywhere. We’ll let Didier Toubia, cofounder and CEO of Aleph Farms, explain: “In space, we don’t have 10,000 or 15,000 liter (3962.58 gallon) of water available to produce 1 kilogram (2.205 pounds) of beef.” It’s all about sustainable food production.

The next phase of the project, we think, is going to be even more interesting. For a proper fine dining experience in space, they’re going to grow a snooty French waiter to serve cultivated steak to the astronauts.
 

Pollution Hair Club for Men

Chmiel/iStock/Getty Images Plus

By now, most people are well aware that air pollution is linked with cancer. And chronic obstructive pulmonary disease. And asthma. And cardiovascular disease. And Germanic automotive emissions system cheating. Yawn.

 

 

But there’s a newly revealed association sure to make even the most jaded health news consumer’s hair stand on end: Exposure to pollution’s particulate matter is linked to ... hair loss.

Researchers from the Future Science Research Center in South Korea exposed cells from the base of human hair follicles to assorted concentrations of diesel and dust particulates. After 24 hours, the pollutants had suppressed production of beta-catenin, the primary protein crucial to the maintenance of George Clooney’s luxurious mane. And three other proteins supporting hair growth and hair retention also went AWOL in the presence of pollutants. Plus more particulate matter meant fewer hair-restoring proteins.

Diesel particulates and baldness? It all makes so much more sense now. Given the pollutant-rich Big Apple air in which lollipop-loving TV detective Theo Kojak’s smooth pate was steeped, is it any wonder he was famously so follicularly challenged? The Clean Air Act – who loves ya, baby?




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Neanderthal otitis media and why you can’t chillax

Article Type
Changed
Thu, 10/03/2019 - 14:47

 

Dude, just chill out and relax ... or not

Smitt/iStock/Getty Images Plus

It’s been a tough week. You’ve struggled to get all your work done on time, you’ve had to put in long hours, you’re exhausted and stressed out, and you know that next week will be just as tough. But for now, it’s the weekend. Time to relax, right?

According to research from Penn State University published in the Journal of Affective Disorders, if you have anxiety disorder, not only will you have difficulty relaxing (hence the anxiety disorder), you may actually actively resist it, experiencing something called “relaxation-induced anxiety.”

The researchers recruited a group of students, some with anxiety disorder, some with major depressive disorder, and a control group, and administered a series of relaxation exercises both before and after watching a series of potentially upsetting videos. The people with anxiety disorders were more likely to experience spikes of negative emotion after the second relaxation exercise than the other two groups; these spikes were linked to a feeling of anxiety during relaxation exercise.

The researchers theorized that people with anxiety disorder were attempting to avoid large jumps in their stress level by remaining stressed at all times. But the investigators also noted that experiencing a range of emotions is natural and far healthier.

So, as annoying as it is to suffer through constant “stop worrying, just live in the moment” speeches from that one dudebro acquaintance who spends all his free time partying, he does have a point. We don’t recommend participating in the Edward Fortyhands game, though. Leave that to your “friend.” He’s used to it.
 

A salty surgeon general’s warning

Sebalos/iStock/Getty Images Plus

Grab a pack of Marlboro Reds at the corner convenience store, and you’ll find the iconic red and white box adorned with dire warnings from the surgeon general.

Grab a salt shaker at the corner diner, and you’ll find ... salt. In a shaker. Perhaps adorned with the red residue from a prior diner’s ketchup addiction.

The World Hypertension League would like to make that salt shaker look a lot more like those Marlboros.

In a position statement in the Journal of Clinical Hypertension, the league outlined the case for giving sodium chloride the cancer-stick treatment. Exhibit A: “Unhealthy diets are a leading cause of death globally, and excess salt consumption is the biggest culprit, estimated to cause over 3 million deaths globally in 2017.”

Despite that tobacco-rivaling body count, the league says no country has demanded that salt containers wear warning labels.

But isn’t it enough to list sodium levels on food labels? Well, when’s the last time you studied the salty facts before binging on that entire party-size bag of Cheetos, Chester? (You’ll be hotboxing 4,500 mg of sodium, by the way.) The league rests its case.

What’s needed is a message that stops you mid fistful. It’s time to add warning labels to all salt packaging, implores the league. Even to that communal salt shaker. Helpfully, the league’s offering suggested wording for that harbinger-of-doom missive: “Excess sodium can cause high blood pressure and promote stomach cancer. Limit your use.”

Catchy, right? But we at the Bureau of LOTME believe a picture is worth a thousand words of warning. Which is why we’ve taped a simple biohazard logo to our office Cheetos stash. Because of the sodium, you ask? Hardly. But just imagine that much optic-orange food coloring finding its way into the groundwater.
 

 

 

The anatomy of extinction

Halamka/iStock/Getty Images Plus

Barely a day goes by without a new theory about What Killed the Dinosaurs. A meteor killed the dinosaurs. Volcanoes killed the dinosaurs. Donald Trump asked the Ukrainians to kill the dinosaurs. Hilary Clinton’s emails killed the dinosaurs. Donald Trump asked the Australians to say that Robert Mueller killed the dinosaurs. The liberal media are covering up the existence of dinosaurs.

Enough already. What about the primates? We humans are still around – at least for the time being. But when was the last time you heard a good theory about what killed the Neanderthals?

Well, hang on to your earmuffs, because here comes one now.

Researchers have reconstructed the Neanderthal Eustachian tubes and determined that those early rivals of Homo sapiens were done in by … chronic ear infections.

The Neanderthal Eustachian tubes were very similar to those of human infants, and “middle ear infections are nearly ubiquitous among infants because the flat angle of an infant’s Eustachian tubes is prone to retain the otitis media bacteria that cause these infections – the same flat angle we found in Neanderthals,” coauthor Samuel Márquez, PhD, of the State University of New York said in a statement.

Unlike modern humans, however, the Neanderthal eustachian tube did not change with age, so middle ear infections were a lifelong threat.

“It’s not just the threat of dying of an infection,” said Dr. Márquez. “If you are constantly ill, you would not be as fit and effective in competing with your Homo sapiens cousins for food and other resources. In a world of survival of the fittest, it is no wonder that modern man, not Neanderthal, prevailed.”

In other words, it wasn’t brains that beat the big, bad Neanderthals; it was their own baby ears.

H. sapiens, raise a glass: Ears to you, Charles Darwin.




 

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Dude, just chill out and relax ... or not

Smitt/iStock/Getty Images Plus

It’s been a tough week. You’ve struggled to get all your work done on time, you’ve had to put in long hours, you’re exhausted and stressed out, and you know that next week will be just as tough. But for now, it’s the weekend. Time to relax, right?

According to research from Penn State University published in the Journal of Affective Disorders, if you have anxiety disorder, not only will you have difficulty relaxing (hence the anxiety disorder), you may actually actively resist it, experiencing something called “relaxation-induced anxiety.”

The researchers recruited a group of students, some with anxiety disorder, some with major depressive disorder, and a control group, and administered a series of relaxation exercises both before and after watching a series of potentially upsetting videos. The people with anxiety disorders were more likely to experience spikes of negative emotion after the second relaxation exercise than the other two groups; these spikes were linked to a feeling of anxiety during relaxation exercise.

The researchers theorized that people with anxiety disorder were attempting to avoid large jumps in their stress level by remaining stressed at all times. But the investigators also noted that experiencing a range of emotions is natural and far healthier.

So, as annoying as it is to suffer through constant “stop worrying, just live in the moment” speeches from that one dudebro acquaintance who spends all his free time partying, he does have a point. We don’t recommend participating in the Edward Fortyhands game, though. Leave that to your “friend.” He’s used to it.
 

A salty surgeon general’s warning

Sebalos/iStock/Getty Images Plus

Grab a pack of Marlboro Reds at the corner convenience store, and you’ll find the iconic red and white box adorned with dire warnings from the surgeon general.

Grab a salt shaker at the corner diner, and you’ll find ... salt. In a shaker. Perhaps adorned with the red residue from a prior diner’s ketchup addiction.

The World Hypertension League would like to make that salt shaker look a lot more like those Marlboros.

In a position statement in the Journal of Clinical Hypertension, the league outlined the case for giving sodium chloride the cancer-stick treatment. Exhibit A: “Unhealthy diets are a leading cause of death globally, and excess salt consumption is the biggest culprit, estimated to cause over 3 million deaths globally in 2017.”

Despite that tobacco-rivaling body count, the league says no country has demanded that salt containers wear warning labels.

But isn’t it enough to list sodium levels on food labels? Well, when’s the last time you studied the salty facts before binging on that entire party-size bag of Cheetos, Chester? (You’ll be hotboxing 4,500 mg of sodium, by the way.) The league rests its case.

What’s needed is a message that stops you mid fistful. It’s time to add warning labels to all salt packaging, implores the league. Even to that communal salt shaker. Helpfully, the league’s offering suggested wording for that harbinger-of-doom missive: “Excess sodium can cause high blood pressure and promote stomach cancer. Limit your use.”

Catchy, right? But we at the Bureau of LOTME believe a picture is worth a thousand words of warning. Which is why we’ve taped a simple biohazard logo to our office Cheetos stash. Because of the sodium, you ask? Hardly. But just imagine that much optic-orange food coloring finding its way into the groundwater.
 

 

 

The anatomy of extinction

Halamka/iStock/Getty Images Plus

Barely a day goes by without a new theory about What Killed the Dinosaurs. A meteor killed the dinosaurs. Volcanoes killed the dinosaurs. Donald Trump asked the Ukrainians to kill the dinosaurs. Hilary Clinton’s emails killed the dinosaurs. Donald Trump asked the Australians to say that Robert Mueller killed the dinosaurs. The liberal media are covering up the existence of dinosaurs.

Enough already. What about the primates? We humans are still around – at least for the time being. But when was the last time you heard a good theory about what killed the Neanderthals?

Well, hang on to your earmuffs, because here comes one now.

Researchers have reconstructed the Neanderthal Eustachian tubes and determined that those early rivals of Homo sapiens were done in by … chronic ear infections.

The Neanderthal Eustachian tubes were very similar to those of human infants, and “middle ear infections are nearly ubiquitous among infants because the flat angle of an infant’s Eustachian tubes is prone to retain the otitis media bacteria that cause these infections – the same flat angle we found in Neanderthals,” coauthor Samuel Márquez, PhD, of the State University of New York said in a statement.

Unlike modern humans, however, the Neanderthal eustachian tube did not change with age, so middle ear infections were a lifelong threat.

“It’s not just the threat of dying of an infection,” said Dr. Márquez. “If you are constantly ill, you would not be as fit and effective in competing with your Homo sapiens cousins for food and other resources. In a world of survival of the fittest, it is no wonder that modern man, not Neanderthal, prevailed.”

In other words, it wasn’t brains that beat the big, bad Neanderthals; it was their own baby ears.

H. sapiens, raise a glass: Ears to you, Charles Darwin.




 

 

Dude, just chill out and relax ... or not

Smitt/iStock/Getty Images Plus

It’s been a tough week. You’ve struggled to get all your work done on time, you’ve had to put in long hours, you’re exhausted and stressed out, and you know that next week will be just as tough. But for now, it’s the weekend. Time to relax, right?

According to research from Penn State University published in the Journal of Affective Disorders, if you have anxiety disorder, not only will you have difficulty relaxing (hence the anxiety disorder), you may actually actively resist it, experiencing something called “relaxation-induced anxiety.”

The researchers recruited a group of students, some with anxiety disorder, some with major depressive disorder, and a control group, and administered a series of relaxation exercises both before and after watching a series of potentially upsetting videos. The people with anxiety disorders were more likely to experience spikes of negative emotion after the second relaxation exercise than the other two groups; these spikes were linked to a feeling of anxiety during relaxation exercise.

The researchers theorized that people with anxiety disorder were attempting to avoid large jumps in their stress level by remaining stressed at all times. But the investigators also noted that experiencing a range of emotions is natural and far healthier.

So, as annoying as it is to suffer through constant “stop worrying, just live in the moment” speeches from that one dudebro acquaintance who spends all his free time partying, he does have a point. We don’t recommend participating in the Edward Fortyhands game, though. Leave that to your “friend.” He’s used to it.
 

A salty surgeon general’s warning

Sebalos/iStock/Getty Images Plus

Grab a pack of Marlboro Reds at the corner convenience store, and you’ll find the iconic red and white box adorned with dire warnings from the surgeon general.

Grab a salt shaker at the corner diner, and you’ll find ... salt. In a shaker. Perhaps adorned with the red residue from a prior diner’s ketchup addiction.

The World Hypertension League would like to make that salt shaker look a lot more like those Marlboros.

In a position statement in the Journal of Clinical Hypertension, the league outlined the case for giving sodium chloride the cancer-stick treatment. Exhibit A: “Unhealthy diets are a leading cause of death globally, and excess salt consumption is the biggest culprit, estimated to cause over 3 million deaths globally in 2017.”

Despite that tobacco-rivaling body count, the league says no country has demanded that salt containers wear warning labels.

But isn’t it enough to list sodium levels on food labels? Well, when’s the last time you studied the salty facts before binging on that entire party-size bag of Cheetos, Chester? (You’ll be hotboxing 4,500 mg of sodium, by the way.) The league rests its case.

What’s needed is a message that stops you mid fistful. It’s time to add warning labels to all salt packaging, implores the league. Even to that communal salt shaker. Helpfully, the league’s offering suggested wording for that harbinger-of-doom missive: “Excess sodium can cause high blood pressure and promote stomach cancer. Limit your use.”

Catchy, right? But we at the Bureau of LOTME believe a picture is worth a thousand words of warning. Which is why we’ve taped a simple biohazard logo to our office Cheetos stash. Because of the sodium, you ask? Hardly. But just imagine that much optic-orange food coloring finding its way into the groundwater.
 

 

 

The anatomy of extinction

Halamka/iStock/Getty Images Plus

Barely a day goes by without a new theory about What Killed the Dinosaurs. A meteor killed the dinosaurs. Volcanoes killed the dinosaurs. Donald Trump asked the Ukrainians to kill the dinosaurs. Hilary Clinton’s emails killed the dinosaurs. Donald Trump asked the Australians to say that Robert Mueller killed the dinosaurs. The liberal media are covering up the existence of dinosaurs.

Enough already. What about the primates? We humans are still around – at least for the time being. But when was the last time you heard a good theory about what killed the Neanderthals?

Well, hang on to your earmuffs, because here comes one now.

Researchers have reconstructed the Neanderthal Eustachian tubes and determined that those early rivals of Homo sapiens were done in by … chronic ear infections.

The Neanderthal Eustachian tubes were very similar to those of human infants, and “middle ear infections are nearly ubiquitous among infants because the flat angle of an infant’s Eustachian tubes is prone to retain the otitis media bacteria that cause these infections – the same flat angle we found in Neanderthals,” coauthor Samuel Márquez, PhD, of the State University of New York said in a statement.

Unlike modern humans, however, the Neanderthal eustachian tube did not change with age, so middle ear infections were a lifelong threat.

“It’s not just the threat of dying of an infection,” said Dr. Márquez. “If you are constantly ill, you would not be as fit and effective in competing with your Homo sapiens cousins for food and other resources. In a world of survival of the fittest, it is no wonder that modern man, not Neanderthal, prevailed.”

In other words, it wasn’t brains that beat the big, bad Neanderthals; it was their own baby ears.

H. sapiens, raise a glass: Ears to you, Charles Darwin.




 

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